Abstract:
PURPOSE:To evaluate the biomechanical properties of the cornea using Corneal Visualization Scheimpflug Technology (CorVis ST, Oculus) in eyes with primary open-angle glaucoma (POAG) and normal control eyes. METHODS:A comparative cross-sectional study that included 42 patients with POAG and 60 normal control subjects matched for intraocular pressure (IOP) and central corneal thickness (CCT). IOP was measured with a Goldmann applanation tonometer (GAT). Corneal tomography and biomechanical parameters were measured with Pentacam (Oculus) and CorVis ST, respectively. Corneal biomechanical properties were compared between groups, and the associations between corneal biomechanical parameters and ocular characteristics were evaluated. Receiver operating characteristic (ROC) curves were used to establish a cut-off value for the biomechanical parameters. RESULTS:The following parameters of the CorVis ST showed a significant difference between eyes with POAG and normal eyes: first applanation velocity (Vin ), second applanation time (A-time2 ), peak distance (PD) and deformation amplitude (DA). In the univariate analysis, DA was negatively correlated with IOP in both groups. For all biomechanical parameters, the areas under the ROC curve were <0.80 and thus did not reach a good level of predictive accuracy for detecting POAG. CONCLUSION:CorVis ST offers an alternative method for measuring corneal biomechanical properties. Eyes with POAG exhibit a faster Vin , longer A-time2 , lower DA and longer PD than do IOP- and CCT-matched normal control eyes. The biomechanical parameters of the CorVis ST cannot readily be used for diagnosis of POAG in the individual patient.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Tian L,Wang D,Wu Y,Meng X,Chen B,Ge M,Huang Ydoi
10.1111/aos.12672subject
Has Abstractpub_date
2016-08-01 00:00:00pages
e317-24issue
5eissn
1755-375Xissn
1755-3768journal_volume
94pub_type
杂志文章abstract:PURPOSE:To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients. METHODS:A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients. RESULTS:The overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly,...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13551
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:This study aimed to investigate intraocular pressure (IOP) measurements taken using the dynamic contour tonometer (DCT) and the non-contact tonometer (NCT) in subjects with keratoconus. METHODS:Intraocular pressure was measured in 20 keratoconus subjects and 20 age-matched control subjects using the DCT and NC...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01690.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. METHODS:Three study groups (oxygen...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13154
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To describe the clinical appearance and the visual outcome of a cohort of patients with vasoproliferative retinal tumours (VPRTs) that were diagnosed and treated between 2002 and 2007 at the University Hospital of Örebro. METHODS:Nine patients with diagnosed VPRTs were included in a retrospective study. The me...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01662.x
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To identify the causes of failure of the different surgical corneal graft techniques: penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS:This multicentric retrosp...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14708
更新日期:2021-01-09 00:00:00
abstract:PURPOSE:Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). METHODS:The wireless CLS is a disposable silicone soft contact lens with a sensor embedded in it, allowing the wireless me...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01404.x
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy. METHODS:Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with m...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0420.2007.01036.x
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To explore the association between retinal vein occlusion (RVO) and incident cancer. METHODS:All Danish citizens with a first-time diagnosis of RVO and no previous diagnosis of cancer in the period from 1 January 2004 to 31 December 2014 were included. Five likewise cancer-free, age- and gender-matched control...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13860
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate changes in the anterior chamber depth (ACD) in primary open-angle glaucoma (POAG) patients during latanoprost therapy. METHODS:We carried out a prospective study in which we enrolled 66 newly diagnosed POAG patients treated with latanoprost 0.005% (group 1) and 50 ocular h...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01683.x
更新日期:2011-05-01 00:00:00
abstract::Corneal refractive surgery disrupts corneal integrity and reduces biomechanical stability in consequence of the beneficial refractive alteration. The minimal invasive cap-based refractive procedure, small-incision lenticule extraction (SMILE), has been proposed to affect corneal integrity less than flap-based procedur...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13906
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. METHODS:Participants of the Raine Study Generation 2 cohort had 25(OH...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14709
更新日期:2021-01-10 00:00:00
abstract:PURPOSE:To test the validity of the eyesi surgical simulator as an assessment tool in a virtual reality vitreoretinal training programme. METHODS:In collaboration with an experienced vitreoretinal surgeon, a virtual vitreoretinal training programme was composed on the eyesi surgical simulator, software version 2.9.2 (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13209
更新日期:2017-02-01 00:00:00
abstract:PURPOSE: To determine the effect of pars plana vitrectomy (PPV) on oxygen saturation in retinal vessels. METHODS: We performed a prospective consecutive interventional case series of 20 eyes of 20 patients with macular hole or epiretinal membrane. We performed automatic retinal oximetry (Oxymap Inc., Reykjavik, Icel...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12238
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To examine the influence of light source on letter contrast sensitivity in subjects with age-related macular degeneration (AMD). METHODS:Halogen incandescent bulbs and low-energy fluorescent tubes were tested with 70 subjects with AMD. The subjects' contrast sensitivity was determined in a randomized single-bl...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2009.01809.x
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To analyse characteristics from the SMR to explore the risk factors for visual acuity (VA) below ≤ 35 letters of the Early Treatment Diabetic Retinopathy Study (ETDRS) due to nAMD during a two-year follow-up. METHODS:This study evaluates 6142 treatment-naïve eyes, with focus on a subgroup of 780 eyes with fina...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14239
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To examine the prevalence of anisometropia of spherical refraction (AnisoSR), astigmatism (AnisoAST) and spherical equivalent (AnisoSE) and their associations with spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE) and interocular differences of ocular biometric parameters among ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13125
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care. METHODS:A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retinopathy was eva...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12954
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13453
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). METHODS:We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.01048.x
更新日期:2008-05-01 00:00:00
abstract::To review binocular and accommodative disorders documented after corneal or intraocular refractive surgery, in normal healthy prepresbyopic patients. A bibliographic revision was performed; it included works published before 1st July 2017 where accommodation and/or binocularity was assessed following any type of refra...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.13891
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To investigate and analyse one hundred-year-old endothelial cells of human transplanted corneal grafts and compare them with intact endothelium of unoperated eyes. SUBJECTS AND METHODS:Specular microscopy was performed on seven individuals (14 eyes) aged >100 years and on seven transplanted corneas with endoth...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12715
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To evaluate and compare corneal biomechanical changes after deep anterior lamellar keratoplasty (DALK) versus penetrating keratoplasty (PK) using the ocular response analyzer (ORA). METHODS:This prospective comparative study included 65 eyes (65 patients). Patients were divided into three groups: DALK (20 eyes...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12136
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To examine whether real-world clinical patients with macular oedema (MO) receiving intravitreal antivascular endothelial growth factor (VEGF) therapy have a higher mortality compared with a matched reference population. METHODS:A population-based, retrospective cohort study of 26 386 patients from Finland, fro...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14717
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS:Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than in Denmark. RESULTS:No signi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01488.x
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13332
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To characterize pre- and perioperative factors associated with treatment for wet age-related macular degeneration (wet AMD) after cataract surgery. METHODS:This register-based cohort study with data from the Swedish National Cataract Register (NCR) and the Swedish Macula Register (SMR) from 2010 to 2017 compar...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14519
更新日期:2020-06-23 00:00:00
abstract:PURPOSE:To identify causes of reduced visual acuity after Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK) and to determine whether such eyes can be successfully 'repaired' with a secondary Descemet membrane endothelial keratoplasty (DMEK). METHODS:Twelve eyes of 12 patients, who underwent secondar...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02504.x
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To determine whether excimer laser ablation of guttae is a viable strategy for removal of diseased tissue in Fuchs' endothelial corneal dystrophy (FECD) on excised human Descemet membranes and whether an excimer laser-created wound on healthy human corneas ex vivo is recolonized with corneal endothelial cells. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14366
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients. METHODS:Keratoconus match index and KMP from 114 KC eyes, randomly selected from 114 patients with bilateral kerat...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12056
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Orally administered angiotensin II receptor blockers (ARBs) decrease intraocular pressure (IOP). Topical administration may reduce systemic side effects and result in a useful glaucoma drug. The aim of this study is to test the ocular delivery and pharmacologic effect of nanoparticle eye drops containing ARBs (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14639
更新日期:2020-11-16 00:00:00