Abstract:
Background:The ability to predict the severity of disease is important to reduce morbidity and mortality in patients with acute pancreatitis (AP). Vitamin D deficiency has been associated with severity in various diseases. Objective:This study was conducted to assess vitamin D as a predictor of disease severity in patients with AP. Methods:Patients with AP were prospectively enrolled at Yonsei University Wonju College of Medicine from March 2015 to September 2017. Serum vitamin D was analyzed as soon as AP was diagnosed. The level of vitamin D was classified as normal (>20 ng/ml), insufficient (>10 and ≤20 ng/ml) or deficient (≤10 ng/ml). Results:Among 242 patients with AP, the prevalence of vitamin D deficiency was 56.2%, and 28.5% of patients had vitamin D insufficiency. Serum vitamin D level was negatively correlated with severity indexes, such as the Atlanta classification, Computed Tomography Severity Index, Bedside Index for Severity of Acute Pancreatitis, and Ranson score. The prevalence of vitamin D deficiency increased with severity of AP according to the Atlanta classification. Vitamin D deficiency was the independent factor for predicting severe AP (OR 5.37, 95% CI 1.13-25.57, p = 0.015) and intensive care unit admission (OR 3.09, 95% CI 1.24-7.69, p = 0.035). Conclusion:Vitamin D deficiency is associated with increased severity of AP and is a predictor for intensive care unit admission.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Huh JH,Kim JW,Lee KJdoi
10.1177/2050640618811489subject
Has Abstractpub_date
2019-02-01 00:00:00pages
90-95issue
1eissn
2050-6406issn
2050-6414pii
10.1177_2050640618811489journal_volume
7pub_type
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journal_title:United European gastroenterology journal
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更新日期:2014-12-01 00:00:00
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更新日期:2016-10-01 00:00:00
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更新日期:2017-11-01 00:00:00