A natural toroidal microswimmer with a rotary eukaryotic flagellum.

abstract：:For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica serovar Typhimurium, revealing how a channel forms to allow genome tr...

journal_title：Nature microbiology

authors： Wang C,Tu J,Liu J,Molineux IJ

更新日期：2019-06-01 00:00:00

abstract：:Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...

journal_title：Nature microbiology

authors： Patrono LV,Pléh K,Samuni L,Ulrich M,Röthemeier C,Sachse A,Muschter S,Nitsche A,Couacy-Hymann E,Boesch C,Wittig RM,Calvignac-Spencer S,Leendertz FH

更新日期：2020-07-01 00:00:00

abstract：:The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against pathogens. During infection, NLRP3, which is a pattern recognition r...

journal_title：Nature microbiology

authors： Dufies O,Doye A,Courjon J,Torre C,Michel G,Loubatier C,Jacquel A,Chaintreuil P,Majoor A,Guinamard RR,Gallerand A,Saavedra PHV,Verhoeyen E,Rey A,Marchetti S,Ruimy R,Czerucka D,Lamkanfi M,Py BF,Munro P,Visvikis O,

更新日期：2021-01-11 00:00:00

abstract：:Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...

journal_title：Nature microbiology

authors： Pruneda JN,Bastidas RJ,Bertsoulaki E,Swatek KN,Santhanam B,Clague MJ,Valdivia RH,Urbé S,Komander D

更新日期：2018-12-01 00:00:00

abstract：:The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...

journal_title：Nature microbiology

authors： Wilson ST,Aylward FO,Ribalet F,Barone B,Casey JR,Connell PE,Eppley JM,Ferrón S,Fitzsimmons JN,Hayes CT,Romano AE,Turk-Kubo KA,Vislova A,Armbrust EV,Caron DA,Church MJ,Zehr JP,Karl DM,DeLong EF

更新日期：2017-07-31 00:00:00

abstract：:Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...

journal_title：Nature microbiology

authors： Guo T,Zuo Y,Qian L,Liu J,Yuan Y,Xu K,Miao Y,Feng Q,Chen X,Jin L,Zhang L,Dong C,Xiong S,Zheng H

更新日期：2019-11-01 00:00:00

abstract：:How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...

journal_title：Nature microbiology

authors： Noda-García L,Davidi D,Korenblum E,Elazar A,Putintseva E,Aharoni A,Tawfik DS

更新日期：2019-07-01 00:00:00

abstract：:CRISPR-Cas adaptive immune systems protect bacteria and archaea against their invading genetic parasites, including bacteriophages/viruses and plasmids. In response to this immunity, many phages have anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas targeting. To date, anti-CRISPR genes have primarily been discovered...

journal_title：Nature microbiology

authors： Mahendra C,Christie KA,Osuna BA,Pinilla-Redondo R,Kleinstiver BP,Bondy-Denomy J

更新日期：2020-04-01 00:00:00

abstract：:The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

journal_title：Nature microbiology

authors： Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

更新日期：2018-11-01 00:00:00

abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors：

更新日期：2019-03-01 00:00:00

abstract：:Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...

journal_title：Nature microbiology

authors： Grau KR,Zhu S,Peterson ST,Helm EW,Philip D,Phillips M,Hernandez A,Turula H,Frasse P,Graziano VR,Wilen CB,Wobus CE,Baldridge MT,Karst SM

更新日期：2020-01-01 00:00:00

abstract：:Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...

journal_title：Nature microbiology

authors： Capurro MI,Greenfield LK,Prashar A,Xia S,Abdullah M,Wong H,Zhong XZ,Bertaux-Skeirik N,Chakrabarti J,Siddiqui I,O'Brien C,Dong X,Robinson L,Peek RM Jr,Philpott DJ,Zavros Y,Helmrath M,Jones NL

更新日期：2019-08-01 00:00:00

abstract：:The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...

journal_title：Nature microbiology

authors： Matos RC,Schwarzer M,Gervais H,Courtin P,Joncour P,Gillet B,Ma D,Bulteau AL,Martino ME,Hughes S,Chapot-Chartier MP,Leulier F

更新日期：2017-12-01 00:00:00

abstract：:Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...

journal_title：Nature microbiology

authors： International Committee on Taxonomy of Viruses Executive Committee.

更新日期：2020-05-01 00:00:00

abstract：:Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...

journal_title：Nature microbiology

authors： Mondotte JA,Gausson V,Frangeul L,Blanc H,Lambrechts L,Saleh MC

更新日期：2018-12-01 00:00:00

abstract：:Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...

journal_title：Nature microbiology

authors： Cohen NR,McIlvin MR,Moran DM,Held NA,Saunders JK,Hawco NJ,Brosnahan M,DiTullio GR,Lamborg C,McCrow JP,Dupont CL,Allen AE,Saito MA

更新日期：2021-02-01 00:00:00

abstract：:Despite the sporadic detection of fluoroquinolone-resistant Shigella in Asia in the early 2000s and the subsequent global spread of ciprofloxacin-resistant (cipR) Shigella sonnei from 2010, fluoroquinolones remain the recommended therapy for shigellosis1-7. The potential for cipR S. sonnei to develop resistance to alt...

journal_title：Nature microbiology

authors： Thanh Duy P,Thi Nguyen TN,Vu Thuy D,Chung The H,Alcock F,Boinett C,Dan Thanh HN,Thanh Tuyen H,Thwaites GE,Rabaa MA,Baker S

更新日期：2020-02-01 00:00:00

abstract：:Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to associations between Zika virus infection and a range of fetal maladies(1,2), the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. Asce...

journal_title：Nature microbiology

authors： Perkins TA,Siraj AS,Ruktanonchai CW,Kraemer MU,Tatem AJ

更新日期：2016-07-25 00:00:00

abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

journal_title：Nature microbiology

authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

更新日期：2018-03-01 00:00:00

abstract：:Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...

journal_title：Nature microbiology

authors： Haddock E,Feldmann F,Hawman DW,Zivcec M,Hanley PW,Saturday G,Scott DP,Thomas T,Korva M,Avšič-Županc T,Safronetz D,Feldmann H

更新日期：2018-05-01 00:00:00

abstract：:Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

journal_title：Nature microbiology

authors： Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

更新日期：2016-12-12 00:00:00

abstract：:Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are...

journal_title：Nature microbiology

authors： Mor A,White A,Zhang K,Thompson M,Esparza M,Muñoz-Moreno R,Koide K,Lynch KW,García-Sastre A,Fontoura BM

更新日期：2016-05-27 00:00:00

abstract：:In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

journal_title：Nature microbiology

authors： Gerardin Y,Springer M,Kishony R

更新日期：2016-09-26 00:00:00

abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

journal_title：Nature microbiology

authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

更新日期：2016-11-21 00:00:00

abstract：:Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...

journal_title：Nature microbiology

authors： Luo H,Huang Y,Stepanauskas R,Tang J

更新日期：2017-06-12 00:00:00

abstract：:Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...

journal_title：Nature microbiology

authors： López-Lozano JM,Lawes T,Nebot C,Beyaert A,Bertrand X,Hocquet D,Aldeyab M,Scott M,Conlon-Bingham G,Farren D,Kardos G,Fésűs A,Rodríguez-Baño J,Retamar P,Gonzalo-Jiménez N,Gould IM,THRESHOLDS study group.

更新日期：2019-07-01 00:00:00

abstract：:Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...

journal_title：Nature microbiology

authors： Shen P,Lees JA,Bee GCW,Brown SP,Weiser JN

更新日期：2019-01-01 00:00:00

abstract：:Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...

journal_title：Nature microbiology

authors： Hartl J,Kiefer P,Meyer F,Vorholt JA

更新日期：2017-05-15 00:00:00