HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.


:Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.


Nat Med


Nature medicine


Janes H,Herbeck JT,Tovanabutra S,Thomas R,Frahm N,Duerr A,Hural J,Corey L,Self SG,Buchbinder SP,McElrath MJ,O'Connell RJ,Paris RM,Rerks-Ngarm S,Nitayaphan S,Pitisuttihum P,Kaewkungwal J,Robb ML,Michael NL,Mullins JI




Has Abstract


2015-10-01 00:00:00














  • CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.

    abstract::Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this malignancy is clinically still treated as a single disease. Here we present patient-derived models representing the full spectrum of previously identified quasi-mesenchymal (QM-PDA), classical and exocrine-like PDAC subtypes, and id...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Noll EM,Eisen C,Stenzinger A,Espinet E,Muckenhuber A,Klein C,Vogel V,Klaus B,Nadler W,Rösli C,Lutz C,Kulke M,Engelhardt J,Zickgraf FM,Espinosa O,Schlesner M,Jiang X,Kopp-Schneider A,Neuhaus P,Bahra M,Sinn BV,Eil

    更新日期:2016-03-01 00:00:00

  • Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.

    abstract::Direct evidence in humans for the impact of the microbiome on nutrient absorption is lacking. We conducted an extended inpatient study using two interventions that we hypothesized would alter the gut microbiome and nutrient absorption. In each, stool calorie loss, a direct proxy of nutrient absorption, was measured. T...

    journal_title:Nature medicine

    pub_type: 杂志文章,随机对照试验


    authors: Basolo A,Hohenadel M,Ang QY,Piaggi P,Heinitz S,Walter M,Walter P,Parrington S,Trinidad DD,von Schwartzenberg RJ,Turnbaugh PJ,Krakoff J

    更新日期:2020-04-01 00:00:00

  • A chimeric human-cat fusion protein blocks cat-induced allergy.

    abstract::Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

    更新日期:2005-04-01 00:00:00

  • A new penumbra: transitioning from injury into repair after stroke.

    abstract::The penumbra is an area of brain tissue that is damaged but not yet dead after focal ischemia. The existence of a penumbra implies that therapeutic salvage is theoretically possible after stroke. The first decade of penumbral science investigated the ischemic regulation of electrophysiology, cerebral blood flow and me...

    journal_title:Nature medicine

    pub_type: 杂志文章,评审


    authors: Lo EH

    更新日期:2008-05-01 00:00:00

  • Inhibition of gastric inhibitory polypeptide signaling prevents obesity.

    abstract::Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited both hypersecretion of GIP and extreme visceral and subcutaneous fat deposition with ins...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Miyawaki K,Yamada Y,Ban N,Ihara Y,Tsukiyama K,Zhou H,Fujimoto S,Oku A,Tsuda K,Toyokuni S,Hiai H,Mizunoya W,Fushiki T,Holst JJ,Makino M,Tashita A,Kobara Y,Tsubamoto Y,Jinnouchi T,Jomori T,Seino Y

    更新日期:2002-07-01 00:00:00

  • Patient-derived induced pluripotent stem cells in cancer research and precision oncology.

    abstract::Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how t...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Papapetrou EP

    更新日期:2016-12-06 00:00:00

  • Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.

    abstract::Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. We report that transgenic expression of the microRNA miR-193a in mice rapidly induces FSGS with extensive podocyte foot process effacement. Mechanistically, miR-193a inhibi...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Gebeshuber CA,Kornauth C,Dong L,Sierig R,Seibler J,Reiss M,Tauber S,Bilban M,Wang S,Kain R,Böhmig GA,Moeller MJ,Gröne HJ,Englert C,Martinez J,Kerjaschki D

    更新日期:2013-04-01 00:00:00

  • Microbiota depletion promotes browning of white adipose tissue and reduces obesity.

    abstract::Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin sensitivity. In response to cold or exercise, brown fat cells also emerge in the white adipose tissue (WAT; also known as beige cells), a process known as browning. Here we show that the development of functional beige fat in the ing...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Suárez-Zamorano N,Fabbiano S,Chevalier C,Stojanović O,Colin DJ,Stevanović A,Veyrat-Durebex C,Tarallo V,Rigo D,Germain S,Ilievska M,Montet X,Seimbille Y,Hapfelmeier S,Trajkovski M

    更新日期:2015-12-01 00:00:00

  • Vaccines: past, present and future.

    abstract::The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied. Pasteur's early approaches to vaccine development, attenuation and inactivation, are even now the two poles of vaccine technology. Today, purification of micr...

    journal_title:Nature medicine

    pub_type: 历史文章,杂志文章


    authors: Plotkin SA

    更新日期:2005-04-01 00:00:00

  • Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever.

    abstract::Massive release of tumor necrosis factor is responsible for the potentially fatal larisch-Herxheimer reaction that follows antibiotic treatment of relapsing fever due to Borrelia recurrentis. We have undertaken the quantitative purification of the components of B. recurrentis that stimulate human monocytes to produce ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Vidal V,Scragg IG,Cutler SJ,Rockett KA,Fekade D,Warrell DA,Wright DJ,Kwiatkowski D

    更新日期:1998-12-01 00:00:00

  • Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.

    abstract::Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein. The MDR1 gene encoding P-glycoprotein may be transcriptionally regulated by a Y-bo...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Bargou RC,Jürchott K,Wagener C,Bergmann S,Metzner S,Bommert K,Mapara MY,Winzer KJ,Dietel M,Dörken B,Royer HD

    更新日期:1997-04-01 00:00:00

  • Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats.

    abstract::Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Zawada WM,Cibelli JB,Choi PK,Clarkson ED,Golueke PJ,Witta SE,Bell KP,Kane J,Ponce de Leon FA,Jerry DJ,Robl JM,Freed CR,Stice SL

    更新日期:1998-05-01 00:00:00

  • Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

    abstract::Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lun...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Savai R,Al-Tamari HM,Sedding D,Kojonazarov B,Muecke C,Teske R,Capecchi MR,Weissmann N,Grimminger F,Seeger W,Schermuly RT,Pullamsetti SS

    更新日期:2014-11-01 00:00:00

  • Translational value of mouse models in oncology drug development.

    abstract::Much has been written about the advantages and disadvantages of various oncology model systems, with the overall finding that these models lack the predictive power required to translate preclinical efficacy into clinical activity. Despite assertions that some preclinical model systems are superior to others, no singl...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Gould SE,Junttila MR,de Sauvage FJ

    更新日期:2015-05-01 00:00:00

  • HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.

    abstract::Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

    更新日期:2017-04-01 00:00:00

  • GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

    abstract::GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

    更新日期:1997-10-01 00:00:00

  • SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

    abstract::Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5(+/-) mice were resistant to high fat-induced obesity, hypercholesterolemia and glucose intoleranc...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Oishi Y,Manabe I,Tobe K,Ohsugi M,Kubota T,Fujiu K,Maemura K,Kubota N,Kadowaki T,Nagai R

    更新日期:2008-06-01 00:00:00

  • The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.

    abstract::Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for effi...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Liu P,Aitken K,Kong YY,Opavsky MA,Martino T,Dawood F,Wen WH,Kozieradzki I,Bachmaier K,Straus D,Mak TW,Penninger JM

    更新日期:2000-04-01 00:00:00

  • TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.

    abstract::Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Yamamoto S,Shimizu S,Kiyonaka S,Takahashi N,Wajima T,Hara Y,Negoro T,Hiroi T,Kiuchi Y,Okada T,Kaneko S,Lange I,Fleig A,Penner R,Nishi M,Takeshima H,Mori Y

    更新日期:2008-07-01 00:00:00

  • Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma.

    abstract::Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Schalper KA,Rodriguez-Ruiz ME,Diez-Valle R,López-Janeiro A,Porciuncula A,Idoate MA,Inogés S,de Andrea C,López-Diaz de Cerio A,Tejada S,Berraondo P,Villarroel-Espindola F,Choi J,Gúrpide A,Giraldez M,Goicoechea I,Gallego Pe

    更新日期:2019-03-01 00:00:00

  • Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect.

    abstract::Photoreceptor ciliopathies constitute the most common molecular mechanism of the childhood blindness Leber congenital amaurosis. Ten patients with Leber congenital amaurosis carrying the c.2991+1655A>G allele in the ciliopathy gene centrosomal protein 290 (CEP290) were treated ( no. NCT03140969 ) wit...

    journal_title:Nature medicine

    pub_type: 临床试验,杂志文章


    authors: Cideciyan AV,Jacobson SG,Drack AV,Ho AC,Charng J,Garafalo AV,Roman AJ,Sumaroka A,Han IC,Hochstedler MD,Pfeifer WL,Sohn EH,Taiel M,Schwartz MR,Biasutto P,Wit W,Cheetham ME,Adamson P,Rodman DM,Platenburg G,Tome MD,

    更新日期:2019-02-01 00:00:00

  • Immunity or tolerance: opposite outcomes of microchimerism from skin grafts.

    abstract::Solid organ transplants contain small numbers of leukocytes that can migrate into the host and establish long-lasting microchimerism. Although such microchimerism is often associated with graft acceptance and tolerance, it has been difficult to demonstrate a true causal link. Using skin from mutant mice deficient for ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Anderson CC,Matzinger P

    更新日期:2001-01-01 00:00:00

  • Polygenic architecture informs potential vulnerability to drug-induced liver injury.

    abstract::Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Koido M,Kawakami E,Fukumura J,Noguchi Y,Ohori M,Nio Y,Nicoletti P,Aithal GP,Daly AK,Watkins PB,Anayama H,Dragan Y,Shinozawa T,Takebe T

    更新日期:2020-10-01 00:00:00

  • Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.

    abstract::Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmi...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Cantalupo A,Zhang Y,Kothiya M,Galvani S,Obinata H,Bucci M,Giordano FJ,Jiang XC,Hla T,Di Lorenzo A

    更新日期:2015-09-01 00:00:00

  • Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.

    abstract::Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Kozal MJ,Shah N,Shen N,Yang R,Fucini R,Merigan TC,Richman DD,Morris D,Hubbell E,Chee M,Gingeras TR

    更新日期:1996-07-01 00:00:00

  • In vivo imaging of glucose uptake and metabolism in tumors.

    abstract::Tumors have a greater reliance on anaerobic glycolysis for energy production than normal tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based on magnetic resonance imaging and allows the uptake of unlabeled glucose to be measured through the chemical exchange of protons between h...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Walker-Samuel S,Ramasawmy R,Torrealdea F,Rega M,Rajkumar V,Johnson SP,Richardson S,Gonçalves M,Parkes HG,Arstad E,Thomas DL,Pedley RB,Lythgoe MF,Golay X

    更新日期:2013-08-01 00:00:00

  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

    abstract::In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Yachida S,Mizutani S,Shiroma H,Shiba S,Nakajima T,Sakamoto T,Watanabe H,Masuda K,Nishimoto Y,Kubo M,Hosoda F,Rokutan H,Matsumoto M,Takamaru H,Yamada M,Matsuda T,Iwasaki M,Yamaji T,Yachida T,Soga T,Kurokawa K,Toy

    更新日期:2019-06-01 00:00:00

  • Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.

    abstract::Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potentia...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Cerezo M,Guemiri R,Druillennec S,Girault I,Malka-Mahieu H,Shen S,Allard D,Martineau S,Welsch C,Agoussi S,Estrada C,Adam J,Libenciuc C,Routier E,Roy S,Désaubry L,Eggermont AM,Sonenberg N,Scoazec JY,Eychène A,Vagner

    更新日期:2018-12-01 00:00:00

  • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.

    abstract::Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward the latter is an established mechanism whereby cancer cells evade apoptosis. The therapeutic potential of directly inhibiting pr...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Souers AJ,Leverson JD,Boghaert ER,Ackler SL,Catron ND,Chen J,Dayton BD,Ding H,Enschede SH,Fairbrother WJ,Huang DC,Hymowitz SG,Jin S,Khaw SL,Kovar PJ,Lam LT,Lee J,Maecker HL,Marsh KC,Mason KD,Mitten MJ,Nimmer PM

    更新日期:2013-02-01 00:00:00

  • A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.

    abstract::We report the involvement of an evolutionarily conserved set of mycobacterial genes, the esx-3 region, in evasion of bacterial killing by innate immunity. Whereas high-dose intravenous infections of mice with the rapidly growing mycobacterial species Mycobacterium smegmatis bearing an intact esx-3 locus were rapidly l...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Sweeney KA,Dao DN,Goldberg MF,Hsu T,Venkataswamy MM,Henao-Tamayo M,Ordway D,Sellers RS,Jain P,Chen B,Chen M,Kim J,Lukose R,Chan J,Orme IM,Porcelli SA,Jacobs WR Jr

    更新日期:2011-09-04 00:00:00