Abstract:
PURPOSE:Angiogenic inhibitors, alone or combined with other therapies, are believed to represent a promising treatment for neovascularization in age-related macular degeneration (wet AMD). They can maintain or improve visual acuity (VA), at least for the first 2years. However, evolution to retinal atrophy cannot be ruled out and it may be useful to assess the effects of antiangiogenic therapy on retinal and choroidal circulation. METHODS:We carried out a pilot study in 15 patients with wet AMD. Time-averaged mean blood flow velocities (BFVs) in the central retinal, temporal posterior ciliary and ophthalmic arteries (CRA, TPCA and OA) were measured by ultrasound imaging before and 4weeks after a single intravitreal injection of 1.25mg bevacizumab in 0.05ml. Patients underwent two ophthalmic examinations, before and 4weeks after injection, including VA measurement and optical coherence tomography (OCT3) examination. RESULTS: In treated eyes, bevacizumab injection was followed by a significant improvement in VA (from 20/125 to 20/80; p=0.0214), and a decrease in mean central macular thickness (from 392±96μm to 271±50μm; p=0.0038). Mean BFV decreased by 10% in the CRA (p=0.0226), 20% in the TPCA (p=0.0026) and 20% in the OA (p=0.0003). No effect was observed in fellow eyes. CONCLUSIONS: Intravitreal bevacizumab acutely improved VA and reduced central macular thickness in wet AMD. Ultrasound imaging revealed that BFVs decreased in all retrobulbar arteries, suggesting that after local diffusion, bevacizumab exerts a short-term regional effect. Bevacizumab might therefore induce hypoperfusion of the whole eye, which may correspond to a vascular side-effect.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Bonnin P,Pournaras JA,Lazrak Z,Cohen SY,Legargasson JF,Gaudric A,Levy BI,Massin Pdoi
10.1111/j.1755-3768.2009.01526.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
641-5issue
6eissn
1755-375Xissn
1755-3768pii
AOS1526journal_volume
88pub_type
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journal_title:Acta ophthalmologica
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pub_type: 传,历史文章,杂志文章
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2009.01710.x
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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pub_type: 杂志文章
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abstract:PURPOSE:To investigate the clinical features and outcomes of diffuse large B-cell lymphoma (DLBCL) involving the eye and ocular adnexa in an East Asian population and emphasize the importance of prompt biopsy and treatment in unusually progressive ocular adnexal DLBCL for better visual outcomes. METHODS:Retrospective ...
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pub_type: 杂志文章
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-13 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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更新日期:2013-08-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2016-03-01 00:00:00
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更新日期:2020-12-23 00:00:00
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