Abstract:
PURPOSE:To employ ultrahigh-resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium. METHODS:A custom-built UHR-OCT system assessed epithelial healing in human keratoconic cornea after epi-off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic corneal injury. 3D OCT data sets enhanced obtaining epithelial thickness maps and evaluation of reepithelization stage. Accompanying changes in deeper corneal microarchitecture were analysed. RESULTS:The mean central corneal thickness in 40 eyes with keratoconus at baseline was 482.7 ± 38.2 μm, while mean central epithelial thickness (CET) was 43.8 ± 6.4 μm. At the final visit 20 ± 5 days post-CXL procedure, CET was 35.0 ± 5.8 μm, significantly thinner after reepithelization (p < 0.001). Surgical success was assessed at the final visit through the demarcation line (DL), identified at 43.7 ± 13.5% stromal depth. In rabbits, the mean CET in 20 eyes at baseline was 35.9 ± 2.6 μm. In rabbits that revealed complete wound closure (10/20 eyes) at the last study day at 72 hr, CET was significantly thinner compared to baseline (30.4 ± 2.8 μm versus 35.4 ± 2.9 μm, p = 0.005). An intra-stromal landmark indicating early keratocyte apoptosis was measured at 30.0 ± 5.1% stromal depth. Epithelial thickness maps showed the time-course of corneal healing. CONCLUSION:Ultrahigh-resolution (UHR)-OCT provided precise assessment of epithelial wound and its healing by 3D-mapping. In addition, microarchitectural changes in the cornea in early phases of epithelial healing were revealed.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Pantalon A,Pfister M,Aranha Dos Santos V,Sapeta S,Unterhuber A,Pircher N,Schmidinger G,Garhöfer G,Schmidl D,Schmetterer L,Werkmeister RMdoi
10.1111/aos.14053subject
Has Abstractpub_date
2019-08-01 00:00:00pages
e761-e771issue
5eissn
1755-375Xissn
1755-3768journal_volume
97pub_type
杂志文章,随机对照试验abstract::Surgical approaches for rhegmatogenous retinal detachment (RRD) have evolved rapidly in the past century. This has resulted in an increase in the anatomical success rate from zero per cent in the beginning of the 1900s to now almost 100 per cent. Rhegmatogenous retinal detachment is regarded as an acute eye disease th...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/aos.12991
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Pathological alterations within optic nerve axons and progressive loss of the parental retinal ganglion cell (RGC) bodies are characteristics of glaucomatous neuropathy. Abnormally elevated intraocular pressure (IOP) is thought to be the major risk factor for most forms of glaucomatous changes, while lowering o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14333
更新日期:2019-12-29 00:00:00
abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13332
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the retinal thickness analyser (RTA) as a means to identify the presence of cystoid macular oedema (CMO) in children with uveitis, whether the course of CMO can be monitored using this method, and whether there is a trend towards a correlation between macular oedema and visual ac...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.01009.x
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:Angiogenic inhibitors, alone or combined with other therapies, are believed to represent a promising treatment for neovascularization in age-related macular degeneration (wet AMD). They can maintain or improve visual acuity (VA), at least for the first 2years. However, evolution to retinal atrophy cannot be rul...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01526.x
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02300.x
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. METHODS:Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery....
journal_title:Acta ophthalmologica
pub_type:
doi:10.1111/aos.13223
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma (PA) using optical coherence tomography angiography (OCTA). METHODS:Cross-sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro-ophthalmol...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14322
更新日期:2019-12-06 00:00:00
abstract:PURPOSE: To evaluate the precision of techniques for measuring intraocular pressure (IOP) in corneas with presumably altered biomechanical properties. METHODS: Intraocular pressure was measured with a Goldmann applanation tonometer (GAT), ocular response analyzer (ORA) and dynamic contour tonometer (DCT) in 70 eyes....
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12137
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To investigate the prevalence of potential age-related eye conditions in elderly who are assisted by home healthcare nurses. The number of referrals to the general practitioner (GP), feasibility of screening and associations between vision loss and health outcomes were also studied. METHODS:Cross-sectional stu...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13956
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To compare pars plana vitrectomy and 360° endolaser therapy with pars plana vitrectomy and an encircling scleral buckle for the treatment of primary rhegmatogenous retinal detachments in a randomized pilot study including 60 patients. METHODS:Main outcome measures were single-surgery anatomic success rate and ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.12663
更新日期:2015-08-01 00:00:00
abstract::Asteroid hyalosis is defined by the presence of white, snowball-like non-crystalline vitreous opacities that move with the vitreous and appear to be anchored to its matrix. Asteroid hyalosis commonly occurs in the absence of other identifiable ocular abnormalities and is usually an incidental finding. The vitreous opa...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.14465
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To analyse the anterior lens capsule thickness and ultrastructure changes of intumescent white cataracts in comparison with nuclear cataracts to prove possible structural reasons for surgical difficulties with the intumescent white cataract. METHODS:Anterior lens capsules from 35 eyes with intumescent white an...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.02102.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT). METHODS:A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular press...
journal_title:Acta ophthalmologica
pub_type: 临床试验,杂志文章
doi:10.1111/aos.14136
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To assess the effects of multifocal soft contact lenses (MF SCLs) used for myopia control on visual acuity (VA) and subjective quality of vision. METHODS:Twenty-four young adult myopes had baseline high and low-contrast VAs and refractions measured and quality of vision assessed by the Quality of Vision (QoV) ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13173
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Clinical risk management aims to identify, analyse and avoid errors and risks systematically to improve patient's safety. Preoperative checklists to prevent mistakes have gained importance in the last few years. A so-called team timeout checklist was introduced in October 2011 at the Department of Ophthalmology...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13155
更新日期:2017-03-01 00:00:00
abstract::Endoscopic Cyclophotocoagulation (ECP) is a glaucoma surgery designed to reduce the intraocular pressure (IOP) by partially ablating the ciliary processes to decrease aqueous humour production and secretion. The aim of this paper is to review the literature regarding the background, indications and results of the surg...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/aos.12529
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To determine the effect of the axial length on the supernormal and false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic (SD-OCT) instrument. METHODS:This was a prospective, observati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12382
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy. METHODS:Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with m...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0420.2007.01036.x
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:Enzyme replacement therapy (ERT) was offered from year 2001 to patients with Fabry disease. The ophthalmic experience was analysed, as part of a general 10-year status. METHODS:A retrospective observational series comprising 39 patients (25 females, 14 males) closely followed by the endocrinologists, and with ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12588
更新日期:2015-05-01 00:00:00
abstract:PURPOSE: To describe and evaluate a cryo-assisted, minimally invasive, anterior approach for orbital tumour surgery. METHODS: Retrospective, non-comparative, consecutive, interventional case series of 103 patients who were operated on by the same surgeon for retroocular orbital tumours over the last 16 years. RESUL...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01515.x
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To investigate changes in retinal metabolism, function, structure and morphology in relation to initiation of insulin pump therapy (continuous subcutaneous insulin infusion, CSII). METHODS:Visual acuity, retinopathy level, dark adaptation kinetics, retinal and subfoveal choroidal thickness, macular perfusion v...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13066
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Study the clinical and microbiological characteristics and the prognostic factors of post-traumatic endophthalmitis. METHODS:Seventeen eyes were included between 2004 and 2010, with clinical and microbiological data collected prospectively. Conventional cultures and panbacterial PCR were performed on aqueous a...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1755-3768.2011.02349.x
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To investigate incidence, clinicopathological features and prognosis of BRAF-mutated conjunctival melanoma in Denmark. Furthermore, to determine BRAF mutations in paired premalignant lesions and evaluate immunohistochemical BRAF V600E oncoprotein detection. METHODS:Data from 139 patients with conjunctival mela...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13007
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To evaluate the incidence of central hole-induced ring-shaped dysphotopsia after posterior chamber phakic implantable collamer lens (ICL) with central hole (hole ICL) implantation and to investigate the causes of central hole-induced dysphotopsia. METHODS:The clinical study enrolled 29 eyes of 15 consecutive m...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13248
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To test the validity of the eyesi surgical simulator as an assessment tool in a virtual reality vitreoretinal training programme. METHODS:In collaboration with an experienced vitreoretinal surgeon, a virtual vitreoretinal training programme was composed on the eyesi surgical simulator, software version 2.9.2 (...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13209
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To evaluate the effect of ZY1, a novel 21-amino acid peptide from human placenta growth factor-1 (PlGF-1), against ocular neovascularization, and to study its possible toxicity to the retina and the underlying mechanism of antiangiogenic effect. METHODS:MTS assays, a modified Boyden chamber and Matrigel(™) wer...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02476.x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To present clinical results regarding the treatment of patients with age-related macular degeneration (neovascular form) after the implementation of a 'virtual' type of follow-up in a single retina service centre. METHODS:Retrospective study based on the clinical records of the Leicester Royal Infirmary Retina...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12832
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To study the connection between parental myopia and their children's myopia from school age to adulthood. METHODS:Two hundred and forty myopic schoolchildren (119 boys, 121 girls, mean age 10.9 years) with no previous spectacles for myopia were recruited to a 3-year treatment trial with different use of specta...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13043
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Metrics that capture changes in the retinal microvascular structure are relevant in the context of cardiometabolic disease development. The microvascular topology is typically quantified using monofractals, although it obeys more complex multifractal rules. We study mono- and multifractals of the retinal microv...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14598
更新日期:2020-09-16 00:00:00