Abstract:
PURPOSE:To study healing of retinal laser lesions in patients undergoing PRP using SD-OCT. METHODS:Moderate, light and barely visible retinal burns were produced in patients with proliferative diabetic retinopathy scheduled for PRP using 100-, 20- and 10-ms pulses of 532-nm laser, with retinal spot sizes of 100, 200 and 400 μm. Lesions were measured with OCT at 1 hr, 1 week, 1, 2, 4, 6, 9 and 12 months. OCT imaging was correlated with histology in a separate study in rabbits. RESULTS:Lesions produced by the standard 100-ms exposures exhibited steady scarring, with the damage zone stabilized after 2 months. For 400- and 200-μm spots and 100-ms pulses, the residual scar area at 12 months was approximately 50% of the initial lesion size for moderate, light and barely visible burns. In contrast, lesions produced by shorter exposures demonstrated enhanced restoration of the photoreceptor layer, especially in smaller burns. With 20-ms pulses, the damage zone decreased to 32%, 24% and 20% for moderate, light and barely visible burns of 400 μm, respectively, and down to 12% for barely visible burns of 200 μm. In the 100-μm spots, the residual scar area of the moderate 100-ms burns was 41% of the initial lesion, while barely visible 10-ms burns contracted to 6% of the initial size. Histological observations in rabbits were useful for proper interpretation of the damage zone boundaries in OCT. CONCLUSIONS:Traditional photocoagulation parameters (400 μm, 100 ms and moderate burn) result in a stable scar similar in size to the beam diameter. Restoration of the damaged photoreceptor layer in lighter lesions produced by shorter pulses should allow reducing the common side-effects of photocoagulation such as scotomata and scarring.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Lavinsky D,Cardillo JA,Mandel Y,Huie P,Melo LA,Farah ME,Belfort R,Palanker Ddoi
10.1111/aos.12045subject
Has Abstractpub_date
2013-06-01 00:00:00pages
e315-23issue
4eissn
1755-375Xissn
1755-3768journal_volume
91pub_type
杂志文章,随机对照试验abstract:PURPOSE:To evaluate the effect of early intravitreal bevacizumab injections for the treatment of macular oedema caused by non-ischaemic central retinal vein occlusion (CRVO). METHODS:The study included 25 patients (25 eyes) with macular oedema caused by non-ischaemic central retinal vein occlusion, who received three ...
journal_title:Acta ophthalmologica
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Acta ophthalmologica
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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