Human bone marrow mesenchymal stem cells for retinal vascular injury.

Abstract:

PURPOSE:To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. METHODS:Three study groups (oxygen-induced retinopathy group: 18 C57BL/6J mice; diabetic retinopathy group: 15 rats; retinal ischaemia-reperfusion model: 18 rats) received BMSCs injected intravitreally. Control groups (oxygen-induced retinopathy group: 12 C57BL/6J mice; diabetic retinopathy group: 15 rats; retinal ischaemia-reperfusion model: 18 rats) received an intravitreal injection of phosphate-buffered saline. We applied immunohistological techniques to measure retinal vascularization, spectroscopic measurements of intraretinally extravasated fluorescein-conjugated dextran to quantify the blood-retina barrier breakdown, and histomorphometry to assess retinal thickness and retinal ganglion cell count. RESULTS:In the oxygen-induced retinopathy model, the study group with intravitreally injected BMSCs as compared with the control group showed a significantly (p = 0.001) smaller area of retinal neovascularization. In the diabetic retinopathy model, study group and control group did not differ significantly in the amount of intraretinally extravasated dextran. In the retinal ischaemia-reperfusion model, on the 7th day after retina injury, the retina was significantly thicker in the study group than in the control group (p = 0.02), with no significant difference in the retinal ganglion cell count (p = 0.36). CONCLUSIONS:Intravitreally implanted human BMSCs were associated with a reduced retinal neovascularization in the oxygen-induced retinopathy model and with a potentially cell preserving effect in the retinal ischaemia-reperfusion model. Intravitreal BMSCs may be of potential interest for the therapy of retinal vascular disorders.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Wang JD,An Y,Zhang JS,Wan XH,Jonas JB,Xu L,Zhang W

doi

10.1111/aos.13154

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

e453-e461

issue

6

eissn

1755-375X

issn

1755-3768

journal_volume

95

pub_type

杂志文章
  • A detailed in vivo analysis of the retinal nerve fibre layer in choroideremia.

    abstract:PURPOSE:Choroideremia is a currently incurable X-linked recessive retinal degeneration that leads to blindness. Gene therapy approaches to date target the outer retinal layers. However, the choroideremia (CHM) gene is expressed in all retinal layers, and a previous study on a small cohort of choroideremia patients sugg...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13973

    authors: Fu DJ,Xue K,Jolly JK,MacLaren RE

    更新日期:2019-06-01 00:00:00

  • A multicentre prospective study of post-traumatic endophthalmitis.

    abstract:PURPOSE:Study the clinical and microbiological characteristics and the prognostic factors of post-traumatic endophthalmitis. METHODS:Seventeen eyes were included between 2004 and 2010, with clinical and microbiological data collected prospectively. Conventional cultures and panbacterial PCR were performed on aqueous a...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1755-3768.2011.02349.x

    authors: Cornut PL,Youssef el B,Bron A,Thuret G,Gain P,Burillon C,Romanet JP,Vandenesch F,Maurin M,Creuzot-Garcher C,Chiquet C,French Institutional Endophthalmitis Study (FRIENDS) Group.

    更新日期:2013-08-01 00:00:00

  • Primary angle closure and primary angle closure glaucoma in retinal vein occlusion.

    abstract:PURPOSE:To investigate the frequency of primary angle closure (PAC) and primary angle closure glaucoma (PACG) in patients with retinal vein occlusion (RVO) based on a hospital population. METHODS:A total of 375 consecutive cases newly diagnosed with RVO by fluorescein fundus angiography at a single eye centre in Pekin...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13879

    authors: Xu K,Wu L,Ma Z,Liu Y,Qian F

    更新日期:2019-05-01 00:00:00

  • Selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabeculoplasty.

    abstract:PURPOSE:To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT). METHODS:A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular press...

    journal_title:Acta ophthalmologica

    pub_type: 临床试验,杂志文章

    doi:10.1111/aos.14136

    authors: Ilveskoski L,Taipale C,Tuuminen R

    更新日期:2020-02-01 00:00:00

  • Heritability of corneal refraction and corneal astigmatism: a population-based twin study among 66- to 79-year-old female twins.

    abstract:PURPOSE:To examine the heritability of corneal refraction power (CR) and corneal astigmatism (AST) in older women. METHODS:Corneal refraction and AST were measured by IOL master in 52 monozygotic (MZ) and 47 dizygotic (DZ) female twin pairs aged 66-79 years. The relative contribution of genetic and environmental facto...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2011.02332.x

    authors: Pärssinen O,Kauppinen M,Kaprio J,Koskenvuo M,Rantanen T

    更新日期:2013-03-01 00:00:00

  • Ring-shaped dysphotopsia associated with posterior chamber phakic implantable collamer lenses with a central hole.

    abstract:PURPOSE:To evaluate the incidence of central hole-induced ring-shaped dysphotopsia after posterior chamber phakic implantable collamer lens (ICL) with central hole (hole ICL) implantation and to investigate the causes of central hole-induced dysphotopsia. METHODS:The clinical study enrolled 29 eyes of 15 consecutive m...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13248

    authors: Eom Y,Kim DW,Ryu D,Kim JH,Yang SK,Song JS,Kim SW,Kim HM

    更新日期:2017-05-01 00:00:00

  • Retinal microvascular complexity comparing mono- and multifractal dimensions in relation to cardiometabolic risk factors in a Middle Eastern population.

    abstract:PURPOSE:Metrics that capture changes in the retinal microvascular structure are relevant in the context of cardiometabolic disease development. The microvascular topology is typically quantified using monofractals, although it obeys more complex multifractal rules. We study mono- and multifractals of the retinal microv...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14598

    authors: Van Craenendonck T,Gerrits N,Buelens B,Petropoulos IN,Shuaib A,Standaert A,Malik RA,De Boever P

    更新日期:2020-09-16 00:00:00

  • Influence of different keratoplasty techniques on the biomechanical properties of the cornea.

    abstract:PURPOSE:To evaluate and compare corneal biomechanical changes after deep anterior lamellar keratoplasty (DALK) versus penetrating keratoplasty (PK) using the ocular response analyzer (ORA). METHODS:This prospective comparative study included 65 eyes (65 patients). Patients were divided into three groups: DALK (20 eyes...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12136

    authors: Abdelkader A

    更新日期:2013-11-01 00:00:00

  • Vitreomacular traction and exudative age-related macular degeneration.

    abstract::Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-3768.2008.01210.x

    authors: Schulze S,Hoerle S,Mennel S,Kroll P

    更新日期:2008-08-01 00:00:00

  • Restoration of retinal morphology and residual scarring after photocoagulation.

    abstract:PURPOSE:To study healing of retinal laser lesions in patients undergoing PRP using SD-OCT. METHODS:Moderate, light and barely visible retinal burns were produced in patients with proliferative diabetic retinopathy scheduled for PRP using 100-, 20- and 10-ms pulses of 532-nm laser, with retinal spot sizes of 100, 200 a...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.12045

    authors: Lavinsky D,Cardillo JA,Mandel Y,Huie P,Melo LA,Farah ME,Belfort R,Palanker D

    更新日期:2013-06-01 00:00:00

  • Haemorheopheresis could block the progression of the dry form of age-related macular degeneration with soft drusen to the neovascular form.

    abstract:PURPOSE:To evaluate the influence of haemorheopheresis on anatomical and functional findings in patients with soft-drusen maculopathy. METHODS:We investigated 29 eyes (16 patients) and randomized 25 eyes (16 controls) with soft-drusen maculopathy [soft, confluent and reticular drusen, drusenoid retinal pigment epithel...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1755-3768.2009.01710.x

    authors: Rencová E,Bláha M,Studnička J,Blažek M,Bláha V,Dusová J,Malý J,Kyprianou G,Vašátko T,Langrová H

    更新日期:2011-08-01 00:00:00

  • Intravitreal anti-VEGF therapy is not associated with a higher risk of all-cause mortality in patients with macular oedema caused by posterior segment vascular diseases.

    abstract:PURPOSE:To examine whether real-world clinical patients with macular oedema (MO) receiving intravitreal antivascular endothelial growth factor (VEGF) therapy have a higher mortality compared with a matched reference population. METHODS:A population-based, retrospective cohort study of 26 386 patients from Finland, fro...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14717

    authors: Loukovaara S,Haukka J

    更新日期:2021-01-02 00:00:00

  • Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood.

    abstract:PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.13405

    authors: Pärssinen O,Kauppinen M

    更新日期:2017-08-01 00:00:00

  • Variability in short-wavelength automated perimetry among peri- or postmenopausal women: a dependence on phyto-oestrogen consumption?

    abstract:PURPOSE:To determine whether the hill of vision for Short-Wavelength Automated Perimetry (SWAP) is shallower for women who consume phyto-oestrogen-rich foods than for women who do not. METHODS:Visual field data were compared for two groups of healthy amenorrhoeic women 48-69 years-old with normal vision and not using ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2009.01799.x

    authors: Eisner A,Demirel S

    更新日期:2011-05-01 00:00:00

  • Intra- and interobserver reproducibility of Bruch's membrane opening minimum rim width measurements with spectral domain optical coherence tomography.

    abstract:PURPOSE:To investigate the reproducibility of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) measurements using spectral domain optical coherence tomography (SD-OCT). Additionally, to investigate the reproducibility of BMO area measurements and fovea to BMO centre (...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13464

    authors: Reis ASC,Zangalli CES,Abe RY,Silva AL,Vianna JR,Vasconcellos JPC,Costa VP

    更新日期:2017-11-01 00:00:00

  • Postoperative aqueous humour flare as a surrogate marker for proliferative vitreoretinopathy development.

    abstract:PURPOSE:As some surgical procedures have been shown to increase postoperative flare values and thus contribute to blood-ocular barrier breakdown, retinal reattachment surgery might influence the risk of developing proliferative vitreoretinopathy (PVR). Therefore, we investigated whether postoperative aqueous flare valu...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13560

    authors: Mulder VC,van Dijk EHC,van Meurs IA,La Heij EC,van Meurs JC

    更新日期:2018-03-01 00:00:00

  • Redefining tissue engineering for nanomedicine in ophthalmology.

    abstract::Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular. In nanomedicine, tissue engineering is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its pu...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-3768.2010.01982.x

    authors: Ellis-Behnke R,Jonas JB

    更新日期:2011-03-01 00:00:00

  • A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors.

    abstract:PURPOSE:Choroideremia is an X-linked retinal disease characterized by early retinal pigment epithelium (RPE) loss and subsequent retinal degeneration. The RPE adopts either a smooth or mottled appearance on fundus autofluorescence (FAF). It is not known how RPE changes predict the health of the overlying ellipsoid zone...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14281

    authors: Stevanovic M,Cehajic Kapetanovic J,Jolly JK,MacLaren RE

    更新日期:2020-05-01 00:00:00

  • Effect of glaucoma drainage implant surgery on corneal topography: a prospective study.

    abstract:PURPOSE:To study the effect of glaucoma drainage implant (GDI) surgery on corneal topography during the first postoperative year. METHODS:Twenty-one adult glaucoma patients were implanted with a Molteno3 or a Baerveldt 250 GDI. Corneal topography measurements were taken preoperatively and at 6 and 12 months after surg...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14247

    authors: Koivusalo R,Välimäki J

    更新日期:2020-05-01 00:00:00

  • Effects of core vitrectomy in the treatment of age-related macular degeneration.

    abstract:PURPOSE:To investigate the clinical efficacy and safety of an additional core vitrectomy to the standard therapy in patients with exudative age-related macular degeneration (ARMD). METHODS:In this prospective, controlled, single-centre study, 50 eyes of 50 patients (mean age: 74.1 ± 7.1; median 74 (69/78)) with ARMD w...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.12326

    authors: Schramm K,Mueller M,Koch FH,Singh P,Kohnen T,Koss MJ

    更新日期:2014-08-01 00:00:00

  • Fundus imaging in newborn children with wide-field scanning laser ophthalmoscope.

    abstract:PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13453

    authors: Magnusdottir V,Vehmeijer WB,Eliasdottir TS,Hardarson SH,Schalij-Delfos NE,Stefánsson E

    更新日期:2017-12-01 00:00:00

  • A study of stromal riboflavin absorption in ex vivo porcine corneas using new and existing delivery protocols for corneal cross-linking.

    abstract:PURPOSE:To indirectly measure stromal riboflavin penetration using commercially available riboflavin solutions and new and existing epithelium-off, trans-epithelial and iontophoresis-assisted delivery protocols. METHODS:Forty porcine eyes were divided into eight groups. Group 1: Ricrolin applied to the de-epithelialis...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12884

    authors: Hayes S,Morgan SR,O'Brart DP,O'Brart N,Meek KM

    更新日期:2016-03-01 00:00:00

  • Comparison of corneal biomechanical changes after refractive surgery by noncontact tonometry: small-incision lenticule extraction versus flap-based refractive surgery - a systematic review.

    abstract::Corneal refractive surgery disrupts corneal integrity and reduces biomechanical stability in consequence of the beneficial refractive alteration. The minimal invasive cap-based refractive procedure, small-incision lenticule extraction (SMILE), has been proposed to affect corneal integrity less than flap-based procedur...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13906

    authors: Raevdal P,Grauslund J,Vestergaard AH

    更新日期:2019-03-01 00:00:00

  • Perforin expression in eyelid sebaceous carcinomas: a useful and specific immunomarker for the differential diagnosis of eyelid carcinomas.

    abstract:PURPOSE:Eyelid sebaceous carcinoma (SC) remains a common diagnostic pitfall for both the clinician and histopathologist. The aim of this study was to describe perforin as a new marker in the immunohistochemistry panel for SC. METHODS:A total of 29 cases were retrieved from the Pathology archives, including 11 sebaceou...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12972

    authors: Mittal R,Araujo I,Czanner G,Coupland SE

    更新日期:2016-08-01 00:00:00

  • Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography.

    abstract:PURPOSE:The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). METHODS:I...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13050

    authors: Mendez-Hernandez C,Rodriguez-Uña I,Gonzalez-de-la Rosa M,Arribas-Pardo P,Garcia-Feijoo J

    更新日期:2016-11-01 00:00:00

  • What is the influence of parents' myopia on their children's myopic progression? A 22-year follow-up study.

    abstract:PURPOSE:To study the connection between parental myopia and their children's myopia from school age to adulthood. METHODS:Two hundred and forty myopic schoolchildren (119 boys, 121 girls, mean age 10.9 years) with no previous spectacles for myopia were recruited to a 3-year treatment trial with different use of specta...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.13043

    authors: Pärssinen O,Kauppinen M

    更新日期:2016-09-01 00:00:00

  • Long-term follow-up of an amblyopia treatment study: change in visual acuity 15 years after occlusion therapy.

    abstract:PURPOSE:To determine change in visual acuity (VA) in the population of a previous amblyopia treatment study (Loudon 2006) and assess risk factors for VA decrease. METHODS:Subjects treated between 2001 and 2003 were contacted between December 2015 and July 2017. Orthoptic examination was conducted under controlled circ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14499

    authors: Kadhum A,Simonsz-Tóth B,van Rosmalen J,Pijnenburg SJM,Janszen BM,Simonsz HJ,Loudon SE

    更新日期:2020-07-13 00:00:00

  • Indications and outcomes of keratoplasties in children during a 40-year period.

    abstract:PURPOSE:To report the indications and the outcomes of keratoplasties in children over four decades. METHODS:A retrospective cohort study of patients aged 16 years or younger who underwent keratoplasty in the Helsinki University Eye Hospital during 1968-2011. Diagnosis, preoperative status, age at the time of surgery, ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13040

    authors: Majander A,Kivelä TT,Krootila K

    更新日期:2016-09-01 00:00:00

  • High prevalence of myopia in children and their parents in Hong Kong Chinese Population: the Hong Kong Children Eye Study.

    abstract:PURPOSE:To determine the myopia prevalence in Hong Kong Chinese children and their parents. METHODS:It was a population-based cross-sectional study. A total of 4257 children aged 6-8 years, and 5880 parents were recruited in the Hong Kong Children Eye Study. Cycloplegic autorefraction was measured for children; and no...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14350

    authors: Yam JC,Tang SM,Kam KW,Chen LJ,Yu M,Law AK,Yip BH,Wang YM,Cheung CYL,Ng DSC,Young AL,Tham CC,Pang CP

    更新日期:2020-01-24 00:00:00

  • Retinal oxygen saturation as a non-invasive estimate for mixed venous oxygen saturation and cardiac output.

    abstract:PURPOSE:To investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO2-mixed ) and cardiac output (CO). METHODS:Retinal arterial (SaO2-retinal ) and venous (SvO2-retinal ) oxygen saturation were measured non-invasively with dual-wavelength retinal oximetry in subjects ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13890

    authors: Van Keer K,Van Keer J,Barbosa Breda J,Nassiri V,Van Cleemput J,Abegão Pinto L,Stalmans I,Vandewalle E

    更新日期:2019-03-01 00:00:00