当前位置： SCI文献检索 > ACTA OPHTHALMOLOGICA期刊下所有文献 > Redefining tissue engineering for nanomedicine in ophthalmology.

Redefining tissue engineering for nanomedicine in ophthalmology.

Abstract：

:Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular. In nanomedicine, tissue engineering is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its purpose. The goal is to function at the optimum state, or to return to that optimum state. Additive tissue engineering replaces cells or tissue, or tries to get something to grow that is no longer there. Arrestive tissue engineering tries to stop aberrant growth which, if left uncontrolled, would result in a decrease in function. Nano delivery of therapeutics can perform both additive and arrestive functions influencing the environment either way, depending on the targeting. By manipulating the environment at the nanoscale, the rate and distribution of healing can be controlled. It infers that potential applications of nanomedicine in ophthalmology include procedures, such as corneal endothelial cell transplantation, single retinal ganglion cell repair, check of retinal ganglion cell viability, building of nanofibre scaffolds, such as self-assembling peptides, to create a scaffold-like tissue-bridging structure to provide a framework for axonal regeneration in the case of optic nerve reconnection or eye transplantation, and ocular drug delivery. Examples of potential arrestive therapies include gene-related treatment modalities to inhibit intraocular neovascularization and to block retinal cell apoptosis. Looking towards the future, this review focuses on how nanoscale tissue engineering can be and is being used to influence that local environment.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Ellis-Behnke R,Jonas JB

doi

10.1111/j.1755-3768.2010.01982.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

e108-14

issue

2

eissn

1755-375X

issn

1755-3768

pii

AOS1982

journal_volume

89

pub_type

杂志文章,评审

相关文献

ACTA OPHTHALMOLOGICA文献大全
  • Highest reported visual acuity after electronic retinal implantation.

    abstract：PURPOSE:To report the highest attained visual acuity with an electronic retinal implant for the treatment of advanced retinal degeneration following a novel intensive period of visual training. METHODS:A case study as part of the prospective, international, multi-centre, interventional clinical trial (ClinicalTrials.g...

    journal_title：Acta ophthalmologica

    pub_type：

    doi：10.1111/aos.14443

    authors： Cehajic Kapetanovic J,Troelenberg N,Edwards TL,Xue K,Ramsden JD,Stett A,Zrenner E,MacLaren RE

    更新日期：2020-11-01 00:00:00

  • Lattice corneal dystrophy, gelsolin type (Meretoja's syndrome).

    abstract：PURPOSE:This paper reviews current knowledge about the pathogenesis, clinical manifestations and treatment of lattice corneal dystrophy, gelsolin type (LCD2, Meretoja's syndrome). METHODS:Material is derived from literature searches, a case study of a Finnish patient living in Sweden, and interviews in Helsinki with P...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章,评审

    doi：10.1111/j.1755-3768.2009.01686.x

    authors： Carrwik C,Stenevi U

    更新日期：2009-11-01 00:00:00

  • Intraocular pressure control over 24 hours using travoprost and timolol fixed combination administered in the morning or evening in primary open-angle and exfoliative glaucoma.

    abstract：PURPOSE:To evaluate intraocular pressure (IOP) control over 24 hours using travoprost and timolol fixed combination (TTFC) administered in the morning or evening in primary open-angle and exfoliative glaucoma. METHODS:Patients were randomized to TTFC administered in either the morning or evening for 8 weeks. Previousl...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1755-3768.2007.01145.x

    authors： Konstas AG,Tsironi S,Vakalis AN,Nasr MB,Stewart JA,Nelson LA,Stewart WC

    更新日期：2009-02-01 00:00:00

  • Incidence and prevalence of keratoconus in Denmark - an update.

    abstract：PURPOSE:To describe the annual incidence rate of keratoconus in Denmark 1995-2015 and prevalence of keratoconus in the National Danish Patient Register 1977-2015. METHODS:All patients diagnosed with keratoconus in the National Danish Patient Register 1977-2015 were included in the study. The annual incidence rates and...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章,多中心研究

    doi：10.1111/aos.14082

    authors： Bak-Nielsen S,Ramlau-Hansen CH,Ivarsen A,Plana-Ripoll O,Hjortdal J

    更新日期：2019-12-01 00:00:00

  • Ziv-aflibercept: A cost-effective, off-label, highly potent antagonist of vascular endothelial growth factor.

    abstract：:Ziv-aflibercept (Zaltrap® ), a recombinant fusion protein that binds diffusible vascular endothelial growth factor (VEGF), is approved for the treatment of metastatic colorectal carcinoma. Its molecular structure is the same as aflibercept (Eylea® ), thus making it an attractive option for the off-label treatment of c...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14328

    authors： Mansour AM,Stewart MW,Farah ME,Mansour HA,Chhablani J

    更新日期：2019-12-20 00:00:00

  • Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome.

    abstract：PURPOSE:To review the incidence, aetiology and outcomes of endophthalmitis during a 20-year period in a Norwegian university hospital. METHODS:Single-centre retrospective review. Medical records of all patients admitted to Stavanger University Hospital with suspected endophthalmitis between January 1999 and December 2...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14511

    authors： Malmin A,Syre H,Ushakova A,Utheim TP,Forsaa VA

    更新日期：2020-06-22 00:00:00

  • Identifying causes for poor visual outcome after DSEK/DSAEK following secondary DMEK in the same eye.

    abstract：PURPOSE:To identify causes of reduced visual acuity after Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK) and to determine whether such eyes can be successfully 'repaired' with a secondary Descemet membrane endothelial keratoplasty (DMEK). METHODS:Twelve eyes of 12 patients, who underwent secondar...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2012.02504.x

    authors： Dirisamer M,Parker J,Naveiras M,Liarakos VS,Ham L,van Dijk K,Melles GR

    更新日期：2013-03-01 00:00:00

  • Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy.

    abstract：PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investig...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2011.02151.x

    authors： Qian J,Jiang YR

    更新日期：2011-06-01 00:00:00

  • Long-term follow-up of an amblyopia treatment study: change in visual acuity 15 years after occlusion therapy.

    abstract：PURPOSE:To determine change in visual acuity (VA) in the population of a previous amblyopia treatment study (Loudon 2006) and assess risk factors for VA decrease. METHODS:Subjects treated between 2001 and 2003 were contacted between December 2015 and July 2017. Orthoptic examination was conducted under controlled circ...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14499

    authors： Kadhum A,Simonsz-Tóth B,van Rosmalen J,Pijnenburg SJM,Janszen BM,Simonsz HJ,Loudon SE

    更新日期：2020-07-13 00:00:00

  • Reconstruction of corneal stroma with decellularized porcine xenografts in a rabbit model.

    abstract：PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2011.02300.x

    authors： Yoeruek E,Bayyoud T,Maurus C,Hofmann J,Spitzer MS,Bartz-Schmidt KU,Szurman P

    更新日期：2012-05-01 00:00:00

  • Peripapillary choroidal vascular layers: the Beijing Eye Study.

    abstract：PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章,多中心研究

    doi：10.1111/aos.13379

    authors： Xu J,Wang YX,Jiang R,Wei WB,Xu L,Jonas JB

    更新日期：2017-09-01 00:00:00

  • Visual outcomes of treated periocular capillary haemangiomas in childhood: a 10-year review.

    abstract：PURPOSE:To report our experiences of treating periocular capillary haemangioma with particular emphasis on visual outcomes. METHODS:Patients who underwent treatment for periocular capillary haemangioma were identified, and a chart review was performed. RESULTS:There were seventeen patients in the study. The main indi...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2009.01789.x

    authors： Gawley SD,Bingham EA,McGinnity G

    更新日期：2011-06-01 00:00:00

  • Presenting characteristics and prevalence of polypoidal choroidal vasculopathy in Scandinavian patients with treatment-naïve exudative age-related macular degeneration.

    abstract：PURPOSE:To study presenting characteristics and prevalence of polypoidal choroidal vasculopathy (PCV) in Scandinavian Caucasians with treatment-naïve exudative age-related macular degeneration (AMD). METHODS:We reviewed all patients referred in year 2014 and diagnosed using fundus examination, optical coherence tomogr...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.13646

    authors： Lorentzen TD,Subhi Y,Sørensen TL

    更新日期：2018-08-01 00:00:00

  • Relationship between supernormal sectors of retinal nerve fibre layer and axial length in normal eyes.

    abstract：PURPOSE:To determine the effect of the axial length on the supernormal and false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic (SD-OCT) instrument. METHODS:This was a prospective, observati...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.12382

    authors： Yamashita T,Kii Y,Tanaka M,Yoshinaga W,Yamashita T,Nakao K,Sakamoto T

    更新日期：2014-09-01 00:00:00

  • Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

    abstract：PURPOSE:Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained i...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.13667

    authors： Andreasen S,von Holstein SL,Homøe P,Heegaard S

    更新日期：2018-11-01 00:00:00

  • Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1β and TIMP1 and the risk of primary open-angle glaucoma.

    abstract：BACKGROUND:Primary open-angle glaucoma (POAG) is the main cause of irreversible blindness worldwide. Matrix metalloproteinases (MMPs) and their regulators (TIMPs and ILs) have been extensively studied as POAG risk factors. Recent reports have showed several single-nucleotide polymorphisms (SNPs) for MMPs, TIMPs and ILs...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.12149

    authors： Markiewicz L,Majsterek I,Przybylowska K,Dziki L,Waszczyk M,Gacek M,Kaminska A,Szaflik J,Szaflik JP

    更新日期：2013-11-01 00:00:00

  • The effect of bariatric surgery on intraocular pressure.

    abstract：PURPOSE:Study purpose was to investigate the effects of bariatric surgery on intraocular pressure (IOP) and other ophthalmic parameters in a prospective observational follow-up study. METHODS:Ophthalmic examination was performed on 22 obese women before and 6 months after bariatric surgery. A control group of 15 non-o...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.13826

    authors： Viljanen A,Hannukainen JC,Soinio M,Karlsson HK,Salminen P,Nuutila P,Vesti E

    更新日期：2018-12-01 00:00:00

  • Refraction and visual acuity in a national Danish cohort of 4-year-old children of extremely preterm delivery.

    abstract：PURPOSE:A recent threefold increase in laser treatment for advanced retinopathy of prematurity (ROP) triggered a nationwide preschool ophthalmic and developmental status among extremely preterm survivors. Here, we discuss refraction and visual acuity. METHODS:Survivors (n = 178) from a national birth cohort (February ...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.12643

    authors： Fledelius HC,Bangsgaard R,Slidsborg C,laCour M

    更新日期：2015-06-01 00:00:00

  • The need and total cost of Finnish eyecare services: a simulation model for 2005-2040.

    abstract：PURPOSE:The aims of this study were: (i) to create a structural simulation model capable of predicting the future need and cost of eyecare services in Finland; and (ii) to test and rank different policy alternatives for access to care and the required physician workforce. METHODS:Using the system dynamics approach, th...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2009.01532.x

    authors： Tuulonen A,Salminen H,Linna M,Perkola M

    更新日期：2009-11-01 00:00:00

  • Mechanism and prognostic indicators for explosion-related eye trauma: eye injury vitrectomy study.

    abstract：PURPOSE:To explore the clinical features, surgical interventions and prognosis of injured eyes following explosion and to develop the risk factors for poor prognosis. METHODS:A nested case-control study. To the date of 31 December 2018, 99 explosion-related eye globes were selected from the Eye Injury Vitrectomy Study...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14713

    authors： Feng K,Yao Y,Wang ZJ,Nie HP,Pang XQ,Chen HJ,Jiang YR,Hu YT,Ma ZZ

    更新日期：2021-01-08 00:00:00

  • Elevated intraocular pressure induces neuron-specific β-III-tubulin expression in non-neuronal vascular cells.

    abstract：PURPOSE:Pathological alterations within optic nerve axons and progressive loss of the parental retinal ganglion cell (RGC) bodies are characteristics of glaucomatous neuropathy. Abnormally elevated intraocular pressure (IOP) is thought to be the major risk factor for most forms of glaucomatous changes, while lowering o...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14333

    authors： Prokosch V,Brockhaus K,Anders F,Liu H,Mercieca K,Gericke A,Melkonyan H,Thanos S

    更新日期：2019-12-29 00:00:00

  • Swept-source optical coherence tomography objective composite activity score for uveitis.

    abstract：PURPOSE:To develop an objective intraocular inflammation composite score. METHODS:Cross-sectional study. Non-invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation-grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After ...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14739

    authors： Llorenç V,Serrano AR,Mesquida M,Lin P,Esquinas C,Sainz-de-la-Maza M,Metea C,Bosch A,Calvo M,Balter A,Nakamura Y,Molins B,Alba C,Suhler E,Adán A

    更新日期：2021-01-09 00:00:00

  • Intraocular pressure in an ophthalmologically normal Japanese population.

    abstract：PURPOSE:To investigate the distribution of intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) and factors correlating with IOP, with special attention to age, in a large sample of ophthalmologically normal Japanese subjects. METHODS:A total of 7313 subjects (2847 male, 4466 female) were select...

    journal_title：Acta ophthalmologica

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1600-0420.2007.01068.x

    authors： Fukuoka S,Aihara M,Iwase A,Araie M

    更新日期：2008-06-01 00:00:00

  • Retinal microvascular complexity comparing mono- and multifractal dimensions in relation to cardiometabolic risk factors in a Middle Eastern population.

    abstract：PURPOSE:Metrics that capture changes in the retinal microvascular structure are relevant in the context of cardiometabolic disease development. The microvascular topology is typically quantified using monofractals, although it obeys more complex multifractal rules. We study mono- and multifractals of the retinal microv...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14598

    authors： Van Craenendonck T,Gerrits N,Buelens B,Petropoulos IN,Shuaib A,Standaert A,Malik RA,De Boever P

    更新日期：2020-09-16 00:00:00

  • Macular blood flow measured by blue-field entoptoscopy and Heidelberg retinal flowmetry: comparison of two techniques in type 1 diabetes women during pregnancy.

    abstract：PURPOSE:This study compared macular capillary leucocyte velocity values measured with a psychophysical blue-field entoptic simulation (BFS) technique and confocal scanning laser Doppler flowmetry. METHODS:A cross-sectional study was performed where macular capillary leucocyte velocity was measured by BFS using an Ocul...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2008.01303.x

    authors： Loukovaara S,Harju M,Immonen I

    更新日期：2009-08-01 00:00:00

  • Twelve per cent of 6142 eyes treated for neovascular age-related macular degeneration (nAMD) presented with low visual outcome within 2 years. Analysis from the Swedish Macula Registry (SMR).

    abstract：PURPOSE:To analyse characteristics from the SMR to explore the risk factors for visual acuity (VA) below ≤ 35 letters of the Early Treatment Diabetic Retinopathy Study (ETDRS) due to nAMD during a two-year follow-up. METHODS:This study evaluates 6142 treatment-naïve eyes, with focus on a subgroup of 780 eyes with fina...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14239

    authors： Schroeder M,Westborg I,Lövestam Adrian M

    更新日期：2020-05-01 00:00:00

  • Vitreomacular traction and exudative age-related macular degeneration.

    abstract：:Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章,评审

    doi：10.1111/j.1755-3768.2008.01210.x

    authors： Schulze S,Hoerle S,Mennel S,Kroll P

    更新日期：2008-08-01 00:00:00

  • Intravitreal bevacizumab for the treatment of choroidal neovascularization secondary to angioid streaks: one year of follow-up.

    abstract：PURPOSE:To evaluate the efficacy and safety of intravitreal bevacizumab at one year follow-up, for the treatment of choroidal neovascularization (CNV) associated with angioid streaks. METHODS:A retrospective case series of eighteen eyes of 17 patients with CNV secondary to angioid streaks treated with intravitreal bev...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/j.1755-3768.2009.01836.x

    authors： El Matri L,Kort F,Bouraoui R,Karim B,Chebil A,Chaker N

    更新日期：2011-11-01 00:00:00

  • Complications of intrastromal corneal ring segment implantation using a femtosecond laser for channel creation: a survey of 850 eyes with keratoconus.

    abstract：PURPOSE:To report complications after the implantation of intrastromal corneal ring segments (Keraring; Mediphacos, Belo Horizonte, Brazil) in keratoconic eyes using a femtosecond laser (IntraLase; Advanced Medical Optics, Santa Ana, California, USA) for channel creation. METHODS:Retrospective chart review of 531 pati...

    journal_title：Acta ophthalmologica

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1755-3768.2009.01605.x

    authors： Coskunseven E,Kymionis GD,Tsiklis NS,Atun S,Arslan E,Siganos CS,Jankov M,Pallikaris IG

    更新日期：2011-02-01 00:00:00

  • Detailed optical coherence tomography angiographic short-term response of type 3 neovascularization to combined treatment with photodynamic therapy and intravitreal bevacizumab.

    abstract：PURPOSE:To explore the short-term vascular and structural changes of type 3 neovascularization using optical coherence tomography angiography (OCT-A) when treated with a combination of photodynamic therapy (PDT) and intravitreal bevacizumab (IVB), and to evaluate the course of different sequences of the combined therap...

    journal_title：Acta ophthalmologica

    pub_type： 杂志文章

    doi：10.1111/aos.14525

    authors： Smid LM,Vermeer KA,Wong KT,Martinez Ciriano JP,de Jong JH,Davidoiu V,de Boer JF,van Velthoven MEJ

    更新日期：2020-06-29 00:00:00