Abstract:
BACKGROUND AND AIMS:The search for a source of gastrointestinal bleeding is associated with two distinct approaches of trying to rule in a specific diagnosis or rule out any potential source of bleeding. The study aim was to understand the conceptual differences underlying the two searches. METHODS:The performance of endoscopy as diagnostic test is analyzed in terms of Bayes' formula. RESULTS:The performance of gastrointestinal endoscopy to rule in a suspected lesion is mostly influenced by its underlying specificity. Because the specificity of endoscopy is less likely to be affected by procedural exigencies, the demands on pre-procedural prep and general quality can be more relaxed. In contradistinction, the performance of endoscopy to rule out a suspected bleeding site is mostly influenced by its sensitivity, which can easily be compromised by suboptimal procedural conditions. CONCLUSIONS:Paradoxically, the more urgent, focused, and important search (to rule in a bleeding site), carries less stringent criteria for its execution than the more general and aimless search (to rule out a bleeding site) that frequently ends up just empty handed.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Sonnenberg Adoi
10.1177/2050640614557319subject
Has Abstractpub_date
2014-12-01 00:00:00pages
471-4issue
6eissn
2050-6406issn
2050-6414pii
10.1177_2050640614557319journal_volume
2pub_type
杂志文章abstract:Objective:The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods:Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617732651
更新日期:2018-04-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may he...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...
journal_title:United European gastroenterology journal
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615585688
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journal_title:United European gastroenterology journal
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doi:10.1177/2050640616663397
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abstract:Introduction:Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain largely elusive. The aim of the present study w...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND:Symptomatically 'silent' gastro-oesophageal reflux disease (GORD) may be underdiagnosed. OBJECTIVE:To determine the prevalence of untreated GORD without heartburn and/or regurgitation in primary care. METHODS:Patients were included if they had frequent upper gastrointestinal symptoms and had not taken a pr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characte...
journal_title:United European gastroenterology journal
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journal_title:United European gastroenterology journal
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abstract:BACKGROUND:Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE:We tested whether cytokine release after gluten ingestion differentiates patients with CD from those with self-rep...
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doi:10.1177/2050640619874173
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abstract:BACKGROUND:Prevalence estimates for celiac disease (CD) depend on the method used. The role of deamidated gliadin peptide (DGP) and genetic testing in epidemiological studies and diagnostic settings of celiac disease (CD) has still to be established. OBJECTIVES:The objective of this article is to assess the prevalence...
journal_title:United European gastroenterology journal
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更新日期:2015-04-01 00:00:00
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abstract:Background:Recent studies suggest that the prevalence of celiac disease is rising. We previously established the prevalence of celiac disease in healthy blood donors in 2002. Objective:The purpose of this study was to examine whether the prevalence of celiac disease and celiac disease autoimmunity has changed over tim...
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abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...
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更新日期:2018-02-01 00:00:00
abstract:Background:Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce. Objective:The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy a...
journal_title:United European gastroenterology journal
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doi:10.1177/2050640618764940
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...
journal_title:United European gastroenterology journal
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doi:10.1177/2050640616687836
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pub_type: 杂志文章,多中心研究
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更新日期:2019-11-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2020-10-01 00:00:00
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更新日期:2019-05-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 新闻
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更新日期:2020-03-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2020-07-28 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
abstract::Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to bowel damage, defined as strictures, fistulas and abscesses. These complications require intestinal resection and lead to further irreversible structural damage. Cross-sectional imaging, such as magnetic resonance imaging, computed...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620908696
更新日期:2020-05-01 00:00:00