Colonic motility in ulcerative colitis.

Abstract:

BACKGROUND:Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM:To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic. METHODS:A comprehensive online search of Medline and the Science Citation Index was carried out. RESULTS:Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process. CONCLUSIONS:A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.

authors

Bassotti G,Antonelli E,Villanacci V,Baldoni M,Dore MP

doi

10.1177/2050640614548096

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

457-62

issue

6

eissn

2050-6406

issn

2050-6414

pii

10.1177_2050640614548096

journal_volume

2

pub_type

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