Efficacy and safety of infliximab in very early onset inflammatory bowel disease: a national comparative retrospective study.


Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab were identified within the Italian IBD registry. The primary outcome was the rate of clinical remission at weeks 14 and 54. Secondary outcomes included the proportion of partial clinical response, treatment duration, and incidence of adverse events. Results:Forty-two children with VEO-IBD were compared with 130 children with IBD. Despite significantly higher infliximab withdrawals in VEO-IBD patients during induction (42.9% vs 7.7% p < 0.01), remission rates at week 14 were similar (28.6% vs 43.8%, p = 0.10). At week 54 fewer VEO-IBD children were in remission (15.8% vs 54.3%, p < 0.01). The treatment duration was shorter in VEO-IBD (median 12.0 vs 18.4 months, p < 0.01). During the induction phase, adverse events were more common in the VEO-IBD group (p < 0.01). Conclusion:Compared with older children, VEO-IBD patients have higher rates of infliximab failures, lower remission rates at one year, and more often experience adverse events during induction.


Bramuzzo M,Arrigo S,Romano C,Filardi MC,Lionetti P,Agrusti A,Dipasquale V,Paci M,Zuin G,Aloi M,Strisciuglio C,Miele E,Pastore M,Martelossi S,Alvisi P,SIGENP IBD Working Group.




Has Abstract


2019-07-01 00:00:00














  • Absence of high-risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding.

    abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Horibe M,Ogura Y,Matsuzaki J,Kaneko T,Yokota T,Okawa O,Nakatani Y,Iwasaki E,Nishizawa T,Hosoe N,Masaoka T,Yahagi N,Namiki S,Kanai T

    更新日期:2018-06-01 00:00:00

  • Systematic review and meta-analysis: Efficacy and safety of POEM for achalasia.

    abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Barbieri LA,Hassan C,Rosati R,Romario UF,Correale L,Repici A

    更新日期:2015-08-01 00:00:00

  • Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood.

    abstract:Background:The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. Objective:To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods:After thorough evaluat...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Kivelä L,Popp A,Arvola T,Huhtala H,Kaukinen K,Kurppa K

    更新日期:2018-08-01 00:00:00

  • Underwater endoscopic mucosal resection: The third way for en bloc resection of colonic lesions?

    abstract:BACKGROUND:Underwater endoscopic mucosal resection without submucosal injection has been described for removing large flat colorectal lesions. OBJECTIVE:We aim to evaluate the reproducibility of this technique in terms of ease of implementation, safety and efficacy. METHODS:A prospective observational study of consec...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Amato A,Radaelli F,Spinzi G

    更新日期:2016-08-01 00:00:00

  • Prevalence of constipation in the German population - a representative survey (GECCO).

    abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Enck P,Leinert J,Smid M,Köhler T,Schwille-Kiuntke J

    更新日期:2016-06-01 00:00:00

  • Clinical outcomes using a faecal immunochemical test for haemoglobin as a first-line test in a national programme constrained by colonoscopy capacity.

    abstract:INTRODUCTION:Because of their many advantages, faecal immunochemical tests (FIT) are superseding traditional guaiac-based faecal occult blood tests in bowel screening programmes. METHODS:A quantitative FIT was adopted for use in two evaluation National Health Service (NHS) Boards in Scotland using a cut-off faecal hae...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Steele RJ,McDonald PJ,Digby J,Brownlee L,Strachan JA,Libby G,McClements PL,Birrell J,Carey FA,Diament RH,Balsitis M,Fraser CG

    更新日期:2013-06-01 00:00:00

  • Impact of obesity on disease activity and disease outcome in inflammatory bowel disease: Results from the Swiss inflammatory bowel disease cohort.

    abstract:OBJECTIVE:The purpose of this study was to investigate the impact of obesity on disease activity and disease outcome in patients with inflammatory bowel disease. PATIENTS AND METHODS:The impact of obesity on inflammatory bowel disease disease activity and outcome was retrospectively assessed in 3075 patients enrolled ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Greuter T,Porchet F,Braga-Neto MB,Rossel JB,Biedermann L,Schreiner P,Scharl M,Schoepfer AM,Safroneeva E,Straumann A,Rogler G,Vavricka SR

    更新日期:2020-12-01 00:00:00

  • Italian consensus conference for colonic diverticulosis and diverticular disease.

    abstract::The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. Topics such as epidemiology, risk factors, diagnosis, medical and surgical treatment of diverticular disease (DD) in patients wit...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Cuomo R,Barbara G,Pace F,Annese V,Bassotti G,Binda GA,Casetti T,Colecchia A,Festi D,Fiocca R,Laghi A,Maconi G,Nascimbeni R,Scarpignato C,Villanacci V,Annibale B

    更新日期:2014-10-01 00:00:00

  • The XL probe: A luxury or a necessity? Risk stratification in an obese community cohort using transient elastography.

    abstract:Background:Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective:The purpose of this study was to analyse the performance of two probes (M/XL) on ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Harris R,Card TR,Delahooke T,Aithal GP,Guha IN

    更新日期:2018-11-01 00:00:00

  • Effect of aspirin cessation before endoscopy in Japanese patients with low-dose-aspirin-associated gastroduodenal mucosal injury.

    abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Ito Y,Sasaki M,Noguchi S,Yamaguchi S,Okaniwa N,Tanabe A,Noda H,Yanamoto K,Tamura Y,Kondo Y,Masui R,Izawa S,Iida A,Mizuno M,Ogasawara N,Funaki Y,Kasugai K

    更新日期:2013-08-01 00:00:00

  • Risk and outcomes of coronavirus disease (COVID-19) in patients with inflammatory bowel disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:The risk of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection and clinical outcomes of coronavirus disease (COVID-19) in inflammatory bowel disease are unclear. METHODS:We searched PubMed and Embase with the keywords: inflammatory bowel disease, Crohn's disease, ulcerative colit...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Singh AK,Jena A,Kumar-M P,Sharma V,Sebastian S

    更新日期:2020-11-19 00:00:00

  • Fecal SCFAs and SCFA-producing bacteria in gut microbiome of human NAFLD as a putative link to systemic T-cell activation and advanced disease.

    abstract:Background:Intestinal microbiota and their metabolites (e.g. short-chain fatty acids (SCFAs)) may influence nonalcoholic fatty liver disease (NAFLD). Objective:The objective of this article is to analyze gut bacterial diversity together with fecal SCFA concentrations and immunophenotyping of peripheral blood in histol...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Rau M,Rehman A,Dittrich M,Groen AK,Hermanns HM,Seyfried F,Beyersdorf N,Dandekar T,Rosenstiel P,Geier A

    更新日期:2018-12-01 00:00:00

  • Estimation of the prevalence of intraductal papillary mucinous neoplasm of the pancreas in the French population through patients waiting for liver transplantation.

    abstract:BACKGROUND AND AIMS:Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically on intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim of this study was to evaluate th...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Laurent L,Vullierme MP,Rebours V,Maire F,Hentic O,Francoz C,Durand F,Ruszniewski P,Lévy P

    更新日期:2017-06-01 00:00:00

  • Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease.

    abstract:INTRODUCTION:Patients with inflammatory bowel disease suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients' subjective need for integrated psychosomatic support and psychothera...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Kutschera M,Waldhör T,Gröchenig HP,Haas T,Wenzl H,Steiner P,Koch R,Feichtenschlager T,Eckhardt G,Mayer A,Kirchgatterer A,Ludwiczek O,Platzer R,Papay P,Gartner J,Fuchssteiner H,Peters PG,Reicht G,Moser G,Dejaco C,V

    更新日期:2020-07-28 00:00:00

  • Gray scale and contrast-enhanced ultrasound imaging of malignant liver tumors of vascular origin.

    abstract:OBJECTIVES:Malignant vascular tumors of the liver are rare. The aim of this study was to investigate the applicability of gray scale and contrast-enhanced ultrasonography in patients with epithelioid hemangioendothelioma (EHE) of the liver and hepatic angiosarcoma (HA) and to describe the clinical presentation. METHOD...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Schweitzer N,Soudah B,Gebel M,Manns MP,Boozari B

    更新日期:2015-02-01 00:00:00

  • Effects of conventional and a novel colonic-release bile acid sequestrant, A3384, on fibroblast growth factor 19 and bile acid metabolism in healthy volunteers and patients with bile acid diarrhoea.

    abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Appleby RN,Bajor A,Gillberg PG,Graffner H,Simrén M,Ung KA,Walters J

    更新日期:2017-04-01 00:00:00

  • When to let the fellow do the procedure.

    abstract:Background and aims:In complex endoscopies, the initial attempt is often associated with the highest success and subsequent attempts to achieve the same outcome have a higher failure rate. An attending physician needs to decide how the ultimate success may become compromised by letting a fellow start the procedure. A d...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Sonnenberg A

    更新日期:2017-11-01 00:00:00

  • Cognitive impairment in Crohn's disease is associated with systemic inflammation, symptom burden and sleep disturbance.

    abstract:BACKGROUND:Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE:The objective of this article is to objectively measure cognitive i...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: van Langenberg DR,Yelland GW,Robinson SR,Gibson PR

    更新日期:2017-06-01 00:00:00

  • Risk of histologic Barrett's esophagus between African Americans and non-Hispanic whites: A meta-analysis.

    abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Alkaddour A,Palacio C,Vega KJ

    更新日期:2018-02-01 00:00:00

  • Clostridium difficile fecal toxin level is associated with disease severity and prognosis.

    abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Cohen NA,Miller T,Na'aminh W,Hod K,Adler A,Cohen D,Guzner-Gur H,Santo E,Halpern Z,Carmeli Y,Maharshak N

    更新日期:2018-06-01 00:00:00

  • Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity.

    abstract:BACKGROUND:Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE:We tested whether cytokine release after gluten ingestion differentiates patients with CD from those with self-rep...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Tye-Din JA,Skodje GI,Sarna VK,Dzuris JL,Russell AK,Goel G,Wang S,Goldstein KE,Williams LJ,Sollid LM,Lundin KE,Anderson RP

    更新日期:2020-02-01 00:00:00

  • The organisation and needs of young sections belonging to UEG National Societies: Results of a Europe-wide survey.

    abstract::One of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive for young fellows interested in gastroenterology, and to involve them actively in UEG activities, by collaborating with young GI sections (YGIS) across Europe. Therefore, the YTG launched a survey to colle...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Ianiro G,Castro V,Dolak W,Ilie M,Holleran G,Salaga M,van Herwaarden Y,Burisch J,UEG Young Talent Group.

    更新日期:2017-08-01 00:00:00

  • Suboptimal care for chronic pancreatitis patients revealed by moderate to low adherence to the United European Gastroenterology evidence-based guidelines (HaPanEU): A Netherlands nationwide analysis.

    abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: de Rijk FE,Kempeneers MA,Bruno MJ,Besselink MG,van Goor H,Boermeester MA,van Geenen EJ,van Hooft JE,van Santvoort HC,Verdonk RC,Dutch Pancreatitis Study Group.

    更新日期:2020-08-01 00:00:00

  • Ethanol sclerotherapy or polidocanol sclerotherapy for symptomatic hepatic cysts.

    abstract:Background:Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce. Objective:The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy a...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Wijnands TF,Schoenemeier B,Potthoff A,Gevers TJ,Groenewoud H,Gebel MJ,Rifai K,Manns MP,Drenth JP

    更新日期:2018-07-01 00:00:00

  • Impact of therapies on bowel damage in Crohn's disease.

    abstract::Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to bowel damage, defined as strictures, fistulas and abscesses. These complications require intestinal resection and lead to further irreversible structural damage. Cross-sectional imaging, such as magnetic resonance imaging, computed...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Fiorino G,Bonifacio C,Allocca M,Danese S

    更新日期:2020-05-01 00:00:00

  • Feasibility study of minimal prepared hydroflush screening colonoscopy.

    abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Moshkowitz M,Fokra A,Itzhak Y,Arber N,Santo E

    更新日期:2016-02-01 00:00:00

  • A multicentre prospective cohort study assessing the effectiveness of budesonide MMX® (Cortiment®MMX®) for active, mild-to-moderate ulcerative colitis.

    abstract:Background:Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods:This was a multicentre observational prospective cohort study conducted in Europe...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,多中心研究


    authors: Danese S,Hart A,Dignass A,Fiorino G,Louis E,Bonovas S,D'Haens G,Dotan I,Rogler G,Paridaens K,Peyrin-Biroulet L

    更新日期:2019-11-01 00:00:00

  • Standard versus Endocuff versus cap-assisted colonoscopy for adenoma detection: A randomised controlled clinical trial.

    abstract:BACKGROUND AND AIMS:Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colono...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Floer M,Tschaikowski L,Schepke M,Kempinski R,Neubauer K,Poniewierka E,Kunsch S,Ameis D,Heinzow HS,Auer A,Schmidt HH,Ellenrieder V,Meister T

    更新日期:2020-12-21 00:00:00

  • The effect of off-hours hospital admission on mortality and clinical outcomes for patients with upper gastrointestinal hemorrhage: A systematic review and meta-analysis of 20 cohorts.

    abstract:Objective:The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods:Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Xia XF,Chiu PWY,Tsoi KKF,Chan FKL,Sung JJY,Lau JYW

    更新日期:2018-04-01 00:00:00

  • Changes in inflammatory bowel disease patients' perspectives on biosimilars: A follow-up survey.

    abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Peyrin-Biroulet L,Lönnfors S,Avedano L,Danese S

    更新日期:2019-12-01 00:00:00