Abstract:
PURPOSE:To investigate whether exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans. METHODS:All women giving live birth between 1997 and 2011 in Denmark were included in this nationwide cohort study. All women redeeming at least one prescription of antazoline-naphazoline eye drops during the first 84 days of pregnancy were identified. Logistic regression was used to estimate the odds ratios of malformations among exposed offspring compared to non-exposed offspring. RESULTS:We identified 977 706 births between 1997 and 2011. A total of 3061 women (0.32%) were exposed to antazoline-naphazoline eye drops in the first trimester of pregnancy. The rate of congenital malformations was 3.0% (n = 93) in exposed offspring and 3.5% (n = 33 594) in unexposed offspring. First-trimester exposure to antazoline-naphazoline was not associated with major congenital malformations overall (odds ratio: 0.88, 95% confidence interval: 0.71-1.09) or with any specific major malformation. The number of redeemed prescriptions was unchanged during all trimesters of pregnancy as compared to before and after pregnancy (p < 0.05). CONCLUSION:Exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy appears not to be associated with increased teratogenic risk.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Thomseth V,Cejvanovic V,Jimenez-Solem E,Poulsen HE,Utheim TP,Andersen JTdoi
10.1111/aos.13980subject
Has Abstractpub_date
2019-08-01 00:00:00pages
505-509issue
5eissn
1755-375Xissn
1755-3768journal_volume
97pub_type
杂志文章,多中心研究abstract:PURPOSE:To investigate serial changes in the bleb wall using anterior segment optical coherence tomography (AS-OCT) in patients who had undergone Ahmed glaucoma valve (AGV) implantation. METHODS:A total of 52 patients who had undergone AGV implantation were enrolled. Reflectivity and mean thickness of the bleb wall we...
journal_title:Acta ophthalmologica
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pub_type: 杂志文章,多中心研究
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journal_title:Acta ophthalmologica
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doi:10.1111/j.1755-3768.2011.02216.x
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journal_title:Acta ophthalmologica
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/aos.13007
更新日期:2016-08-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14191
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13502
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13665
更新日期:2018-11-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01313.x
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/aos.14620
更新日期:2020-09-11 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0420.2007.01091.x
更新日期:2008-08-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14701
更新日期:2020-12-23 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01580.x
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02151.x
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12744
更新日期:2015-08-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13482
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.02102.x
更新日期:2011-06-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13259
更新日期:2017-06-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.00994.x
更新日期:2008-02-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12238
更新日期:2014-06-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13217
更新日期:2017-02-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13070
更新日期:2016-12-01 00:00:00
abstract::Surgical approaches for rhegmatogenous retinal detachment (RRD) have evolved rapidly in the past century. This has resulted in an increase in the anatomical success rate from zero per cent in the beginning of the 1900s to now almost 100 per cent. Rhegmatogenous retinal detachment is regarded as an acute eye disease th...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/aos.12991
更新日期:2016-03-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01941.x
更新日期:2010-08-01 00:00:00