Abstract：
PURPOSE:Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. METHODS:We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson-Trick-Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value <0.05 was considered significant. RESULTS:After adjusting for multiple comparisons, both the light-adapted 3.0 a-wave implicit time (p < 0.001) and 30-Hertz flicker peak time (p = 0.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light-adapted 3.0 a-wave implicit time (p = 0.011) between patients with early AMD and the control group, but the difference in 30 Hz flicker peak time was not significant (p = 0.256). CONCLUSION:The difference in cone function measured by light-adapted 3.0 a-wave implicit time and 30-Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Forshaw TRJ,Kjaer TW,Andréasson S,Sørensen TLdoi
10.1111/aos.14571subject
Has Abstractpub_date
2020-08-24 00:00:00eissn
1755-375Xissn
1755-3768pub_type
杂志文章abstract：PURPOSE:To examine agreement between intraocular pressure (IOP) measurements made using the rebound tonometer Icare ic200 (RT200) and the Perkins handheld applanation tonometer (PAT) in patients with primary congenital glaucoma (PCG). The impacts of several covariables on measurements using the two devices were also as...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.14701
更新日期：2020-12-23 00:00:00
abstract：PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13453
更新日期：2017-12-01 00:00:00
abstract：PURPOSE: To describe sequential phacoemulsification-intraocular lens (IOL) implantation-posterior capsulorhexis-anterior vitrectomy in the management of phakic malignant glaucoma. METHODS: Twenty consecutive patients (25 eyes) with phakic malignant glaucoma were enrolled at the Zhongshan Ophthalmic Center, Sun Yat-s...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2012.02451.x
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:To investigate whether introduction of item-response theory (IRT) analysis, in parallel to the 'traditional' statistical analysis methods available for performance evaluation of multiple T/F items as used in the European Board of Ophthalmology Diploma (EBOD) examination, has proved beneficial, and secondly, to ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12135
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:Diabetic retinopathy is diagnosed by fundus photography and optical coherence tomography (OCT) scanning. However, adaptive optics (AO) imaging can be expected to add new aspects to the knowledge of diabetic retinopathy because photographic resolution is improved by reducing the influence of optical aberrations ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12464
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:To characterize frequency, morphological cause and time-dependent change of boundary line artefacts in optical coherence tomography (OCT) examinations of centre-involved diabetic macular oedema (ciDME) patients who underwent ranibizumab treatment with 1-year follow-up and to evaluate the impact of artefacts on ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12494
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma (PA) using optical coherence tomography angiography (OCTA). METHODS:Cross-sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro-ophthalmol...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.14322
更新日期：2019-12-06 00:00:00
abstract：:In the time of Vesalius, knowledge of ocular anatomy was limited. The first description of the anatomy of the eye comes from Democrites, for whom the eye was surrounded by two 'coats', filled with a homogenous fluid. The optic nerve was hollow and the lens was considered to be a postmortem artefact. Until the 15th cen...
journal_title：Acta ophthalmologica
pub_type： 传,历史文章,杂志文章
doi：10.1111/j.1755-3768.2009.01679.x
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:To determine the spectrum of BEST1 mutations and to study the phenotype in Slovenian families with Best vitelliform macular dystrophy (BVMD) to identify genotype-phenotype correlations. METHODS:Twenty patients from five families underwent the ophthalmological examination including electrooculogram (EOG; N = 17...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13202
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12389
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:To moderate the capsular opacification (CO) response after lens surgery, an experimental study was performed in which nanofibre-based hydrogels (nanogels) with different ratios of attached peptides were applied to provide extracellular matrix-related cues for lens epithelial cells (LECs) in a porcine eye model....
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13047
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To investigate the prevalence of potential age-related eye conditions in elderly who are assisted by home healthcare nurses. The number of referrals to the general practitioner (GP), feasibility of screening and associations between vision loss and health outcomes were also studied. METHODS:Cross-sectional stu...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,多中心研究
doi：10.1111/aos.13956
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To assess retinal perfusion in eyes with unilateral ocular ischaemic syndrome (OIS) and to compare with control subjects. METHODS:Retrospective case series. Linear blood flow velocities in macular vessels were estimated using motion-contrast fundus photography in eight patients with unilateral OIS (eight OIS e...
journal_title：Acta ophthalmologica
pub_type：
doi：10.1111/aos.13950
更新日期：2019-02-01 00:00:00
abstract：:Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,评审
doi：10.1111/j.1755-3768.2008.01210.x
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:This study aimed to investigate whether mild laser treatment of soft drusen maculopathy might reduce the incidence of choroidal neovascularization (CNV) and/or significantly reduce loss of visual acuity compared with outcomes in a control group. METHODS: A total of 135 patients (mean age 70.4 years) were rando...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1755-3768.2008.01396.x
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To assess the effect of donor tissue diameter in Descemet Membrane Endothelial Keratoplasty (DMEK) on postoperative endothelial cell density (ECD) mainly in Fuchs Endothelial Corneal Dystrophy (FECD) patients. METHODS:Retrospective review of 693 consecutive DMEK surgeries from the prospective Cologne DMEK data...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13943
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To test the validity of the eyesi surgical simulator as an assessment tool in a virtual reality vitreoretinal training programme. METHODS:In collaboration with an experienced vitreoretinal surgeon, a virtual vitreoretinal training programme was composed on the eyesi surgical simulator, software version 2.9.2 (...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13209
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS:In this prospe...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13397
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:This study aimed to investigate the rise in aqueous humour (AH) levels of levofloxacin after a specific perioperative pulsed topical drop regimen. METHODS:Thirty patients undergoing phacoemulsification surgery were administered two preoperative drops of levofloxacin 0.5%, 30 mins apart, and three pulsed drops ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1755-3768.2008.01358.x
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:The clinical use and comparison of two recently developed A-scan ultrasound devices. METHODS:The same investigator determined central corneal thickness (CCT), anterior chamber depth (ACD) and axial length (AL) with an OcuScan RxP (Alcon, Forth Worth, Texas, USA) and an AL-2000 (Tomey, Erlangen, Germany) ultras...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1600-0420.2007.00994.x
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:Proliferative diabetic retinopathy (PDR) is characterized by ischaemia- and inflammation-induced neovascularization, but the pathological vascular differentiation in PDR remains poorly characterized. Here, endothelial progenitor and growth properties, as well as potential lymphatic differentiation, were investi...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12741
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:To evaluate the effect of ZY1, a novel 21-amino acid peptide from human placenta growth factor-1 (PlGF-1), against ocular neovascularization, and to study its possible toxicity to the retina and the underlying mechanism of antiangiogenic effect. METHODS:MTS assays, a modified Boyden chamber and Matrigel(™) wer...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2012.02476.x
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To assess the noninferiority of the treat-and-extend (T&E) and fixed bimonthly regimens of 0.5 mg intravitreal ranibizumab as compared with the pro re nata (PRN) in naïve patients with neovascular age-related macular degeneration (nAMD). METHODS:Phase IV, randomized, 12-month, multicentre trial. Patients aged ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.14399
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To report normative data on visual acuity (VA) for near and distance, refraction, ocular alignment, ocular motility and stereo acuity in a cohort of children aged 4.5-7 years. METHODS:A total of 950 children with normal development from the municipality of Roskilde, Denmark, were invited to participate in an o...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13650
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:To investigate the incidence and cause of severe visual loss following use and removal of intraocular silicone oil (SiO) after uncomplicated vitrectomy and SiO injection for primary rhegmatogenous retinal detachment (RRD). METHODS:Consecutive case series of 216 patients operated with vitrectomy for primary RRD...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2011.02248.x
更新日期：2012-12-01 00:00:00
abstract：:Topically applied carbonic anhydrase inhibitors (CAIs) in eye drop solutions are commonly used to treat glaucoma. However, local eye irritation and multiple daily administrations may hamper their clinical usefulness. Aqueous eye drop formulations that improve their topical bioavailability and reduce their eye irritati...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,评审
doi：10.1111/j.1755-3768.2011.02299.x
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To describe three cases of Charles Bonnet syndrome (CBS) in glaucoma patients with preserved visual acuity. METHODS:Three glaucoma patients who had taken part in a recent CBS study were interviewed about their hallucinations. The patients underwent macular optical coherence tomography (OCT) of both eyes. The v...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.14620
更新日期：2020-09-11 00:00:00
abstract：PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,随机对照试验
doi：10.1111/aos.13405
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:A free autologous retinal pigment epithelium (RPE)-choroid graft can be harvested during transplantation surgery from a 6 or 12 o'clock site in the midperiphery. This study evaluated whether proliferative vitreoretinopathy (PVR) occurs more frequently in patients with an inferior donor site retinotomy, which is...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12178
更新日期：2014-05-01 00:00:00
abstract：PURPOSE:We report the epidemiology, findings, treatment, long-term outcome and use of resources for eye injuries caused by toy guns in southern Finland. METHODS:All new patients injured by toy guns in one year (2011-2012) and treated at Helsinki University Eye Hospital were included. Follow-ups occurred at 3 months an...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13948
更新日期：2019-06-01 00:00:00
