Swept-source optical coherence tomography objective composite activity score for uveitis.

Abstract:

PURPOSE:To develop an objective intraocular inflammation composite score. METHODS:Cross-sectional study. Non-invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation-grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After clinical assessment, four anterior and posterior segment image acquisition protocols per eye, using swept-source optical coherence tomography (SS-OCT), were performed at inclusion. Eight imaging biomarkers in three domains: anterior, intermediate and posterior were studied. They were ranked and selected by discriminatory power and correlation with clinical scores. A final SS-OCT-derived composite uveitis activity score (SS-UAS) was developed through multiple linear regression. RESULTS:We studied 224 eyes with uveitis (165 active and 59 inactive) from 165 patients (mean age 46.6 SD 15.5 years; 55.3% women) and 38 eyes from 19 healthy controls (mean age 43.6 SD 17.1; 47% women). The selected SS-OCT-derived biomarkers to build the final score were anterior chamber hyper-reflective dots (anterior), high-definition relative vitreous intensity (intermediate) and the averaged thickened retinal index (posterior). Swept-source (SS)-UAS was highly discriminant between active and inactive, and between active and healthy eyes (means 2.06 SD 1.86, 0.93 SD 0.44, and 0.96 SD 0.38, respectively, both p -, Mann-Whitney U). Construct validity (Cronbach's alpha = 0.7), internal consistency, criterion validity and reliability (concordance correlation coefficient intra-rater = 0.99, 95% CI: 0.98-0.99; inter-rater = 0.98, 95% CI: 0.96-0.99) were favourable. CONCLUSIONS:Global intraocular inflammation can potentially be staged and scored objectively, continuously, consistently and in a valid manner through the combined processing of SS-OCT scans.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Llorenç V,Serrano AR,Mesquida M,Lin P,Esquinas C,Sainz-de-la-Maza M,Metea C,Bosch A,Calvo M,Balter A,Nakamura Y,Molins B,Alba C,Suhler E,Adán A

doi

10.1111/aos.14739

subject

Has Abstract

pub_date

2021-01-09 00:00:00

eissn

1755-375X

issn

1755-3768

pub_type

杂志文章
  • Low intravitreal angiopoietin-2 and VEGF levels in vitrectomized diabetic patients with simvastatin treatment.

    abstract:PURPOSE:To investigate the intravitreal levels of potent vasoactive, angiogenic and extracellular matrix remodelling factors in the diabetic patients with simvastatin treatment. METHODS:This is an institutional, prospective, observational case-control study. Type-1 and type-2 diabetic patients on lipophilic simvastati...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12363

    authors: Tuuminen R,Sahanne S,Loukovaara S

    更新日期:2014-11-01 00:00:00

  • Fundus imaging in newborn children with wide-field scanning laser ophthalmoscope.

    abstract:PURPOSE:Current fundus imaging in newborn babies requires mydriatics, eye specula and corneal contact. We propose that a scanning laser ophthalmoscope (SLO) allows ultra wide-field imaging with reduced stress for the child. METHODS:This prospective observational single centre study was conducted in Landspítali, Univer...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13453

    authors: Magnusdottir V,Vehmeijer WB,Eliasdottir TS,Hardarson SH,Schalij-Delfos NE,Stefánsson E

    更新日期:2017-12-01 00:00:00

  • Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions.

    abstract::A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/aos.14392

    authors: Bekkers A,Borren N,Ederveen V,Fokkinga E,Andrade De Jesus D,Sánchez Brea L,Klein S,van Walsum T,Barbosa-Breda J,Stalmans I

    更新日期:2020-09-01 00:00:00

  • Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes.

    abstract:PURPOSE:To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. METHODS:Corneal measurements of 110 normal eyes (one eye per subject) and 70 k...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12622

    authors: Viswanathan D,Kumar NL,Males JJ,Graham SL

    更新日期:2015-09-01 00:00:00

  • Retinopathy and visual impairment in diabetes, impaired glucose tolerance and normal glucose tolerance: the Nord-Trøndelag Health Study (the HUNT study).

    abstract:PURPOSE:The aim of the study was to describe the prevalence of visual impairment and retinopathy and to investigate risk factors for retinopathy in persons with diabetes, screen-detected diabetes, impaired glucose tolerance and normal glucose tolerance in a subpopulation of the HUNT study. METHODS:We used a sample (n ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2010.01998.x

    authors: Sundling V,Platou CG,Jansson RW,Bertelsen G,Wøllo E,Gulbrandsen P

    更新日期:2012-05-01 00:00:00

  • Effects of core vitrectomy in the treatment of age-related macular degeneration.

    abstract:PURPOSE:To investigate the clinical efficacy and safety of an additional core vitrectomy to the standard therapy in patients with exudative age-related macular degeneration (ARMD). METHODS:In this prospective, controlled, single-centre study, 50 eyes of 50 patients (mean age: 74.1 ± 7.1; median 74 (69/78)) with ARMD w...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.12326

    authors: Schramm K,Mueller M,Koch FH,Singh P,Kohnen T,Koss MJ

    更新日期:2014-08-01 00:00:00

  • Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.

    abstract:PURPOSE:To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia. METHODS:This cross-sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was us...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14372

    authors: Wu Q,Chen Q,Lin B,Huang S,Wang Y,Zhang L,Lin H,Wang J,Lu F,Shen M

    更新日期:2020-09-01 00:00:00

  • Human bone marrow mesenchymal stem cells for retinal vascular injury.

    abstract:PURPOSE:To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. METHODS:Three study groups (oxygen...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13154

    authors: Wang JD,An Y,Zhang JS,Wan XH,Jonas JB,Xu L,Zhang W

    更新日期:2017-09-01 00:00:00

  • Forgotten achievements of Polish retinal research in international ophthalmology.

    abstract::The development of ophthalmology was greatly restricted in Poland in the 19th century, because it was partitioned and occupied by its three dominant neighbours. Polish medical universities were closed, and in Polish hospitals, only clinical work was possible. Those who wanted to study medicine and become ophthalmologi...

    journal_title:Acta ophthalmologica

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1755-3768.2009.01856.x

    authors: Grzybowski A

    更新日期:2012-03-01 00:00:00

  • Myopic shift and lens turbidity following hyperbaric oxygen therapy - a prospective, longitudinal, observational cohort study.

    abstract:PURPOSE:To examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT). METHODS:Twenty-nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured at baseline and after ten, 20, 30 and 40 trea...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14010

    authors: Riedl P,Škiljić D,Arnell P,Wannholt R,Zetterberg M,Andersson Grönlund M

    更新日期:2019-09-01 00:00:00

  • OPA1 analysis in an international series of probands with bilateral optic atrophy.

    abstract:PURPOSE:To determine the molecular genetic cause in previously unreported probands with optic atrophy from the United Kingdom, Czech Republic and Canada. METHODS:OPA1 coding regions and flanking intronic sequences were screened by direct sequencing in 82 probands referred with a diagnosis of bilateral optic atrophy. D...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13285

    authors: Liskova P,Tesarova M,Dudakova L,Svecova S,Kolarova H,Honzik T,Seto S,Votruba M

    更新日期:2017-06-01 00:00:00

  • Clinical and genetic heterogeneity in Slovenian patients with BEST disease.

    abstract:PURPOSE:To determine the spectrum of BEST1 mutations and to study the phenotype in Slovenian families with Best vitelliform macular dystrophy (BVMD) to identify genotype-phenotype correlations. METHODS:Twenty patients from five families underwent the ophthalmological examination including electrooculogram (EOG; N = 17...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13202

    authors: Glavač D,Jarc-Vidmar M,Vrabec K,Ravnik-Glavač M,Fakin A,Hawlina M

    更新日期:2016-12-01 00:00:00

  • Treatment of age-related macular degeneration after cataract surgery: a study from the Swedish National Cataract and Macula Registers.

    abstract:PURPOSE:To characterize pre- and perioperative factors associated with treatment for wet age-related macular degeneration (wet AMD) after cataract surgery. METHODS:This register-based cohort study with data from the Swedish National Cataract Register (NCR) and the Swedish Macula Register (SMR) from 2010 to 2017 compar...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14519

    authors: Westborg I,Albrecht S,Granstam E,Karlsson N,Kugelberg M,Lundström M,Montan P,Behndig A

    更新日期:2020-06-23 00:00:00

  • Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood.

    abstract:PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.13405

    authors: Pärssinen O,Kauppinen M

    更新日期:2017-08-01 00:00:00

  • Correlation between Genotype and Phenotype in 69 Chinese Patients with USH2A Mutations: A comparative study of the patients with Usher Syndrome and Nonsyndromic Retinitis Pigmentosa.

    abstract:PURPOSE:The aim of this study was to analyse 69 Chinese patients with USH2A mutations and to assess the genotype-phenotype correlation. METHODS:All 36 Usher syndrome type IIA patients and 33 nonsyndromic RP (retinitis pigmentosa) patients underwent clinical examinations. Eye examinations included best-corrected visual...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14626

    authors: Meng X,Liu X,Li Y,Guo T,Yang L

    更新日期:2020-10-29 00:00:00

  • Central corneal thickness in children with growth hormone deficiency.

    abstract:PURPOSE:  To evaluate central corneal thickness (CCT), intraocular pressure (IOP) and eye refraction in patients with congenital growth hormone (GH) deficiency. METHODS:Retrospective case series. Forty-five patients with growth defect treated with recombinant GH and 45 healthy children underwent ophthalmological exami...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2009.01519.x

    authors: Parentin F,Pensiero S

    更新日期:2010-09-01 00:00:00

  • Retinal microvascular complexity comparing mono- and multifractal dimensions in relation to cardiometabolic risk factors in a Middle Eastern population.

    abstract:PURPOSE:Metrics that capture changes in the retinal microvascular structure are relevant in the context of cardiometabolic disease development. The microvascular topology is typically quantified using monofractals, although it obeys more complex multifractal rules. We study mono- and multifractals of the retinal microv...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14598

    authors: Van Craenendonck T,Gerrits N,Buelens B,Petropoulos IN,Shuaib A,Standaert A,Malik RA,De Boever P

    更新日期:2020-09-16 00:00:00

  • The concept of virtual clinics in monitoring patients with age-related macular degeneration.

    abstract:PURPOSE:To present clinical results regarding the treatment of patients with age-related macular degeneration (neovascular form) after the implementation of a 'virtual' type of follow-up in a single retina service centre. METHODS:Retrospective study based on the clinical records of the Leicester Royal Infirmary Retina...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12832

    authors: Tsaousis KT,Empeslidis T,Konidaris VE,Kapoor B,Deane J

    更新日期:2016-08-01 00:00:00

  • Segregation analysis suggests that keratoconus is a complex non-mendelian disease.

    abstract:PURPOSE:Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset. METHODS:Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic examination. Family aggre...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12389

    authors: Kriszt A,Losonczy G,Berta A,Vereb G,Takács L

    更新日期:2014-11-01 00:00:00

  • Changes of saccadic eye movements in thyroid-associated ophthalmopathy.

    abstract:PURPOSE:To establish whether or not the dynamics of saccadic eye movements are significantly changed in patients with different stages of thyroid-associated ophthalmopathy (TAO) and, subsequently, if analysis of saccades could serve as an additional diagnostic tool for early detection of inflammatory activity in TAO. ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2011.02216.x

    authors: Schworm HD,Bolzani R,Benassi M,Tallstedt L,Rydberg A,Lennerstrand G,Ygge J

    更新日期:2012-12-01 00:00:00

  • C-Reactive protein and progression of vision loss in retinitis pigmentosa.

    abstract:PURPOSE:Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship bet...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13502

    authors: Murakami Y,Ikeda Y,Nakatake S,Fujiwara K,Tachibana T,Yoshida N,Notomi S,Hisatomi T,Yoshida S,Ishibashi T,Sonoda KH

    更新日期:2018-03-01 00:00:00

  • Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits.

    abstract:PURPOSE:To investigate the ability of mesenchymal stem cells (MSC) to transdifferentiate to corneal epithelial cells in experimental limbal stem cell deficiency in rabbits. METHODS:Total limbal stem cell deficiency was produced in 21 right eyes of 21 New Zealand rabbits; 6 eyes served as controls (group 1, G1). After ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2009.01812.x

    authors: Reinshagen H,Auw-Haedrich C,Sorg RV,Boehringer D,Eberwein P,Schwartzkopff J,Sundmacher R,Reinhard T

    更新日期:2011-12-01 00:00:00

  • Preoperative and postoperative measurements of retinal vessel oxygen saturation in patients with different grades of cataracts.

    abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13332

    authors: Chen H,Lin H,Chen W,Zhang B,Xiang W,Gao Q,Chen W,Liu Y

    更新日期:2017-09-01 00:00:00

  • Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography.

    abstract:PURPOSE:The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). METHODS:I...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13050

    authors: Mendez-Hernandez C,Rodriguez-Uña I,Gonzalez-de-la Rosa M,Arribas-Pardo P,Garcia-Feijoo J

    更新日期:2016-11-01 00:00:00

  • Effects of peptide ratios in nanofibre-based hydrogels for the prevention of capsular opacification.

    abstract:PURPOSE:To moderate the capsular opacification (CO) response after lens surgery, an experimental study was performed in which nanofibre-based hydrogels (nanogels) with different ratios of attached peptides were applied to provide extracellular matrix-related cues for lens epithelial cells (LECs) in a porcine eye model....

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13047

    authors: Nibourg LM,Gelens E,Nibourg SA,de Jong MR,Kuijer R,van Kooten TG,Koopmans SA

    更新日期:2016-11-01 00:00:00

  • Binocular vision alterations after refractive and cataract surgery: a review.

    abstract::To review binocular and accommodative disorders documented after corneal or intraocular refractive surgery, in normal healthy prepresbyopic patients. A bibliographic revision was performed; it included works published before 1st July 2017 where accommodation and/or binocularity was assessed following any type of refra...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/aos.13891

    authors: García-Montero M,Albarrán Diego C,Garzón-Jiménez N,Pérez-Cambrodí RJ,López-Artero E,Ondategui-Parra JC

    更新日期:2019-03-01 00:00:00

  • Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.

    abstract:PURPOSE:The cyclolignan picropodophyllin (PPP) efficiently blocks the activity of insulin-like growth factor-1 receptor (IGF-1R) and inhibits growth of uveal melanoma cells in vitro and in vivo. In this study, we aimed to investigate the efficiency of orally administered PPP on growth of uveal melanoma xenografts. Furt...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2008.01184.x

    authors: Economou MA,Andersson S,Vasilcanu D,All-Ericsson C,Menu E,Girnita A,Girnita L,Axelson M,Seregard S,Larsson O

    更新日期:2008-11-01 00:00:00

  • Regulation of oxygen saturation in retinal blood vessels in response to dynamic exercise.

    abstract:PURPOSE:To evaluate the impact of dynamic exercise on retinal vessel oxygen saturation in healthy individuals. METHODS:Twenty-six healthy participants underwent moderate dynamic exercise (modified Master's two-step exercise). In all subjects, intraocular pressures (IOP), systolic and diastolic blood pressures (SBP and...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13576

    authors: Heitmar R,Vekria P,Cubbidge RP

    更新日期:2018-05-01 00:00:00

  • Topical dexamethasone-cyclodextrin nanoparticle eye drops for non-infectious Uveitic macular oedema and vitritis - a pilot study.

    abstract:PURPOSE:To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis. METHODS:In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another 4 weeks. Fol...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12744

    authors: Shulman S,Jóhannesson G,Stefánsson E,Loewenstein A,Rosenblatt A,Habot-Wilner Z

    更新日期:2015-08-01 00:00:00

  • Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy.

    abstract:PURPOSE:To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. METHODS:Eighty-nine patients received primary IVB (1.25 mg) in one eye were investig...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2011.02151.x

    authors: Qian J,Jiang YR

    更新日期:2011-06-01 00:00:00