Abstract:
PURPOSE:To investigate the clinical efficacy and safety of an additional core vitrectomy to the standard therapy in patients with exudative age-related macular degeneration (ARMD). METHODS:In this prospective, controlled, single-centre study, 50 eyes of 50 patients (mean age: 74.1 ± 7.1; median 74 (69/78)) with ARMD were enrolled and randomized 1:1 to group 1 - core vitrectomy additional to three times injections of ranibizumab (3x Rbz) and Group 2 - 3x Rbz (control). 1 16 of 25 eyes in Group 1(64%) and 12 of 25 (48%) in Group 2 had a posterior vitreous detachment (PVD) prior to start of the study. Changes in best-corrected visual acuity (BCVA) using ETDRS charts, central macular thickness and macular volume (OCT) as well as the rate of reinjection with an OCT-based pro renata (PRN) protocol were monitored prospectively over 48 weeks. Forty-seven eyes completed follow-up at week 48. RESULTS:In Group 1, 4 of 24 lost 1 line of BCVA (16.7%) and 3 of 24 lost 2 lines (12.5%), whereas 17 of 24 gained more than 1 line (70.8%) and improved in average by 9.8 letters. In Group 2, 3 of 23 remained stable and 20 of 23 gained more than or exactly 1 line (78.3%), resulting in 14.3 letters, with no loss of lines. Central macular thickness decreased by 85.58 μm (28.8%) in Group 1 and by 121.43 μm (32.68%) in Group 2 compared with baseline. In Group 1, four patients received three additional and two patients, two additional Rbz injections. In Group 2, three patients received three additional, three patients two and 12 patients one additional Rbz injections. This yielded in an average injection rate of 3.66 in Group 1 and 4.17 in Group 2 over 48 weeks. Posterior vitreous detachment (PVD) was identified in Group 1 in 16 of 24 (66.7%) and in Group 2 in 12 of 23 (52.2%) patients at baseline. At week 48, 6 of 8 (75%) of the patients in Group 1 with initial attached vitreous showed a vitreal detachment, whereas only 1 of 11 (9%) in Group 2 had a new occurred detachment of the vitreous. No systemic or ocular adverse events were noticed. CONCLUSION:An initial core vitrectomy combined with a conventional ranibizumab injection regimen for exudative AMD patients was safe and lead to similar functional results with less intravitreal ranibizumab injections over 48 weeks.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Schramm K,Mueller M,Koch FH,Singh P,Kohnen T,Koss MJdoi
10.1111/aos.12326subject
Has Abstractpub_date
2014-08-01 00:00:00pages
465-72issue
5eissn
1755-375Xissn
1755-3768journal_volume
92pub_type
杂志文章,随机对照试验abstract:PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13379
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:Approximately 50% of patients with uveal melanomas develop metastases. Thus, it is important to improve our understanding of how melanoma metastases develop. METHODS:As part of a uveal melanoma micrometastasis study, we compared the detection rates of immunomagnetically selected (IMS) tumour cells in bone marr...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02449.x
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To explore the association between retinal vein occlusion (RVO) and incident cancer. METHODS:All Danish citizens with a first-time diagnosis of RVO and no previous diagnosis of cancer in the period from 1 January 2004 to 31 December 2014 were included. Five likewise cancer-free, age- and gender-matched control...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13860
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To examine the patient's subjective visual sensations during cataract surgery performed under topical anaesthesia. METHODS:Prospective, non-randomized, cohort study. One hundred and thirty-two patients were interviewed by standard questionnaire within 1 hr of uncomplicated cataract surgery performed under topi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2007.01153.x
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To determine whether decreasing illumination of the Pelli-Robson contrast sensitivity (CS) chart and MP-1 microperimeter to low mesopic conditions is more sensitive to vision changes occurring with healthy ageing and in early and intermediate age-related macular degeneration (AMD) and whether these mesopic test...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13112
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate the EyeSi(™) simulator in regard to assessing competence in cataract surgery. The primary objective was to explore all simulator metrics to establish a proficiency-based test with solid evidence. The secondary objective was to evaluate whether the skill assessment was specific to cataract surgery. ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12691
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To evaluate the positivity rate of temporal artery biopsies (TAB) performed in suspects of giant cell arteritis (GCA) and to study the epidemiological and clinical factors associated to the biopsy result. METHODS:A retrospective, multicenter, case-control study was performed, including three hundred and thirty...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1755-3768.2012.02505.x
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:This study aimed to investigate intraocular pressure (IOP) measurements taken using the dynamic contour tonometer (DCT) and the non-contact tonometer (NCT) in subjects with keratoconus. METHODS:Intraocular pressure was measured in 20 keratoconus subjects and 20 age-matched control subjects using the DCT and NC...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01690.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To examine the role of systemic medication on the risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery. METHODS:A total of 269 eyes undergoing routine cataract surgery. Spectral-domain optical coherence tomography imaging was conducted before surgery and at 28 days. Informati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13911
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To describe the different clinical presentations of periocular molluscum contagiosum (MC) lesions and their epidemiological, clinical and histopathological features. METHODS:Medical records and histopathological sections of all cases of periocular MC treated at the oculoplastic clinic of the Goldschleger Eye I...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13717
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). METHODS:I...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13050
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:To study high-resolution ultrasound biomicroscopy (UBM) findings in anterior scleral inflammatory disease and evaluate the efficacy of high-resolution UBM as an adjunctive diagnostic tool. METHODS:A cross-sectional study. The medical records of 30 patients (33 eyes) with episcleritis or anterior scleritis were...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12995
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) as compared to elevated intraocular pressure (IOP) on axonal morphology and axonal motor proteins in retinal ganglion cells (RGCs). METHODS:The experimental study included 39 rats which underwent cerebrospinal fluid drainage...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12768
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Proliferative diabetic retinopathy (PDR) is characterized by ischaemia- and inflammation-induced neovascularization, but the pathological vascular differentiation in PDR remains poorly characterized. Here, endothelial progenitor and growth properties, as well as potential lymphatic differentiation, were investi...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12741
更新日期:2015-09-01 00:00:00
abstract::The main purpose of this thesis was to examine whether the Danish National Patient Registry (NPR) could be used to monitor and assess the quality of cataract surgery in Denmark by studying the risks of two serious postoperative complications following cataract surgery - retinal detachment (RD) and postoperative endoph...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12676
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:This work aimed to study and evaluate the effect of subconjunctival bevacizumab injection in patients with corneal neovascularization (CNV) resulting from different ocular surface disorders. METHODS:Ten eyes with CNV caused by different ocular surface disorders were studied. All eyes had both major and minor v...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01585.x
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained i...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13667
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To assess the condition of the corneal endothelium an extended period after cataract surgery in eyes with and without pseudoexfoliation syndrome (PES). METHODS:Forty-six patients with PES who underwent cataract surgery in the Eye Department, Oslo University Hospital, in 2001 and 2002 were enrolled and compared...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.02012.x
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Contact lenses have direct contact with the corneal surface and can induce sight-threatening infection of the cornea known as Acanthamoeba keratitis. The objective of this study was to evaluate the dysprosium-based nanoparticles (Dy-based NPs), namely Fe3 O4 -PEG-Dy2 O3 nanocomposites and Dy(OH)3 nanorods, as a...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14541
更新日期:2020-07-23 00:00:00
abstract:PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13502
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Previous studies have indicated that the immune system is involved in the pathogenesis of the AMD. Increased visceral fat, in addition, has a pro-inflammatory effect on the organism by producing or influencing different kinds of inflammatory factors. The aim of this study is to determine the relationship of bod...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12670
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To investigate incidence, clinicopathological features and prognosis of BRAF-mutated conjunctival melanoma in Denmark. Furthermore, to determine BRAF mutations in paired premalignant lesions and evaluate immunohistochemical BRAF V600E oncoprotein detection. METHODS:Data from 139 patients with conjunctival mela...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13007
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To assess the effects of multifocal soft contact lenses (MF SCLs) used for myopia control on visual acuity (VA) and subjective quality of vision. METHODS:Twenty-four young adult myopes had baseline high and low-contrast VAs and refractions measured and quality of vision assessed by the Quality of Vision (QoV) ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13173
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Aquaporins (AQPs) are widely expressed and have diverse distribution patterns in the eye. AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye. METHODS:RT-PCR was performed on fresh tissue from two human eyes d...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02547.x
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery. METHODS:Randomized, placebo-controlled superiority trial in three tertiary referral centres in the Netherlands. Patie...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/aos.13610
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To study healing of retinal laser lesions in patients undergoing PRP using SD-OCT. METHODS:Moderate, light and barely visible retinal burns were produced in patients with proliferative diabetic retinopathy scheduled for PRP using 100-, 20- and 10-ms pulses of 532-nm laser, with retinal spot sizes of 100, 200 a...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.12045
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To analyse intraocular cytokine levels and prevalence of intraocular antiretinal antibodies (ARAs) in patients with retinitis pigmentosa (RP), age-related macular degeneration (AMD), glaucoma and cataract, and correlate the results to clinical manifestations. METHODS:We collected intraocular fluid samples from...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13899
更新日期:2019-03-01 00:00:00
abstract::In the context of the COVID-19 pandemic, this paper provides recommendations for medical eye care during the easing of control measures after lockdown. The guidelines presented are based on a literature review and consensus among all Spanish Ophthalmology Societies regarding protection measures recommended for the oph...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.14752
更新日期:2021-01-12 00:00:00
abstract::Although the work for which Emil von Behring (1854-1917) was awarded the first Nobel Prize Winner for Medicine or Physiology in 1901 was on serum therapy, not only was he trained and worked as an ophthalmologist but he also wrote his doctoral dissertation on a practical ophthalmological topic whilst in Berlin under Ca...
journal_title:Acta ophthalmologica
pub_type: 传,历史文章
doi:10.1111/j.1755-3768.2011.02343.x
更新日期:2013-06-01 00:00:00
abstract::Surgical approaches for rhegmatogenous retinal detachment (RRD) have evolved rapidly in the past century. This has resulted in an increase in the anatomical success rate from zero per cent in the beginning of the 1900s to now almost 100 per cent. Rhegmatogenous retinal detachment is regarded as an acute eye disease th...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/aos.12991
更新日期:2016-03-01 00:00:00