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HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.

Abstract：

:Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.

journal_name

Nat Med

journal_title

Nature medicine

authors

Janes H,Herbeck JT,Tovanabutra S,Thomas R,Frahm N,Duerr A,Hural J,Corey L,Self SG,Buchbinder SP,McElrath MJ,O'Connell RJ,Paris RM,Rerks-Ngarm S,Nitayaphan S,Pitisuttihum P,Kaewkungwal J,Robb ML,Michael NL,Mullins JI

doi

10.1038/nm.3932

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1139-41

issue

10

eissn

1078-8956

issn

1546-170X

pii

nm.3932

journal_volume

21

pub_type

杂志文章

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