Abstract:
PURPOSE:To explore the short-term vascular and structural changes of type 3 neovascularization using optical coherence tomography angiography (OCT-A) when treated with a combination of photodynamic therapy (PDT) and intravitreal bevacizumab (IVB), and to evaluate the course of different sequences of the combined therapies. METHODS:Thirty eyes of 29 treatment-naïve patients with a type 3 neovascularization were included in this prospective observational cohort study. They were all treated with PDT and IVB 2 weeks apart, starting either with PDT (PDT-first group) or IVB (IVB-first group). Optical coherence tomography angiography (OCT-A) imaging was performed at week 0, 2, 4 and 18, and best corrected visual acuity (BCVA) at week 0 and 18. Vascular, structural and functional features were graded and analysed over time. RESULTS:In all patients, at all follow-up visits, vascular and structural features were significantly more often decreased or resolved than unchanged or increased. Best corrected visual acuity (BCVA) significantly improved at 18 weeks. Vascular, structural and functional outcomes were all slightly better in the PDT-first group compared to the IVB-first group, although not statistically significant. CONCLUSION:Combined treatment of PDT and IVB is effective in short-term for type 3 neovascularization based on vascular and structural features. Initial treatment with PDT tended to be more effective than with IVB.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Smid LM,Vermeer KA,Wong KT,Martinez Ciriano JP,de Jong JH,Davidoiu V,de Boer JF,van Velthoven MEJdoi
10.1111/aos.14525subject
Has Abstractpub_date
2020-06-29 00:00:00eissn
1755-375Xissn
1755-3768pub_type
杂志文章abstract:PURPOSE:To examine the role of systemic medication on the risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery. METHODS:A total of 269 eyes undergoing routine cataract surgery. Spectral-domain optical coherence tomography imaging was conducted before surgery and at 28 days. Informati...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
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journal_title:Acta ophthalmologica
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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journal_title:Acta ophthalmologica
pub_type:
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2010.01941.x
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pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02271.x
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pub_type: 杂志文章
doi:10.1111/aos.12382
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13451
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/aos.12964
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2020-06-23 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-22 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
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更新日期:2009-02-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.12990
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14293
更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01812.x
更新日期:2011-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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