Abstract:
Background:Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective:The purpose of this study was to analyse the performance of two probes (M/XL) on a portable transient elastography device within an obese community population. Method:The method involved a prospective study with recruitment from a primary care practice. Patients identified with a risk factor for chronic liver disease were invited to a community-based risk stratification pathway for transient elastography readings with both probes. A threshold of ≥8.0 kPa defined elevated liver stiffness. Results:A total of 477 patients attended the pathway. Of the patients, 21% had no valid measurements with the M probe. There was a significant difference between the probes in the proportion achieving ≥10 valid readings (M versus XL probe: 66.2% versus 90.2%; p ≤ 0.001) and in their reliability (M versus XL probe: 77.4% versus 98.5%; p = 0.028). Unreliable readings with the M probe increased as the body mass index increased. The XL probe re-stratified 5.2% of patients to have a normal reading. Conclusion:The XL probe on a portable device significantly improves the applicability of transient elastography within a community-based risk stratification pathway.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Harris R,Card TR,Delahooke T,Aithal GP,Guha INdoi
10.1177/2050640618772944subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1372-1379issue
9eissn
2050-6406issn
2050-6414pii
10.1177_2050640618772944journal_volume
6pub_type
杂志文章abstract:OBJECTIVES:Malignant vascular tumors of the liver are rare. The aim of this study was to investigate the applicability of gray scale and contrast-enhanced ultrasonography in patients with epithelioid hemangioendothelioma (EHE) of the liver and hepatic angiosarcoma (HA) and to describe the clinical presentation. METHOD...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614560604
更新日期:2015-02-01 00:00:00
abstract:Background:Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effect...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619825719
更新日期:2019-05-01 00:00:00
abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619883704
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620948802
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Multiple medications are associated with an increased risk of incident hepatic encephalopathy. Despite this known risk, medications such as opioids, benzodiazepines, gabapentin/pregabalin, and/or proton pump inhibitors are increasingly prescribed to persons with cirrhosis. Deprescribing is a promisi...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620975224
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615581732
更新日期:2015-08-01 00:00:00
abstract:Background:Modulating gut microbiota is a potential treatment for irritable bowel syndrome (IBS). This meta-analysis explored whether fecal microbiota transplantation (FMT) is successful in treating IBS. Methods:A systematic review was performed to find trials on FMT in IBS. Ratios and relative ratios (RR) of improvem...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,meta分析
doi:10.1177/2050640619866990
更新日期:2019-10-01 00:00:00
abstract::One of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive for young fellows interested in gastroenterology, and to involve them actively in UEG activities, by collaborating with young GI sections (YGIS) across Europe. Therefore, the YTG launched a survey to colle...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617713936
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically on intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim of this study was to evaluate th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616664842
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616687836
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Prevalence estimates for celiac disease (CD) depend on the method used. The role of deamidated gliadin peptide (DGP) and genetic testing in epidemiological studies and diagnostic settings of celiac disease (CD) has still to be established. OBJECTIVES:The objective of this article is to assess the prevalence...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615569379
更新日期:2015-04-01 00:00:00
abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617750809
更新日期:2018-06-01 00:00:00
abstract:Background:Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce. Objective:The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy a...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764940
更新日期:2018-07-01 00:00:00
abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707862
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Acute abdominal pain (AAP) is one of the most common causes of referral to an emergency department (ED), but information about its impact is limited. OBJECTIVES:The objectives of this article are to define the prevalence of AAP among ED visits in a large university hospital and analyze its main clinical fea...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615606012
更新日期:2016-04-01 00:00:00
abstract:Background:Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis. Objective:A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618817689
更新日期:2019-03-01 00:00:00
abstract:Background:Since introduction of the MELD score in the liver allograft allocation system, renal insufficiency has emerged as an increasing problem. Here we evaluated the course of kidney function in patients with advanced renal insufficiency prior to liver transplantation (LT). Methods:A total of 254 patients undergoi...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707089
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND AIM:The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS:We searched PubMed, the Cochrane library, and the Igaku-chuo-z...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640616687837
更新日期:2017-10-01 00:00:00
abstract::Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to bowel damage, defined as strictures, fistulas and abscesses. These complications require intestinal resection and lead to further irreversible structural damage. Cross-sectional imaging, such as magnetic resonance imaging, computed...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620908696
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Patients with inflammatory bowel disease suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients' subjective need for integrated psychosomatic support and psychothera...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620946874
更新日期:2020-07-28 00:00:00
abstract:Background:Intestinal microbiota and their metabolites (e.g. short-chain fatty acids (SCFAs)) may influence nonalcoholic fatty liver disease (NAFLD). Objective:The objective of this article is to analyze gut bacterial diversity together with fecal SCFA concentrations and immunophenotyping of peripheral blood in histol...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618804444
更新日期:2018-12-01 00:00:00
abstract:Background:Recent studies suggest that the prevalence of celiac disease is rising. We previously established the prevalence of celiac disease in healthy blood donors in 2002. Objective:The purpose of this study was to examine whether the prevalence of celiac disease and celiac disease autoimmunity has changed over tim...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618818227
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616662432
更新日期:2017-04-01 00:00:00
abstract:Introduction:Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain largely elusive. The aim of the present study w...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619839918
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The risk of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection and clinical outcomes of coronavirus disease (COVID-19) in inflammatory bowel disease are unclear. METHODS:We searched PubMed and Embase with the keywords: inflammatory bowel disease, Crohn's disease, ulcerative colit...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620972602
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Acute upper abdominal pain is a frequent symptom leading to hospital admission. OBJECTIVE:To determine whether a primary intra- and extraluminal diagnostic approach enabled by endoscopic ultrasound is as effective as a conventional diagnostic algorithm of transabdominal ultrasound followed by oesophagogastr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613498589
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615603009
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptors (S1PRs) signaling plays a key role in inflammatory responses. Lei et al. showed that SphK1 inhibition presented a hepatoprotective effect on acute liver damage via decreasing hepatic high-mobility group box 1 (HMGB1)...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616637968
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613491254
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To determine the survival outcome and prognostic factors of hepatocellular carcinoma (HCC) survival in patients who underwent radiofrequency ablation (RFA). METHODS:The Surveillance, Epidemiology and End Results (SEER) database was queried: There were 2588 HCC patients from 2004 to 2012 who underwent RFA. Th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616659024
更新日期:2017-03-01 00:00:00