Abstract:
PURPOSE:To assess the effect of donor tissue diameter in Descemet Membrane Endothelial Keratoplasty (DMEK) on postoperative endothelial cell density (ECD) mainly in Fuchs Endothelial Corneal Dystrophy (FECD) patients. METHODS:Retrospective review of 693 consecutive DMEK surgeries from the prospective Cologne DMEK database performed between 07/2011 and 07/2016 at the Department of Ophthalmology, University of Cologne. Eight- versus ten-millimetre large donor DMEK grafts of two different surgeons using identical surgical techniques were compared. RESULTS:A total of 693 consecutive DMEK surgeries were included. Two groups (8 versus 10 mm DMEK graft diameter) were compared: 23% of eyes received 8-mm grafts (group 1, n = 160) and 77% 10-mm grafts (group 2, n = 533). Mean preoperative ECD (±SD) of donor tissue was 2736 ± 224 cells/mm2 in group 1 and 2714 ± 232 in group 2. Group 1 showed a mean ECD of 1740 ± 439 cells/mm2 (mean ± SD; n = 67) 12 months after DMEK compared to 1664 ± 404 cells/mm2 (mean ± SD; n = 344) in group 2. The difference between the 6- and 12-month ECD of both groups was not significant (p = 0.675; p = 0.161). Total decrease in ECD 6- and 12-months postoperatively was 38 ± 14 (n = 128) and 36 ± 16% in group 1 (n = 66) versus 37 ± 15% (n = 398) and 38 ± 15% in group 2 (n = 342; p = 0.414; p = 0.198, respectively). CONCLUSION:Our data suggest that postoperative central endothelial cell density is not significantly associated with DMEK graft diameters in the range of 8-10 mm in cases with healthy peripheral host endothelium (such as FECD).
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Schrittenlocher S,Bachmann B,Cursiefen Cdoi
10.1111/aos.13943subject
Has Abstractpub_date
2019-06-01 00:00:00pages
e618-e622issue
4eissn
1755-375Xissn
1755-3768journal_volume
97pub_type
杂志文章abstract:PURPOSE:To evaluate the association between the macular structure on spectral-domain optical coherence tomography (SD-CT) and visual outcome after vitrectomy for lamellar macular hole (LMH). METHODS:Best-corrected visual acuity (VA) and SD-OCT images of the macula were assessed before and after surgery in 30 eyes of 3...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02456.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To test the validity of the eyesi surgical simulator as an assessment tool in a virtual reality vitreoretinal training programme. METHODS:In collaboration with an experienced vitreoretinal surgeon, a virtual vitreoretinal training programme was composed on the eyesi surgical simulator, software version 2.9.2 (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13209
更新日期:2017-02-01 00:00:00
abstract::Our review aims to provide an update of management protocols for congenital nasolacrimal duct obstruction (CNDO). Although early probing performed before the age of 1 year was traditionally recommended, many reports have since confirmed high frequencies of spontaneous resolution during the first year of life. Accordin...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/j.1755-3768.2009.01592.x
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma has been reported. We, therefore, investigated the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE in a cell culture model. METHODS:The e...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12990
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the safety and efficacy of phacocanaloplasty with suprachoroidal drainage (PCscD) and to compare its intraocular pressure (IOP)-lowering and drug-sparing effect to canaloplasty with suprachoroidal drainage (CscD). METHODS:The study retrospective interventional study...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13393
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Congenital anophthalmia (A) and microphthalmia (M) are rare developmental defects, which could be isolated or syndromic. Our objective was to describe a cohort of children and young adults with A/M treated with ocular prosthesis, emphasizing clinical features, diagnosis, treatment, and follow-up. METHODS:Eight...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14427
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. METHODS:Corneal measurements of 110 normal eyes (one eye per subject) and 70 k...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12622
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To report our experiences of treating periocular capillary haemangioma with particular emphasis on visual outcomes. METHODS:Patients who underwent treatment for periocular capillary haemangioma were identified, and a chart review was performed. RESULTS:There were seventeen patients in the study. The main indi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01789.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis. METHODS:In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another 4 weeks. Fol...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12744
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of intravitreal bevacizumab at one year follow-up, for the treatment of choroidal neovascularization (CNV) associated with angioid streaks. METHODS:A retrospective case series of eighteen eyes of 17 patients with CNV secondary to angioid streaks treated with intravitreal bev...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01836.x
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti® ) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA). METHODS:This was an age- and refraction-matched case-control study. Consecutive patients with a best-corrected visual ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13680
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To assess the noninferiority of the treat-and-extend (T&E) and fixed bimonthly regimens of 0.5 mg intravitreal ranibizumab as compared with the pro re nata (PRN) in naïve patients with neovascular age-related macular degeneration (nAMD). METHODS:Phase IV, randomized, 12-month, multicentre trial. Patients aged ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14399
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To determine the effect of the axial length on the supernormal and false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic (SD-OCT) instrument. METHODS:This was a prospective, observati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12382
更新日期:2014-09-01 00:00:00
abstract::Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Using the Medical Subject Heading (MeSH) terms: hypothyroidism, myxoed...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/aos.13412
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS:Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. Al...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13003
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of a prospective protocol for the treatment of chronic central serous chorioretinopathy (CSC). METHODS:Interventional prospective case series in 59 eyes (59 patients) with active chronic CSC. All patients were first treated with indocyanine green angiography (ICGA)-guided half-dose phot...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12938
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To report the functional and anatomical outcomes resulting from the use of intravitreal pegaptanib sodium (Macugen) in patients with diabetic macular oedema (DMO). METHODS:We conducted a retrospective outcome analysis, by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), of eyes with ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01580.x
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:The clinical use and comparison of two recently developed A-scan ultrasound devices. METHODS:The same investigator determined central corneal thickness (CCT), anterior chamber depth (ACD) and axial length (AL) with an OcuScan RxP (Alcon, Forth Worth, Texas, USA) and an AL-2000 (Tomey, Erlangen, Germany) ultras...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.00994.x
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:A recent threefold increase in laser treatment for advanced retinopathy of prematurity (ROP) triggered a nationwide preschool ophthalmic and developmental status among extremely preterm survivors. Here, we discuss refraction and visual acuity. METHODS:Survivors (n = 178) from a national birth cohort (February ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12643
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13502
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To investigate changes in retinal metabolism, function, structure and morphology in relation to initiation of insulin pump therapy (continuous subcutaneous insulin infusion, CSII). METHODS:Visual acuity, retinopathy level, dark adaptation kinetics, retinal and subfoveal choroidal thickness, macular perfusion v...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13066
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Keratoconus is a progressive disorder and one of the primary indications for corneal transplantation. Anterior lamellar keratoplasty offers several advantages over other techniques, including endothelial preservation and longer graft survival. In this study, we examined the recent trend of using lamellar techni...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13041
更新日期:2016-08-01 00:00:00
abstract::Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular. In nanomedicine, tissue engineering is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its pu...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/j.1755-3768.2010.01982.x
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To investigate whether exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans. METHODS:All women giving live birth between 1997 and 2011 in Denmark were included in this nationwide cohort study. All women redeeming at le...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13980
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To investigate serial changes in the bleb wall using anterior segment optical coherence tomography (AS-OCT) in patients who had undergone Ahmed glaucoma valve (AGV) implantation. METHODS:A total of 52 patients who had undergone AGV implantation were enrolled. Reflectivity and mean thickness of the bleb wall we...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12571
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained i...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13667
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To assess retinal perfusion in eyes with unilateral ocular ischaemic syndrome (OIS) and to compare with control subjects. METHODS:Retrospective case series. Linear blood flow velocities in macular vessels were estimated using motion-contrast fundus photography in eight patients with unilateral OIS (eight OIS e...
journal_title:Acta ophthalmologica
pub_type:
doi:10.1111/aos.13950
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To evaluate association of the van Herick (VH) grades with the ultrasound biomicroscopic (UBM) parameters, appositional irido-trabecular contact (A-ITC) and plateau iris (PI) in a randomly sampled population. METHODS:A 10% random sample of all residents aged 40 or older of the Kumejima study underwent UBM unde...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14502
更新日期:2020-06-22 00:00:00
abstract:PURPOSE:To describe the clinical appearance and the visual outcome of a cohort of patients with vasoproliferative retinal tumours (VPRTs) that were diagnosed and treated between 2002 and 2007 at the University Hospital of Örebro. METHODS:Nine patients with diagnosed VPRTs were included in a retrospective study. The me...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01662.x
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma (PA) using optical coherence tomography angiography (OCTA). METHODS:Cross-sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro-ophthalmol...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14322
更新日期:2019-12-06 00:00:00