Abstract:
PURPOSE:To evaluate effectiveness, tolerability and safety of repeated intravitreal injections of 0.5 mg ranibizumab for the treatment of neovascular age-related macular degeneration in routine medical practice in Germany. METHODS:A noninterventional study with 3470 patients treated in 274 medical centres according to German guidelines, with monthly intravitreal injections of 0.5 mg ranibizumab during upload (3 months) followed by a maintenance phase (9 months) with reinjections if medically indicated. RESULTS:Mean injection rate was 4.34 (SE = 0.05; median = 3.0). Best-corrected visual acuity (BCVA) remained stable (mean change 0.02 LogMAR, SE = 0.01, p = 0.0169) and central retinal thickness (CRT) decreased (by -78.9 μm, SE = 2.95 μm, p < 0.0001). The NEI-VFQ 25 summary score showed a positive stabilization with a mean change of 0.73 (SE = 0.37, p = 0.0501) compared with baseline. Adverse events were documented for 6.5% of the patients with 3.9% of these events being classified as serious. CONCLUSIONS:The number of administered intravitreal injections of ranibizumab over the first year of treatment was very low but still achieved a stabilization of BCVA, a reduction in CRT and maintained vision-related quality of life. The management of patients with neovascular AMD in Germany needs to be improved to achieve better treatment results.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Finger RP,Wiedemann P,Blumhagen F,Pohl K,Holz FGdoi
10.1111/j.1755-3768.2012.02493.xsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
540-6issue
6eissn
1755-375Xissn
1755-3768journal_volume
91pub_type
杂志文章,多中心研究abstract::The development of ophthalmology was greatly restricted in Poland in the 19th century, because it was partitioned and occupied by its three dominant neighbours. Polish medical universities were closed, and in Polish hospitals, only clinical work was possible. Those who wanted to study medicine and become ophthalmologi...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/j.1755-3768.2009.01856.x
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Photodynamic riboflavin/ultraviolet-A (UVA)-induced collagen cross-linking, which increases the biomechanical stiffness of the human cornea by about 300%, has been introduced recently as a possible treatment for progressive keratoconus. The present study was undertaken to evaluate the longterm biomechanical eff...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01190.x
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13665
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13379
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To report the postoperative results after enucleation of using an acrylic orbital implant covered in donor sclera for implantation. METHODS:We retrospectively analysed the charts of patients who were enucleated between 2007 and 2011. Only patients who received an acrylic implant covered with donor sclera were ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12960
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. METHODS:Fifty eyes with megalopapilla and 80 normal control eyes of totally ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12545
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To investigate the coexistence of ocular microvascular and systemic macrovascular abnormalities in early stage, newly diagnosed and previously untreated normal tension glaucoma patients (NTG). METHODS:Retinal vascular reactivity to flickering light was assessed in 19 NTG and 28 age-matched controls by means of...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02494.x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. METHODS:Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery....
journal_title:Acta ophthalmologica
pub_type:
doi:10.1111/aos.13223
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To analyse intraocular cytokine levels and prevalence of intraocular antiretinal antibodies (ARAs) in patients with retinitis pigmentosa (RP), age-related macular degeneration (AMD), glaucoma and cataract, and correlate the results to clinical manifestations. METHODS:We collected intraocular fluid samples from...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13899
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To analyse the postoperative foveal avascular zone (FAZ) area, superficial vessel density (SVD) and deep vessel density (DVD) and their correlation with functional (best-corrected visual acuity, BCVA) and anatomical outcomes (foveal macular thickness, FMT) after surgery for rhegmatogenous retinal detachment (RR...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14315
更新日期:2019-11-26 00:00:00
abstract:PURPOSE:To evaluate the prognosis of mortality in patients with spontaneous subarachnoid haemorrhage associated with Terson's syndrome. METHODS:A prospective, consecutive case series study was conducted in patients admitted to the emergency room with a diagnosis of acute subarachnoid haemorrhage. After a complete neur...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01735.x
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To evaluate the EyeSi(™) simulator in regard to assessing competence in cataract surgery. The primary objective was to explore all simulator metrics to establish a proficiency-based test with solid evidence. The secondary objective was to evaluate whether the skill assessment was specific to cataract surgery. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12691
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To identify the causes of failure of the different surgical corneal graft techniques: penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS:This multicentric retrosp...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14708
更新日期:2021-01-09 00:00:00
abstract:PURPOSE:To assess the prevalence of end-of-life visual impairment in patients followed for glaucoma. METHODS:Data of 122 patients followed for glaucoma who had died between July 2008 and July 2010 and who had visited the ophthalmology outpatient department of a large non-academic Dutch hospital were collected from the...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02555.x
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Retinal Vessel Analyser (RVA) is a validated instrument to measure retinal vessel diameter in humans. The purpose of this study was to assess the reproducibility (inter-observer reliability) and the repeatability (test-retest reliability) of RVA with a microscope-mounted fundus camera to determine retinal vesse...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02374.x
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:Metrics that capture changes in the retinal microvascular structure are relevant in the context of cardiometabolic disease development. The microvascular topology is typically quantified using monofractals, although it obeys more complex multifractal rules. We study mono- and multifractals of the retinal microv...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14598
更新日期:2020-09-16 00:00:00
abstract:PURPOSE:To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT). METHODS:A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular press...
journal_title:Acta ophthalmologica
pub_type: 临床试验,杂志文章
doi:10.1111/aos.14136
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To establish whether differences in the assessment of diabetic macular oedema (DME) with either optical coherence tomography (OCT) or stereoscopic biomicroscopy lead to variability in the photocoagulation treatment of DME. METHODS:The differences in the assessment of DME with either OCT or stereoscopic biomicr...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02524.x
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To examine the movement of air injected in the cornea in simulated deep anterior lamellar keratoplasty (DALK), from the needle tip to the formation of different types of big bubbles (BB) and to ascertain how air travels through the stroma and pre-Descemet's layer [Dua's layer (PDL)] to create a type-1 (air betw...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13460
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To establish whether or not the dynamics of saccadic eye movements are significantly changed in patients with different stages of thyroid-associated ophthalmopathy (TAO) and, subsequently, if analysis of saccades could serve as an additional diagnostic tool for early detection of inflammatory activity in TAO. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02216.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To evaluate the influence of haemorheopheresis on anatomical and functional findings in patients with soft-drusen maculopathy. METHODS:We investigated 29 eyes (16 patients) and randomized 25 eyes (16 controls) with soft-drusen maculopathy [soft, confluent and reticular drusen, drusenoid retinal pigment epithel...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2009.01710.x
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To examine the correlation between health-related quality of life (HRQOL) scores [assessed using the generic Short Form Health Survey (SF-36) questionnaire] and vision-related quality of life (VRQOL) scores [assessed using the National Eye Institute Visual Function Questionnaire (NEI-VFQ25)]. METHODS:Cross-sec...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01203.x
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:Using OCT-A to investigate the association between neurodegeneration and vascular morphology in diabetic retinopathy (DR). METHODS:Cross-sectional study. One hundred and sixty-two patients were enrolled and following fundoscopy were assigned to two groups according to DR severity: 54 patients to the group of n...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14754
更新日期:2021-01-10 00:00:00
abstract::A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.14392
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To determine whether anthropomorphic measurements are associated with ocular and general parameters. METHODS:The population-based Beijing Eye Study, which included 4439 participants (age > 40 years) out of 5324 individuals invited to be examined in 2001, was repeated in 2006 with 3251 (73.2% of 4439, or 61.1% ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01734.x
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients. METHODS:A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients. RESULTS:The overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly,...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13551
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To compare posterior capsular opacification in patients with and without pseudoexfoliation syndrome 6-7 years following surgery. METHODS:Forty-four eyes of 44 patients with pseudoexfoliation syndrome who underwent cataract surgery with phacoemulsification in 2001 and 2002 were available for follow-up in 2008. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02380.x
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To assess the effects of multifocal soft contact lenses (MF SCLs) used for myopia control on visual acuity (VA) and subjective quality of vision. METHODS:Twenty-four young adult myopes had baseline high and low-contrast VAs and refractions measured and quality of vision assessed by the Quality of Vision (QoV) ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13173
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To compare the postoperative anatomic success rates and the frequency of complications between prone or supine postoperative positioning after transconjunctival sutureless vitrectomy (TSV) for rhegmatogenous retinal detachment (RRD). METHODS:All patients underwent primary 27-gauge TSV for the treatment of prim...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13482
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To describe three cases of Charles Bonnet syndrome (CBS) in glaucoma patients with preserved visual acuity. METHODS:Three glaucoma patients who had taken part in a recent CBS study were interviewed about their hallucinations. The patients underwent macular optical coherence tomography (OCT) of both eyes. The v...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14620
更新日期:2020-09-11 00:00:00