Abstract:
PURPOSE:To investigate the clinical features and outcomes of diffuse large B-cell lymphoma (DLBCL) involving the eye and ocular adnexa in an East Asian population and emphasize the importance of prompt biopsy and treatment in unusually progressive ocular adnexal DLBCL for better visual outcomes. METHODS:Retrospective case series of 38 patients diagnosed with DLBCL involving the eye and ocular adnexa between 1995 and 2018 at a single tertiary institution. RESULTS:There were 38 patients (22 men, 16 women), 22 (57.9%) of which had ocular adnexal lymphoma (OAL) and 16 (42.1%), vitreoretinal lymphoma (VRL). The OAL group showed higher rates of unilateral involvement (p = 0.01) and localized disease presentation (p = 0.01). Thirteen (59.1%) of 22 OAL patients were primary diseases and 9 (40.9%) were secondary. Between primary and secondary OAL groups, there was no statistical difference in clinical characteristics such as age, gender and laterality (p = 0.47, p = 0.19 and p = 0.66, respectively). All secondary OAL cases were either disseminated or relapsed by definition and only two cases (15%) of primary OAL showed disseminated presentation (p < 0.01). Six (37.3%) of 22 OAL patients showed a rapid decrease in visual acuity within 15 days and the visual recovery was irreversible in 3 of them. CONCLUSION:OA-DLBCL has a grave prognosis and its visual outcomes largely depend on the timing of diagnosis and treatment. When a high-grade lymphoma is suspected, prompt biopsy and treatment should be performed to ensure optimal visual, clinical and survival outcomes.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Han SH,Kim YD,Jang J,Park JW,Young SM,Woo KIdoi
10.1111/aos.14725subject
Has Abstractpub_date
2021-01-09 00:00:00eissn
1755-375Xissn
1755-3768pub_type
杂志文章abstract::The main purpose of this thesis was to examine whether the Danish National Patient Registry (NPR) could be used to monitor and assess the quality of cataract surgery in Denmark by studying the risks of two serious postoperative complications following cataract surgery - retinal detachment (RD) and postoperative endoph...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12676
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To evaluate the prognosis of mortality in patients with spontaneous subarachnoid haemorrhage associated with Terson's syndrome. METHODS:A prospective, consecutive case series study was conducted in patients admitted to the emergency room with a diagnosis of acute subarachnoid haemorrhage. After a complete neur...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01735.x
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To determine whether anthropomorphic measurements are associated with ocular and general parameters. METHODS:The population-based Beijing Eye Study, which included 4439 participants (age > 40 years) out of 5324 individuals invited to be examined in 2001, was repeated in 2006 with 3251 (73.2% of 4439, or 61.1% ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01734.x
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To compare subconjunctival scarring after vitrectomy in rabbit eyes using different gauge systems by analysing anterior segment optical coherence tomography (AS-OCT) images and histological sections. METHODS:Vitrectomy using 20-, 23-, 25- and 27-gauge systems was performed for rabbits. Anterior segment optical...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13459
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To evaluate the correlation between refractive astigmatism (RA) and anterior corneal astigmatism (ACA), and determine the internal astigmatism (IA) in 184 pseudophakic eyes. METHODS:The study was a prospective non-masked single-centre study. Patients were examined 8 weeks after phacoemulsification with implant...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12418
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Central retinal vein occlusion (CRVO) entails retinal hypoxia that often causes visual impairment. It has been shown that oxygen saturation in larger retinal vessels correlates with the visual acuity at the time of diagnosis of CRVO but has no predictive value for the visual outcome in patients treated with ant...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14744
更新日期:2021-01-09 00:00:00
abstract:PURPOSE:To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS:Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than in Denmark. RESULTS:No signi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01488.x
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS:In this prospe...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13397
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To report our experiences of treating periocular capillary haemangioma with particular emphasis on visual outcomes. METHODS:Patients who underwent treatment for periocular capillary haemangioma were identified, and a chart review was performed. RESULTS:There were seventeen patients in the study. The main indi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01789.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of the ultrasonic circular cyclocoagulation procedure in patients with open-angle glaucoma naïve of previous filtering surgery. METHODS:Prospective non-comparative interventional clinical study conducted in five French University Hospitals. Thirty eyes of 30 patients with op...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/aos.12913
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To examine the influence of light source on letter contrast sensitivity in subjects with age-related macular degeneration (AMD). METHODS:Halogen incandescent bulbs and low-energy fluorescent tubes were tested with 70 subjects with AMD. The subjects' contrast sensitivity was determined in a randomized single-bl...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2009.01809.x
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14571
更新日期:2020-08-24 00:00:00
abstract::The development of ophthalmology was greatly restricted in Poland in the 19th century, because it was partitioned and occupied by its three dominant neighbours. Polish medical universities were closed, and in Polish hospitals, only clinical work was possible. Those who wanted to study medicine and become ophthalmologi...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/j.1755-3768.2009.01856.x
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:The introduction of vascular endothelial growth factor inhibitors for the treatment of exudative age-related macular degeneration (AMD) has increased the referral rates of AMD patients with visual symptoms to treating centres considerably. However, a large proportion of the referred patients do not qualify for ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.02074.x
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To evaluate and compare corneal biomechanical changes after deep anterior lamellar keratoplasty (DALK) versus penetrating keratoplasty (PK) using the ocular response analyzer (ORA). METHODS:This prospective comparative study included 65 eyes (65 patients). Patients were divided into three groups: DALK (20 eyes...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12136
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To study the effect of glaucoma drainage implant (GDI) surgery on corneal topography during the first postoperative year. METHODS:Twenty-one adult glaucoma patients were implanted with a Molteno3 or a Baerveldt 250 GDI. Corneal topography measurements were taken preoperatively and at 6 and 12 months after surg...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14247
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To assess the trend patterns and gender disparity in global burden of vision loss due to diabetic retinopathy (DR) by year, age, region and socioeconomic status using prevalence and years lived with disability (YLDs) from Global Burden of Disease (GBD) study 2017. METHODS:Prevalence and YLDs data of vision los...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14644
更新日期:2020-10-29 00:00:00
abstract:PURPOSE:Enzyme replacement therapy (ERT) was offered from year 2001 to patients with Fabry disease. The ophthalmic experience was analysed, as part of a general 10-year status. METHODS:A retrospective observational series comprising 39 patients (25 females, 14 males) closely followed by the endocrinologists, and with ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12588
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Orally administered angiotensin II receptor blockers (ARBs) decrease intraocular pressure (IOP). Topical administration may reduce systemic side effects and result in a useful glaucoma drug. The aim of this study is to test the ocular delivery and pharmacologic effect of nanoparticle eye drops containing ARBs (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14639
更新日期:2020-11-16 00:00:00
abstract:PURPOSE:We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function. METHODS:Thirty-seven 3-8 years old c...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13536
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Contact lenses have direct contact with the corneal surface and can induce sight-threatening infection of the cornea known as Acanthamoeba keratitis. The objective of this study was to evaluate the dysprosium-based nanoparticles (Dy-based NPs), namely Fe3 O4 -PEG-Dy2 O3 nanocomposites and Dy(OH)3 nanorods, as a...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14541
更新日期:2020-07-23 00:00:00
abstract:PURPOSE:The aim of this study was to analyse 69 Chinese patients with USH2A mutations and to assess the genotype-phenotype correlation. METHODS:All 36 Usher syndrome type IIA patients and 33 nonsyndromic RP (retinitis pigmentosa) patients underwent clinical examinations. Eye examinations included best-corrected visual...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14626
更新日期:2020-10-29 00:00:00
abstract:PURPOSE:To determine alterations in the retina of patients with Alzheimer's disease (AD) by the newly developed technique of fluorescence lifetime imaging ophthalmoscopy (FLIO) in a pilot study. METHODS:FLIO set-up uses a scanning laser ophthalmoscope (HRA2, Heidelberg Engineering, Germany), which was modified by the ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12609
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. METHODS:Corneal measurements of 110 normal eyes (one eye per subject) and 70 k...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12622
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:We investigated the natural course of the intraretinal hyperreflective (IRH) sign after macular haemorrhage (MHE) absorption in eyes with pathologic myopia. METHODS:This prospective observational cohort study evaluated 28 patients with pathologic myopia and MHE. The eyes were categorized into IRH and non-IRH s...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14332
更新日期:2019-12-06 00:00:00
abstract:PURPOSE:To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. METHODS:Participants of the Raine Study Generation 2 cohort had 25(OH...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14709
更新日期:2021-01-10 00:00:00
abstract:PURPOSE:To investigate the reproducibility of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) measurements using spectral domain optical coherence tomography (SD-OCT). Additionally, to investigate the reproducibility of BMO area measurements and fovea to BMO centre (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13464
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care. METHODS:A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retinopathy was eva...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12954
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To report normative data on visual acuity (VA) for near and distance, refraction, ocular alignment, ocular motility and stereo acuity in a cohort of children aged 4.5-7 years. METHODS:A total of 950 children with normal development from the municipality of Roskilde, Denmark, were invited to participate in an o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13650
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To identify and determine differences in lipid profile of aqueous humour (AH) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:Lipidomic profile of eight AH samples of FECD patients and 10 control samples was analysed. Patients with previous history of anterior segment surgery, anterior seg...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13374
更新日期:2017-11-01 00:00:00