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Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy.

Abstract：

:Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models3-10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits13. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.

journal_name

Nat Med

journal_title

Nature medicine

authors

Koo J,MacEwan MR,Kang SK,Won SM,Stephen M,Gamble P,Xie Z,Yan Y,Chen YY,Shin J,Birenbaum N,Chung S,Kim SB,Khalifeh J,Harburg DV,Bean K,Paskett M,Kim J,Zohny ZS,Lee SM,Zhang R,Luo K,Ji B,Banks A,Lee HM,Hua

doi

10.1038/s41591-018-0196-2

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1830-1836

issue

12

eissn

1078-8956

issn

1546-170X

pii

10.1038/s41591-018-0196-2

journal_volume

24

pub_type

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