Abstract：
:Although believed to be widely distributed among the animal kingdom, transforming growth factor-beta (TGF-beta) superfamily members have mainly been characterized in vertebrate and in invertebrate model organisms such as Drosophila and C. elegans. To characterize such new factors in invertebrates, a PCR screen was performed on genomic DNA from different animal phyla, using degenerate primers deduced from consensus sequences of known members of the TGF-beta superfamily. Four new members were identified from a cnidaria, an echinoderm and from two classes of molluscs. These new proteins exhibit a high degree of identity with human bone morphogenetic proteins (BMP2/4). Sequence comparisons suggest an early origin and an evolutionary conservation of the molecular conformation. However, their possible involvement in distinct regulatory pathways is discussed.
journal_name
Biochimiejournal_title
Biochimieauthors
Lelong C,Mathieu M,Favrel Pdoi
10.1016/s0300-9084(01)01260-3keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
423-6issue
5eissn
0300-9084issn
1638-6183pii
S0300-9084(01)01260-3journal_volume
83pub_type
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