Abstract:
PURPOSE:As some surgical procedures have been shown to increase postoperative flare values and thus contribute to blood-ocular barrier breakdown, retinal reattachment surgery might influence the risk of developing proliferative vitreoretinopathy (PVR). Therefore, we investigated whether postoperative aqueous flare values are a surrogate marker for the development of postoperative PVR. METHODS:We prospectively included 195 patients with primary rhegmatogenous retinal detachment (RRD) and measured aqueous laser flare preoperatively, and at 2 and 6 weeks postoperatively. Postoperative PVR was defined as reoperation for redetachment due to PVR membranes, within 6 months of initial surgery. Logistic regression and receiver operating characteristic (ROC) analysis determined whether higher postoperative flare values were associated with an increased risk of developing PVR later on. RESULTS:Reoperation for postoperative PVR was needed in 12 (6.2%) patients; in 18 (9.2%), reoperation was not related to PVR. The median flare value for patients who would develop PVR was significantly higher than that of patients who would not develop PVR, both at 2 weeks (p = 0.001) and 6 weeks (p < 0.001) postoperatively. Logistic regression analyses showed that a higher flare value significantly increased the odds of developing PVR, either at 2 weeks [odds ratio (OR) 1.027; 95% CI: 1.010-1.044] or 6 weeks (OR 1.076; 95% CI: 1.038-1.115). CONCLUSION:Flare values both at 2 and 6 weeks postoperatively seem a good surrogate marker in terms of sensitivity and specificity for the development of postoperative PVR but have only a modest positive predictive value. The 2-week value would be more useful in terms of early recognition of high-risk patients and hence give the possibility to better study effects of treatment methods.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Mulder VC,van Dijk EHC,van Meurs IA,La Heij EC,van Meurs JCdoi
10.1111/aos.13560subject
Has Abstractpub_date
2018-03-01 00:00:00pages
192-196issue
2eissn
1755-375Xissn
1755-3768journal_volume
96pub_type
杂志文章abstract::Surgical approaches for rhegmatogenous retinal detachment (RRD) have evolved rapidly in the past century. This has resulted in an increase in the anatomical success rate from zero per cent in the beginning of the 1900s to now almost 100 per cent. Rhegmatogenous retinal detachment is regarded as an acute eye disease th...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/aos.12991
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To compare posterior capsular opacification in patients with and without pseudoexfoliation syndrome 6-7 years following surgery. METHODS:Forty-four eyes of 44 patients with pseudoexfoliation syndrome who underwent cataract surgery with phacoemulsification in 2001 and 2002 were available for follow-up in 2008. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02380.x
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma has been reported. We, therefore, investigated the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE in a cell culture model. METHODS:The e...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12990
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:We aimed to evaluate the effectiveness of bicanalicular double silicone intubation in dacryocystorhinostomy (DCR) and canaliculoplasty for distal or common canalicular obstruction. METHODS:We reviewed the medical records of patients with distal or common canalicular obstruction who had undergone bicanalicular ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01292.x
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To investigate the amount of systemic oxidative stress-related DNA damage and serum total antioxidant status of patients with normal-tension glaucoma compared with healthy controls. METHODS:Forty-three patients with normal-tension glaucoma selected from 60 consecutive newly diagnosed patients with primary open...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01997.x
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To evaluate the trends and variations in global health burden of glaucoma by year, age and sex, region and socio-economic status, using disability-adjusted life years (DALYs). METHOD:The DALY numbers, crude DALY rate and age-standardized DALY rate globally and in each country were obtained the GBD 2015 study d...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.14044
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To determine whether excimer laser ablation of guttae is a viable strategy for removal of diseased tissue in Fuchs' endothelial corneal dystrophy (FECD) on excised human Descemet membranes and whether an excimer laser-created wound on healthy human corneas ex vivo is recolonized with corneal endothelial cells. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14366
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To determine whether decreasing illumination of the Pelli-Robson contrast sensitivity (CS) chart and MP-1 microperimeter to low mesopic conditions is more sensitive to vision changes occurring with healthy ageing and in early and intermediate age-related macular degeneration (AMD) and whether these mesopic test...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13112
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To report the postoperative results after enucleation of using an acrylic orbital implant covered in donor sclera for implantation. METHODS:We retrospectively analysed the charts of patients who were enucleated between 2007 and 2011. Only patients who received an acrylic implant covered with donor sclera were ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12960
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To investigate the utility of biomechanical property measurements using a Scheimpflug-based tonometer (SBT) and/or anterior segment optical coherence tomography (AS-OCT) for diagnosing forme fruste keratoconus (FFK). METHODS:In this retrospective interventional case series, 23 eyes with FFK of 23 consecutive p...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14700
更新日期:2020-12-16 00:00:00
abstract:PURPOSE:To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients. METHODS:A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients. RESULTS:The overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly,...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13551
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To investigate the presence and distribution of l-kynurenine aminotransferases immunoreactivity in human and animal lenses during cataract formation. METHODS:Immunohistochemistry was conducted using polyclonal antibodies against KAT I, KAT II and KAT III on sections of 26 anterior capsules from patients underg...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12138
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:To explore the association between retinal vein occlusion (RVO) and incident cancer. METHODS:All Danish citizens with a first-time diagnosis of RVO and no previous diagnosis of cancer in the period from 1 January 2004 to 31 December 2014 were included. Five likewise cancer-free, age- and gender-matched control...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13860
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13332
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02300.x
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13405
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To study the effect of glaucoma drainage implant (GDI) surgery on corneal topography during the first postoperative year. METHODS:Twenty-one adult glaucoma patients were implanted with a Molteno3 or a Baerveldt 250 GDI. Corneal topography measurements were taken preoperatively and at 6 and 12 months after surg...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14247
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To establish whether differences in the assessment of diabetic macular oedema (DME) with either optical coherence tomography (OCT) or stereoscopic biomicroscopy lead to variability in the photocoagulation treatment of DME. METHODS:The differences in the assessment of DME with either OCT or stereoscopic biomicr...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02524.x
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13502
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT). METHODS:Twenty-nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured at baseline and after ten, 20, 30 and 40 trea...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14010
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Aquaporins (AQPs) are widely expressed and have diverse distribution patterns in the eye. AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye. METHODS:RT-PCR was performed on fresh tissue from two human eyes d...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02547.x
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:To examine the public health impact of presbyopia regarding its effect on quality of life (QoL) and society in both the developed and developing worlds. METHODS:A database was created from articles found on PubMed, the Cochrane Library and Science Direct using the following search terms: presbyopia, QoL, accom...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.12308
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To determine whether the hill of vision for Short-Wavelength Automated Perimetry (SWAP) is shallower for women who consume phyto-oestrogen-rich foods than for women who do not. METHODS:Visual field data were compared for two groups of healthy amenorrhoeic women 48-69 years-old with normal vision and not using ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01799.x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To evaluate the association between the macular structure on spectral-domain optical coherence tomography (SD-CT) and visual outcome after vitrectomy for lamellar macular hole (LMH). METHODS:Best-corrected visual acuity (VA) and SD-OCT images of the macula were assessed before and after surgery in 30 eyes of 3...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02456.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:A recent threefold increase in laser treatment for advanced retinopathy of prematurity (ROP) triggered a nationwide preschool ophthalmic and developmental status among extremely preterm survivors. Here, we discuss refraction and visual acuity. METHODS:Survivors (n = 178) from a national birth cohort (February ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12643
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To compare pars plana vitrectomy and 360° endolaser therapy with pars plana vitrectomy and an encircling scleral buckle for the treatment of primary rhegmatogenous retinal detachments in a randomized pilot study including 60 patients. METHODS:Main outcome measures were single-surgery anatomic success rate and ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.12663
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To evaluate the regenerating potential and the mechanisms through which the autologous serum derived from plasma rich in growth factors (s-PRGF) favours corneal wound healing in vitro and in vivo. METHODS:We compared the effect of various concentrations of s-PRGF versus fetal bovine serum (FBS) and control tre...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13371
更新日期:2017-12-01 00:00:00
abstract::Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/j.1755-3768.2008.01210.x
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:This study aimed to study the incidence and clinical characteristics of patients diagnosed with actinomycotic canaliculitis in Iceland. METHODS:We present a nationwide, retrospective case series for which cases were identified by searches of hospital diagnostic registries and pathology databases. Case historie...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01367.x
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:Tissue inhibitors of metalloproteinases (TIMPs) block the catalysis by matrix metalloproteinases (MMPs) and have additional biologic activities, including regulation of cell growth and differentiation, apoptosis, angiogenesis and oncogenesis. We investigated the expression levels of all the four human TIMPs and...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13451
更新日期:2018-02-01 00:00:00