Abstract:
PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investigated. The patients were divided into three groups: 34 PDR (diabetic group), 26 nondiabetic (nondiabetic group) patients received IVB and 29 PDR patients without IVB (control group). The levels of PT were detected before and after IVB in study groups and at corresponding time-points in the control group. Paired samples t-test was conducted to compare the statistical differences of PT in each group. RESULTS:Significant difference (p < 0.001) of the levels of PT before and after IVB was observed in diabetic group in the early period, and the PT changes (11.0 ± 0.56 before and 10.6 ± 0.45 after IVB) were in fact within the normal range. There were no significant differences in other groups and other time-points (all p > 0.05). CONCLUSIONS:Intravitreal bevacizumab may lead to a decrease in the levels of PT in the early period after IVB in PDR patients, suggesting a temporarily potential effect of IVB on the extrinsic clotting pathway of blood coagulation cascade in diabetic patients.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Qian J,Jiang YRdoi
10.1111/j.1755-3768.2011.02151.xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
e332-5issue
4eissn
1755-375Xissn
1755-3768journal_volume
89pub_type
杂志文章abstract:PURPOSE:To determine the myopia prevalence in Hong Kong Chinese children and their parents. METHODS:It was a population-based cross-sectional study. A total of 4257 children aged 6-8 years, and 5880 parents were recruited in the Hong Kong Children Eye Study. Cycloplegic autorefraction was measured for children; and no...
journal_title:Acta ophthalmologica
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更新日期:2020-01-24 00:00:00
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doi:10.1111/aos.12960
更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Life expectancy is increasing. When corneal donors become older and corneal-grafted patients live longer with their graft, the need for good-quality donor tissue becomes more crucial. The aim of the present investigation is to study grafted recipients with a donor cornea with a total tissue age of more than 100...
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abstract:PURPOSE:Photoscreening assesses risk factors for amblyopia, as an alternative to measurement of visual acuity (VA) to detect amblyopia, on the premise that its early correction could prevent development of amblyopia. We studied implementations of Plusoptix photoscreening in existing population-based screening in Flande...
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abstract::Ziv-aflibercept (Zaltrap® ), a recombinant fusion protein that binds diffusible vascular endothelial growth factor (VEGF), is approved for the treatment of metastatic colorectal carcinoma. Its molecular structure is the same as aflibercept (Eylea® ), thus making it an attractive option for the off-label treatment of c...
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journal_title:Acta ophthalmologica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1755-3768.2009.01605.x
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To evaluate the potential use of decellularized porcine stromal matrix (PSM) for reconstruction of corneal stroma in a rabbit model. METHODS:Ten chinchilla bastard rabbit corneas were exposed to a circular half-thickness keratotomy with a 3.0 mm diameter at the central cornea. Porcine corneas were decellulariz...
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doi:10.1111/j.1755-3768.2011.02300.x
更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the rise in aqueous humour (AH) levels of levofloxacin after a specific perioperative pulsed topical drop regimen. METHODS:Thirty patients undergoing phacoemulsification surgery were administered two preoperative drops of levofloxacin 0.5%, 30 mins apart, and three pulsed drops ...
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pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2008.01358.x
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abstract:PURPOSE:To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. METHODS:Fifty eyes with megalopapilla and 80 normal control eyes of totally ...
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pub_type: 杂志文章
doi:10.1111/aos.12545
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To investigate the ability of mesenchymal stem cells (MSC) to transdifferentiate to corneal epithelial cells in experimental limbal stem cell deficiency in rabbits. METHODS:Total limbal stem cell deficiency was produced in 21 right eyes of 21 New Zealand rabbits; 6 eyes served as controls (group 1, G1). After ...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01812.x
更新日期:2011-12-01 00:00:00
abstract:PURPOSE: To evaluate central corneal thickness (CCT), intraocular pressure (IOP) and eye refraction in patients with congenital growth hormone (GH) deficiency. METHODS:Retrospective case series. Forty-five patients with growth defect treated with recombinant GH and 45 healthy children underwent ophthalmological exami...
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doi:10.1111/j.1755-3768.2009.01519.x
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...
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pub_type: 杂志文章
doi:10.1111/aos.12389
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1111/aos.13441
更新日期:2017-12-01 00:00:00
abstract:AIM:To report basic epidemiological data concerning surgically treated childhood cataract in Sweden and Denmark. METHODS:Data were derived from the Paediatric Cataract Register (PECARE), a binational, web-based surgical register representing Sweden and Denmark. All children operated before 8 years of age between 1 Jan...
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pub_type: 杂志文章,多中心研究
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/aos.13513
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/aos.13332
更新日期:2017-09-01 00:00:00
abstract::Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Using the Medical Subject Heading (MeSH) terms: hypothyroidism, myxoed...
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-12-01 00:00:00
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pub_type:
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1755-3768.2012.02505.x
更新日期:2013-12-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02248.x
更新日期:2012-12-01 00:00:00
abstract::A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...
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pub_type: 杂志文章,评审
doi:10.1111/aos.14392
更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aos.13106
更新日期:2016-09-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01190.x
更新日期:2009-02-01 00:00:00