Abstract:
PURPOSE:To investigate long-term visual results of treatment with anti-vascular endothelial growth factor (VEGF) agents for neovascular age-related macular degeneration (nAMD) following a treat-and-extend regimen. METHODS:Retrospective review of 155 patients who initiated treatment with bevacizumab for nAMD in one eye. At the final 8-year visit, 40 patients (26%) remained for follow-up. Mean change in best-corrected visual acuity (BCVA) was calculated compared to baseline values. RESULTS:Mean BCVA improved significantly from baseline during the first year of treatment, with -0.11 logMAR units equivalent to 6.1 approximate Early Treatment Diabetic Retinopathy Study (approxETDRS) letters (p = <0.001). Mean BCVA was still significantly improved after 4 years of treatment for the entire group of patients and after 6 years of treatment for the subgroup of 40 patients who remained at the final 8-year visit. Thereafter, BCVA gradually declined and at 8 years, there was a mean change of 0.05 logMAR units equivalent to 2.1 approxETDRS letters below baseline (p = 0.530). Mean number of injections during the first year was 6.1 ± 2.8 and during year 8 was 5.4 ± 3.5. At 5 years, fundus autofluorescence showed some degree of macular atrophy in all eyes. At the final 8-year visit, 87.5% of the eyes had stable neovascular lesions with no fluid on optical coherence tomography (OCT). CONCLUSION:In an everyday clinical setting, treatment of nAMD patients with a treat-and-extend modality provided improvement and stability of vision for several years. After 8 years of follow-up, there was a decline in visual acuity (VA) that could be explained by macular atrophic development.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Berg K,Roald AB,Navaratnam J,Bragadóttir Rdoi
10.1111/aos.13522subject
Has Abstractpub_date
2017-12-01 00:00:00pages
796-802issue
8eissn
1755-375Xissn
1755-3768journal_volume
95pub_type
杂志文章abstract:PURPOSE:To report normative data on visual acuity (VA) for near and distance, refraction, ocular alignment, ocular motility and stereo acuity in a cohort of children aged 4.5-7 years. METHODS:A total of 950 children with normal development from the municipality of Roskilde, Denmark, were invited to participate in an o...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13650
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To examine the role of systemic medication on the risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery. METHODS:A total of 269 eyes undergoing routine cataract surgery. Spectral-domain optical coherence tomography imaging was conducted before surgery and at 28 days. Informati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13911
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. METHODS:Participants of the Raine Study Generation 2 cohort had 25(OH...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14709
更新日期:2021-01-10 00:00:00
abstract::Although the work for which Emil von Behring (1854-1917) was awarded the first Nobel Prize Winner for Medicine or Physiology in 1901 was on serum therapy, not only was he trained and worked as an ophthalmologist but he also wrote his doctoral dissertation on a practical ophthalmological topic whilst in Berlin under Ca...
journal_title:Acta ophthalmologica
pub_type: 传,历史文章
doi:10.1111/j.1755-3768.2011.02343.x
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To develop an objective intraocular inflammation composite score. METHODS:Cross-sectional study. Non-invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation-grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14739
更新日期:2021-01-09 00:00:00
abstract::The development of ophthalmology was greatly restricted in Poland in the 19th century, because it was partitioned and occupied by its three dominant neighbours. Polish medical universities were closed, and in Polish hospitals, only clinical work was possible. Those who wanted to study medicine and become ophthalmologi...
journal_title:Acta ophthalmologica
pub_type: 历史文章,杂志文章
doi:10.1111/j.1755-3768.2009.01856.x
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To provide a systematic review of the published studies pertaining to the lifestyle modification, dietary, nutritional and vitamins supplements for preventing occurrence or halting deterioration of age-related macular degeneration (AMD). METHODS:The literature searches from 1990 to December 2010 with following...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
doi:10.1111/j.1755-3768.2011.02357.x
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS:In this prospe...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13397
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients. METHODS:A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.14018
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To evaluate the changes of vascular endothelial growth factor (VEGF) plasma levels after intravitreal injections of ranibizumab or bevacizumab in patients with exudative age-related macular degeneration (AMD). METHODS:Forty-three patients with exudative AMD and 19 age- and sex-matched control patients without ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02240.x
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:Current evidence indicates that alteration in ocular blood flow may be relevant in open-angle glaucoma (OAG) patients independent of intraocular pressure (IOP). Presently, the lack of an adequate methodology capable of assessing all vascular beds limits the clinical role of blood flow parameters in glaucoma man...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0420.2007.01091.x
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:Tissue inhibitors of metalloproteinases (TIMPs) block the catalysis by matrix metalloproteinases (MMPs) and have additional biologic activities, including regulation of cell growth and differentiation, apoptosis, angiogenesis and oncogenesis. We investigated the expression levels of all the four human TIMPs and...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13451
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:The cyclolignan picropodophyllin (PPP) efficiently blocks the activity of insulin-like growth factor-1 receptor (IGF-1R) and inhibits growth of uveal melanoma cells in vitro and in vivo. In this study, we aimed to investigate the efficiency of orally administered PPP on growth of uveal melanoma xenografts. Furt...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01184.x
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To perform in vivo imaging of the Schlemm's canal (SC) with anterior segment spectral-domain optical coherence tomography [AS-spectral-domain (SD)-OCT] and also to measure its biometric parameters including the SC length and SC area in patients with pseudoexfoliation (PEX) glaucoma. METHODS:Forty-one consecuti...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13080
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investig...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02151.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To present clinical results regarding the treatment of patients with age-related macular degeneration (neovascular form) after the implementation of a 'virtual' type of follow-up in a single retina service centre. METHODS:Retrospective study based on the clinical records of the Leicester Royal Infirmary Retina...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12832
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02300.x
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13453
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To describe in detail the phenotype of CORD5 in two families segregating a mutation c.1878G>C (p.Q626H) in the PITPNM3 gene. METHODS:The study included 35 individuals from two different families of Swedish origin, all heterozygous for a PITPNM3 p.Q626H mutation. All participants underwent ophthalmological exam...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02381.x
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To investigate the incidence and cause of severe visual loss following use and removal of intraocular silicone oil (SiO) after uncomplicated vitrectomy and SiO injection for primary rhegmatogenous retinal detachment (RRD). METHODS:Consecutive case series of 216 patients operated with vitrectomy for primary RRD...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02248.x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To assess the prevalence of end-of-life visual impairment in patients followed for glaucoma. METHODS:Data of 122 patients followed for glaucoma who had died between July 2008 and July 2010 and who had visited the ophthalmology outpatient department of a large non-academic Dutch hospital were collected from the...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2012.02555.x
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. METHODS:Fifty eyes with megalopapilla and 80 normal control eyes of totally ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12545
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13665
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To determine change in visual acuity (VA) in the population of a previous amblyopia treatment study (Loudon 2006) and assess risk factors for VA decrease. METHODS:Subjects treated between 2001 and 2003 were contacted between December 2015 and July 2017. Orthoptic examination was conducted under controlled circ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14499
更新日期:2020-07-13 00:00:00
abstract:PURPOSE:To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy. METHODS:Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with m...
journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0420.2007.01036.x
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. METHODS:Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery....
journal_title:Acta ophthalmologica
pub_type:
doi:10.1111/aos.13223
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to establish a standardized in vitro phacoemulsification damage model for future investigations of the effects of phacoemulsification, surgical devices, protective ophthalmic viscoelastic devices (OVDs), irrigation solutions and other aspects related to cataract phacoemulsification...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14235
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To compare structural and functional improvements in patients with vitreous haemorrhage (VH) with different IOPs re-established at the end of pars plana vitrectomy (PPV). METHODS:It is a prospective, randomized, comparative, interventional study. Ninety-five patients with nonclearing VH were randomized to rece...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14293
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:The aim of the study was to describe the prevalence of visual impairment and retinopathy and to investigate risk factors for retinopathy in persons with diabetes, screen-detected diabetes, impaired glucose tolerance and normal glucose tolerance in a subpopulation of the HUNT study. METHODS:We used a sample (n ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01998.x
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To review the incidence, aetiology and outcomes of endophthalmitis during a 20-year period in a Norwegian university hospital. METHODS:Single-centre retrospective review. Medical records of all patients admitted to Stavanger University Hospital with suspected endophthalmitis between January 1999 and December 2...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14511
更新日期:2020-06-22 00:00:00