Abstract:
PURPOSE:To develop an objective intraocular inflammation composite score. METHODS:Cross-sectional study. Non-invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation-grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After clinical assessment, four anterior and posterior segment image acquisition protocols per eye, using swept-source optical coherence tomography (SS-OCT), were performed at inclusion. Eight imaging biomarkers in three domains: anterior, intermediate and posterior were studied. They were ranked and selected by discriminatory power and correlation with clinical scores. A final SS-OCT-derived composite uveitis activity score (SS-UAS) was developed through multiple linear regression. RESULTS:We studied 224 eyes with uveitis (165 active and 59 inactive) from 165 patients (mean age 46.6 SD 15.5 years; 55.3% women) and 38 eyes from 19 healthy controls (mean age 43.6 SD 17.1; 47% women). The selected SS-OCT-derived biomarkers to build the final score were anterior chamber hyper-reflective dots (anterior), high-definition relative vitreous intensity (intermediate) and the averaged thickened retinal index (posterior). Swept-source (SS)-UAS was highly discriminant between active and inactive, and between active and healthy eyes (means 2.06 SD 1.86, 0.93 SD 0.44, and 0.96 SD 0.38, respectively, both p -, Mann-Whitney U). Construct validity (Cronbach's alpha = 0.7), internal consistency, criterion validity and reliability (concordance correlation coefficient intra-rater = 0.99, 95% CI: 0.98-0.99; inter-rater = 0.98, 95% CI: 0.96-0.99) were favourable. CONCLUSIONS:Global intraocular inflammation can potentially be staged and scored objectively, continuously, consistently and in a valid manner through the combined processing of SS-OCT scans.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Llorenç V,Serrano AR,Mesquida M,Lin P,Esquinas C,Sainz-de-la-Maza M,Metea C,Bosch A,Calvo M,Balter A,Nakamura Y,Molins B,Alba C,Suhler E,Adán Adoi
10.1111/aos.14739subject
Has Abstractpub_date
2021-01-09 00:00:00eissn
1755-375Xissn
1755-3768pub_type
杂志文章abstract:PURPOSE:To investigate the intravitreal levels of potent vasoactive, angiogenic and extracellular matrix remodelling factors in the diabetic patients with simvastatin treatment. METHODS:This is an institutional, prospective, observational case-control study. Type-1 and type-2 diabetic patients on lipophilic simvastati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
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pub_type: 杂志文章
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