The microbiome in pancreatic diseases: Recent advances and future perspectives.

Abstract:

:The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about the microbiome and its interaction with host cells and organisms. There is now emerging evidence that microorganisms also contribute to inflammatory and neoplastic diseases of the pancreas. This review summarizes current clinical and translational microbiome studies in acute and chronic pancreatitis as well as pancreatic cancer and provides evidence that the microbiome has a high potential for biomarker discovery. Furthermore, the intestinal and pancreas-specific microbiome may also become an integrative part of diagnostic and therapeutic approaches of pancreatic diseases in the near future.

authors

Ammer-Herrmenau C,Pfisterer N,Weingarten MF,Neesse A

doi

10.1177/2050640620944720

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

878-885

issue

8

eissn

2050-6406

issn

2050-6414

journal_volume

8

pub_type

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