Abstract:
Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab were identified within the Italian IBD registry. The primary outcome was the rate of clinical remission at weeks 14 and 54. Secondary outcomes included the proportion of partial clinical response, treatment duration, and incidence of adverse events. Results:Forty-two children with VEO-IBD were compared with 130 children with IBD. Despite significantly higher infliximab withdrawals in VEO-IBD patients during induction (42.9% vs 7.7% p < 0.01), remission rates at week 14 were similar (28.6% vs 43.8%, p = 0.10). At week 54 fewer VEO-IBD children were in remission (15.8% vs 54.3%, p < 0.01). The treatment duration was shorter in VEO-IBD (median 12.0 vs 18.4 months, p < 0.01). During the induction phase, adverse events were more common in the VEO-IBD group (p < 0.01). Conclusion:Compared with older children, VEO-IBD patients have higher rates of infliximab failures, lower remission rates at one year, and more often experience adverse events during induction.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Bramuzzo M,Arrigo S,Romano C,Filardi MC,Lionetti P,Agrusti A,Dipasquale V,Paci M,Zuin G,Aloi M,Strisciuglio C,Miele E,Pastore M,Martelossi S,Alvisi P,SIGENP IBD Working Group.doi
10.1177/2050640619847592subject
Has Abstractpub_date
2019-07-01 00:00:00pages
759-766issue
6eissn
2050-6406issn
2050-6414pii
10.1177_2050640619847592journal_volume
7pub_type
杂志文章abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764161
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615581732
更新日期:2015-08-01 00:00:00
abstract:Background:The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. Objective:To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods:After thorough evaluat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618778386
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Underwater endoscopic mucosal resection without submucosal injection has been described for removing large flat colorectal lesions. OBJECTIVE:We aim to evaluate the reproducibility of this technique in terms of ease of implementation, safety and efficacy. METHODS:A prospective observational study of consec...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615617635
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615603009
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Because of their many advantages, faecal immunochemical tests (FIT) are superseding traditional guaiac-based faecal occult blood tests in bowel screening programmes. METHODS:A quantitative FIT was adopted for use in two evaluation National Health Service (NHS) Boards in Scotland using a cut-off faecal hae...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613489281
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the impact of obesity on disease activity and disease outcome in patients with inflammatory bowel disease. PATIENTS AND METHODS:The impact of obesity on inflammatory bowel disease disease activity and outcome was retrospectively assessed in 3075 patients enrolled ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620954556
更新日期:2020-12-01 00:00:00
abstract::The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. Topics such as epidemiology, risk factors, diagnosis, medical and surgical treatment of diverticular disease (DD) in patients wit...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614547068
更新日期:2014-10-01 00:00:00
abstract:Background:Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective:The purpose of this study was to analyse the performance of two probes (M/XL) on ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618772944
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613491254
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The risk of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection and clinical outcomes of coronavirus disease (COVID-19) in inflammatory bowel disease are unclear. METHODS:We searched PubMed and Embase with the keywords: inflammatory bowel disease, Crohn's disease, ulcerative colit...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620972602
更新日期:2020-11-19 00:00:00
abstract:Background:Intestinal microbiota and their metabolites (e.g. short-chain fatty acids (SCFAs)) may influence nonalcoholic fatty liver disease (NAFLD). Objective:The objective of this article is to analyze gut bacterial diversity together with fecal SCFA concentrations and immunophenotyping of peripheral blood in histol...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618804444
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically on intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim of this study was to evaluate th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616664842
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Patients with inflammatory bowel disease suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients' subjective need for integrated psychosomatic support and psychothera...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620946874
更新日期:2020-07-28 00:00:00
abstract:OBJECTIVES:Malignant vascular tumors of the liver are rare. The aim of this study was to investigate the applicability of gray scale and contrast-enhanced ultrasonography in patients with epithelioid hemangioendothelioma (EHE) of the liver and hepatic angiosarcoma (HA) and to describe the clinical presentation. METHOD...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614560604
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616662432
更新日期:2017-04-01 00:00:00
abstract:Background and aims:In complex endoscopies, the initial attempt is often associated with the highest success and subsequent attempts to achieve the same outcome have a higher failure rate. An attending physician needs to decide how the ultimate success may become compromised by letting a fellow start the procedure. A d...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617696401
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE:The objective of this article is to objectively measure cognitive i...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616663397
更新日期:2017-06-01 00:00:00
abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707862
更新日期:2018-02-01 00:00:00
abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617750809
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE:We tested whether cytokine release after gluten ingestion differentiates patients with CD from those with self-rep...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619874173
更新日期:2020-02-01 00:00:00
abstract::One of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive for young fellows interested in gastroenterology, and to involve them actively in UEG activities, by collaborating with young GI sections (YGIS) across Europe. Therefore, the YTG launched a survey to colle...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617713936
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620937610
更新日期:2020-08-01 00:00:00
abstract:Background:Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce. Objective:The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy a...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764940
更新日期:2018-07-01 00:00:00
abstract::Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to bowel damage, defined as strictures, fistulas and abscesses. These complications require intestinal resection and lead to further irreversible structural damage. Cross-sectional imaging, such as magnetic resonance imaging, computed...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620908696
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615583409
更新日期:2016-02-01 00:00:00
abstract:Background:Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods:This was a multicentre observational prospective cohort study conducted in Europe...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619864848
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colono...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620982952
更新日期:2020-12-21 00:00:00
abstract:Objective:The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods:Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617732651
更新日期:2018-04-01 00:00:00
abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619883704
更新日期:2019-12-01 00:00:00