Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy.


PURPOSE:Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age-related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). METHODS:This was a prospective case-control study. A total of 125 participants were included consecutively during a period of 18 months. We included 46 patients with neovascular AMD, 46 patients with GA without any sign of choroidal neovascularization in either eye, and 33 healthy aged controls. Patients with immune-affecting disorders were not included. Commercial immunoassay kits were used to quantify levels of TIMP-1, TIMP-3, MMP-2 and MMP-9 in blood plasma. RESULTS:We found that patients with neovascular AMD had lower plasma concentration of TIMP-3 (p = 0.028) than healthy controls. Patients with GA had higher plasma levels of TIMP-1 (p < 0.001) and MMP-9 (p = 0.022) compared to healthy controls. Also, we found that TIMP-1 levels in patients with GA increased with age (Spearman's rho = 0.04, p = 0.006). CONCLUSION:Matrix metalloproteinases (MMPs) and TIMPs, which are known to be involved in age-related changes in Bruch's membrane, are significantly altered systemically, suggesting the presence of an imbalance in the homeostasis of the extracellular matrix. These imbalances may explain differences in the clinical manifestation of late AMD.


Acta Ophthalmol


Acta ophthalmologica


Krogh Nielsen M,Subhi Y,Rue Molbech C,Nilsson LL,Nissen MH,Sørensen TL




Has Abstract


2019-02-01 00:00:00












  • Heritability of corneal refraction and corneal astigmatism: a population-based twin study among 66- to 79-year-old female twins.

    abstract:PURPOSE:To examine the heritability of corneal refraction power (CR) and corneal astigmatism (AST) in older women. METHODS:Corneal refraction and AST were measured by IOL master in 52 monozygotic (MZ) and 47 dizygotic (DZ) female twin pairs aged 66-79 years. The relative contribution of genetic and environmental facto...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Pärssinen O,Kauppinen M,Kaprio J,Koskenvuo M,Rantanen T

    更新日期:2013-03-01 00:00:00

  • Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy.

    abstract:PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investig...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Qian J,Jiang YR

    更新日期:2011-06-01 00:00:00

  • Subconjunctival bevacizumab for corneal neovascularization.

    abstract:PURPOSE:This work aimed to study and evaluate the effect of subconjunctival bevacizumab injection in patients with corneal neovascularization (CNV) resulting from different ocular surface disorders. METHODS:Ten eyes with CNV caused by different ocular surface disorders were studied. All eyes had both major and minor v...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Zaki AA,Farid SF

    更新日期:2010-12-01 00:00:00

  • Ultrasound biomicroscopic study of the stability of intraocular lens implants after phacoemulsification cataract surgery.

    abstract:PURPOSE:To assess the postoperative stability of three-piece intraocular lens (IOL) implants using ultrasound biomicroscopy (UBM). METHODS:This is a prospective observational cohort case series. Best-corrected visual acuity (BCVA) assessment, slit lamp examination, refraction and UBM evaluation were performed preopera...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Ang GS,Duncan L,Atta HR

    更新日期:2012-03-01 00:00:00

  • Plusoptix photoscreener use for paediatric vision screening in Flanders and Iran.

    abstract:PURPOSE:Photoscreening assesses risk factors for amblyopia, as an alternative to measurement of visual acuity (VA) to detect amblyopia, on the premise that its early correction could prevent development of amblyopia. We studied implementations of Plusoptix photoscreening in existing population-based screening in Flande...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审


    authors: Bostamzad P,Horwood AM,Schalij-Delfos NE,Boelaert K,de Koning HJ,Simonsz HJ

    更新日期:2020-02-01 00:00:00

  • Factors associated to temporal artery biopsy result in suspects of giant cell arteritis: a retrospective, multicenter, case-control study.

    abstract:PURPOSE:To evaluate the positivity rate of temporal artery biopsies (TAB) performed in suspects of giant cell arteritis (GCA) and to study the epidemiological and clinical factors associated to the biopsy result. METHODS:A retrospective, multicenter, case-control study was performed, including three hundred and thirty...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,多中心研究


    authors: González-López JJ,González-Moraleja J,Burdaspal-Moratilla A,Rebolleda G,Núñez-Gómez-Álvarez MT,Muñoz-Negrete FJ

    更新日期:2013-12-01 00:00:00

  • Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.

    abstract:PURPOSE:The cyclolignan picropodophyllin (PPP) efficiently blocks the activity of insulin-like growth factor-1 receptor (IGF-1R) and inhibits growth of uveal melanoma cells in vitro and in vivo. In this study, we aimed to investigate the efficiency of orally administered PPP on growth of uveal melanoma xenografts. Furt...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Economou MA,Andersson S,Vasilcanu D,All-Ericsson C,Menu E,Girnita A,Girnita L,Axelson M,Seregard S,Larsson O

    更新日期:2008-11-01 00:00:00

  • Visual outcomes of treated periocular capillary haemangiomas in childhood: a 10-year review.

    abstract:PURPOSE:To report our experiences of treating periocular capillary haemangioma with particular emphasis on visual outcomes. METHODS:Patients who underwent treatment for periocular capillary haemangioma were identified, and a chart review was performed. RESULTS:There were seventeen patients in the study. The main indi...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Gawley SD,Bingham EA,McGinnity G

    更新日期:2011-06-01 00:00:00

  • Endothelial cell loss and refractive predictability in femtosecond laser-assisted cataract surgery compared with conventional cataract surgery.

    abstract:PURPOSE:To investigate the amount of endothelial cell loss (ECL) and refractive predictability by femtosecond laser-assisted cataract surgery (FLACS) compared to conventional phacoemulsification cataract surgery (CPS). METHODS:Forty-seven patients had one eye operated by FLACS and the contralateral eye operated by CPS...

    journal_title:Acta ophthalmologica

    pub_type: 临床试验,杂志文章


    authors: Krarup T,Holm LM,la Cour M,Kjaerbo H

    更新日期:2014-11-01 00:00:00

  • Aquaporins 6-12 in the human eye.

    abstract:PURPOSE:Aquaporins (AQPs) are widely expressed and have diverse distribution patterns in the eye. AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye. METHODS:RT-PCR was performed on fresh tissue from two human eyes d...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Tran TL,Bek T,Holm L,la Cour M,Nielsen S,Prause JU,Rojek A,Hamann S,Heegaard S

    更新日期:2013-09-01 00:00:00

  • Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography.

    abstract:PURPOSE:The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). METHODS:I...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Mendez-Hernandez C,Rodriguez-Uña I,Gonzalez-de-la Rosa M,Arribas-Pardo P,Garcia-Feijoo J

    更新日期:2016-11-01 00:00:00

  • Diabetic macular oedema quantified with spectral-domain optical coherence tomography--evaluation of boundary line artefacts and the effect on retinal thickness.

    abstract:PURPOSE:To characterize frequency, morphological cause and time-dependent change of boundary line artefacts in optical coherence tomography (OCT) examinations of centre-involved diabetic macular oedema (ciDME) patients who underwent ranibizumab treatment with 1-year follow-up and to evaluate the impact of artefacts on ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Hodzic-Hadzibegovic D,Sander BA,Lund-Andersen H

    更新日期:2015-02-01 00:00:00

  • Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes.

    abstract:PURPOSE:To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. METHODS:Corneal measurements of 110 normal eyes (one eye per subject) and 70 k...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Viswanathan D,Kumar NL,Males JJ,Graham SL

    更新日期:2015-09-01 00:00:00

  • Prevalence of end-of-life visual impairment in patients followed for glaucoma.

    abstract:PURPOSE:To assess the prevalence of end-of-life visual impairment in patients followed for glaucoma. METHODS:Data of 122 patients followed for glaucoma who had died between July 2008 and July 2010 and who had visited the ophthalmology outpatient department of a large non-academic Dutch hospital were collected from the...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Ernest PJ,Busch MJ,Webers CA,Beckers HJ,Hendrikse F,Prins MH,Schouten JS

    更新日期:2013-12-01 00:00:00

  • Retinal microvasculature in pituitary adenoma patients: is optical coherence tomography angiography useful?

    abstract:PURPOSE:To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma (PA) using optical coherence tomography angiography (OCTA). METHODS:Cross-sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro-ophthalmol...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Dallorto L,Lavia C,Jeannerot AL,Shor N,Jublanc C,Boch AL,Bodaghi B,Tadayoni R,Touitou V,Bonnin S

    更新日期:2019-12-06 00:00:00

  • The eye of Vesalius.

    abstract::In the time of Vesalius, knowledge of ocular anatomy was limited. The first description of the anatomy of the eye comes from Democrites, for whom the eye was surrounded by two 'coats', filled with a homogenous fluid. The optic nerve was hollow and the lens was considered to be a postmortem artefact. Until the 15th cen...

    journal_title:Acta ophthalmologica

    pub_type: 传,历史文章,杂志文章


    authors: De Laey JJ

    更新日期:2011-05-01 00:00:00

  • Systemic use of calcium channel blockers associated with less increase in central retinal thickness after uncomplicated cataract surgery.

    abstract:PURPOSE:To examine the role of systemic medication on the risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery. METHODS:A total of 269 eyes undergoing routine cataract surgery. Spectral-domain optical coherence tomography imaging was conducted before surgery and at 28 days. Informati...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Danni R,Taipale C,Holmström EJ,Ilveskoski L,Tuuminen R

    更新日期:2019-03-01 00:00:00

  • Anisometropia of ocular refractive and biometric measures among 66- to 79-year-old female twins.

    abstract:PURPOSE:To examine the prevalence of anisometropia of spherical refraction (AnisoSR), astigmatism (AnisoAST) and spherical equivalent (AnisoSE) and their associations with spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE) and interocular differences of ocular biometric parameters among ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Pärssinen O,Kauppinen M,Kaprio J,Rantanen T

    更新日期:2016-12-01 00:00:00

  • Agreement between rebound (Icare ic200) and applanation tonometry (Perkins) in patients with primary congenital glaucoma.

    abstract:PURPOSE:To examine agreement between intraocular pressure (IOP) measurements made using the rebound tonometer Icare ic200 (RT200) and the Perkins handheld applanation tonometer (PAT) in patients with primary congenital glaucoma (PCG). The impacts of several covariables on measurements using the two devices were also as...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Morales-Fernandez L,Pérez-García P,Saenz-Frances F,Molero-Senosiain M,Garcia-Saenz S,Dora Mendez C,Santos Bueso E,Garcia-Feijoo J,Martinez-de-la-Casa JM

    更新日期:2020-12-23 00:00:00

  • Preoperative anti-inflammatory treatment of diabetic patients does not improve recovery from cataract surgery when postoperatively treated with a combination of prednisolone acetate and nepafenac.

    abstract:PURPOSE:To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients. METHODS:A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验


    authors: Danni R,Viljanen A,Aaronson A,Tuuminen R

    更新日期:2019-09-01 00:00:00

  • Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

    abstract:PURPOSE:Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained i...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Andreasen S,von Holstein SL,Homøe P,Heegaard S

    更新日期:2018-11-01 00:00:00

  • Analysis of retinal function using chromatic pupillography in retinitis pigmentosa and the relationship to electrically evoked phosphene thresholds.

    abstract:PURPOSE:To analyse pupil responses to specific chromatic stimuli in patients with advanced retinitis pigmentosa (RP) to ascertain whether chromatic pupillography can be used as an objective marker for residual retinal function. To examine correlations between parameters of the pupil response and the perception threshol...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Kelbsch C,Maeda F,Lisowska J,Lisowski L,Strasser T,Stingl K,Wilhelm B,Wilhelm H,Peters T

    更新日期:2017-06-01 00:00:00

  • Preoperative and postoperative measurements of retinal vessel oxygen saturation in patients with different grades of cataracts.

    abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Chen H,Lin H,Chen W,Zhang B,Xiang W,Gao Q,Chen W,Liu Y

    更新日期:2017-09-01 00:00:00

  • Increased anterior chamber penetration of topical levofloxacin 0.5% after pulsed dosing in cataract patients.

    abstract:PURPOSE:This study aimed to investigate the rise in aqueous humour (AH) levels of levofloxacin after a specific perioperative pulsed topical drop regimen. METHODS:Thirty patients undergoing phacoemulsification surgery were administered two preoperative drops of levofloxacin 0.5%, 30 mins apart, and three pulsed drops ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验


    authors: Sundelin K,Seal D,Gardner S,Ropo A,Geldsetzer K,Lokkila J,Stenevi U

    更新日期:2009-03-01 00:00:00

  • Phacoemulsification combined with posterior capsulorhexis and anterior vitrectomy in the management of malignant glaucoma in phakic eyes.

    abstract:PURPOSE:  To describe sequential phacoemulsification-intraocular lens (IOL) implantation-posterior capsulorhexis-anterior vitrectomy in the management of phakic malignant glaucoma. METHODS:  Twenty consecutive patients (25 eyes) with phakic malignant glaucoma were enrolled at the Zhongshan Ophthalmic Center, Sun Yat-s...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Liu X,Li M,Cheng B,Mao Z,Zhong Y,Wang D,Cao D,Yu F,Congdon NG

    更新日期:2013-11-01 00:00:00

  • Value of posterior keratometry in the assessment of surgically induced astigmatic change in cataract surgery.

    abstract:PURPOSE:To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS:Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. Al...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Klijn S,van der Sommen CM,Sicam VA,Reus NJ

    更新日期:2016-08-01 00:00:00

  • The Groningen Longitudinal Glaucoma Study. II. A prospective comparison of frequency doubling perimetry, the GDx nerve fibre analyser and standard automated perimetry in glaucoma suspect patients.

    abstract:PURPOSE:We aimed to determine prospectively the incidence of abnormal test results on frequency doubling perimetry (FDT), the nerve fibre analyser (GDx) and standard automated perimetry (SAP) in a cohort of glaucoma suspect patients with normal findings for all these tests at baseline. METHODS:Seventy glaucoma suspect...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Jansonius NM,Heeg GP

    更新日期:2009-06-01 00:00:00

  • Trends in penetrating and anterior lamellar corneal grafting techniques for keratoconus: a national registry study.

    abstract:PURPOSE:Keratoconus is a progressive disorder and one of the primary indications for corneal transplantation. Anterior lamellar keratoplasty offers several advantages over other techniques, including endothelial preservation and longer graft survival. In this study, we examined the recent trend of using lamellar techni...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Godefrooij DA,Gans R,Imhof SM,Wisse RP

    更新日期:2016-08-01 00:00:00

  • Changes in lipidomic profile of aqueous humour in Fuchs endothelial dystrophy.

    abstract:PURPOSE:To identify and determine differences in lipid profile of aqueous humour (AH) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:Lipidomic profile of eight AH samples of FECD patients and 10 control samples was analysed. Patients with previous history of anterior segment surgery, anterior seg...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Cabrerizo J,Urcola JA,Vecino E,Melles G

    更新日期:2017-11-01 00:00:00

  • Cryo-assisted anterior approach for surgery of retroocular orbital tumours avoids the need for lateral or transcranial orbitotomy in most cases.

    abstract:PURPOSE:  To describe and evaluate a cryo-assisted, minimally invasive, anterior approach for orbital tumour surgery. METHODS:  Retrospective, non-comparative, consecutive, interventional case series of 103 patients who were operated on by the same surgeon for retroocular orbital tumours over the last 16 years. RESUL...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章


    authors: Rosen N,Priel A,Simon GJ,Rosner M

    更新日期:2010-09-01 00:00:00