Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure.

abstract：PURPOSE:To study presenting characteristics and prevalence of polypoidal choroidal vasculopathy (PCV) in Scandinavian Caucasians with treatment-naïve exudative age-related macular degeneration (AMD). METHODS:We reviewed all patients referred in year 2014 and diagnosed using fundus examination, optical coherence tomogr...

journal_title：Acta ophthalmologica

authors： Lorentzen TD,Subhi Y,Sørensen TL

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Angiogenic inhibitors, alone or combined with other therapies, are believed to represent a promising treatment for neovascularization in age-related macular degeneration (wet AMD). They can maintain or improve visual acuity (VA), at least for the first 2years. However, evolution to retinal atrophy cannot be rul...

journal_title：Acta ophthalmologica

authors： Bonnin P,Pournaras JA,Lazrak Z,Cohen SY,Legargasson JF,Gaudric A,Levy BI,Massin P

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To report our experience in endoscopic dacryocystorhinostomy in treating nasolacrimal duct obstruction over a 14-year period. METHODS:Retrospective case series carried out over a 14-year period from 1999 to 2014. A total of 624 endoscopic dacryocystorhinostomy procedures were performed in 442 patients who were...

journal_title：Acta ophthalmologica

authors： Coumou AD,Genders SW,Smid TM,Saeed P

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To determine the molecular genetic cause in previously unreported probands with optic atrophy from the United Kingdom, Czech Republic and Canada. METHODS:OPA1 coding regions and flanking intronic sequences were screened by direct sequencing in 82 probands referred with a diagnosis of bilateral optic atrophy. D...

journal_title：Acta ophthalmologica

authors： Liskova P,Tesarova M,Dudakova L,Svecova S,Kolarova H,Honzik T,Seto S,Votruba M

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:  To evaluate the precision of techniques for measuring intraocular pressure (IOP) in corneas with presumably altered biomechanical properties. METHODS:  Intraocular pressure was measured with a Goldmann applanation tonometer (GAT), ocular response analyzer (ORA) and dynamic contour tonometer (DCT) in 70 eyes....

journal_title：Acta ophthalmologica

authors： Clemmensen K,Hjortdal J

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Choroideremia is a currently incurable X-linked recessive retinal degeneration that leads to blindness. Gene therapy approaches to date target the outer retinal layers. However, the choroideremia (CHM) gene is expressed in all retinal layers, and a previous study on a small cohort of choroideremia patients sugg...

journal_title：Acta ophthalmologica

authors： Fu DJ,Xue K,Jolly JK,MacLaren RE

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:To examine the prevalence of anisometropia of spherical refraction (AnisoSR), astigmatism (AnisoAST) and spherical equivalent (AnisoSE) and their associations with spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE) and interocular differences of ocular biometric parameters among ...

journal_title：Acta ophthalmologica

authors： Pärssinen O,Kauppinen M,Kaprio J,Rantanen T

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To describe the annual incidence rate of keratoconus in Denmark 1995-2015 and prevalence of keratoconus in the National Danish Patient Register 1977-2015. METHODS:All patients diagnosed with keratoconus in the National Danish Patient Register 1977-2015 were included in the study. The annual incidence rates and...

journal_title：Acta ophthalmologica

authors： Bak-Nielsen S,Ramlau-Hansen CH,Ivarsen A,Plana-Ripoll O,Hjortdal J

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To explore associations of lamina cribrosa thickness with axial length and thickness of the posterior sclera in monkeys. METHODS:Examining histological sections by light microscopy, we measured the thickness of the lamina cribrosa and posterior sclera and axial length. RESULTS:The study included 28 animals (2...

journal_title：Acta ophthalmologica

authors： Jonas JB,Kutscher JN,Panda-Jonas S,Hayreh SS

更新日期：2016-12-01 00:00:00

abstract：:Although the work for which Emil von Behring (1854-1917) was awarded the first Nobel Prize Winner for Medicine or Physiology in 1901 was on serum therapy, not only was he trained and worked as an ophthalmologist but he also wrote his doctoral dissertation on a practical ophthalmological topic whilst in Berlin under Ca...

journal_title：Acta ophthalmologica

authors： Grzybowski A,Wilhelm H

更新日期：2013-06-01 00:00:00

abstract：:Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular. In nanomedicine, tissue engineering is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its pu...

journal_title：Acta ophthalmologica

authors： Ellis-Behnke R,Jonas JB

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...

journal_title：Acta ophthalmologica

authors： Kriszt A,Losonczy G,Berta A,Vereb G,Takács L

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To describe the retinal structure of a group of patients affected by methylmalonic aciduria with homocystinuria cblC type, caused by mutations in the MMACHC gene, using spectral domain optical coherence tomography (SD-OCT). METHODS:Young patients (n = 11, age 0-74 months) with cblC disease, detected by newborn...

journal_title：Acta ophthalmologica

authors： Bacci GM,Donati MA,Pasquini E,Munier F,Cavicchi C,Morrone A,Sodi A,Murro V,Garcia Segarra N,Defilippi C,Bussolin L,Caputo R

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To analyse pupil responses to specific chromatic stimuli in patients with advanced retinitis pigmentosa (RP) to ascertain whether chromatic pupillography can be used as an objective marker for residual retinal function. To examine correlations between parameters of the pupil response and the perception threshol...

journal_title：Acta ophthalmologica

authors： Kelbsch C,Maeda F,Lisowska J,Lisowski L,Strasser T,Stingl K,Wilhelm B,Wilhelm H,Peters T

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To evaluate microperimetric changes 1year after macular hole surgery with triamcinolone acetonide assisted internal limiting membrane (ILM) peeling. METHODS:Twenty-two eyes of 22 patients with stage 3 and 4 idiopathic macular holes of <6months' duration underwent vitrectomy with triamcinolone acetonide assiste...

journal_title：Acta ophthalmologica

authors： Ozdemir H,Karacorlu M,Senturk F,Karacorlu SA,Uysal O

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To indirectly measure stromal riboflavin penetration using commercially available riboflavin solutions and new and existing epithelium-off, trans-epithelial and iontophoresis-assisted delivery protocols. METHODS:Forty porcine eyes were divided into eight groups. Group 1: Ricrolin applied to the de-epithelialis...

journal_title：Acta ophthalmologica

authors： Hayes S,Morgan SR,O'Brart DP,O'Brart N,Meek KM

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To describe the concordance of keratoconus in 18 sets of twins. METHODS:Thirteen monozygotic (MZ) and five dizygotic (DZ) pairs of twins were identified during an investigation of familial keratoconus. We used 16 forensic microsatellite markers to confirm the zygosity of same sex twins. Patients and available ...

journal_title：Acta ophthalmologica

authors： Tuft SJ,Hassan H,George S,Frazer DG,Willoughby CE,Liskova P

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. METHODS:Corneal measurements of 110 normal eyes (one eye per subject) and 70 k...

journal_title：Acta ophthalmologica

authors： Viswanathan D,Kumar NL,Males JJ,Graham SL

更新日期：2015-09-01 00:00:00

abstract：AIMS:This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (POAG) treated with morning-dosed bimatoprost 0.03%. METHODS:Eighty...

journal_title：Acta ophthalmologica

authors： Stankiewicz A,Misiuk-Hojło M,Grabska-Liberek I,Romanowska-Dixon B,Wierzbowska J,Wasyluk J,Mulak M,Szuścik I,Sierdziński J,Ehrlich R,Siesky B,Harris A

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and o...

journal_title：Acta ophthalmologica

authors： Nadal J,Deverdun J,de Champfleur NM,Carriere I,Creuzot-Garcher C,Delcourt C,Chiquet C,Kawasaki R,Villain M,Ritchie K,Le Bars E,Daien V

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To evaluate a pro re nata administration of Ozurdex® implant versus a single administration for treating diabetic macular oedema (DME). METHODS:This exploratory study is designed as a comparative, multicentre, randomized study with a follow-up of 6 months. Patients with DME were assigned to treatment at baseli...

journal_title：Acta ophthalmologica

authors： Sarao V,Veritti D,Furino C,Giancipoli E,Alessio G,Boscia F,Lanzetta P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:We report the epidemiology, findings, treatment, long-term outcome and use of resources for eye injuries caused by toy guns in southern Finland. METHODS:All new patients injured by toy guns in one year (2011-2012) and treated at Helsinki University Eye Hospital were included. Follow-ups occurred at 3 months an...

journal_title：Acta ophthalmologica

authors： Haavisto AK,Sahraravand A,Puska P,Leivo T

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...

journal_title：Acta ophthalmologica

authors： Chen H,Lin H,Chen W,Zhang B,Xiang W,Gao Q,Chen W,Liu Y

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to analyse 69 Chinese patients with USH2A mutations and to assess the genotype-phenotype correlation. METHODS:All 36 Usher syndrome type IIA patients and 33 nonsyndromic RP (retinitis pigmentosa) patients underwent clinical examinations. Eye examinations included best-corrected visual...

journal_title：Acta ophthalmologica

authors： Meng X,Liu X,Li Y,Guo T,Yang L

更新日期：2020-10-29 00:00:00

abstract：PURPOSE:To compare structural and functional improvements in patients with vitreous haemorrhage (VH) with different IOPs re-established at the end of pars plana vitrectomy (PPV). METHODS:It is a prospective, randomized, comparative, interventional study. Ninety-five patients with nonclearing VH were randomized to rece...

journal_title：Acta ophthalmologica

authors： Zhou C,Zhang Z,Luo D,Gu C,Lahm T,Draga D,Qiu Q

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The aims of this study were: (i) to create a structural simulation model capable of predicting the future need and cost of eyecare services in Finland; and (ii) to test and rank different policy alternatives for access to care and the required physician workforce. METHODS:Using the system dynamics approach, th...

journal_title：Acta ophthalmologica

authors： Tuulonen A,Salminen H,Linna M,Perkola M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients. METHODS:Keratoconus match index and KMP from 114 KC eyes, randomly selected from 114 patients with bilateral kerat...

journal_title：Acta ophthalmologica

authors： Labiris G,Gatzioufas Z,Sideroudi H,Giarmoukakis A,Kozobolis V,Seitz B

更新日期：2013-06-01 00:00:00

abstract：:Endoscopic Cyclophotocoagulation (ECP) is a glaucoma surgery designed to reduce the intraocular pressure (IOP) by partially ablating the ciliary processes to decrease aqueous humour production and secretion. The aim of this paper is to review the literature regarding the background, indications and results of the surg...

journal_title：Acta ophthalmologica

authors： Kaplowitz K,Kuei A,Klenofsky B,Abazari A,Honkanen R

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:This study aimed to investigate whether mild laser treatment of soft drusen maculopathy might reduce the incidence of choroidal neovascularization (CNV) and/or significantly reduce loss of visual acuity compared with outcomes in a control group. METHODS: A total of 135 patients (mean age 70.4 years) were rando...

journal_title：Acta ophthalmologica

authors： Frennesson CI,Bek T,Jaakkola A,Nilsson SE,Prophylactic Laser Treatment Study Group.

更新日期：2009-11-01 00:00:00

abstract：:A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...

journal_title：Acta ophthalmologica

authors： Bekkers A,Borren N,Ederveen V,Fokkinga E,Andrade De Jesus D,Sánchez Brea L,Klein S,van Walsum T,Barbosa-Breda J,Stalmans I

更新日期：2020-09-01 00:00:00