Abstract：
PURPOSE:To assess the noninferiority of the treat-and-extend (T&E) and fixed bimonthly regimens of 0.5 mg intravitreal ranibizumab as compared with the pro re nata (PRN) in naïve patients with neovascular age-related macular degeneration (nAMD). METHODS:Phase IV, randomized, 12-month, multicentre trial. Patients aged ≥50 years with nAMD and visual impairment [best-corrected visual acuity (BCVA) between 23 and 78 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] were eligible. Patients (one eye per patient) were randomized to bimonthly, n = 103, T&E, n = 99 or PRN, n = 104. Noninferiority was established at five letters ETDRS. RESULTS:The mean (95% CI) difference in BCVA at 12 months was 7.2 (4.2-10.2), 6.4 (2.9-9.8), and 8.0 (51.1-11.0) in the bimonthly, T&E and PRN, respectively. The bimonthly or T&E regimens were not inferior to the PRN scheme. All regimens were associated with a significant reduction of central subfield thickness and volume. The mean (95% CI) number of injections in the bimonthly regimen (7.6, 7.5-7.7) was similar as compared with the PRN regimen (7.4, 6.7-8.0) (p = 0.159) but lower than in the T&E regimen (9.3, 8.9-9.7) (p < 0.001). CONCLUSION:At 12 months, bimonthly and T&E ranibizumab were noninferior to PRN in naïve nAMD.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
López Gálvez MI,Arias Barquet L,S Figueroa M,García-Layana A,Ruiz Moreno JM,In-Eye Study Group.doi
10.1111/aos.14399subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e820-e829issue
7eissn
1755-375Xissn
1755-3768journal_volume
98pub_type
杂志文章abstract：PURPOSE:To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients. METHODS:A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,随机对照试验
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doi：10.1111/aos.12464
更新日期：2014-12-01 00:00:00
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更新日期：2016-05-01 00:00:00
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doi：10.1111/j.1755-3768.2008.01367.x
更新日期：2010-05-01 00:00:00
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更新日期：2018-11-01 00:00:00
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doi：10.1111/aos.14571
更新日期：2020-08-24 00:00:00
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更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,多中心研究
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更新日期：2019-06-01 00:00:00
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更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1600-0420.2007.00940.x
更新日期：2008-02-01 00:00:00
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更新日期：2021-01-09 00:00:00
