Author Correction: Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection.


:An amendment to this paper has been published and can be accessed via a link at the top of the paper.


Nat Microbiol


Nature microbiology


Rowe SE,Wagner NJ,Li L,Beam JE,Wilkinson AD,Radlinski LC,Zhang Q,Miao EA,Conlon BP




Has Abstract


2020-03-01 00:00:00












  • A competitive trade-off limits the selective advantage of increased antibiotic production.

    abstract::In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Gerardin Y,Springer M,Kishony R

    更新日期:2016-09-26 00:00:00

  • Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.

    abstract::Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Huang KA,Rijal P,Jiang H,Wang B,Schimanski L,Dong T,Liu YM,Chang P,Iqbal M,Wang MC,Chen Z,Song R,Huang CC,Yang JH,Qi J,Lin TY,Li A,Powell TJ,Jan JT,Ma C,Gao GF,Shi Y,Townsend AR

    更新日期:2019-02-01 00:00:00

  • Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.

    abstract::Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing cells through the ability of the capsid protein1 to engage the c...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Dharan A,Bachmann N,Talley S,Zwikelmaier V,Campbell EM

    更新日期:2020-09-01 00:00:00

  • Phosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform.

    abstract::Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Bisio H,Lunghi M,Brochet M,Soldati-Favre D

    更新日期:2019-03-01 00:00:00

  • Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity.

    abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Patrono LV,Pléh K,Samuni L,Ulrich M,Röthemeier C,Sachse A,Muschter S,Nitsche A,Couacy-Hymann E,Boesch C,Wittig RM,Calvignac-Spencer S,Leendertz FH

    更新日期:2020-07-01 00:00:00

  • Spermine-mediated tight sealing of the Magnaporthe oryzae appressorial pore-rice leaf surface interface.

    abstract::Cellular adhesion mediates many important plant-microbe interactions. In the devastating blast fungus Magnaporthe oryzae1, powerful glycoprotein-rich mucilage adhesives2 cement melanized and pressurized dome-shaped infection cells-appressoria-to host rice leaf surfaces. Enormous internal turgor pressure is directed on...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Rocha RO,Elowsky C,Pham NTT,Wilson RA

    更新日期:2020-12-01 00:00:00

  • Evolution of host adaptation in the Salmonella typhoid toxin.

    abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

    更新日期:2017-12-01 00:00:00

  • The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.

    abstract::Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Dahl JU,Gray MJ,Bazopoulou D,Beaufay F,Lempart J,Koenigsknecht MJ,Wang Y,Baker JR,Hasler WL,Young VB,Sun D,Jakob U

    更新日期:2017-01-23 00:00:00

  • Co-occurring genomic capacity for anaerobic methane and dissimilatory sulfur metabolisms discovered in the Korarchaeota.

    abstract::Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: McKay LJ,Dlakić M,Fields MW,Delmont TO,Eren AM,Jay ZJ,Klingelsmith KB,Rusch DB,Inskeep WP

    更新日期:2019-04-01 00:00:00

  • Dinoflagellates alter their carbon and nutrient metabolic strategies across environmental gradients in the central Pacific Ocean.

    abstract::Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Cohen NR,McIlvin MR,Moran DM,Held NA,Saunders JK,Hawco NJ,Brosnahan M,DiTullio GR,Lamborg C,McCrow JP,Dupont CL,Allen AE,Saito MA

    更新日期:2021-02-01 00:00:00

  • The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon.

    abstract::Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Grau KR,Zhu S,Peterson ST,Helm EW,Philip D,Phillips M,Hernandez A,Turula H,Frasse P,Graziano VR,Wilen CB,Wobus CE,Baldridge MT,Karst SM

    更新日期:2020-01-01 00:00:00

  • Species-function relationships shape ecological properties of the human gut microbiome.

    abstract::Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic data analysis, we studied species-function relationships in gut microbial genomes and microbiomes. Half of gu...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Vieira-Silva S,Falony G,Darzi Y,Lima-Mendez G,Garcia Yunta R,Okuda S,Vandeputte D,Valles-Colomer M,Hildebrand F,Chaffron S,Raes J

    更新日期:2016-06-13 00:00:00

  • TRIM23 mediates virus-induced autophagy via activation of TBK1.

    abstract::Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Sparrer KMJ,Gableske S,Zurenski MA,Parker ZM,Full F,Baumgart GJ,Kato J,Pacheco-Rodriguez G,Liang C,Pornillos O,Moss J,Vaughan M,Gack MU

    更新日期:2017-11-01 00:00:00

  • A natural toroidal microswimmer with a rotary eukaryotic flagellum.

    abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Hess S,Eme L,Roger AJ,Simpson AGB

    更新日期:2019-10-01 00:00:00

  • Crystal structure of Clostridium difficile toxin A.

    abstract::Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Chumbler NM,Rutherford SA,Zhang Z,Farrow MA,Lisher JP,Farquhar E,Giedroc DP,Spiller BW,Melnyk RA,Lacy DB

    更新日期:2016-01-11 00:00:00

  • Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.

    abstract::Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) ag...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Kim AS,Austin SK,Gardner CL,Zuiani A,Reed DS,Trobaugh DW,Sun C,Basore K,Williamson LE,Crowe JE Jr,Slifka MK,Fremont DH,Klimstra WB,Diamond MS

    更新日期:2019-01-01 00:00:00

  • Probing the metabolic heterogeneity of live Euglena gracilis with stimulated Raman scattering microscopy.

    abstract::Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Eugl...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Wakisaka Y,Suzuki Y,Iwata O,Nakashima A,Ito T,Hirose M,Domon R,Sugawara M,Tsumura N,Watarai H,Shimobaba T,Suzuki K,Goda K,Ozeki Y

    更新日期:2016-08-01 00:00:00

  • SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.

    abstract::Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Xiong X,Wu G,Wei Y,Liu L,Zhang Y,Su R,Jiang X,Li M,Gao H,Tian X,Zhang Y,Hu L,Chen S,Tang Y,Jiang S,Huang R,Li Z,Wang Y,Deng Z,Wang J,Dedon PC,Chen S,Wang L

    更新日期:2020-07-01 00:00:00

  • A cynomolgus macaque model for Crimean-Congo haemorrhagic fever.

    abstract::Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...

    journal_title:Nature microbiology

    pub_type: 信件


    authors: Haddock E,Feldmann F,Hawman DW,Zivcec M,Hanley PW,Saturday G,Scott DP,Thomas T,Korva M,Avšič-Županc T,Safronetz D,Feldmann H

    更新日期:2018-05-01 00:00:00

  • Transcriptional regulation by σ factor phosphorylation in bacteria.

    abstract::A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Iyer SC,Casas-Pastor D,Kraus D,Mann P,Schirner K,Glatter T,Fritz G,Ringgaard S

    更新日期:2020-03-01 00:00:00

  • Methods for phylogenetic analysis of microbiome data.

    abstract::How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...

    journal_title:Nature microbiology

    pub_type: 杂志文章,评审


    authors: Washburne AD,Morton JT,Sanders J,McDonald D,Zhu Q,Oliverio AM,Knight R

    更新日期:2018-06-01 00:00:00

  • Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB.

    abstract::The IncC family of broad-host-range plasmids enables the spread of antibiotic resistance genes among human enteric pathogens1-3. Although aspects of IncC plasmid conjugation have been well studied4-9, many roles of conjugation genes have been assigned based solely on sequence similarity. We applied hypersaturated tran...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Hancock SJ,Phan MD,Luo Z,Lo AW,Peters KM,Nhu NTK,Forde BM,Whitfield J,Yang J,Strugnell RA,Paterson DL,Walsh TR,Kobe B,Beatson SA,Schembri MA

    更新日期:2020-11-01 00:00:00

  • Growth control switch by a DNA-damage-inducible toxin-antitoxin system in Caulobacter crescentus.

    abstract::Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Kirkpatrick CL,Martins D,Redder P,Frandi A,Mignolet J,Chapalay JB,Chambon M,Turcatti G,Viollier PH

    更新日期:2016-02-22 00:00:00

  • Exaggerated headline shock.

    abstract:: ...

    journal_title:Nature microbiology

    pub_type: 社论



    更新日期:2019-03-01 00:00:00

  • Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.

    abstract::Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Nakamoto N,Sasaki N,Aoki R,Miyamoto K,Suda W,Teratani T,Suzuki T,Koda Y,Chu PS,Taniki N,Yamaguchi A,Kanamori M,Kamada N,Hattori M,Ashida H,Sakamoto M,Atarashi K,Narushima S,Yoshimura A,Honda K,Sato T,Kanai T

    更新日期:2019-03-01 00:00:00

  • Mini viral RNAs act as innate immune agonists during influenza virus infection.

    abstract::The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

    journal_title:Nature microbiology

    pub_type: 信件


    authors: Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

    更新日期:2018-11-01 00:00:00

  • Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature microbiology

    pub_type: 已发布勘误


    authors: Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

    更新日期:2019-11-01 00:00:00

  • A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation.

    abstract::Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

    更新日期:2018-11-01 00:00:00

  • Modulation of membrane phosphoinositide dynamics by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector.

    abstract::Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

    更新日期:2016-12-12 00:00:00

  • Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.

    abstract::CRISPR-Cas adaptive immune systems protect bacteria and archaea against their invading genetic parasites, including bacteriophages/viruses and plasmids. In response to this immunity, many phages have anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas targeting. To date, anti-CRISPR genes have primarily been discovered...

    journal_title:Nature microbiology

    pub_type: 杂志文章


    authors: Mahendra C,Christie KA,Osuna BA,Pinilla-Redondo R,Kleinstiver BP,Bondy-Denomy J

    更新日期:2020-04-01 00:00:00