Impact of donor tissue diameter on postoperative central endothelial cell density in Descemet Membrane Endothelial Keratoplasty.

Abstract:

PURPOSE:To assess the effect of donor tissue diameter in Descemet Membrane Endothelial Keratoplasty (DMEK) on postoperative endothelial cell density (ECD) mainly in Fuchs Endothelial Corneal Dystrophy (FECD) patients. METHODS:Retrospective review of 693 consecutive DMEK surgeries from the prospective Cologne DMEK database performed between 07/2011 and 07/2016 at the Department of Ophthalmology, University of Cologne. Eight- versus ten-millimetre large donor DMEK grafts of two different surgeons using identical surgical techniques were compared. RESULTS:A total of 693 consecutive DMEK surgeries were included. Two groups (8 versus 10 mm DMEK graft diameter) were compared: 23% of eyes received 8-mm grafts (group 1, n = 160) and 77% 10-mm grafts (group 2, n = 533). Mean preoperative ECD (±SD) of donor tissue was 2736 ± 224 cells/mm2 in group 1 and 2714 ± 232 in group 2. Group 1 showed a mean ECD of 1740 ± 439 cells/mm2 (mean ± SD; n = 67) 12 months after DMEK compared to 1664 ± 404 cells/mm2 (mean ± SD; n = 344) in group 2. The difference between the 6- and 12-month ECD of both groups was not significant (p = 0.675; p = 0.161). Total decrease in ECD 6- and 12-months postoperatively was 38 ± 14 (n = 128) and 36 ± 16% in group 1 (n = 66) versus 37 ± 15% (n = 398) and 38 ± 15% in group 2 (n = 342; p = 0.414; p = 0.198, respectively). CONCLUSION:Our data suggest that postoperative central endothelial cell density is not significantly associated with DMEK graft diameters in the range of 8-10 mm in cases with healthy peripheral host endothelium (such as FECD).

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Schrittenlocher S,Bachmann B,Cursiefen C

doi

10.1111/aos.13943

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

e618-e622

issue

4

eissn

1755-375X

issn

1755-3768

journal_volume

97

pub_type

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