Segregation analysis suggests that keratoconus is a complex non-mendelian disease.

abstract：PURPOSE:Aquaporins (AQPs) are widely expressed and have diverse distribution patterns in the eye. AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye. METHODS:RT-PCR was performed on fresh tissue from two human eyes d...

journal_title：Acta ophthalmologica

authors： Tran TL,Bek T,Holm L,la Cour M,Nielsen S,Prause JU,Rojek A,Hamann S,Heegaard S

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) as compared to elevated intraocular pressure (IOP) on axonal morphology and axonal motor proteins in retinal ganglion cells (RGCs). METHODS:The experimental study included 39 rats which underwent cerebrospinal fluid drainage...

journal_title：Acta ophthalmologica

authors： Zhang Z,Wu S,Jonas JB,Zhang J,Liu K,Lu Q,Wang N

更新日期：2016-05-01 00:00:00

abstract：AIMS:This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (POAG) treated with morning-dosed bimatoprost 0.03%. METHODS:Eighty...

journal_title：Acta ophthalmologica

authors： Stankiewicz A,Misiuk-Hojło M,Grabska-Liberek I,Romanowska-Dixon B,Wierzbowska J,Wasyluk J,Mulak M,Szuścik I,Sierdziński J,Ehrlich R,Siesky B,Harris A

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of collagen matrix implant (Ologen® ; OLO) with mitomycin C (MMC) in phacotrabeculectomy. METHODS:Prospective, single-centre, nonblinded, randomized controlled trial. A total of 53 eyes of 45 patients were enrolled in the study protocol with 27 eyes randomly assigned to OLO a...

journal_title：Acta ophthalmologica

authors： Wlaź A,Wilkos-Kuc A,Rozegnał-Madej A,Żarnowski T

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To assess thickness and associations of the peripapillary choroidal layers. METHODS:The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of...

journal_title：Acta ophthalmologica

authors： Xu J,Wang YX,Jiang R,Wei WB,Xu L,Jonas JB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia. METHODS:This cross-sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was us...

journal_title：Acta ophthalmologica

authors： Wu Q,Chen Q,Lin B,Huang S,Wang Y,Zhang L,Lin H,Wang J,Lu F,Shen M

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate the cerebrospinal fluid (CSF) dynamics along the entire optic nerve (ON) in patients with normal-tension glaucoma (NTG). METHODS:Retrospective analysis of computed tomographic (CT) cisternographies in Caucasian patients with NTG. Fifty-six patients (99 of 112 eyes) fulfilled the diagnostic crite...

journal_title：Acta ophthalmologica

authors： Pircher A,Montali M,Wostyn P,Pircher J,Berberat J,Remonda L,Killer HE

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients. METHODS:A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative...

journal_title：Acta ophthalmologica

authors： Danni R,Viljanen A,Aaronson A,Tuuminen R

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To determine (i) whether, compared to controls, visual complaints of glaucoma patients are more pronounced under extreme luminance conditions than in the optimal luminance condition and (ii) whether complaints belonging to different extreme luminance conditions are associated. METHODS:We developed a luminance-...

journal_title：Acta ophthalmologica

authors： Bierings RAJM,van Sonderen FLP,Jansonius NM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To report the highest attained visual acuity with an electronic retinal implant for the treatment of advanced retinal degeneration following a novel intensive period of visual training. METHODS:A case study as part of the prospective, international, multi-centre, interventional clinical trial (ClinicalTrials.g...

journal_title：Acta ophthalmologica

authors： Cehajic Kapetanovic J,Troelenberg N,Edwards TL,Xue K,Ramsden JD,Stett A,Zrenner E,MacLaren RE

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:This study aimed to investigate the retinal thickness analyser (RTA) as a means to identify the presence of cystoid macular oedema (CMO) in children with uveitis, whether the course of CMO can be monitored using this method, and whether there is a trend towards a correlation between macular oedema and visual ac...

journal_title：Acta ophthalmologica

authors： Maca SM,Garhofer G,Kiss C,Barisani-Asenbauer T

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To report the functional and anatomical outcomes resulting from the use of intravitreal pegaptanib sodium (Macugen) in patients with diabetic macular oedema (DMO). METHODS:We conducted a retrospective outcome analysis, by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), of eyes with ...

journal_title：Acta ophthalmologica

authors： Querques G,Bux AV,Martinelli D,Iaculli C,Noci ND

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To determine the myopia prevalence in Hong Kong Chinese children and their parents. METHODS:It was a population-based cross-sectional study. A total of 4257 children aged 6-8 years, and 5880 parents were recruited in the Hong Kong Children Eye Study. Cycloplegic autorefraction was measured for children; and no...

journal_title：Acta ophthalmologica

authors： Yam JC,Tang SM,Kam KW,Chen LJ,Yu M,Law AK,Yip BH,Wang YM,Cheung CYL,Ng DSC,Young AL,Tham CC,Pang CP

更新日期：2020-01-24 00:00:00

abstract：PURPOSE:To determine associations between physical activity (PA) and myopia in Danish school children and investigate the prevalence of myopia. METHODS:This is a prospective study with longitudinal data on PA in a Danish child cohort. Physical activity (PA) was measured objectively by repeated ActiGraph accelerometer ...

journal_title：Acta ophthalmologica

authors： Lundberg K,Suhr Thykjaer A,Søgaard Hansen R,Vestergaard AH,Jacobsen N,Goldschmidt E,Lima RA,Peto T,Wedderkopp N,Grauslund J

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To investigate the associations between ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) and ocular and systemic factors in patients with open angle glaucoma (OAG) and in glaucoma suspects. METHODS:One hundred and seventy-three glaucoma-suspect patients were consecutively enrolled. A...

journal_title：Acta ophthalmologica

authors： Choi J,Lee J,Park SB,Lee KS,Sung KR,Kook MS

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. METHODS:Three study groups (oxygen...

journal_title：Acta ophthalmologica

authors： Wang JD,An Y,Zhang JS,Wan XH,Jonas JB,Xu L,Zhang W

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To describe the different clinical presentations of periocular molluscum contagiosum (MC) lesions and their epidemiological, clinical and histopathological features. METHODS:Medical records and histopathological sections of all cases of periocular MC treated at the oculoplastic clinic of the Goldschleger Eye I...

journal_title：Acta ophthalmologica

authors： Rosner M,Zloto O

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To study high-resolution ultrasound biomicroscopy (UBM) findings in anterior scleral inflammatory disease and evaluate the efficacy of high-resolution UBM as an adjunctive diagnostic tool. METHODS:A cross-sectional study. The medical records of 30 patients (33 eyes) with episcleritis or anterior scleritis were...

journal_title：Acta ophthalmologica

authors： Zur D,Neudorfer M,Shulman S,Rosenblatt A,Habot-Wilner Z

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To investigate the distribution of intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) and factors correlating with IOP, with special attention to age, in a large sample of ophthalmologically normal Japanese subjects. METHODS:A total of 7313 subjects (2847 male, 4466 female) were select...

journal_title：Acta ophthalmologica

authors： Fukuoka S,Aihara M,Iwase A,Araie M

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. METHODS:Participants of the Raine Study Generation 2 cohort had 25(OH...

journal_title：Acta ophthalmologica

authors： Lingham G,Mackey DA,Zhu K,Lucas RM,Black LJ,Oddy WH,Holt P,Walsh JP,Sanfilippo PG,Chan She Ping-Delfos W,Yazar S

更新日期：2021-01-10 00:00:00

abstract：:A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...

journal_title：Acta ophthalmologica

authors： Bekkers A,Borren N,Ederveen V,Fokkinga E,Andrade De Jesus D,Sánchez Brea L,Klein S,van Walsum T,Barbosa-Breda J,Stalmans I

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the brain regions associated with impaired performance in a virtual, dynamic collision avoidance task, in a group of patients with homonymous visual field defects (HVFDs) because of unilateral vascular brain lesions. METHODS:Overall task performance was quantitatively assess...

journal_title：Acta ophthalmologica

authors： Papageorgiou E,Hardiess G,Wiethölter H,Ackermann H,Dietz K,Mallot HA,Schiefer U

更新日期：2012-05-01 00:00:00

abstract：PURPOSE: This study aimed to compare scanning laser polarimetry measurements of retinal nerve fibre layer (RNFL) thickness in eyes of migraine patients with those in eyes of age-matched, healthy subjects. METHODS: The study was designed as an observational, prospective, cross-sectional study. It included 57 eyes of 57...

journal_title：Acta ophthalmologica

authors： Martinez A,Proupim N,Sanchez M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To identify the causes of failure of the different surgical corneal graft techniques: penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS:This multicentric retrosp...

journal_title：Acta ophthalmologica

authors： Gómez-Benlloch A,Montesel A,Pareja-Aricò L,Mingo-Botín D,Michael R,Barraquer RI,Alió J

更新日期：2021-01-09 00:00:00

abstract：PURPOSE:Central retinal vein occlusion (CRVO) entails retinal hypoxia that often causes visual impairment. It has been shown that oxygen saturation in larger retinal vessels correlates with the visual acuity at the time of diagnosis of CRVO but has no predictive value for the visual outcome in patients treated with ant...

journal_title：Acta ophthalmologica

authors： Krejberg Jeppesen S,Sín M,Hakon Hardarson S,Bek T

更新日期：2021-01-09 00:00:00

abstract：PURPOSE:To describe the clinical phenotype and the molecular pathology in a group of patients with congenital stationary night blindness due to mutations in GRM6, a gene encoding the ON bipolar metabotropic glutamate receptor 6 (mGluR6). METHODS:Nine patients from seven families (age range, 7-75; median, 10 years) wit...

journal_title：Acta ophthalmologica

authors： Sergouniotis PI,Robson AG,Li Z,Devery S,Holder GE,Moore AT,Webster AR

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Our purpose was to evaluate the surgical outcome after intra-ocular lens exchange in patients who presented impairing visual complaints after primary multifocal intra-ocular lens (MIOL) implantation. In particular, the study was undertaken to look at the number of eyes that could be equipped with the bag-in-the...

journal_title：Acta ophthalmologica

authors： Tassignon MJ,Bartholomeeusen E,Rozema JJ,Jongenelen S,Mathysen DG

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:To investigate the presence and distribution of l-kynurenine aminotransferases immunoreactivity in human and animal lenses during cataract formation. METHODS:Immunohistochemistry was conducted using polyclonal antibodies against KAT I, KAT II and KAT III on sections of 26 anterior capsules from patients underg...

journal_title：Acta ophthalmologica

authors： Rejdak R,Oleszczuk A,Rummelt C,Turski WA,Choragiewicz T,Nowomiejska K,Ksiazek K,Thaler S,Zarnowski T,Okuno E,Grieb P,Zrenner E,Kruse F,Junemann AG

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). METHODS:We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previ...

journal_title：Acta ophthalmologica

authors： Soliman W,Sander B,Soliman KA,Yehya S,Rahamn MS,Larsen M

更新日期：2008-05-01 00:00:00

abstract：:Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...

journal_title：Acta ophthalmologica

authors： Schulze S,Hoerle S,Mennel S,Kroll P

更新日期：2008-08-01 00:00:00