Abstract:
PURPOSE:The aim of this study was to analyse 69 Chinese patients with USH2A mutations and to assess the genotype-phenotype correlation. METHODS:All 36 Usher syndrome type IIA patients and 33 nonsyndromic RP (retinitis pigmentosa) patients underwent clinical examinations. Eye examinations included best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination with dilated pupils, fundus fluorescent angiography, visual field test, full-field electroretinography and optic coherence tomography; audiological assessment included pure tone audiometry and hearing thresholds. The molecular diagnosis of genotype combined the single-gene Sanger sequencing and next-generation sequencing. This study is a retrospective study. RESULTS:The mean age of first symptoms with Usher syndrome type IIa and nonsyndromic RP patients was 13.7 versus 29.8 years (ocular phenotypes, p < 0.001); 17.7 versus 29.9 years (nyctalopia, p < 0.001); 44.7 versus 54.8 years (low vision based on VF, p < 0.001); 41.7 versus 54.7 years (low vision based on VA, p < 0.001); and 46.0 versus 56.7 years (legal blindness based on VF, p < 0.001). There was significant difference in variants in the two groups (p < 0.05). Among patients with mutation c.2802T > G (p.Cys934Trp), more (66.7%) presented with normal hearing. All patients (3/3, 100%) with the variant c.8232G > C (p.Trp2744Cys) had hearing loss. Furthermore, we identified 23 novel variants in USH2A. CONCLUSIONS:Patients with Usher syndrome type IIa had an earlier onset of the disease, inferior visual function and presented with more truncating variants, compared with the nonsyndromic RP patients.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Meng X,Liu X,Li Y,Guo T,Yang Ldoi
10.1111/aos.14626subject
Has Abstractpub_date
2020-10-29 00:00:00eissn
1755-375Xissn
1755-3768pub_type
杂志文章abstract:PURPOSE:Limited knowledge exists about the influence of donor age and death-to-preservation interval (DPI) on the metabolic properties of the cornea. The aim of this study is to investigate the relationship between both factors and metabolite content of the cornea. METHODS:Corneas from 15 human donors (age: 41-78 year...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02271.x
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Proliferative diabetic retinopathy (PDR) is characterized by ischaemia- and inflammation-induced neovascularization, but the pathological vascular differentiation in PDR remains poorly characterized. Here, endothelial progenitor and growth properties, as well as potential lymphatic differentiation, were investi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12741
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT). METHODS:A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular press...
journal_title:Acta ophthalmologica
pub_type: 临床试验,杂志文章
doi:10.1111/aos.14136
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To report the postoperative results after enucleation of using an acrylic orbital implant covered in donor sclera for implantation. METHODS:We retrospectively analysed the charts of patients who were enucleated between 2007 and 2011. Only patients who received an acrylic implant covered with donor sclera were ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12960
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Pathological alterations within optic nerve axons and progressive loss of the parental retinal ganglion cell (RGC) bodies are characteristics of glaucomatous neuropathy. Abnormally elevated intraocular pressure (IOP) is thought to be the major risk factor for most forms of glaucomatous changes, while lowering o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14333
更新日期:2019-12-29 00:00:00
abstract:PURPOSE:To evaluate the changes of vascular endothelial growth factor (VEGF) plasma levels after intravitreal injections of ranibizumab or bevacizumab in patients with exudative age-related macular degeneration (AMD). METHODS:Forty-three patients with exudative AMD and 19 age- and sex-matched control patients without ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02240.x
更新日期:2012-02-01 00:00:00
abstract:UNLABELLED:In this thesis the term eye amputation (EA) covers the removing of an eye by: evisceration, enucleation and exenteration. Amputation of an eye is most frequently the end-stage in a complicated disease, or the primary treatment in trauma and neoplasm. In 2010 the literature is extensive due to knowledge about...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.02039.x
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Eyelid sebaceous carcinoma (SC) remains a common diagnostic pitfall for both the clinician and histopathologist. The aim of this study was to describe perforin as a new marker in the immunohistochemistry panel for SC. METHODS:A total of 29 cases were retrieved from the Pathology archives, including 11 sebaceou...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12972
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To determine whether bilateral implantation of an aspheric apodized diffractive multifocal intraocular lens (IOL) with +3.00 diopters (D) results in optical adverse effects compared with an aspheric monofocal IOL. METHODS: In a prospective, randomized study of 204 eyes (102 patients) with bilateral implantati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2012.02497.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To describe the different clinical presentations of periocular molluscum contagiosum (MC) lesions and their epidemiological, clinical and histopathological features. METHODS:Medical records and histopathological sections of all cases of periocular MC treated at the oculoplastic clinic of the Goldschleger Eye I...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13717
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of big-bubble (BB) technique in separating Dua's layer together with the Descemet's membrane endothelial (DE) graft and the effect of 7-day storage of the prepared tissues on the endothelial cells. METHOD:This is an experimental study in which 21 human corneo-scleral tissues unsuitable...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12823
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To assess the association between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract. METHODS:People aged 49+ years living in a defined geographic region were invited to participate in this prospective population-based survey. Of 2072 women (83% of those eligible)...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01565.x
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14232
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To indirectly measure stromal riboflavin penetration using commercially available riboflavin solutions and new and existing epithelium-off, trans-epithelial and iontophoresis-assisted delivery protocols. METHODS:Forty porcine eyes were divided into eight groups. Group 1: Ricrolin applied to the de-epithelialis...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12884
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To establish whether or not the dynamics of saccadic eye movements are significantly changed in patients with different stages of thyroid-associated ophthalmopathy (TAO) and, subsequently, if analysis of saccades could serve as an additional diagnostic tool for early detection of inflammatory activity in TAO. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02216.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE: To evaluate central corneal thickness (CCT), intraocular pressure (IOP) and eye refraction in patients with congenital growth hormone (GH) deficiency. METHODS:Retrospective case series. Forty-five patients with growth defect treated with recombinant GH and 45 healthy children underwent ophthalmological exami...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01519.x
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS:In this prospe...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13397
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients. METHODS:A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients. RESULTS:The overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly,...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13551
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To investigate the ability of mesenchymal stem cells (MSC) to transdifferentiate to corneal epithelial cells in experimental limbal stem cell deficiency in rabbits. METHODS:Total limbal stem cell deficiency was produced in 21 right eyes of 21 New Zealand rabbits; 6 eyes served as controls (group 1, G1). After ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01812.x
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To investigate the associations between ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) and ocular and systemic factors in patients with open angle glaucoma (OAG) and in glaucoma suspects. METHODS:One hundred and seventy-three glaucoma-suspect patients were consecutively enrolled. A...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01954.x
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients. METHODS:Keratoconus match index and KMP from 114 KC eyes, randomly selected from 114 patients with bilateral kerat...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12056
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate changes in the anterior chamber depth (ACD) in primary open-angle glaucoma (POAG) patients during latanoprost therapy. METHODS:We carried out a prospective study in which we enrolled 66 newly diagnosed POAG patients treated with latanoprost 0.005% (group 1) and 50 ocular h...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01683.x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:Study purpose was to investigate the effects of bariatric surgery on intraocular pressure (IOP) and other ophthalmic parameters in a prospective observational follow-up study. METHODS:Ophthalmic examination was performed on 22 obese women before and 6 months after bariatric surgery. A control group of 15 non-o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13826
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia. METHODS:This cross-sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was us...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14372
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To investigate serial changes in the bleb wall using anterior segment optical coherence tomography (AS-OCT) in patients who had undergone Ahmed glaucoma valve (AGV) implantation. METHODS:A total of 52 patients who had undergone AGV implantation were enrolled. Reflectivity and mean thickness of the bleb wall we...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12571
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To explore associations of lamina cribrosa thickness with axial length and thickness of the posterior sclera in monkeys. METHODS:Examining histological sections by light microscopy, we measured the thickness of the lamina cribrosa and posterior sclera and axial length. RESULTS:The study included 28 animals (2...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13070
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13502
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13379
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro-aneurysms in individuals with and without type 2 diabetes. METHODS:Using spectral domain optical coherence tomogr...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14677
更新日期:2020-11-30 00:00:00
abstract:PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13405
更新日期:2017-08-01 00:00:00