Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy.

Abstract:

PURPOSE:Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age-related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). METHODS:This was a prospective case-control study. A total of 125 participants were included consecutively during a period of 18 months. We included 46 patients with neovascular AMD, 46 patients with GA without any sign of choroidal neovascularization in either eye, and 33 healthy aged controls. Patients with immune-affecting disorders were not included. Commercial immunoassay kits were used to quantify levels of TIMP-1, TIMP-3, MMP-2 and MMP-9 in blood plasma. RESULTS:We found that patients with neovascular AMD had lower plasma concentration of TIMP-3 (p = 0.028) than healthy controls. Patients with GA had higher plasma levels of TIMP-1 (p < 0.001) and MMP-9 (p = 0.022) compared to healthy controls. Also, we found that TIMP-1 levels in patients with GA increased with age (Spearman's rho = 0.04, p = 0.006). CONCLUSION:Matrix metalloproteinases (MMPs) and TIMPs, which are known to be involved in age-related changes in Bruch's membrane, are significantly altered systemically, suggesting the presence of an imbalance in the homeostasis of the extracellular matrix. These imbalances may explain differences in the clinical manifestation of late AMD.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Krogh Nielsen M,Subhi Y,Rue Molbech C,Nilsson LL,Nissen MH,Sørensen TL

doi

10.1111/aos.13894

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

84-90

issue

1

eissn

1755-375X

issn

1755-3768

journal_volume

97

pub_type

杂志文章
  • Comparison of corneal biomechanical changes after refractive surgery by noncontact tonometry: small-incision lenticule extraction versus flap-based refractive surgery - a systematic review.

    abstract::Corneal refractive surgery disrupts corneal integrity and reduces biomechanical stability in consequence of the beneficial refractive alteration. The minimal invasive cap-based refractive procedure, small-incision lenticule extraction (SMILE), has been proposed to affect corneal integrity less than flap-based procedur...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13906

    authors: Raevdal P,Grauslund J,Vestergaard AH

    更新日期:2019-03-01 00:00:00

  • Optimizing the treatment of rhegmatogenous retinal detachment.

    abstract::Surgical approaches for rhegmatogenous retinal detachment (RRD) have evolved rapidly in the past century. This has resulted in an increase in the anatomical success rate from zero per cent in the beginning of the 1900s to now almost 100 per cent. Rhegmatogenous retinal detachment is regarded as an acute eye disease th...

    journal_title:Acta ophthalmologica

    pub_type: 历史文章,杂志文章

    doi:10.1111/aos.12991

    authors: Hajari JN

    更新日期:2016-03-01 00:00:00

  • Value of posterior keratometry in the assessment of surgically induced astigmatic change in cataract surgery.

    abstract:PURPOSE:To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS:Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. Al...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13003

    authors: Klijn S,van der Sommen CM,Sicam VA,Reus NJ

    更新日期:2016-08-01 00:00:00

  • Difference in the posterior pole profiles associated with the initial location of visual field defect in early-stage normal tension glaucoma.

    abstract:PURPOSE:To identify the differences in posterior pole profiles between early normal tension glaucoma (NTG) patients with an initial central visual field (VF) loss and those with a peripheral VF loss. METHODS:Normal tension glaucoma patients with parafoveal scotoma (PFS; within a central 10° of fixation; superior, n=47...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12492

    authors: Choi JA,Park HY,Park CK

    更新日期:2015-03-01 00:00:00

  • Optical coherence tomography morphology and evolution in cblC disease-related maculopathy in a case series of very young patients.

    abstract:PURPOSE:To describe the retinal structure of a group of patients affected by methylmalonic aciduria with homocystinuria cblC type, caused by mutations in the MMACHC gene, using spectral domain optical coherence tomography (SD-OCT). METHODS:Young patients (n = 11, age 0-74 months) with cblC disease, detected by newborn...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aos.13441

    authors: Bacci GM,Donati MA,Pasquini E,Munier F,Cavicchi C,Morrone A,Sodi A,Murro V,Garcia Segarra N,Defilippi C,Bussolin L,Caputo R

    更新日期:2017-12-01 00:00:00

  • Subjective visual sensations during cataract surgery performed under topical anaesthesia.

    abstract:PURPOSE:To examine the patient's subjective visual sensations during cataract surgery performed under topical anaesthesia. METHODS:Prospective, non-randomized, cohort study. One hundred and thirty-two patients were interviewed by standard questionnaire within 1 hr of uncomplicated cataract surgery performed under topi...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2007.01153.x

    authors: Biró Z,Schvöller M

    更新日期:2008-12-01 00:00:00

  • Intraocular lens dislocation in pseudoexfoliation: a systematic review and meta-analysis.

    abstract:PURPOSE:To evaluate the impact of pseudoexfoliation syndrome on intraocular lens (IOL) dislocation after phacoemulsification cataract surgery and explore possible associations related to surgical technique. METHODS:We systematically searched the MEDLINE, Embase, Web of Science, Cochrane, and Lilacs databases and grey ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/aos.13234

    authors: Vazquez-Ferreiro P,Carrera-Hueso FJ,Fikri-Benbrahim N,Barreiro-Rodriguez L,Diaz-Rey M,Ramón Barrios MA

    更新日期:2017-05-01 00:00:00

  • Serial changes in the bleb wall after glaucoma drainage implant surgery: characteristics during the hypertensive phase.

    abstract:PURPOSE:To investigate serial changes in the bleb wall using anterior segment optical coherence tomography (AS-OCT) in patients who had undergone Ahmed glaucoma valve (AGV) implantation. METHODS:A total of 52 patients who had undergone AGV implantation were enrolled. Reflectivity and mean thickness of the bleb wall we...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12571

    authors: Jung KI,Park H,Jung Y,Park CK

    更新日期:2015-06-01 00:00:00

  • Optimal refraction with monofocal intraocular lenses: no beneficial effect of astigmatism.

    abstract:PURPOSE:This study aimed to determine the optimal spherocylindrical refraction in the monofocal, pseudophakic eye using power vectors in dioptric space. METHODS:For parallel incident light the defocus of a spherocylinder may be described in dioptric space as: Defocus equivalent for distance fixation = D((SEP,M,x=∞)) =...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2009.01650.x

    authors: Naeser K,Hjortdal J

    更新日期:2011-03-01 00:00:00

  • Simulation-based certification for cataract surgery.

    abstract:PURPOSE:To evaluate the EyeSi(™) simulator in regard to assessing competence in cataract surgery. The primary objective was to explore all simulator metrics to establish a proficiency-based test with solid evidence. The secondary objective was to evaluate whether the skill assessment was specific to cataract surgery. ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12691

    authors: Thomsen AS,Kiilgaard JF,Kjaerbo H,la Cour M,Konge L

    更新日期:2015-08-01 00:00:00

  • Ultrasound biomicroscopy of zonular anatomy in clinically unilateral exfoliation syndrome.

    abstract:PURPOSE:To evaluate the ability of ultrasound biomicroscopy (UBM) to detect abnormalities in the zonular apparatus in unaffected eyes of patients with clinically unilateral exfoliation syndrome (XFS) using a standardized grading system. METHODS:The affected and unaffected eyes of 17 patients with clinically unilateral...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0420.2007.01105.x

    authors: Sbeity Z,Dorairaj SK,Reddy S,Tello C,Liebmann JM,Ritch R

    更新日期:2008-08-01 00:00:00

  • Toy gun eye injuries - eye protection needed Helsinki ocular trauma study.

    abstract:PURPOSE:We report the epidemiology, findings, treatment, long-term outcome and use of resources for eye injuries caused by toy guns in southern Finland. METHODS:All new patients injured by toy guns in one year (2011-2012) and treated at Helsinki University Eye Hospital were included. Follow-ups occurred at 3 months an...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13948

    authors: Haavisto AK,Sahraravand A,Puska P,Leivo T

    更新日期:2019-06-01 00:00:00

  • Epidemiological variations and trends in health burden of glaucoma worldwide.

    abstract:PURPOSE:To evaluate the trends and variations in global health burden of glaucoma by year, age and sex, region and socio-economic status, using disability-adjusted life years (DALYs). METHOD:The DALY numbers, crude DALY rate and age-standardized DALY rate globally and in each country were obtained the GBD 2015 study d...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aos.14044

    authors: Wang W,He M,Li Z,Huang W

    更新日期:2019-05-01 00:00:00

  • Physical activity and myopia in Danish children-The CHAMPS Eye Study.

    abstract:PURPOSE:To determine associations between physical activity (PA) and myopia in Danish school children and investigate the prevalence of myopia. METHODS:This is a prospective study with longitudinal data on PA in a Danish child cohort. Physical activity (PA) was measured objectively by repeated ActiGraph accelerometer ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13513

    authors: Lundberg K,Suhr Thykjaer A,Søgaard Hansen R,Vestergaard AH,Jacobsen N,Goldschmidt E,Lima RA,Peto T,Wedderkopp N,Grauslund J

    更新日期:2018-03-01 00:00:00

  • Topical dexamethasone-cyclodextrin nanoparticle eye drops for non-infectious Uveitic macular oedema and vitritis - a pilot study.

    abstract:PURPOSE:To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis. METHODS:In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another 4 weeks. Fol...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12744

    authors: Shulman S,Jóhannesson G,Stefánsson E,Loewenstein A,Rosenblatt A,Habot-Wilner Z

    更新日期:2015-08-01 00:00:00

  • E-PTFE (Gore-Tex) implant with or without low-dosage mitomycin-C as an adjuvant in penetrating glaucoma surgery: 2 year randomized clinical trial.

    abstract:PURPOSE:To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy. METHODS:Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with m...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0420.2007.01036.x

    authors: Cillino S,Zeppa L,Di Pace F,Casuccio A,Morreale D,Bocchetta F,Lodato G

    更新日期:2008-05-01 00:00:00

  • Elevated intraocular pressure induces neuron-specific β-III-tubulin expression in non-neuronal vascular cells.

    abstract:PURPOSE:Pathological alterations within optic nerve axons and progressive loss of the parental retinal ganglion cell (RGC) bodies are characteristics of glaucomatous neuropathy. Abnormally elevated intraocular pressure (IOP) is thought to be the major risk factor for most forms of glaucomatous changes, while lowering o...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14333

    authors: Prokosch V,Brockhaus K,Anders F,Liu H,Mercieca K,Gericke A,Melkonyan H,Thanos S

    更新日期:2019-12-29 00:00:00

  • Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions.

    abstract::A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/aos.14392

    authors: Bekkers A,Borren N,Ederveen V,Fokkinga E,Andrade De Jesus D,Sánchez Brea L,Klein S,van Walsum T,Barbosa-Breda J,Stalmans I

    更新日期:2020-09-01 00:00:00

  • Scanning laser polarimetry with variable corneal compensation in migraine patients.

    abstract:PURPOSE: This study aimed to compare scanning laser polarimetry measurements of retinal nerve fibre layer (RNFL) thickness in eyes of migraine patients with those in eyes of age-matched, healthy subjects. METHODS: The study was designed as an observational, prospective, cross-sectional study. It included 57 eyes of 57...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2008.01356.x

    authors: Martinez A,Proupim N,Sanchez M

    更新日期:2009-11-01 00:00:00

  • Anterior chamber parameters measured by the Pentacam CES after uneventful phacoemulsification in normotensive eyes.

    abstract:PURPOSE:We set out to quantify changes in the anterior chamber volume (ACV), anterior chamber depth (ACD) and anterior chamber angle (ACA) measurements obtained by the Pentacam rotating Scheimpflug camera following uneventful phacoemulsification surgery in normotensive eyes with open iridocorneal angles. METHODS:We en...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2008.01305.x

    authors: Uçakhan OO,Ozkan M,Kanpolat A

    更新日期:2009-08-01 00:00:00

  • The neural correlates of impaired collision avoidance in hemianopic patients.

    abstract:PURPOSE:The aim of this study was to assess the brain regions associated with impaired performance in a virtual, dynamic collision avoidance task, in a group of patients with homonymous visual field defects (HVFDs) because of unilateral vascular brain lesions. METHODS:Overall task performance was quantitatively assess...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2011.02315.x

    authors: Papageorgiou E,Hardiess G,Wiethölter H,Ackermann H,Dietz K,Mallot HA,Schiefer U

    更新日期:2012-05-01 00:00:00

  • Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity.

    abstract:PURPOSE:To investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti® ) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA). METHODS:This was an age- and refraction-matched case-control study. Consecutive patients with a best-corrected visual ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13680

    authors: Takagi S,Hirami Y,Takahashi M,Fujihara M,Mandai M,Miyakoshi C,Tomita G,Kurimoto Y

    更新日期:2018-08-01 00:00:00

  • Evaluation of CorvisST biomechanical parameters and anterior segment optical coherence tomography for diagnosing forme fruste keratoconus.

    abstract:PURPOSE:To investigate the utility of biomechanical property measurements using a Scheimpflug-based tonometer (SBT) and/or anterior segment optical coherence tomography (AS-OCT) for diagnosing forme fruste keratoconus (FFK). METHODS:In this retrospective interventional case series, 23 eyes with FFK of 23 consecutive p...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14700

    authors: Shiga S,Kojima T,Nishida T,Nakamura T,Ichikawa K

    更新日期:2020-12-16 00:00:00

  • Influences of cyclopentolate hydrochloride on anterior segment parameters with Pentacam in children.

    abstract:PURPOSE:To investigate the effects of cyclopentolate hydrochloride 1% on the main numerical parameters of anterior segment with Pentacam rotating Scheimpflug camera in children. SETTING:Ege University Faculty of Medicine, Department of Ophthalmology. METHODS:Pentacam measurements of 50 (23 boys and 27 girls) children...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2011.02122.x

    authors: Palamar M,Egrilmez S,Uretmen O,Yagci A,Kose S

    更新日期:2011-08-01 00:00:00

  • Keratoconus in 18 pairs of twins.

    abstract:PURPOSE:To describe the concordance of keratoconus in 18 sets of twins. METHODS:Thirteen monozygotic (MZ) and five dizygotic (DZ) pairs of twins were identified during an investigation of familial keratoconus. We used 16 forensic microsatellite markers to confirm the zygosity of same sex twins. Patients and available ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2012.02448.x

    authors: Tuft SJ,Hassan H,George S,Frazer DG,Willoughby CE,Liskova P

    更新日期:2012-09-01 00:00:00

  • A study of stromal riboflavin absorption in ex vivo porcine corneas using new and existing delivery protocols for corneal cross-linking.

    abstract:PURPOSE:To indirectly measure stromal riboflavin penetration using commercially available riboflavin solutions and new and existing epithelium-off, trans-epithelial and iontophoresis-assisted delivery protocols. METHODS:Forty porcine eyes were divided into eight groups. Group 1: Ricrolin applied to the de-epithelialis...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12884

    authors: Hayes S,Morgan SR,O'Brart DP,O'Brart N,Meek KM

    更新日期:2016-03-01 00:00:00

  • The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010.

    abstract:PURPOSE:The Gloucestershire Diabetic Eye Screening Programme offers annual digital photographic screening for diabetic retinopathy to a countywide population of people with diabetes. This study was designed to investigate progression of diabetic retinopathy in this programme of the English NHS Diabetic Eye Screening Pr...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12074

    authors: Scanlon PH,Stratton IM,Histed M,Chave SJ,Aldington SJ

    更新日期:2013-08-01 00:00:00

  • Trends in penetrating and anterior lamellar corneal grafting techniques for keratoconus: a national registry study.

    abstract:PURPOSE:Keratoconus is a progressive disorder and one of the primary indications for corneal transplantation. Anterior lamellar keratoplasty offers several advantages over other techniques, including endothelial preservation and longer graft survival. In this study, we examined the recent trend of using lamellar techni...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13041

    authors: Godefrooij DA,Gans R,Imhof SM,Wisse RP

    更新日期:2016-08-01 00:00:00

  • Vitrectomy combined with endolaser or an encircling scleral buckle in primary retinal detachment surgery: a pilot study.

    abstract:PURPOSE:To compare pars plana vitrectomy and 360° endolaser therapy with pars plana vitrectomy and an encircling scleral buckle for the treatment of primary rhegmatogenous retinal detachments in a randomized pilot study including 60 patients. METHODS:Main outcome measures were single-surgery anatomic success rate and ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.12663

    authors: Falkner-Radler CI,Graf A,Binder S

    更新日期:2015-08-01 00:00:00

  • Variability in short-wavelength automated perimetry among peri- or postmenopausal women: a dependence on phyto-oestrogen consumption?

    abstract:PURPOSE:To determine whether the hill of vision for Short-Wavelength Automated Perimetry (SWAP) is shallower for women who consume phyto-oestrogen-rich foods than for women who do not. METHODS:Visual field data were compared for two groups of healthy amenorrhoeic women 48-69 years-old with normal vision and not using ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2009.01799.x

    authors: Eisner A,Demirel S

    更新日期:2011-05-01 00:00:00