Ziv-aflibercept: A cost-effective, off-label, highly potent antagonist of vascular endothelial growth factor.

abstract：PURPOSE:  To describe and evaluate a cryo-assisted, minimally invasive, anterior approach for orbital tumour surgery. METHODS:  Retrospective, non-comparative, consecutive, interventional case series of 103 patients who were operated on by the same surgeon for retroocular orbital tumours over the last 16 years. RESUL...

journal_title：Acta ophthalmologica

authors： Rosen N,Priel A,Simon GJ,Rosner M

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To evaluate the ability of ultrasound biomicroscopy (UBM) to detect abnormalities in the zonular apparatus in unaffected eyes of patients with clinically unilateral exfoliation syndrome (XFS) using a standardized grading system. METHODS:The affected and unaffected eyes of 17 patients with clinically unilateral...

journal_title：Acta ophthalmologica

authors： Sbeity Z,Dorairaj SK,Reddy S,Tello C,Liebmann JM,Ritch R

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To evaluate the regenerating potential and the mechanisms through which the autologous serum derived from plasma rich in growth factors (s-PRGF) favours corneal wound healing in vitro and in vivo. METHODS:We compared the effect of various concentrations of s-PRGF versus fetal bovine serum (FBS) and control tre...

journal_title：Acta ophthalmologica

authors： Etxebarria J,Sanz-Lázaro S,Hernáez-Moya R,Freire V,Durán JA,Morales MC,Andollo N

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To describe the clinical phenotype and the molecular pathology in a group of patients with congenital stationary night blindness due to mutations in GRM6, a gene encoding the ON bipolar metabotropic glutamate receptor 6 (mGluR6). METHODS:Nine patients from seven families (age range, 7-75; median, 10 years) wit...

journal_title：Acta ophthalmologica

authors： Sergouniotis PI,Robson AG,Li Z,Devery S,Holder GE,Moore AT,Webster AR

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...

journal_title：Acta ophthalmologica

authors： Kriszt A,Losonczy G,Berta A,Vereb G,Takács L

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:This study compared macular capillary leucocyte velocity values measured with a psychophysical blue-field entoptic simulation (BFS) technique and confocal scanning laser Doppler flowmetry. METHODS:A cross-sectional study was performed where macular capillary leucocyte velocity was measured by BFS using an Ocul...

journal_title：Acta ophthalmologica

authors： Loukovaara S,Harju M,Immonen I

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...

journal_title：Acta ophthalmologica

authors： Murakami Y,Ikeda Y,Nakatake S,Fujiwara K,Tachibana T,Yoshida N,Notomi S,Hisatomi T,Yoshida S,Ishibashi T,Sonoda KH

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To evaluate the effect of photodynamic therapy (PDT) on central serous chorioretinopathy (CSC) compared with laser therapy and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, and to find the maximum treatment effect with minimal dose and fluence of PDT. METHODS:A systematic...

journal_title：Acta ophthalmologica

authors： Ma J,Meng N,Xu X,Zhou F,Qu Y

更新日期：2014-12-01 00:00:00

abstract：:In the time of Vesalius, knowledge of ocular anatomy was limited. The first description of the anatomy of the eye comes from Democrites, for whom the eye was surrounded by two 'coats', filled with a homogenous fluid. The optic nerve was hollow and the lens was considered to be a postmortem artefact. Until the 15th cen...

journal_title：Acta ophthalmologica

authors： De Laey JJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...

journal_title：Acta ophthalmologica

authors： Pärssinen O,Kauppinen M

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To investigate whether introduction of item-response theory (IRT) analysis, in parallel to the 'traditional' statistical analysis methods available for performance evaluation of multiple T/F items as used in the European Board of Ophthalmology Diploma (EBOD) examination, has proved beneficial, and secondly, to ...

journal_title：Acta ophthalmologica

authors： Mathysen DG,Aclimandos W,Roelant E,Wouters K,Creuzot-Garcher C,Ringens PJ,Hawlina M,Tassignon MJ

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The present study aimed to investigate and compare the psychometric properties of the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25) and the Visual Function Index-14 (VF-14) in a large sample of patients with cataracts. METHODS:A total of 1052 patients with bilateral age-related catara...

journal_title：Acta ophthalmologica

authors： Wan Y,Zhao L,Huang C,Xu Y,Sun M,Yang Y,An L,Lv S,Yu Y,Chen D,Zhou P,Wang Y,Zhang M,Jiang A,Chen Z,Li X

更新日期：2020-09-17 00:00:00

abstract：PURPOSE:To evaluate the effect of ZY1, a novel 21-amino acid peptide from human placenta growth factor-1 (PlGF-1), against ocular neovascularization, and to study its possible toxicity to the retina and the underlying mechanism of antiangiogenic effect. METHODS:MTS assays, a modified Boyden chamber and Matrigel(™) wer...

journal_title：Acta ophthalmologica

authors： Zheng Y,Gu Q,Xu X

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. METHODS:Three study groups (oxygen...

journal_title：Acta ophthalmologica

authors： Wang JD,An Y,Zhang JS,Wan XH,Jonas JB,Xu L,Zhang W

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To determine (i) whether, compared to controls, visual complaints of glaucoma patients are more pronounced under extreme luminance conditions than in the optimal luminance condition and (ii) whether complaints belonging to different extreme luminance conditions are associated. METHODS:We developed a luminance-...

journal_title：Acta ophthalmologica

authors： Bierings RAJM,van Sonderen FLP,Jansonius NM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To investigate the incidence and cause of severe visual loss following use and removal of intraocular silicone oil (SiO) after uncomplicated vitrectomy and SiO injection for primary rhegmatogenous retinal detachment (RRD). METHODS:Consecutive case series of 216 patients operated with vitrectomy for primary RRD...

journal_title：Acta ophthalmologica

authors： Christensen UC,la Cour M

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To investigate the amount of systemic oxidative stress-related DNA damage and serum total antioxidant status of patients with normal-tension glaucoma compared with healthy controls. METHODS:Forty-three patients with normal-tension glaucoma selected from 60 consecutive newly diagnosed patients with primary open...

journal_title：Acta ophthalmologica

authors： Yuki K,Murat D,Kimura I,Tsubota K

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To compare the efficacy and visual outcomes after femtosecond laser small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) in correcting high myopia. METHODS:This prospective, randomized study included patients who underwent SMILE or FS-LASIK for the ...

journal_title：Acta ophthalmologica

authors： Qian Y,Chen X,Naidu RK,Zhou X

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Enzyme replacement therapy (ERT) was offered from year 2001 to patients with Fabry disease. The ophthalmic experience was analysed, as part of a general 10-year status. METHODS:A retrospective observational series comprising 39 patients (25 females, 14 males) closely followed by the endocrinologists, and with ...

journal_title：Acta ophthalmologica

authors： Fledelius HC,Sandfeld L,Rasmussen ÅK,Madsen CV,Feldt-Rasmussen U

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). METHODS:I...

journal_title：Acta ophthalmologica

authors： Mendez-Hernandez C,Rodriguez-Uña I,Gonzalez-de-la Rosa M,Arribas-Pardo P,Garcia-Feijoo J

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Approximately 50% of patients with uveal melanomas develop metastases. Thus, it is important to improve our understanding of how melanoma metastases develop. METHODS:As part of a uveal melanoma micrometastasis study, we compared the detection rates of immunomagnetically selected (IMS) tumour cells in bone marr...

journal_title：Acta ophthalmologica

authors： Eide N,Hoifødt HK,Nesland JM,Faye RS,Qvale GA,Faber RT,Jebsen P,Kvalheim G,Fodstad Ø

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:To assess the postoperative stability of three-piece intraocular lens (IOL) implants using ultrasound biomicroscopy (UBM). METHODS:This is a prospective observational cohort case series. Best-corrected visual acuity (BCVA) assessment, slit lamp examination, refraction and UBM evaluation were performed preopera...

journal_title：Acta ophthalmologica

authors： Ang GS,Duncan L,Atta HR

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. METHODS:Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery....

journal_title：Acta ophthalmologica

authors： van Overdam KA,Missotten T,Kilic E,Spielberg LH

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:This paper reviews current knowledge about the pathogenesis, clinical manifestations and treatment of lattice corneal dystrophy, gelsolin type (LCD2, Meretoja's syndrome). METHODS:Material is derived from literature searches, a case study of a Finnish patient living in Sweden, and interviews in Helsinki with P...

journal_title：Acta ophthalmologica

authors： Carrwik C,Stenevi U

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To report the prevalence of pseudoexfoliation (PEX) syndrome and glaucoma associated with PEX (PEX-G) and their relating factors of them in a south-western island of Japan. METHODS:A population-based survey of all residents aged ≥ 40 years was conducted in Kumejima, Okinawa, Japan, and 3762 subjects (participa...

journal_title：Acta ophthalmologica

authors： Arakaki Y,Sawaguchi S,Iwase A,Tomidokoro A,Araie M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Limited knowledge exists about the influence of donor age and death-to-preservation interval (DPI) on the metabolic properties of the cornea. The aim of this study is to investigate the relationship between both factors and metabolite content of the cornea. METHODS:Corneas from 15 human donors (age: 41-78 year...

journal_title：Acta ophthalmologica

authors： Kryczka T,Szaflik JP,Szaflik J,Midelfart A

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the safety and efficacy of phacocanaloplasty with suprachoroidal drainage (PCscD) and to compare its intraocular pressure (IOP)-lowering and drug-sparing effect to canaloplasty with suprachoroidal drainage (CscD). METHODS:The study retrospective interventional study...

journal_title：Acta ophthalmologica

authors： Seuthe AM,Januschowski K,Mariacher S,Ebner M,Opitz N,Szurman P,Boden K

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...

journal_title：Acta ophthalmologica

authors： Magnusdottir V,Vehmeijer WB,Eliasdottir TS,Hardarson SH,Schalij-Delfos NE,Stefánsson E

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:As some surgical procedures have been shown to increase postoperative flare values and thus contribute to blood-ocular barrier breakdown, retinal reattachment surgery might influence the risk of developing proliferative vitreoretinopathy (PVR). Therefore, we investigated whether postoperative aqueous flare valu...

journal_title：Acta ophthalmologica

authors： Mulder VC,van Dijk EHC,van Meurs IA,La Heij EC,van Meurs JC

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To investigate long-term visual results of treatment with anti-vascular endothelial growth factor (VEGF) agents for neovascular age-related macular degeneration (nAMD) following a treat-and-extend regimen. METHODS:Retrospective review of 155 patients who initiated treatment with bevacizumab for nAMD in one eye...

journal_title：Acta ophthalmologica

authors： Berg K,Roald AB,Navaratnam J,Bragadóttir R

更新日期：2017-12-01 00:00:00