Abstract:
PURPOSE:To evaluate the efficacy and safety of intravitreal bevacizumab at one year follow-up, for the treatment of choroidal neovascularization (CNV) associated with angioid streaks. METHODS:A retrospective case series of eighteen eyes of 17 patients with CNV secondary to angioid streaks treated with intravitreal bevacizumab between October 2006 and May 2008. Ophthalmic evaluation including best corrected visual acuity (BCVA), slit lamp biomicroscopic examination, optical coherence tomography (OCT) and fluorescein angiography, was performed before and after treatment. Retreatment was given every 4-6 weeks in case of persistent symptoms or CNV activity on OCT. Main outcome measures were changes in BCVA and central retinal thickness on OCT. RESULTS:The mean number of injections was 4.8 at 1 year. Twelve eyes (66.6%) received five injections or more. The mean BCVA at baseline was 20/80 (range 20/400 to 20/32) and improved to 20/44 (range 20/160 to 20/20) at 1 year (p = 0.014). The BCVA improved by three or more lines in eleven eyes (61.11%) and remained within two lines of baseline in seven eyes (38.8%). Mean central retinal thickness was 404.2 μm (range 160-602 μm) at baseline and decreased to 300.5 μm (range 150-523 μm) at 1 year (p = 0.022). No ocular or systemic complications were noted. CONCLUSION:The 1-year outcomes suggest intravitreal bevacizumab to be a promising treatment for CNV associated with angioid streaks, resulting in both functional and anatomical improvements. Repeated injections are needed to maintain these results. Further long term studies are required to confirm these findings.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
El Matri L,Kort F,Bouraoui R,Karim B,Chebil A,Chaker Ndoi
10.1111/j.1755-3768.2009.01836.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
641-6issue
7eissn
1755-375Xissn
1755-3768journal_volume
89pub_type
杂志文章abstract:PURPOSE:Photodynamic riboflavin/ultraviolet-A (UVA)-induced collagen cross-linking, which increases the biomechanical stiffness of the human cornea by about 300%, has been introduced recently as a possible treatment for progressive keratoconus. The present study was undertaken to evaluate the longterm biomechanical eff...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-03-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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更新日期:2015-06-01 00:00:00
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更新日期:2020-11-01 00:00:00
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更新日期:2009-08-01 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-23 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-09-01 00:00:00
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更新日期:2013-11-01 00:00:00