Abstract:
BACKGROUND:Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM:To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic. METHODS:A comprehensive online search of Medline and the Science Citation Index was carried out. RESULTS:Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process. CONCLUSIONS:A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Bassotti G,Antonelli E,Villanacci V,Baldoni M,Dore MPdoi
10.1177/2050640614548096subject
Has Abstractpub_date
2014-12-01 00:00:00pages
457-62issue
6eissn
2050-6406issn
2050-6414pii
10.1177_2050640614548096journal_volume
2pub_type
杂志文章,评审abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707862
更新日期:2018-02-01 00:00:00
abstract:Background and objective:Psychological states may interfere with visceral sensitivity. Here we investigate associations between psychosocial factors and visceral sensitivity in irritable bowel syndrome (IBS). Methods:Two IBS patient cohorts (Cohort 1: n = 231, Rome II; Cohort 2: n = 141, Rome III) underwent rectal bar...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617715851
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptors (S1PRs) signaling plays a key role in inflammatory responses. Lei et al. showed that SphK1 inhibition presented a hepatoprotective effect on acute liver damage via decreasing hepatic high-mobility group box 1 (HMGB1)...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616637968
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND AIM:The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS:We searched PubMed, the Cochrane library, and the Igaku-chuo-z...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640616687837
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Eosinophilic oesophagitis (EoO) has been associated with allergic disorders as well as aeroallergens. The current literature has shown a possible association between seasonal variation, mainly in the spring, and the incidence of EoO. However, this data was based on small population studies that did not exclu...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614525152
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The risk of esophageal adenocarcinoma (EAC) in non-dysplastic Barrett's esophagus (NDBE) is considered to be approximately 0.3% per year or even lower, according to population-based studies. Data from countries with low EAC incidence are scarce. Our principal aim was to determine the incidence of high-grade ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615612409
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620948802
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The search for a source of gastrointestinal bleeding is associated with two distinct approaches of trying to rule in a specific diagnosis or rule out any potential source of bleeding. The study aim was to understand the conceptual differences underlying the two searches. METHODS:The performance of ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614557319
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To determine the survival outcome and prognostic factors of hepatocellular carcinoma (HCC) survival in patients who underwent radiofrequency ablation (RFA). METHODS:The Surveillance, Epidemiology and End Results (SEER) database was queried: There were 2588 HCC patients from 2004 to 2012 who underwent RFA. Th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616659024
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Because of their many advantages, faecal immunochemical tests (FIT) are superseding traditional guaiac-based faecal occult blood tests in bowel screening programmes. METHODS:A quantitative FIT was adopted for use in two evaluation National Health Service (NHS) Boards in Scotland using a cut-off faecal hae...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613489281
更新日期:2013-06-01 00:00:00
abstract:Introduction:Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain largely elusive. The aim of the present study w...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619839918
更新日期:2019-06-01 00:00:00
abstract::Barrett's oesophagus is a pre-malignant condition associated with the development of oesophageal adenocarcinoma. Currently white light endoscopy and biopsy is the mainstay diagnostic tool. Yet this approach is troubled by issues related to cumbersome biopsy sampling, biopsy sampling errors and cost. Therefore in order...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640615619281
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615603009
更新日期:2016-06-01 00:00:00
abstract:Background:The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. Objective:To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods:After thorough evaluat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618778386
更新日期:2018-08-01 00:00:00
abstract:Background:Since introduction of the MELD score in the liver allograft allocation system, renal insufficiency has emerged as an increasing problem. Here we evaluated the course of kidney function in patients with advanced renal insufficiency prior to liver transplantation (LT). Methods:A total of 254 patients undergoi...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707089
更新日期:2018-02-01 00:00:00
abstract::The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) have a vision to create a thriving community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centered and accessible endoscopic care. Whilst the bound...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615624631
更新日期:2016-02-01 00:00:00
abstract:Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab wer...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619847592
更新日期:2019-07-01 00:00:00
abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764161
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620937610
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Prucalopride is a selective, high-affinity, 5-hydroxytryptamine (serotonin) type 4 (5-HT4) receptor agonist with gastrointestinal prokinetic activities. This integrated analysis of data from three double-blind phase III trials (ClinicalTrials.gov: NCT00488137, NCT00483886, NCT00485940) compared the efficacy ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640612474651
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616687836
更新日期:2017-08-01 00:00:00
abstract::The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620944720
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616662432
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Women conceiving following in vitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future. OBJECTIVE:We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF....
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615597836
更新日期:2016-04-01 00:00:00
abstract:Introduction:Endoscopic mucosal resection and endoscopic submucosal dissection are demanding procedures. This study aims to establish face, content and expert validity of the live porcine model in performing endoscopic mucosal resection, endoscopic submucosal dissection, complication management and to assess it as a tr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617742484
更新日期:2018-05-01 00:00:00
abstract:Background:Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effect...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619825719
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colono...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620982952
更新日期:2020-12-21 00:00:00
abstract:Background:There is no consensus on what constitutes adequate training for needle knife precut sphincterotomy. Objective:The purpose of this study was to determine the number of procedures required before effective and safe precut sphincterotomy can be achieved. Methods:This retrospective study examined the cumulativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617701808
更新日期:2017-12-01 00:00:00
abstract::Stricturing Crohn's disease (CD) is a significant clinical problem. The presence of a stricture may be suggested by clinical symptoms. Cross-sectional imaging using computed tomography or magnetic resonance enterography is essential in diagnosing strictures as it allows further characterization and evaluation for comp...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620901960
更新日期:2020-04-01 00:00:00
abstract:Background:The ability to predict the severity of disease is important to reduce morbidity and mortality in patients with acute pancreatitis (AP). Vitamin D deficiency has been associated with severity in various diseases. Objective:This study was conducted to assess vitamin D as a predictor of disease severity in pat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618811489
更新日期:2019-02-01 00:00:00