Abstract：
PURPOSE:Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). METHODS:The wireless CLS is a disposable silicone soft contact lens with a sensor embedded in it, allowing the wireless measurement of changes in corneal curvature induced by IOP variations. A CLS was adapted and tested on enucleated pig eyes. To demonstrate the measurement principle of the device, the enucleated pig eye was cannulated, allowing precise control of IOP. The CLS signal was then compared to the imposed IOP. RESULTS:First, the IOP of enucleated pig eyes was changed between 11 and 14 mmHg, simulating ocular pulsation. Then, IOP was changed with static steps of 1 mmHg between 20 and 30 mmHg to assess the reproducibility and linearity of the CLS. In both cases, measurements from the CLS and IOP showed very good correlation. A calibration graph shows that the CLS is capable of monitoring the IOP of each individual eye with a reproducibility of +/- 0.2 mmHg (95% confidence interval). CONCLUSION:The wireless CLS shows a good functionality to monitor the IOP on enucleated pig eyes. The device is placed in the same way as a soft disposable contact lens. This device would allow a minimally invasive and continuous monitoring of IOP over prolonged periods of up to 24 hr, regardless of patient activity, thus opening up new diagnostic and therapeutic methods to manage glaucoma.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Leonardi M,Pitchon EM,Bertsch A,Renaud P,Mermoud Adoi
10.1111/j.1755-3768.2008.01404.xsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
433-7issue
4eissn
1755-375Xissn
1755-3768pii
AOS1404journal_volume
87pub_type
杂志文章abstract：PURPOSE:To determine the spectrum of BEST1 mutations and to study the phenotype in Slovenian families with Best vitelliform macular dystrophy (BVMD) to identify genotype-phenotype correlations. METHODS:Twenty patients from five families underwent the ophthalmological examination including electrooculogram (EOG; N = 17...
journal_title：Acta ophthalmologica
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doi：10.1111/aos.13202
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Life expectancy is increasing. When corneal donors become older and corneal-grafted patients live longer with their graft, the need for good-quality donor tissue becomes more crucial. The aim of the present investigation is to study grafted recipients with a donor cornea with a total tissue age of more than 100...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
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journal_title：Acta ophthalmologica
pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:To compare the postoperative anatomic success rates and the frequency of complications between prone or supine postoperative positioning after transconjunctival sutureless vitrectomy (TSV) for rhegmatogenous retinal detachment (RRD). METHODS:All patients underwent primary 27-gauge TSV for the treatment of prim...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：BACKGROUND/AIMS:The mitotic count of uveal melanomas correlates with the risk of metastatic death, but with haematoxylin and eosin (H&E)-stained sections, it can be difficult to identify mitotic figures (MF) reliably. We investigated whether this measurement could be enhanced by immunohistochemistry, using the mitosis-...
journal_title：Acta ophthalmologica
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abstract：PURPOSE:To compare the efficacy and safety of collagen matrix implant (Ologen® ; OLO) with mitomycin C (MMC) in phacotrabeculectomy. METHODS:Prospective, single-centre, nonblinded, randomized controlled trial. A total of 53 eyes of 45 patients were enrolled in the study protocol with 27 eyes randomly assigned to OLO a...
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pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:Current evidence indicates that alteration in ocular blood flow may be relevant in open-angle glaucoma (OAG) patients independent of intraocular pressure (IOP). Presently, the lack of an adequate methodology capable of assessing all vascular beds limits the clinical role of blood flow parameters in glaucoma man...
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pub_type： 杂志文章,随机对照试验
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更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To study high-resolution ultrasound biomicroscopy (UBM) findings in anterior scleral inflammatory disease and evaluate the efficacy of high-resolution UBM as an adjunctive diagnostic tool. METHODS:A cross-sectional study. The medical records of 30 patients (33 eyes) with episcleritis or anterior scleritis were...
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更新日期：2016-09-01 00:00:00
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更新日期：2019-12-06 00:00:00
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更新日期：2010-11-01 00:00:00
abstract：PURPOSE:To evaluate the impact of pseudoexfoliation syndrome on intraocular lens (IOL) dislocation after phacoemulsification cataract surgery and explore possible associations related to surgical technique. METHODS:We systematically searched the MEDLINE, Embase, Web of Science, Cochrane, and Lilacs databases and grey ...
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pub_type： 杂志文章,meta分析,评审
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更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To establish whether or not the dynamics of saccadic eye movements are significantly changed in patients with different stages of thyroid-associated ophthalmopathy (TAO) and, subsequently, if analysis of saccades could serve as an additional diagnostic tool for early detection of inflammatory activity in TAO. ...
journal_title：Acta ophthalmologica
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doi：10.1111/j.1755-3768.2011.02216.x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:We present a genetic and clinical analysis of two sisters, 3 and 4 years of age, with nanophthalmos and macular folds. METHODS:Ophthalmological examination, general paediatric examination and molecular genetic analysis of the MFRP gene were performed in both affected siblings. RESULTS:Clinical analysis showed...
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
abstract：PURPOSE:To analyse the postoperative foveal avascular zone (FAZ) area, superficial vessel density (SVD) and deep vessel density (DVD) and their correlation with functional (best-corrected visual acuity, BCVA) and anatomical outcomes (foveal macular thickness, FMT) after surgery for rhegmatogenous retinal detachment (RR...
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更新日期：2019-11-26 00:00:00
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pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
abstract：PURPOSE:To evaluate the effect of photodynamic therapy (PDT) on central serous chorioretinopathy (CSC) compared with laser therapy and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, and to find the maximum treatment effect with minimal dose and fluence of PDT. METHODS:A systematic...
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pub_type： 杂志文章,meta分析,评审
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-11-01 00:00:00
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journal_title：Acta ophthalmologica
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更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Approximately 50% of patients with uveal melanomas develop metastases. Thus, it is important to improve our understanding of how melanoma metastases develop. METHODS:As part of a uveal melanoma micrometastasis study, we compared the detection rates of immunomagnetically selected (IMS) tumour cells in bone marr...
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pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
abstract：PURPOSE:Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age-related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). METHODS:This was a prospective case-control study. A total of 125 participants were ...
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
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更新日期：2021-01-09 00:00:00
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pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1600-0420.2007.01118.x
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care. METHODS:A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retinopathy was eva...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12954
更新日期：2016-05-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13464
更新日期：2017-11-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章,多中心研究
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更新日期：2019-05-01 00:00:00
abstract：PURPOSE:Choroideremia is a currently incurable X-linked recessive retinal degeneration that leads to blindness. Gene therapy approaches to date target the outer retinal layers. However, the choroideremia (CHM) gene is expressed in all retinal layers, and a previous study on a small cohort of choroideremia patients sugg...
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
