Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Rowe SE,Wagner NJ,Li L,Beam JE,Wilkinson AD,Radlinski LC,Zhang Q,Miao EA,Conlon BPdoi
10.1038/s41564-020-0679-zsubject
Has Abstractpub_date
2020-03-01 00:00:00pages
526issue
3issn
2058-5276pii
10.1038/s41564-020-0679-zjournal_volume
5pub_type
已发布勘误abstract::Leishmania are ancient eukaryotes that have retained the exosome pathway through evolution. Leishmania RNA virus 1 (LRV1)-infected Leishmania species are associated with a particularly aggressive mucocutaneous disease triggered in response to the double-stranded RNA (dsRNA) virus. However, it is unclear how LRV1 is ex...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0352-y
更新日期:2019-04-01 00:00:00
abstract::Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.9
更新日期:2017-02-13 00:00:00
abstract::Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0256-x
更新日期:2018-12-01 00:00:00
abstract::Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0441-6
更新日期:2019-08-01 00:00:00
abstract::Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.267
更新日期:2017-01-23 00:00:00
abstract::Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0602-7
更新日期:2020-01-01 00:00:00
abstract::Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0410-0
更新日期:2019-07-01 00:00:00
abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0706-0
更新日期:2020-07-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0333-1
更新日期:2019-03-01 00:00:00
abstract::How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0412-y
更新日期:2019-07-01 00:00:00
abstract::Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/nmicrobiol.2016.150
更新日期:2016-09-05 00:00:00
abstract::The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-017-0070-x
更新日期:2017-12-01 00:00:00
abstract::Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0428-3
更新日期:2019-11-01 00:00:00
abstract::Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.2
更新日期:2016-01-11 00:00:00
abstract::The dysregulation of intestinal microbial communities is associated with inflammatory bowel diseases (IBD). Studies aimed at understanding the contribution of the microbiota to inflammatory diseases have primarily focused on bacteria, yet the intestine harbours a viral component dominated by prokaryotic viruses known ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0210-y
更新日期:2018-09-01 00:00:00
abstract:: ...
journal_title:Nature microbiology
pub_type: 社论
doi:10.1038/s41564-018-0320-6
更新日期:2018-12-01 00:00:00
abstract::In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.154
更新日期:2016-08-15 00:00:00
abstract::Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-020-0709-x
更新日期:2020-05-01 00:00:00
abstract::Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0271-y
更新日期:2018-12-01 00:00:00
abstract::Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0300-x
更新日期:2019-02-01 00:00:00
abstract::Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0496-4
更新日期:2019-09-01 00:00:00
abstract::Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/s41564-018-0141-7
更新日期:2018-05-01 00:00:00
abstract::The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene si...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.274
更新日期:2017-02-06 00:00:00
abstract::The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/s41564-018-0240-5
更新日期:2018-11-01 00:00:00
abstract::Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0314-4
更新日期:2019-01-01 00:00:00
abstract::The evolution of antibiotic resistance is a major threat to society and has been predicted to lead to 10 million casualties annually by 2050(1). Further aggravating the problem, multidrug tolerance in bacteria not only relies on the build-up of resistance mutations, but also on some cells epigenetically switching to a...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.20
更新日期:2016-03-07 00:00:00
abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0033-2
更新日期:2017-12-01 00:00:00
abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0478-6
更新日期:2019-10-01 00:00:00
abstract::The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.118
更新日期:2017-07-31 00:00:00
abstract::Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, ...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/nmicrobiol.2017.8
更新日期:2017-02-22 00:00:00