Abstract:
Background:Hepatic encephalopathy is associated with altered gut microbiota. Proton pump inhibitors increase the risk of small bowel bacterial overgrowth. Objectives:This was a case-control study aimed at exploring the relationship of proton pump inhibitor use with the risk of hepatic encephalopathy during hospitalization in liver cirrhosis. Methods:Case and control groups were defined as cirrhotic patients who developed hepatic encephalopathy during hospitalization and those without hepatic encephalopathy at admission or during hospitalization, respectively. Age, gender, and Child-Pugh score were matched between the groups. Odds ratios with 95% confidence intervals were calculated to express the association of proton pump inhibitors with the risk of hepatic encephalopathy. Four subgroup analyses were performed after excluding patients with acute upper gastrointestinal bleeding, infections, and in-hospital death, and after matching model for end-stage liver disease score. Results:In the overall analysis, 128 patients were included in each group of cases and controls. The proportion of proton pump inhibitor use was significantly higher in the case group than the control group (79.7% vs 43%, p < 0.001). Proton pump inhibitor use (odds ratio = 3.481, 95% confidence interval: 1.651-7.340, p = 0.001) was independently associated with the development of hepatic encephalopathy in the multivariate analysis. In the four subgroup analyses, proton pump inhibitor use remained independently associated with the risk of hepatic encephalopathy. Conclusion:Proton pump inhibitor use might increase the risk of hepatic encephalopathy during hospitalization.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Zhu J,Qi X,Yu H,Yoshida EM,Mendez-Sanchez N,Zhang X,Wang R,Deng H,Li J,Han D,Guo Xdoi
10.1177/2050640618773564subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1179-1187issue
8eissn
2050-6406issn
2050-6414pii
10.1177_2050640618773564journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM:To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640614548096
更新日期:2014-12-01 00:00:00
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journal_title:United European gastroenterology journal
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abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:United European gastroenterology journal
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doi:10.1177/2050640616647816
更新日期:2017-02-01 00:00:00
abstract::The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) have a vision to create a thriving community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centered and accessible endoscopic care. Whilst the bound...
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更新日期:2017-08-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
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更新日期:2019-06-01 00:00:00
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更新日期:2013-06-01 00:00:00
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更新日期:2017-03-01 00:00:00
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journal_title:United European gastroenterology journal
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doi:10.1177/2050640615569379
更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2019-07-01 00:00:00
abstract:Background:Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effect...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619825719
更新日期:2019-05-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2017-02-01 00:00:00
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更新日期:2020-02-01 00:00:00
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更新日期:2017-08-01 00:00:00
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更新日期:2016-06-01 00:00:00
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