Abstract:
Background:The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. Objective:To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods:After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen-detected and clinically-detected patients, and also between originally asymptomatic and symptomatic screen-detected patients. Results:In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen-detected patients (n = 48) had coeliac disease in the family and type 1 diabetes more often, and were less often smokers and members of coeliac societies compared to clinically-detected patients, whereas the groups did not differ in current self-experienced health or health concerns, quality of life or dietary adherence. Screen-detected, originally asymptomatic patients had more anxiety than those presenting with symptoms, whereas the subgroups were comparable in other current characteristics. Conclusion:Comparable long-term outcomes between screen-detected and clinically-detected patients support risk-group screening for coeliac disease. However, asymptomatic patients may require special attention.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Kivelä L,Popp A,Arvola T,Huhtala H,Kaukinen K,Kurppa Kdoi
10.1177/2050640618778386subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1022-1031issue
7eissn
2050-6406issn
2050-6414pii
10.1177_2050640618778386journal_volume
6pub_type
杂志文章abstract:BACKGROUND AND AIMS:The aim of this study was to determine the mortality and re-bleeding rates, and the risk factors involved, in a cohort of patients with previous diverticular bleeding (DB). METHODS:In 2007, data on 2462 patients with lower gastrointestinal (GI) bleeding were collected prospectively at several Frenc...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616647816
更新日期:2017-02-01 00:00:00
abstract::This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,实务指引
doi:10.1177/2050640619844125
更新日期:2019-06-01 00:00:00
abstract:Background:Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of singl...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617733923
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616687836
更新日期:2017-08-01 00:00:00
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doi:10.1177/2050640620982952
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abstract:BACKGROUND:Symptomatically 'silent' gastro-oesophageal reflux disease (GORD) may be underdiagnosed. OBJECTIVE:To determine the prevalence of untreated GORD without heartburn and/or regurgitation in primary care. METHODS:Patients were included if they had frequent upper gastrointestinal symptoms and had not taken a pr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614532458
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE:We tested whether cytokine release after gluten ingestion differentiates patients with CD from those with self-rep...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Underwater endoscopic mucosal resection without submucosal injection has been described for removing large flat colorectal lesions. OBJECTIVE:We aim to evaluate the reproducibility of this technique in terms of ease of implementation, safety and efficacy. METHODS:A prospective observational study of consec...
journal_title:United European gastroenterology journal
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更新日期:2016-08-01 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:2019-03-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614560604
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...
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更新日期:2015-08-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615597836
更新日期:2016-04-01 00:00:00
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journal_title:United European gastroenterology journal
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doi:10.1177/2050640617701808
更新日期:2017-12-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2020-04-01 00:00:00
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更新日期:2018-12-01 00:00:00
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doi:10.1177/2050640618764710
更新日期:2018-07-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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journal_title:United European gastroenterology journal
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更新日期:2014-04-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2018-07-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2020-09-14 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2020-11-23 00:00:00
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更新日期:2019-02-01 00:00:00
abstract:Aims:The purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU-funded digestive health research by providin...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/0142064X19858164
更新日期:2019-07-01 00:00:00