Abstract:
PURPOSE:This paper reviews current knowledge about the pathogenesis, clinical manifestations and treatment of lattice corneal dystrophy, gelsolin type (LCD2, Meretoja's syndrome). METHODS:Material is derived from literature searches, a case study of a Finnish patient living in Sweden, and interviews in Helsinki with Professor Ahti Tarkkanen and Dr Sari Kiuru-Enari, both of whom have extensive first-hand experience in treating patients with the disease. RESULTS:The disease is now reported from several countries in Europe, as well as Japan, the USA and Iran. Treatment is symptomatic and is based on eye lubrication combined with rigorous monitoring of intraocular pressure to reduce corneal haze and postpone the need for keratoplasty. When systemic symptoms occur, the ophthalmologist should consult other specialists. CONCLUSIONS:The disease is probably under-reported and is almost certainly to be found in more countries, including Sweden. Every ophthalmologist should be vigilant and consider this diagnosis when discovering a corneal lattice dystrophy, especially because the disease is an inherited, lifelong chronic condition with systemic symptoms.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Carrwik C,Stenevi Udoi
10.1111/j.1755-3768.2009.01686.xsubject
Has Abstractpub_date
2009-11-01 00:00:00pages
813-9issue
8eissn
1755-375Xissn
1755-3768pii
AOS1686journal_volume
87pub_type
杂志文章,评审abstract:PURPOSE:To identify causes of reduced visual acuity after Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK) and to determine whether such eyes can be successfully 'repaired' with a secondary Descemet membrane endothelial keratoplasty (DMEK). METHODS:Twelve eyes of 12 patients, who underwent secondar...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02504.x
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age-related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). METHODS:This was a prospective case-control study. A total of 125 participants were ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13894
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients. METHODS:A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients. RESULTS:The overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly,...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13551
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Choroideremia is an X-linked retinal disease characterized by early retinal pigment epithelium (RPE) loss and subsequent retinal degeneration. The RPE adopts either a smooth or mottled appearance on fundus autofluorescence (FAF). It is not known how RPE changes predict the health of the overlying ellipsoid zone...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14281
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To describe the annual incidence rate of keratoconus in Denmark 1995-2015 and prevalence of keratoconus in the National Danish Patient Register 1977-2015. METHODS:All patients diagnosed with keratoconus in the National Danish Patient Register 1977-2015 were included in the study. The annual incidence rates and...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.14082
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To compare the effectiveness of intravitreal conbercept and ranibizumab treatment for retinopathy of prematurity (ROP). METHODS:In this retrospective study, the date of patients with ROP treated with intravitreal conbercept or ranibizumab from July 2012 to March 2018 with at least 12 months of follow-up at the...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14460
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abstract:PURPOSE:To investigate the feasibility, effectiveness and acceptability of using prosthetic occluding contact lenses (OCLs) to treat moderate amblyopia in adults and of the role of the multifocal visual evoked potential (mfVEP) as a predictor of postamblyopic therapy. METHODS:A comparative, prospective, interventional...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13585
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate changes in the anterior chamber depth (ACD) in primary open-angle glaucoma (POAG) patients during latanoprost therapy. METHODS:We carried out a prospective study in which we enrolled 66 newly diagnosed POAG patients treated with latanoprost 0.005% (group 1) and 50 ocular h...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01683.x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To identify the causes of failure of the different surgical corneal graft techniques: penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS:This multicentric retrosp...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14708
更新日期:2021-01-09 00:00:00
abstract:PURPOSE:Congenital anophthalmia (A) and microphthalmia (M) are rare developmental defects, which could be isolated or syndromic. Our objective was to describe a cohort of children and young adults with A/M treated with ocular prosthesis, emphasizing clinical features, diagnosis, treatment, and follow-up. METHODS:Eight...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14427
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:The Pyhäjärvi Cataract Study aims to study demand for cataract surgery in the population of a rural town in Finland. METHODS:A random, population-based sample of 881 persons aged > or = 60 years were interviewed by telephone to obtain a Visual Function-14 (VF-14) score. A total of 294 persons were invited for ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.01118.x
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13332
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investig...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02151.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To evaluate a pro re nata administration of Ozurdex® implant versus a single administration for treating diabetic macular oedema (DME). METHODS:This exploratory study is designed as a comparative, multicentre, randomized study with a follow-up of 6 months. Patients with DME were assigned to treatment at baseli...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/aos.13395
更新日期:2017-06-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01367.x
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To investigate the cerebrospinal fluid (CSF) dynamics along the entire optic nerve (ON) in patients with normal-tension glaucoma (NTG). METHODS:Retrospective analysis of computed tomographic (CT) cisternographies in Caucasian patients with NTG. Fifty-six patients (99 of 112 eyes) fulfilled the diagnostic crite...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13647
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:A recent threefold increase in laser treatment for advanced retinopathy of prematurity (ROP) triggered a nationwide preschool ophthalmic and developmental status among extremely preterm survivors. Here, we discuss refraction and visual acuity. METHODS:Survivors (n = 178) from a national birth cohort (February ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12643
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To investigate the utility of biomechanical property measurements using a Scheimpflug-based tonometer (SBT) and/or anterior segment optical coherence tomography (AS-OCT) for diagnosing forme fruste keratoconus (FFK). METHODS:In this retrospective interventional case series, 23 eyes with FFK of 23 consecutive p...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14700
更新日期:2020-12-16 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12135
更新日期:2013-11-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13202
更新日期:2016-12-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13125
更新日期:2016-12-01 00:00:00
abstract::The main purpose of this thesis was to examine whether the Danish National Patient Registry (NPR) could be used to monitor and assess the quality of cataract surgery in Denmark by studying the risks of two serious postoperative complications following cataract surgery - retinal detachment (RD) and postoperative endoph...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12676
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the rise in aqueous humour (AH) levels of levofloxacin after a specific perioperative pulsed topical drop regimen. METHODS:Thirty patients undergoing phacoemulsification surgery were administered two preoperative drops of levofloxacin 0.5%, 30 mins apart, and three pulsed drops ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2008.01358.x
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To study the intraocular pressure (IOP)-reducing effect of deep sclerectomy on normal-tension glaucoma (NTG) patients. METHODS:We retrospectively analysed 21 eyes of 18 consecutive NTG patients who had undergone deep sclerectomy with mitomycin-C and a collagen implant. RESULTS:Median (range) preoperative IOP ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01623.x
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS:Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than in Denmark. RESULTS:No signi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01488.x
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:As some surgical procedures have been shown to increase postoperative flare values and thus contribute to blood-ocular barrier breakdown, retinal reattachment surgery might influence the risk of developing proliferative vitreoretinopathy (PVR). Therefore, we investigated whether postoperative aqueous flare valu...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13560
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate the ability of ultrasound biomicroscopy (UBM) to detect abnormalities in the zonular apparatus in unaffected eyes of patients with clinically unilateral exfoliation syndrome (XFS) using a standardized grading system. METHODS:The affected and unaffected eyes of 17 patients with clinically unilateral...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.01105.x
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:Graves' ophthalmopathy (GO) involves autoimmune process resulting in proptosis, congestion, oedema and diplopia. Werner's NOSPECS classification and clinical activity score (CAS) of GO cannot objectively describe the inflammatory status. Digital infrared thermal imaging (DITI) detects local temperature and may ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01941.x
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Eyelid sebaceous carcinoma (SC) remains a common diagnostic pitfall for both the clinician and histopathologist. The aim of this study was to describe perforin as a new marker in the immunohistochemistry panel for SC. METHODS:A total of 29 cases were retrieved from the Pathology archives, including 11 sebaceou...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12972
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To examine whether real-world clinical patients with macular oedema (MO) receiving intravitreal antivascular endothelial growth factor (VEGF) therapy have a higher mortality compared with a matched reference population. METHODS:A population-based, retrospective cohort study of 26 386 patients from Finland, fro...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14717
更新日期:2021-01-02 00:00:00