Abstract:
PURPOSE:To determine whether decreasing illumination of the Pelli-Robson contrast sensitivity (CS) chart and MP-1 microperimeter to low mesopic conditions is more sensitive to vision changes occurring with healthy ageing and in early and intermediate age-related macular degeneration (AMD) and whether these mesopic tests can differentiate visual function between healthy older participants with and without AMD risk genotypes. METHODS:Retinal sensitivity was measured in 98 healthy participants (19-85 years) and 21 AMD (AREDS Grade 2/3) patients (73.9 ± 6.5 years) using the Pelli-Robson CS chart and MP-1 microperimeter under low mesopic and standard illumination. The effect of ageing and AMD on retinal sensitivity was estimated using regression analysis. Healthy older participants (>50 years; n = 24) were genotyped for AMD risk genes CFH and/or ARMS2 and retinal sensitivity was compared between genotypes. RESULTS:With healthy ageing, photopic and mesopic Pelli-Robson CS showed a similar decline (-0.004 log CS/year). In AMD, photopic CS showed a similar decline to healthy ageing (-0.004 log CS/year) while mesopic CS was significantly reduced (-0.007 log CS/year). Both standard and low mesopic microperimetry showed a significant decline (-0.51 and -0.73% contrast/year) with healthy ageing and greater decline (-0.73 and -0.99% contrast/year) with AMD onset. Pelli-Robson CS and microperimetry sensitivity did not differ between AMD risk genotypes in healthy participants. CONCLUSIONS:Mesopic Pelli-Robson CS detects functional deficits before photopic CS in early and intermediate AMD that can be differentiated from ageing. This test can be easily administered in clinical practice and may provide a means for early detection of retinal dysfunction.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Maynard ML,Zele AJ,Feigl Bdoi
10.1111/aos.13112subject
Has Abstractpub_date
2016-12-01 00:00:00pages
e772-e778issue
8eissn
1755-375Xissn
1755-3768journal_volume
94pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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doi:10.1111/j.1755-3768.2011.02216.x
更新日期:2012-12-01 00:00:00
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更新日期:2010-09-01 00:00:00