Abstract:
INTRODUCTION:Because of their many advantages, faecal immunochemical tests (FIT) are superseding traditional guaiac-based faecal occult blood tests in bowel screening programmes. METHODS:A quantitative FIT was adopted for use in two evaluation National Health Service (NHS) Boards in Scotland using a cut-off faecal haemoglobin concentration chosen to give a positivity rate equivalent to that achieved in the Scottish Bowel Screening Programme. Uptake and clinical outcomes were compared with results obtained contemporaneously in two other similar NHS Boards and before and after the evaluation in the two evaluation NHS Boards. RESULTS:During the evaluation, uptake was 58.5%. This was higher than in the same NHS Boards both before and after the evaluation, higher than in the other two NHS Boards and higher than the 53.7% achieved overall in Scotland. The overall positivity rate was higher in men than in women and increased with age in both genders. Positive predictive values for cancer (4.8%), high-risk adenoma (23.3%), all adenoma (38.2%) and all neoplasia (43.0%) in the two test NHS Boards were similar in all groups. CONCLUSIONS:In summary, this evaluation of the FIT supports the introduction of FIT as a first-line test, even when colonoscopy capacity is limited.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Steele RJ,McDonald PJ,Digby J,Brownlee L,Strachan JA,Libby G,McClements PL,Birrell J,Carey FA,Diament RH,Balsitis M,Fraser CGdoi
10.1177/2050640613489281subject
Has Abstractpub_date
2013-06-01 00:00:00pages
198-205issue
3eissn
2050-6406issn
2050-6414pii
10.1177_2050640613489281journal_volume
1pub_type
杂志文章abstract::The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620944720
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613491254
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptors (S1PRs) signaling plays a key role in inflammatory responses. Lei et al. showed that SphK1 inhibition presented a hepatoprotective effect on acute liver damage via decreasing hepatic high-mobility group box 1 (HMGB1)...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616637968
更新日期:2016-10-01 00:00:00
abstract:Background:Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective:The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case se...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617722901
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND AIM:The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS:We searched PubMed, the Cochrane library, and the Igaku-chuo-z...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640616687837
更新日期:2017-10-01 00:00:00
abstract:Background:Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective:The purpose of this study was to analyse the performance of two probes (M/XL) on ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618772944
更新日期:2018-11-01 00:00:00
abstract:Background:The ability to predict the severity of disease is important to reduce morbidity and mortality in patients with acute pancreatitis (AP). Vitamin D deficiency has been associated with severity in various diseases. Objective:This study was conducted to assess vitamin D as a predictor of disease severity in pat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618811489
更新日期:2019-02-01 00:00:00
abstract::The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) have a vision to create a thriving community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centered and accessible endoscopic care. Whilst the bound...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615624631
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The aim of this study was to determine the mortality and re-bleeding rates, and the risk factors involved, in a cohort of patients with previous diverticular bleeding (DB). METHODS:In 2007, data on 2462 patients with lower gastrointestinal (GI) bleeding were collected prospectively at several Frenc...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616647816
更新日期:2017-02-01 00:00:00
abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619883704
更新日期:2019-12-01 00:00:00
abstract:Background:Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis. Objective:A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618817689
更新日期:2019-03-01 00:00:00
abstract::Barrett's oesophagus is a pre-malignant condition associated with the development of oesophageal adenocarcinoma. Currently white light endoscopy and biopsy is the mainstay diagnostic tool. Yet this approach is troubled by issues related to cumbersome biopsy sampling, biopsy sampling errors and cost. Therefore in order...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640615619281
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Acute abdominal pain (AAP) is one of the most common causes of referral to an emergency department (ED), but information about its impact is limited. OBJECTIVES:The objectives of this article are to define the prevalence of AAP among ED visits in a large university hospital and analyze its main clinical fea...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615606012
更新日期:2016-04-01 00:00:00
abstract:Background:Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods:This was a multicentre observational prospective cohort study conducted in Europe...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619864848
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620948802
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The search for a source of gastrointestinal bleeding is associated with two distinct approaches of trying to rule in a specific diagnosis or rule out any potential source of bleeding. The study aim was to understand the conceptual differences underlying the two searches. METHODS:The performance of ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614557319
更新日期:2014-12-01 00:00:00
abstract:Background:Dysplasia in Barrett's esophagus (BE) biopsies is associated with low observer agreement among general pathologists. Therefore, expert review is advised. We are developing a web-based, national expert review panel for histological review of BE biopsies. Objective:The aim of this study was to create benchmar...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764710
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colono...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620982952
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:Acute upper abdominal pain is a frequent symptom leading to hospital admission. OBJECTIVE:To determine whether a primary intra- and extraluminal diagnostic approach enabled by endoscopic ultrasound is as effective as a conventional diagnostic algorithm of transabdominal ultrasound followed by oesophagogastr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613498589
更新日期:2013-10-01 00:00:00
abstract::Stricturing Crohn's disease (CD) is a significant clinical problem. The presence of a stricture may be suggested by clinical symptoms. Cross-sectional imaging using computed tomography or magnetic resonance enterography is essential in diagnosing strictures as it allows further characterization and evaluation for comp...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620901960
更新日期:2020-04-01 00:00:00
abstract:Background:Intestinal microbiota and their metabolites (e.g. short-chain fatty acids (SCFAs)) may influence nonalcoholic fatty liver disease (NAFLD). Objective:The objective of this article is to analyze gut bacterial diversity together with fecal SCFA concentrations and immunophenotyping of peripheral blood in histol...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618804444
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM:To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640614548096
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Eosinophilic oesophagitis (EoO) has been associated with allergic disorders as well as aeroallergens. The current literature has shown a possible association between seasonal variation, mainly in the spring, and the incidence of EoO. However, this data was based on small population studies that did not exclu...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614525152
更新日期:2014-04-01 00:00:00
abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764161
更新日期:2018-06-01 00:00:00
abstract:Introduction:Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain largely elusive. The aim of the present study w...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619839918
更新日期:2019-06-01 00:00:00
abstract:Background and aims:In complex endoscopies, the initial attempt is often associated with the highest success and subsequent attempts to achieve the same outcome have a higher failure rate. An attending physician needs to decide how the ultimate success may become compromised by letting a fellow start the procedure. A d...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617696401
更新日期:2017-11-01 00:00:00
abstract:Background:The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. Objective:To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods:After thorough evaluat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618778386
更新日期:2018-08-01 00:00:00
abstract::This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,实务指引
doi:10.1177/2050640619844125
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615581732
更新日期:2015-08-01 00:00:00
abstract:Background:Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce. Objective:The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy a...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764940
更新日期:2018-07-01 00:00:00