Abstract：
BACKGROUND:This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical diagnosis and management. This methodology employs a simple waveform contour analysis approach to compare aortic, femoral and central venous pressure waveforms on a beat-by-beat basis and extract lumped metrics pertaining to the pressure drop and pressure-pulse amplitude attenuation as blood passes through the various sections of systemic circulation. RESULTS:Validation encompasses a comparison between novel metrics and well-known, analogous clinical metrics such as mean arterial and venous pressures, across an animal model of induced sepsis. The novel metric Ofe → vc, the direct pressure offset between the femoral artery and vena cava, and the clinical metric, ΔMP, the difference between mean arterial and venous pressure, performed well. However, Ofe → vc reduced the optimal average time to sepsis detection after endotoxin infusion from 46.2 min for ΔMP to 11.6 min, for a slight increase in false positive rate from 1.8 to 6.2%. Thus, the novel Ofe → vc provided the best combination of specificity and sensitivity, assuming an equal weighting to both, of the metrics assessed. CONCLUSIONS:Overall, the potential of these novel metrics in the detection of diagnostic shifts in physiological behaviour, here driven by sepsis, is demonstrated.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Davidson S,Pretty C,Balmer J,Desaive T,Chase JGdoi
10.1186/s12938-018-0603-4subject
Has Abstractpub_date
2018-11-20 00:00:00pages
171issue
1issn
1475-925Xpii
10.1186/s12938-018-0603-4journal_volume
17pub_type
杂志文章abstract：BACKGROUND:This study investigates CAD/CAM ceramic cusp-replacing restoration resistance with and without buccal cusp replacement under static and dynamic cyclic loads, monitored using the acoustic emission (AE) technique. METHOD:The cavity was designed in a typical MODP (mesial-occlusal-distal-palatal) restoration fa...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-165
更新日期：2014-12-13 00:00:00
abstract：PURPOSE:Coronary artery bypass graft (CABG) surgery represents the standard treatment of advanced coronary artery disease. Two major types of anastomosis exist to connect the graft to the coronary artery, i.e., by using an end-to-side or a side-to-side anastomosis. There is still controversy because of the differences ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-6-35
更新日期：2007-09-26 00:00:00
abstract：BACKGROUND:In order to characterize the intracranial pressure-volume reserve capacity, the correlation coefficient (R) between the ICP wave amplitude (A) and the mean ICP level (P), the RAP index, has been used to improve the diagnostic value of ICP monitoring. Baseline pressure errors (BPEs), caused by spontaneous shi...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-99
更新日期：2014-07-23 00:00:00
abstract：BACKGROUND:Xenogeneic bone has been widely used in a variety of clinical bone-related disease to promote bone healing and restore bone defects. However, the adverse effects of immune system limit its application in the clinic. The aim of this study was to evaluate xenogeneic bone safety of immunotoxicity and explore th...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-019-0729-z
更新日期：2019-11-14 00:00:00
abstract：BACKGROUND:Biomedical named entity recognition (Bio-NER) is a fundamental task in handling biomedical text terms, such as RNA, protein, cell type, cell line, and DNA. Bio-NER is one of the most elementary and core tasks in biomedical knowledge discovery from texts. The system described here is developed by using the Bi...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-018-0573-6
更新日期：2018-11-06 00:00:00
abstract：BACKGROUND:A computational model of myocardial energy metabolism was used to assess the metabolic responses to normal and reduced myocardial blood flow. The goal was to examine to what extent glycolysis and lactate formation are controlled by the supply of glycolytic substrate and/or the cellular redox (NADH/NAD+) and ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-3-15
更新日期：2004-06-02 00:00:00
abstract：BACKGROUND:Segmentation is the most crucial part in the computer-aided bone age assessment. A well-known type of segmentation performed in the system is adaptive segmentation. While providing better result than global thresholding method, the adaptive segmentation produces a lot of unwanted noise that could affect the ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-10-87
更新日期：2011-09-28 00:00:00
abstract：BACKGROUND:Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, and increased "breathiness". Modelling and surrogate data studies have s...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-6-23
更新日期：2007-06-26 00:00:00
abstract：BACKGROUND:Falls can cause trauma, disability and death among older people. Ambulatory accelerometer devices are currently capable of detecting falls in a controlled environment. However, research suggests that most current approaches can tend to have insufficient sensitivity and specificity in non-laboratory environme...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-11-9
更新日期：2012-02-16 00:00:00
abstract：BACKGROUND:Perfluorocarbon (PFC) vapour in the expired gases during partial liquid ventilation should be prevented from entering the atmosphere and recovered for potential reuse. This study aimed to determine how much PFC liquid could be recovered using a conventional humidified neonatal ventilator with chilled condens...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-6-19
更新日期：2007-05-31 00:00:00
abstract：BACKGROUND:Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-14-S1-S4
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:In magnetic resonance electrical impedance tomography (MREIT), we reconstruct conductivity images using magnetic flux density data induced by externally injected currents. Since we extract magnetic flux density data from acquired MR phase images, the amount of measurement noise increases in regions of weak M...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-87
更新日期：2014-06-26 00:00:00
abstract：BACKGROUND:A valveless pump generates a unidirectional net flow of fluid around a closed loop of soft viscoelastic tubing that is rhythmically compressed at one point. The tubing must have at least two sections with two different stiffnesses. When a short segment of the tube is squeezed asymmetrically at certain freque...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-9-42
更新日期：2010-08-31 00:00:00
abstract：BACKGROUND:Endovascular intervention using a stent is a mainstream treatment for cerebral aneurysms. To assess the effect of intervention strategies on aneurysm hemodynamics, we have developed a fast virtual stenting (FVS) technique to simulate stent deployment in patient-specific aneurysms. However, quantitative valid...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0250-6
更新日期：2016-12-28 00:00:00
abstract：BACKGROUND:Concerns about the cost-effectiveness of invasive hemodynamic monitoring in critically ill patients using pulmonary artery catheters motivate a renewed search for effective noninvasive methods to measure stroke volume. This paper explores a new approach based on noninvasively measured pulse wave velocity, pu...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-137
更新日期：2014-09-19 00:00:00
abstract：OBJECTIVES:To compare traditional plaster casts, digital models and 3D printed copies of dental plaster casts based on various criteria. To determine whether 3D printed copies obtained using open source system RepRap can replace traditional plaster casts in dental practice. To compare and contrast the qualities of two ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-12-49
更新日期：2013-05-31 00:00:00
abstract：BACKGROUND:State-of-the-art signal processing methods are known to detect information in single-trial event-related EEG data, a crucial aspect in development of real-time applications such as brain computer interfaces. This paper investigates one such novel approach, evaluating how individual classifier and feature sub...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-6-32
更新日期：2007-08-23 00:00:00
abstract：BACKGROUND:Retina degenerative disorders represent the primary cause of blindness in UK and in the developed world. In particular, Age Related Macular Degeneration (AMD) and Retina Pigmentosa (RP) diseases are of interest to this study. We have therefore created new image processing algorithms for enhancing the visual ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-9-27
更新日期：2010-06-18 00:00:00
abstract：BACKGROUND AND AIMS:People with internet addiction (IA) suffer from mental, physical, social, and occupational problems. IA includes psychological and physiological syndromes, and among the syndromes, emotion was suggested important mental and physiological expressions of IA. However, few physiologically emotional char...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0201-2
更新日期：2016-07-04 00:00:00
abstract：BACKGROUND:Surface electromyographic (S-EMG) signal processing has been emerging in the past few years due to its non-invasive assessment of muscle function and structure and because of the fast growing rate of digital technology which brings about new solutions and applications. Factors such as sampling rate, quantiza...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-22
更新日期：2014-02-27 00:00:00
abstract：BACKGROUND:Shape of the dental root canal is highly patient specific. Automated identification methods of the medial line of dental root canals and the reproduction of their 3D shape can be beneficial for planning endodontic interventions as severely curved root canals or multi-rooted teeth may pose treatment challenge...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-11-81
更新日期：2012-10-29 00:00:00
abstract：BACKGROUND:Studies found that treatment symptoms of concern to oncology/hematology patients were greatly under-identified in medical records. On average, 11.0 symptoms were reported of concern to patients compared to 1.5 symptoms identified in their medical records. A solution to this problem is use of an electronic sy...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-14-S2-S1
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as ...
journal_title：Biomedical engineering online
pub_type： 杂志文章,评审
doi：10.1186/s12938-019-0636-3
更新日期：2019-02-13 00:00:00
abstract：:Radiofrequency ablation is an interventional technique that in recent years has come to be employed in very different medical fields, such as the elimination of cardiac arrhythmias or the destruction of tumors in different locations. In order to investigate and develop new techniques, and also to improve those current...
journal_title：Biomedical engineering online
pub_type： 杂志文章,评审
doi：10.1186/1475-925X-5-24
更新日期：2006-04-18 00:00:00
abstract：BACKGROUND:The structure of the anatomical surfaces, e.g., CSF and gray and white matter, could severely influence the flow of volume currents in a head model. This, in turn, will also influence the scalp potentials and the inverse source localizations. This was examined in detail with four different human head models....
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-5-10
更新日期：2006-02-08 00:00:00
abstract：BACKGROUND:Since hemodynamics plays a key role in the development and evolution of cardiovascular pathologies, physician's decision must be based on proper monitoring of relevant physiological flow quantities. METHODS:A numerical analysis of the error introduced by an intravascular Doppler guide wire on the peak veloc...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0234-6
更新日期：2016-10-10 00:00:00
abstract：BACKGROUND:Heart rate can be used to prescribe exercise intensity for development and maintenance of cardiorespiratory fitness. The aim of this study was to identify the dynamics of heart rate response during moderate-to-vigorous treadmill exercise and to explore parameter dependencies with respect to time, intensity l...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-015-0112-7
更新日期：2015-12-21 00:00:00
abstract：BACKGROUND:The emergence and development of robot assistant interventional vascular surgery technologies have benefited many patients with cardiovascular or cerebrovascular diseases. Due to the absence of effective training measures, these new advanced technologies have not been fully utilized and only few experienced ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0148-3
更新日期：2016-04-06 00:00:00
abstract：BACKGROUND:Electrical impedance tomography (EIT) has been used for functional lung imaging of regional air distributions during mechanical ventilation in intensive care units (ICU). From numerous clinical and animal studies focusing on specific lung functions, a consensus about how to use the EIT technique has been for...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-019-0701-y
更新日期：2019-07-25 00:00:00
abstract：BACKGROUND:Magneto-acoustic tomography with current injection involves using electrical impedance imaging technology. To explore the potential applications in imaging biological tissue and enhance image quality, a new scan mode for the transducer is proposed that is based on translational and circular scanning to recor...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0125-x
更新日期：2016-01-27 00:00:00
