Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy.

abstract：PURPOSE:The introduction of vascular endothelial growth factor inhibitors for the treatment of exudative age-related macular degeneration (AMD) has increased the referral rates of AMD patients with visual symptoms to treating centres considerably. However, a large proportion of the referred patients do not qualify for ...

journal_title：Acta ophthalmologica

authors： Hessellund A,Larsen DA,Bek T

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To describe the clinical appearance and the visual outcome of a cohort of patients with vasoproliferative retinal tumours (VPRTs) that were diagnosed and treated between 2002 and 2007 at the University Hospital of Örebro. METHODS:Nine patients with diagnosed VPRTs were included in a retrospective study. The me...

journal_title：Acta ophthalmologica

authors： Makdoumi K,Crafoord S

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To report complications after the implantation of intrastromal corneal ring segments (Keraring; Mediphacos, Belo Horizonte, Brazil) in keratoconic eyes using a femtosecond laser (IntraLase; Advanced Medical Optics, Santa Ana, California, USA) for channel creation. METHODS:Retrospective chart review of 531 pati...

journal_title：Acta ophthalmologica

authors： Coskunseven E,Kymionis GD,Tsiklis NS,Atun S,Arslan E,Siganos CS,Jankov M,Pallikaris IG

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Galectin-1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin-1 may be involved in the pathogenesis of proliferative diabetic retinopathy (PDR). METHODS:Vitreous samples from 36 PDR and 20 nondiabetic patients, epiretinal fibrovascular membranes from 13 ...

journal_title：Acta ophthalmologica

authors： Abu El-Asrar AM,Ahmad A,Allegaert E,Siddiquei MM,Alam K,Gikandi PW,De Hertogh G,Opdenakker G

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To identify causes of reduced visual acuity after Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK) and to determine whether such eyes can be successfully 'repaired' with a secondary Descemet membrane endothelial keratoplasty (DMEK). METHODS:Twelve eyes of 12 patients, who underwent secondar...

journal_title：Acta ophthalmologica

authors： Dirisamer M,Parker J,Naveiras M,Liarakos VS,Ham L,van Dijk K,Melles GR

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To determine the myopia prevalence in Hong Kong Chinese children and their parents. METHODS:It was a population-based cross-sectional study. A total of 4257 children aged 6-8 years, and 5880 parents were recruited in the Hong Kong Children Eye Study. Cycloplegic autorefraction was measured for children; and no...

journal_title：Acta ophthalmologica

authors： Yam JC,Tang SM,Kam KW,Chen LJ,Yu M,Law AK,Yip BH,Wang YM,Cheung CYL,Ng DSC,Young AL,Tham CC,Pang CP

更新日期：2020-01-24 00:00:00

abstract：PURPOSE:Retinal pigment epithelium (RPE) tear is an extremely rare complication in patients with classic neovascular membranes without RPE detachment. We evaluate their incidence and functional outcome following treatment with intravitreal ranibizumab. METHODS:Observational study of 72 consecutive patients (74 eyes) t...

journal_title：Acta ophthalmologica

authors： Konstantinidis L,Ambresin A,Zografos L,Mantel I

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To investigate the coexistence of ocular microvascular and systemic macrovascular abnormalities in early stage, newly diagnosed and previously untreated normal tension glaucoma patients (NTG). METHODS:Retinal vascular reactivity to flickering light was assessed in 19 NTG and 28 age-matched controls by means of...

journal_title：Acta ophthalmologica

authors： Mroczkowska S,Ekart A,Sung V,Negi A,Qin L,Patel SR,Jacob S,Atkins C,Benavente-Perez A,Gherghel D

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care. METHODS:A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retinopathy was eva...

journal_title：Acta ophthalmologica

authors： Olafsdottir E,Andersson DK,Dedorsson I,Svärdsudd K,Jansson SP,Stefánsson E

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis. METHODS:In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another 4 weeks. Fol...

journal_title：Acta ophthalmologica

authors： Shulman S,Jóhannesson G,Stefánsson E,Loewenstein A,Rosenblatt A,Habot-Wilner Z

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not...

journal_title：Acta ophthalmologica

authors： Forshaw TRJ,Kjaer TW,Andréasson S,Sørensen TL

更新日期：2020-08-24 00:00:00

abstract：:A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...

journal_title：Acta ophthalmologica

authors： Bekkers A,Borren N,Ederveen V,Fokkinga E,Andrade De Jesus D,Sánchez Brea L,Klein S,van Walsum T,Barbosa-Breda J,Stalmans I

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...

journal_title：Acta ophthalmologica

authors： Yoeruek E,Bayyoud T,Maurus C,Hofmann J,Spitzer MS,Bartz-Schmidt KU,Szurman P

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To determine (i) whether, compared to controls, visual complaints of glaucoma patients are more pronounced under extreme luminance conditions than in the optimal luminance condition and (ii) whether complaints belonging to different extreme luminance conditions are associated. METHODS:We developed a luminance-...

journal_title：Acta ophthalmologica

authors： Bierings RAJM,van Sonderen FLP,Jansonius NM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To describe the retinal structure of a group of patients affected by methylmalonic aciduria with homocystinuria cblC type, caused by mutations in the MMACHC gene, using spectral domain optical coherence tomography (SD-OCT). METHODS:Young patients (n = 11, age 0-74 months) with cblC disease, detected by newborn...

journal_title：Acta ophthalmologica

authors： Bacci GM,Donati MA,Pasquini E,Munier F,Cavicchi C,Morrone A,Sodi A,Murro V,Garcia Segarra N,Defilippi C,Bussolin L,Caputo R

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical ...

journal_title：Acta ophthalmologica

authors： Gerendas BS,Kroisamer JS,Buehl W,Rezar-Dreindl SM,Eibenberger KM,Pablik E,Schmidt-Erfurth U,Sacu S

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To determine the molecular genetic cause in previously unreported probands with optic atrophy from the United Kingdom, Czech Republic and Canada. METHODS:OPA1 coding regions and flanking intronic sequences were screened by direct sequencing in 82 probands referred with a diagnosis of bilateral optic atrophy. D...

journal_title：Acta ophthalmologica

authors： Liskova P,Tesarova M,Dudakova L,Svecova S,Kolarova H,Honzik T,Seto S,Votruba M

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:We aimed to determine prospectively the incidence of abnormal test results on frequency doubling perimetry (FDT), the nerve fibre analyser (GDx) and standard automated perimetry (SAP) in a cohort of glaucoma suspect patients with normal findings for all these tests at baseline. METHODS:Seventy glaucoma suspect...

journal_title：Acta ophthalmologica

authors： Jansonius NM,Heeg GP

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...

journal_title：Acta ophthalmologica

authors： Xu J,Wang YX,Jiang R,Wei WB,Xu L,Jonas JB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:This study aimed to study the incidence and clinical characteristics of patients diagnosed with actinomycotic canaliculitis in Iceland. METHODS:We present a nationwide, retrospective case series for which cases were identified by searches of hospital diagnostic registries and pathology databases. Case historie...

journal_title：Acta ophthalmologica

authors： Baldursdóttir E,Sigurdsson H,Jónasson L,Gottfredsson M

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To evaluate a pro re nata administration of Ozurdex® implant versus a single administration for treating diabetic macular oedema (DME). METHODS:This exploratory study is designed as a comparative, multicentre, randomized study with a follow-up of 6 months. Patients with DME were assigned to treatment at baseli...

journal_title：Acta ophthalmologica

authors： Sarao V,Veritti D,Furino C,Giancipoli E,Alessio G,Boscia F,Lanzetta P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Posterior capsule opacification (PCO) occurs as a common complication after cataract surgery. Erlotinib is an inhibitor of the epidermal growth factor-Receptor and reduces critical cellular events leading to PCO. In this in vitro study, Erlotinib-modified intraocular lenses (IOLs) employed as a drug delivery de...

journal_title：Acta ophthalmologica

authors： Wertheimer C,Kueres A,Siedlecki J,Braun C,Kassumeh S,Wolf A,Mayer W,Priglinger C,Priglinger S,Eibl-Lindner K

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Limited knowledge exists about the influence of donor age and death-to-preservation interval (DPI) on the metabolic properties of the cornea. The aim of this study is to investigate the relationship between both factors and metabolite content of the cornea. METHODS:Corneas from 15 human donors (age: 41-78 year...

journal_title：Acta ophthalmologica

authors： Kryczka T,Szaflik JP,Szaflik J,Midelfart A

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To study the connection between parental myopia and their children's myopia from school age to adulthood. METHODS:Two hundred and forty myopic schoolchildren (119 boys, 121 girls, mean age 10.9 years) with no previous spectacles for myopia were recruited to a 3-year treatment trial with different use of specta...

journal_title：Acta ophthalmologica

authors： Pärssinen O,Kauppinen M

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To moderate the capsular opacification (CO) response after lens surgery, an experimental study was performed in which nanofibre-based hydrogels (nanogels) with different ratios of attached peptides were applied to provide extracellular matrix-related cues for lens epithelial cells (LECs) in a porcine eye model....

journal_title：Acta ophthalmologica

authors： Nibourg LM,Gelens E,Nibourg SA,de Jong MR,Kuijer R,van Kooten TG,Koopmans SA

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Study the clinical and microbiological characteristics and the prognostic factors of post-traumatic endophthalmitis. METHODS:Seventeen eyes were included between 2004 and 2010, with clinical and microbiological data collected prospectively. Conventional cultures and panbacterial PCR were performed on aqueous a...

journal_title：Acta ophthalmologica

authors： Cornut PL,Youssef el B,Bron A,Thuret G,Gain P,Burillon C,Romanet JP,Vandenesch F,Maurin M,Creuzot-Garcher C,Chiquet C,French Institutional Endophthalmitis Study (FRIENDS) Group.

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS:Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. Al...

journal_title：Acta ophthalmologica

authors： Klijn S,van der Sommen CM,Sicam VA,Reus NJ

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To investigate the prevalence of potential age-related eye conditions in elderly who are assisted by home healthcare nurses. The number of referrals to the general practitioner (GP), feasibility of screening and associations between vision loss and health outcomes were also studied. METHODS:Cross-sectional stu...

journal_title：Acta ophthalmologica

authors： van Nispen R,van der Aa H,Timmermans F,Meijer N,Koster N,de Blok J,Keunen J,van Rens G

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder and one of the primary indications for corneal transplantation. Anterior lamellar keratoplasty offers several advantages over other techniques, including endothelial preservation and longer graft survival. In this study, we examined the recent trend of using lamellar techni...

journal_title：Acta ophthalmologica

authors： Godefrooij DA,Gans R,Imhof SM,Wisse RP

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To study high-resolution ultrasound biomicroscopy (UBM) findings in anterior scleral inflammatory disease and evaluate the efficacy of high-resolution UBM as an adjunctive diagnostic tool. METHODS:A cross-sectional study. The medical records of 30 patients (33 eyes) with episcleritis or anterior scleritis were...

journal_title：Acta ophthalmologica

authors： Zur D,Neudorfer M,Shulman S,Rosenblatt A,Habot-Wilner Z

更新日期：2016-09-01 00:00:00