Serotonin in retina.

abstract：:TP53 is mutated in most types of human cancers and is one of the most popular genes in cancer research. The p53 protein is a sensor of multiple forms of genotoxic, oncogenic and non-genotoxic stress. It suppresses growth and controls survival of stressed cells, and as such, is the focal point of selection pressures in...

journal_title：Biochimie

authors： Guimaraes DP,Hainaut P

更新日期：2002-01-01 00:00:00

abstract：:We present an approach for designing a knowledge-based system, called Sequence Acquisition In Context (SAIC), that will be able to cooperate with a biologist in the analysis of DNA sequences. The main task of the system is the acquisition of the expert knowledge that the biologist uses for solving ambiguities from gel...

journal_title：Biochimie

authors： Brézillon PJ,Zaraté P,Saci F

更新日期：1993-01-01 00:00:00

abstract：:The metabolism of the phospholipids of the submaxillary gland are studied after intraperitoneal injections of [32P]-orthophosphate in several groups of rats. The gland contains mainly phosphatidylcholines and phosphatidylethanolamines and in smaller quantities phosphatidylinositols, phosphatidylserines, sphingomyelins...

journal_title：Biochimie

authors： Leclercq C,Di Costanzo G

更新日期：1976-01-01 00:00:00

abstract：:Phospholipid metabolism of 3T3 mouse fibroblasts has been studied after serum stimulation of arrested cells. The study of [32Pi] incorporation shows : a) in the case of PE and PC an early peak of incorporation in the G1 phase of the cell cycle, 6 hours after serum addition; b) in the case of PI an intense initial incr...

journal_title：Biochimie

authors： Dubois C,Rampini C

更新日期：1978-01-01 00:00:00

abstract：:After exhaustive pronase digestion, purification by gel filtration and affinity chromatography on concanavalin A, three glycopeptide fractions were obtained from rat hemopexin. Two fractions (I and II) were concanavalin A non-reactive and one (III) was concanavalin A reactive. On the basis of carbohydrate composition,...

journal_title：Biochimie

authors： Bernard N,Lombart C,Strecker G,Montreuil J,Van Halbeek H,Vliegenthart JF

更新日期：1983-03-01 00:00:00

abstract：:IbpA/B, 16 kDa heat-shock proteins were recently described as recognizing heterologous protein inclusion bodies in Escherichia coli cells; the corresponding genes formed an operon regulated by the rpoH gene product, sigma 32 protein (Burland et al (1993) Genomics 16, 551; Allen et al (1992) J Bacteriol 174, 6938; Chua...

journal_title：Biochimie

authors： Laskowska E,Wawrzynów A,Taylor A

更新日期：1996-01-01 00:00:00

abstract：:Human prophospholipase A2 was purified from pancreatic juice. The protein has a molecular weight of 14500 and a free N-terminal residue identified as aspartic acid (or asparagine). The amino acid composition was determined. Partial immunological identity has been obtained between human and porcine prophospholipase A2....

journal_title：Biochimie

authors： Grataroli R,De Caro A,Guy O,Amic J,Figarella C

更新日期：1981-08-01 00:00:00

abstract：:The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that "...

journal_title：Biochimie

authors： Selhub J,Rosenberg IH

更新日期：2016-07-01 00:00:00

abstract：:Plasmalogens (Pls) represent a specific subclass of glycerophospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position of glycerol. Pls are quantitatively important in membranes of neuronal tissues, including the brain and the retina, where they can represent until almost two-third of ethano...

journal_title：Biochimie

authors： Saab S,Mazzocco J,Creuzot-Garcher CP,Bron AM,Bretillon L,Acar N

更新日期：2014-12-01 00:00:00

abstract：:GABARAPL1 belongs to the small family of GABARAP proteins (including GABARAP, GABARAPL1 and GABARAPL2/GATE-16), one of the two subfamilies of the yeast Atg8 orthologue. GABARAPL1 is involved in the intracellular transport of receptors, via an interaction with tubulin and GABA(A) or kappa opioid receptors, and also par...

journal_title：Biochimie

authors： Seguin-Py S,Lucchi G,Croizier S,Chakrama FZ,Despouy G,Le Grand JN,Ducoroy P,Boireau W,Boyer-Guittaut M,Jouvenot M,Fraichard A,Delage-Mourroux R

更新日期：2012-03-01 00:00:00

abstract：:The synthesis of holocytochromes in plastids is a catalyzed process. Several proteins, including plastid CcsA, Ccs1, possibly CcdA and a thioredoxin, plus at least two additional Ccs factors, are required in sub-stoichiometric amounts for the conversion of apocytochromes f and c(6) to their respective holoforms. CcsA,...

journal_title：Biochimie

authors： Nakamoto SS,Hamel P,Merchant S

更新日期：2000-06-01 00:00:00

abstract：:Although believed to be widely distributed among the animal kingdom, transforming growth factor-beta (TGF-beta) superfamily members have mainly been characterized in vertebrate and in invertebrate model organisms such as Drosophila and C. elegans. To characterize such new factors in invertebrates, a PCR screen was per...

journal_title：Biochimie

authors： Lelong C,Mathieu M,Favrel P

更新日期：2001-05-01 00:00:00

abstract：:We have studied the kinetics of erythromycin inhibition of translation in growing bacteria. In order to simplify the interpretation of our data, we have used a mutant (envA), known to have an increased permeability to several antibiotics, including erythromycin. The data clearly show that an initial stage of translati...

journal_title：Biochimie

authors： Andersson S,Kurland CG

更新日期：1987-08-01 00:00:00

abstract：:The nuclear metabolism of poly(ADP-ribose) is mainly regulated by poly(ADP-ribose) polymerase-1 (PARP-1) and by poly(ADP-ribose) glycohydrolase (PARG). A PARP-like enzyme, V-PARP, and a PARG isoform are present in the extra-nuclear compartment of mammalian cells, even if poly(ADP-ribose) has never been detected therei...

journal_title：Biochimie

authors： Rossi L,Denegri M,Torti M,Poirier GG,Ivana Scovassi A

更新日期：2002-12-01 00:00:00

abstract：:All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface rece...

journal_title：Biochimie

authors： Kirk CJ,Guillon G,Balestre MN,Creba JA,Michell RH,Jard S

更新日期：1985-10-01 00:00:00

abstract：:GcvB is a non-coding RNA that regulates oppA mRNA in different bacterial species by binding a GcvB GU-rich region named R1 to oppA mRNA. A secondary putative interaction site (PS1) was identified in this study that is able to form a second nearly perfect 10 base-pair duplex between these two RNAs in Escherichia coli. ...

journal_title：Biochimie

authors： Busi F,Le Derout J,Cerciat M,Régnier P,Hajnsdorf E

更新日期：2010-10-01 00:00:00

abstract：:Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. ATX is secreted by adipocytes and contributes to circulating LPA. ATX expression is ...

journal_title：Biochimie

authors： Rancoule C,Dusaulcy R,Tréguer K,Grès S,Attané C,Saulnier-Blache JS

更新日期：2014-01-01 00:00:00

abstract：:The considerable affinity of tissue transglutaminase for heparin was the basis for use of heparin-based affinity matrices for enzyme purification. Interaction of transglutaminase with heparin might mimic the physiological binding to membrane heparan sulfates, accounting for the limited but significant fraction of enzy...

journal_title：Biochimie

authors： Gambetti S,Dondi A,Cervellati C,Squerzanti M,Pansini FS,Bergamini CM

更新日期：2005-06-01 00:00:00

abstract：:LamB, an integral outer membrane protein of E coli K12, is highly resistant to protease digestion. We had previously genetically inserted a foreign sequence corresponding to an epitope from the poliovirus next to amino acids 146, 153, 189, and 374 of LamB. In 3 cases (sites 146, 153, 374), insertion of the foreign pep...

journal_title：Biochimie

authors： Ronco J,Charbit A,Hofnung M

更新日期：1990-02-01 00:00:00

abstract：:The interactions between lactic acid bacteria and their phages are commercially significant. Current research has focused on the elucidation of the mechanisms and genetics of phage resistance. Phage resistance genes have been linked to plasmid DNA for Streptococcus lactis and Streptococcus cremoris, and preliminary st...

journal_title：Biochimie

authors： Sanders ME

更新日期：1988-03-01 00:00:00

abstract：:The poisonous bite by Hippasa partita, a funnel web spider from the Indian subcontinent has been demonstrated to give rise to severe dermo- and myonecrosis. In this work a hemorrhagic metalloprotease, Partitagin was purified from H. partita venom by successive chromatography on Sephadex G-100, DEAE Sephadex A-50 and B...

journal_title：Biochimie

authors： Nagaraju S,Girish KS,Fox JW,Kemparaju K

更新日期：2007-11-01 00:00:00

abstract：:Due to their function as adapters in translation, tRNA molecules share a common structural organization in all kingdoms and organelles with ribosomal protein biosynthesis. A typical tRNA has a cloverleaf-like secondary structure, consisting of acceptor stem, D-arm, anticodon arm, a variable region, and T-arm, with an ...

journal_title：Biochimie

authors： Wende S,Platzer EG,Jühling F,Pütz J,Florentz C,Stadler PF,Mörl M

更新日期：2014-05-01 00:00:00

abstract：:Theoretical and experimental investigations on the conformations of synthetic polytripeptides, with Gly-R2-R3 general repetitive sequence, are of great interest for the comprehension of the factors which contribute to the triple helix stabilization. Using appropriate molecules as models, we have investigated by the PC...

journal_title：Biochimie

authors： Cabrol D,Broch H,Vasilescu D

更新日期：1981-11-01 00:00:00

abstract：:Botulinum neurotoxins (BoNT, serotypes A-G) and tetanus neurotoxin (TeNT) are bacterial proteins that comprise a light chain (M(r) approximately 50) disulfide linked to a heavy chain (M(r) approximately 100). By inhibiting neurotransmitter release at distinct synapses, these toxins cause two severe neuroparalytic dise...

journal_title：Biochimie

authors： Humeau Y,Doussau F,Grant NJ,Poulain B

更新日期：2000-05-01 00:00:00

abstract：:The presence of marker genes encoding antibiotic or herbicide resistances in genetically modified plants poses a number of problems. Various techniques are under development for the removal of unwanted marker genes, while leaving required transgenes in place. The aim of this brief review is to describe the principal m...

journal_title：Biochimie

authors： Scutt CP,Zubko E,Meyer P

更新日期：2002-11-01 00:00:00

abstract：:Glyoxalate is an effector of oxidative phosphorylation in isolated mitochondria : it slows down State 3 but does not affect State 4 respiration. This report presents the findings of our study on the mechanism of action of glyoxalate ; these findings are listed below. The inhibition of Stage 3 respiration by glyoxalate...

journal_title：Biochimie

authors： Lucas M,Pons AM

更新日期：1975-01-01 00:00:00

abstract：:Azelaic acid (AzA), a C9 linear α,ω-dicarboxylic acid, is found in whole grains namely wheat, rye, barley, oat seeds and sorghum. The study was performed to investigate whether AzA exerts beneficial effect on hepatic key enzymes of carbohydrate metabolism in high fat diet (HFD) induced type 2 diabetic C57BL/6J mice. C...

journal_title：Biochimie

authors： Muthulakshmi S,Saravanan R

更新日期：2013-06-01 00:00:00

abstract：:Rat kidney acylase I was characterised by performing site-directed mutagenesis and enzymatic analysis in the presence of various chemical inhibitors. Site-directed mutagenesis on E147 and overexpression of the protein in a bacterial system, revealed the importance of this residue in enzymatic activity, it corresponds ...

journal_title：Biochimie

authors： Durand A,Giardina T,Villard C,Roussel A,Puigserver A,Perrier J

更新日期：2003-10-01 00:00:00

abstract：:The conformation of perch parvalbumin in the Ca-, Mg- and metal-free state was studied by intrinsic fluorescence, trypsin susceptibility, thiol titration and circular dichroism. The data reveal that Ca-parvalbumin has a more compact structure than the metal-free protein, with a high alpha-helical content and a buried ...

journal_title：Biochimie

authors： Cox JA,Winge DR,Stein EA

更新日期：1979-01-01 00:00:00

abstract：:It has been shown that two Proteus morganii strains produce an inducible cephalosporinase. No significative difference was shown between them: they present the same isoelectric poit: 8,3 and very similar kinetic constants. The parameter tau, proportional to the half life of antibiotic at low concentration, in presence...

journal_title：Biochimie

authors： Labia R,Guionie M,Fabre C

更新日期：1976-11-13 00:00:00