Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells.

abstract：PURPOSE:Proliferative diabetic retinopathy (PDR) is characterized by ischaemia- and inflammation-induced neovascularization, but the pathological vascular differentiation in PDR remains poorly characterized. Here, endothelial progenitor and growth properties, as well as potential lymphatic differentiation, were investi...

journal_title：Acta ophthalmologica

authors： Loukovaara S,Gucciardo E,Repo P,Vihinen H,Lohi J,Jokitalo E,Salven P,Lehti K

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To evaluate effectiveness, tolerability and safety of repeated intravitreal injections of 0.5 mg ranibizumab for the treatment of neovascular age-related macular degeneration in routine medical practice in Germany. METHODS:A noninterventional study with 3470 patients treated in 274 medical centres according to...

journal_title：Acta ophthalmologica

authors： Finger RP,Wiedemann P,Blumhagen F,Pohl K,Holz FG

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). METHODS:The wireless CLS is a disposable silicone soft contact lens with a sensor embedded in it, allowing the wireless me...

journal_title：Acta ophthalmologica

authors： Leonardi M,Pitchon EM,Bertsch A,Renaud P,Mermoud A

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Galectin-1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin-1 may be involved in the pathogenesis of proliferative diabetic retinopathy (PDR). METHODS:Vitreous samples from 36 PDR and 20 nondiabetic patients, epiretinal fibrovascular membranes from 13 ...

journal_title：Acta ophthalmologica

authors： Abu El-Asrar AM,Ahmad A,Allegaert E,Siddiquei MM,Alam K,Gikandi PW,De Hertogh G,Opdenakker G

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To report the functional and anatomical outcomes resulting from the use of intravitreal pegaptanib sodium (Macugen) in patients with diabetic macular oedema (DMO). METHODS:We conducted a retrospective outcome analysis, by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), of eyes with ...

journal_title：Acta ophthalmologica

authors： Querques G,Bux AV,Martinelli D,Iaculli C,Noci ND

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To evaluate association of the van Herick (VH) grades with the ultrasound biomicroscopic (UBM) parameters, appositional irido-trabecular contact (A-ITC) and plateau iris (PI) in a randomly sampled population. METHODS:A 10% random sample of all residents aged 40 or older of the Kumejima study underwent UBM unde...

journal_title：Acta ophthalmologica

authors： Uejyo C,Henzan IM,Nakamura Y,Ishikawa S,Sakai H,Sawaguchi S,Kumar RS,Iwase A,Tomidokoro A,Araie M

更新日期：2020-06-22 00:00:00

abstract：PURPOSE:Life expectancy is increasing. When corneal donors become older and corneal-grafted patients live longer with their graft, the need for good-quality donor tissue becomes more crucial. The aim of the present investigation is to study grafted recipients with a donor cornea with a total tissue age of more than 100...

journal_title：Acta ophthalmologica

authors： Visby E,Hjortdal J,Nielsen K

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:The present study aimed to investigate and compare the psychometric properties of the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25) and the Visual Function Index-14 (VF-14) in a large sample of patients with cataracts. METHODS:A total of 1052 patients with bilateral age-related catara...

journal_title：Acta ophthalmologica

authors： Wan Y,Zhao L,Huang C,Xu Y,Sun M,Yang Y,An L,Lv S,Yu Y,Chen D,Zhou P,Wang Y,Zhang M,Jiang A,Chen Z,Li X

更新日期：2020-09-17 00:00:00

abstract：PURPOSE:To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients. METHODS:Keratoconus match index and KMP from 114 KC eyes, randomly selected from 114 patients with bilateral kerat...

journal_title：Acta ophthalmologica

authors： Labiris G,Gatzioufas Z,Sideroudi H,Giarmoukakis A,Kozobolis V,Seitz B

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:To characterize frequency, morphological cause and time-dependent change of boundary line artefacts in optical coherence tomography (OCT) examinations of centre-involved diabetic macular oedema (ciDME) patients who underwent ranibizumab treatment with 1-year follow-up and to evaluate the impact of artefacts on ...

journal_title：Acta ophthalmologica

authors： Hodzic-Hadzibegovic D,Sander BA,Lund-Andersen H

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Photodynamic riboflavin/ultraviolet-A (UVA)-induced collagen cross-linking, which increases the biomechanical stiffness of the human cornea by about 300%, has been introduced recently as a possible treatment for progressive keratoconus. The present study was undertaken to evaluate the longterm biomechanical eff...

journal_title：Acta ophthalmologica

authors： Wollensak G,Iomdina E

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...

journal_title：Acta ophthalmologica

authors： Yoeruek E,Bayyoud T,Maurus C,Hofmann J,Spitzer MS,Bartz-Schmidt KU,Szurman P

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To assess the trend patterns and gender disparity in global burden of vision loss due to diabetic retinopathy (DR) by year, age, region and socioeconomic status using prevalence and years lived with disability (YLDs) from Global Burden of Disease (GBD) study 2017. METHODS:Prevalence and YLDs data of vision los...

journal_title：Acta ophthalmologica

authors： Xu Y,Wang A,Lin X,Xu J,Shan Y,Pan X,Ye J,Shan PF

更新日期：2020-10-29 00:00:00

abstract：PURPOSE:To describe the concordance of keratoconus in 18 sets of twins. METHODS:Thirteen monozygotic (MZ) and five dizygotic (DZ) pairs of twins were identified during an investigation of familial keratoconus. We used 16 forensic microsatellite markers to confirm the zygosity of same sex twins. Patients and available ...

journal_title：Acta ophthalmologica

authors： Tuft SJ,Hassan H,George S,Frazer DG,Willoughby CE,Liskova P

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...

journal_title：Acta ophthalmologica

authors： Kriszt A,Losonczy G,Berta A,Vereb G,Takács L

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To determine whether anthropomorphic measurements are associated with ocular and general parameters. METHODS:The population-based Beijing Eye Study, which included 4439 participants (age > 40 years) out of 5324 individuals invited to be examined in 2001, was repeated in 2006 with 3251 (73.2% of 4439, or 61.1% ...

journal_title：Acta ophthalmologica

authors： Xu L,Wang YX,Zhang HT,Jonas JB

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To determine the molecular genetic cause in previously unreported probands with optic atrophy from the United Kingdom, Czech Republic and Canada. METHODS:OPA1 coding regions and flanking intronic sequences were screened by direct sequencing in 82 probands referred with a diagnosis of bilateral optic atrophy. D...

journal_title：Acta ophthalmologica

authors： Liskova P,Tesarova M,Dudakova L,Svecova S,Kolarova H,Honzik T,Seto S,Votruba M

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To characterize pre- and perioperative factors associated with treatment for wet age-related macular degeneration (wet AMD) after cataract surgery. METHODS:This register-based cohort study with data from the Swedish National Cataract Register (NCR) and the Swedish Macula Register (SMR) from 2010 to 2017 compar...

journal_title：Acta ophthalmologica

authors： Westborg I,Albrecht S,Granstam E,Karlsson N,Kugelberg M,Lundström M,Montan P,Behndig A

更新日期：2020-06-23 00:00:00

abstract：PURPOSE:To evaluate the trends and variations in global health burden of glaucoma by year, age and sex, region and socio-economic status, using disability-adjusted life years (DALYs). METHOD:The DALY numbers, crude DALY rate and age-standardized DALY rate globally and in each country were obtained the GBD 2015 study d...

journal_title：Acta ophthalmologica

authors： Wang W,He M,Li Z,Huang W

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To investigate the feasibility, effectiveness and acceptability of using prosthetic occluding contact lenses (OCLs) to treat moderate amblyopia in adults and of the role of the multifocal visual evoked potential (mfVEP) as a predictor of postamblyopic therapy. METHODS:A comparative, prospective, interventional...

journal_title：Acta ophthalmologica

authors： Garcia-Romo E,Perez-Rico C,Roldán-Díaz I,Arévalo-Serrano J,Blanco R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To investigate the associations between ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) and ocular and systemic factors in patients with open angle glaucoma (OAG) and in glaucoma suspects. METHODS:One hundred and seventy-three glaucoma-suspect patients were consecutively enrolled. A...

journal_title：Acta ophthalmologica

authors： Choi J,Lee J,Park SB,Lee KS,Sung KR,Kook MS

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to establish a standardized in vitro phacoemulsification damage model for future investigations of the effects of phacoemulsification, surgical devices, protective ophthalmic viscoelastic devices (OVDs), irrigation solutions and other aspects related to cataract phacoemulsification...

journal_title：Acta ophthalmologica

authors： Kunzmann BC,Wenzel DA,Bartz-Schmidt KU,Spitzer MS,Schultheiss M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To determine the effect of the axial length on the supernormal and false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic (SD-OCT) instrument. METHODS:This was a prospective, observati...

journal_title：Acta ophthalmologica

authors： Yamashita T,Kii Y,Tanaka M,Yoshinaga W,Yamashita T,Nakao K,Sakamoto T

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To identify the causes of failure of the different surgical corneal graft techniques: penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS:This multicentric retrosp...

journal_title：Acta ophthalmologica

authors： Gómez-Benlloch A,Montesel A,Pareja-Aricò L,Mingo-Botín D,Michael R,Barraquer RI,Alió J

更新日期：2021-01-09 00:00:00

abstract：PURPOSE:To analyse the postoperative foveal avascular zone (FAZ) area, superficial vessel density (SVD) and deep vessel density (DVD) and their correlation with functional (best-corrected visual acuity, BCVA) and anatomical outcomes (foveal macular thickness, FMT) after surgery for rhegmatogenous retinal detachment (RR...

journal_title：Acta ophthalmologica

authors： Bonfiglio V,Ortisi E,Scollo D,Reibaldi M,Russo A,Pizzo A,Faro G,Macchi I,Fallico M,Toro MD,Rejdak R,Nowomiejska K,Toto L,Rinaldi M,Cillino S,Avitabile T,Longo A

更新日期：2019-11-26 00:00:00

abstract：PURPOSE:To evaluate the changes of vascular endothelial growth factor (VEGF) plasma levels after intravitreal injections of ranibizumab or bevacizumab in patients with exudative age-related macular degeneration (AMD). METHODS:Forty-three patients with exudative AMD and 19 age- and sex-matched control patients without ...

journal_title：Acta ophthalmologica

authors： Carneiro AM,Costa R,Falcão MS,Barthelmes D,Mendonça LS,Fonseca SL,Gonçalves R,Gonçalves C,Falcão-Reis FM,Soares R

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To examine the heritability of corneal refraction power (CR) and corneal astigmatism (AST) in older women. METHODS:Corneal refraction and AST were measured by IOL master in 52 monozygotic (MZ) and 47 dizygotic (DZ) female twin pairs aged 66-79 years. The relative contribution of genetic and environmental facto...

journal_title：Acta ophthalmologica

authors： Pärssinen O,Kauppinen M,Kaprio J,Koskenvuo M,Rantanen T

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Aquaporins (AQPs) are widely expressed and have diverse distribution patterns in the eye. AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye. METHODS:RT-PCR was performed on fresh tissue from two human eyes d...

journal_title：Acta ophthalmologica

authors： Tran TL,Bek T,Holm L,la Cour M,Nielsen S,Prause JU,Rojek A,Hamann S,Heegaard S

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Glaucoma filtration surgery (GFS) fails due to fibrosis. The α5β1-integrin plays a pivotal role in fibrosis, angiogenesis and inflammation. This is the first experiment evaluating the prevention of fibrosis after GFS by a specific small molecule α5β1-integrin inhibitor (CLT-28643). METHODS:Twenty-four rabbits ...

journal_title：Acta ophthalmologica

authors： Schultheiss M,Schnichels S,Konrad EM,Bartz-Schmidt KU,Zahn G,Caldirola P,Fsadni MG,Caram-Lelham N,Spitzer MS

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To compare the postoperative anatomic success rates and the frequency of complications between prone or supine postoperative positioning after transconjunctival sutureless vitrectomy (TSV) for rhegmatogenous retinal detachment (RRD). METHODS:All patients underwent primary 27-gauge TSV for the treatment of prim...

journal_title：Acta ophthalmologica

authors： Otsuka K,Imai H,Miki A,Nakamura M

更新日期：2018-03-01 00:00:00