Prevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping.

Abstract:

BACKGROUND:Prevalence estimates for celiac disease (CD) depend on the method used. The role of deamidated gliadin peptide (DGP) and genetic testing in epidemiological studies and diagnostic settings of celiac disease (CD) has still to be established. OBJECTIVES:The objective of this article is to assess the prevalence of CD in Latvia by combining serological tests with DQ2.5/DQ8 testing. METHODS:A total of 1444 adults from a randomly selected cross-sectional general population sample were tested by ELISA for tTG IgA, DGP IgA and IgG antibodies (QUANTA Lite®, Inova Diagnostics Inc). Samples with tTG IgA ≥20U were tested for EMA IgA by indirect immunofluorescence assay, and all specimens with tTG IgA ≥15U were tested by QUANTA-Flash® chemiluminescent assays (CIA) (Inova Diagnostics Inc) for tTG IgA, DGP IgA and IgG. DQ2.5/8 was detected in individuals with any positive ELISA test and a subgroup of controls. RESULTS:Forty-three individuals (2.98%; 95% CI: 2.10-3.86%) tested positive by at least one ELISA test; 41.86% of the serology-positive individuals (any test above the cutoff) were DQ positive. Six individuals (0.42%; 95% CI: 0.09-0.75%) were triple ELISA positive, and DQ2.5 or DQ8 was positive in all; 0.35% (95% CI: 0.05-0.65%) were tTG IgA and EMA positive. Two tTG IgA-negative cases were both DGP IgG and IgA positive, both being DQ positive; including them in the "serology-positive" group would increase the prevalence to 0.49% (95% CI: 0.13-0.85%). CIA tests revealed 2 tTG IgA-positive and EMA-negative cases with a positive genotype. DQ2.5 or DQ8 genotype was positive in 28.6% of the serology-negative population. CONCLUSIONS:Estimates of the prevalence of CD in Latvia based on the serogenetic testing approach range from 0.35% to 0.49% depending on the criteria used. There is a rationale for combining serological tests and DQ2.5/8 genotyping.

authors

Leja M,Shums Z,Nikitina-Zake L,Gavars M,Kikuste I,Milo J,Daugule I,Pahomova J,Pirags V,Dzerve V,Klovins J,Erglis A,Norman GL

doi

10.1177/2050640615569379

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

190-9

issue

2

eissn

2050-6406

issn

2050-6414

pii

10.1177_2050640615569379

journal_volume

3

pub_type

杂志文章
  • A multicentre prospective cohort study assessing the effectiveness of budesonide MMX® (Cortiment®MMX®) for active, mild-to-moderate ulcerative colitis.

    abstract:Background:Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods:This was a multicentre observational prospective cohort study conducted in Europe...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2050640619864848

    authors: Danese S,Hart A,Dignass A,Fiorino G,Louis E,Bonovas S,D'Haens G,Dotan I,Rogler G,Paridaens K,Peyrin-Biroulet L

    更新日期:2019-11-01 00:00:00

  • Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity.

    abstract:BACKGROUND:Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE:We tested whether cytokine release after gluten ingestion differentiates patients with CD from those with self-rep...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640619874173

    authors: Tye-Din JA,Skodje GI,Sarna VK,Dzuris JL,Russell AK,Goel G,Wang S,Goldstein KE,Williams LJ,Sollid LM,Lundin KE,Anderson RP

    更新日期:2020-02-01 00:00:00

  • Capability of processed EEG parameters to monitor conscious sedation in endoscopy is similar to general anaesthesia.

    abstract:BACKGROUND:Reliable and safe sedation is a prerequisite for endoscopic interventions. The current standard is rather safe, yet, an objective device to measure sedation depth is missing. To date, anaesthesia monitors based on processed electroencephalogram (EEG) have not been utilised in conscious sedation. OBJECTIVE:T...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640620959153

    authors: Garbe J,Eisenmann S,Kantelhardt JW,Duenninghaus F,Michl P,Rosendahl J

    更新日期:2020-09-14 00:00:00

  • Young GI Societies in Europe: 2019 update.

    abstract:BACKGROUND:One of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive to young fellows interested in gastroenterology (GI), and to actively involve them in UEG activities and the activities of their respective national societies. In 2017, we conducted a survey amon...

    journal_title:United European gastroenterology journal

    pub_type: 新闻

    doi:10.1177/2050640620906771

    authors: Heinrich H,Rodríguez-Lago I,Nakov R,Skuja V,Acedo P,Nitsche U,Mikolasevic I,van Herwaarden Y

    更新日期:2020-03-01 00:00:00

  • A combined bile and urine proteomic test for cholangiocarcinoma diagnosis in patients with biliary strictures of unknown origin.

    abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640616687836

    authors: Voigtländer T,Metzger J,Schönemeier B,Jäger M,Mischak H,Manns MP,Lankisch TO

    更新日期:2017-08-01 00:00:00

  • Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease.

    abstract:INTRODUCTION:Patients with inflammatory bowel disease suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients' subjective need for integrated psychosomatic support and psychothera...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640620946874

    authors: Kutschera M,Waldhör T,Gröchenig HP,Haas T,Wenzl H,Steiner P,Koch R,Feichtenschlager T,Eckhardt G,Mayer A,Kirchgatterer A,Ludwiczek O,Platzer R,Papay P,Gartner J,Fuchssteiner H,Peters PG,Reicht G,Moser G,Dejaco C,V

    更新日期:2020-07-28 00:00:00

  • The learning curve for needle knife precut sphincterotomy revisited.

    abstract:Background:There is no consensus on what constitutes adequate training for needle knife precut sphincterotomy. Objective:The purpose of this study was to determine the number of procedures required before effective and safe precut sphincterotomy can be achieved. Methods:This retrospective study examined the cumulativ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640617701808

    authors: Li JW,Ang TL,Kam JW,Kwek ABE,Teo EK

    更新日期:2017-12-01 00:00:00

  • Systematic review and meta-analysis: Efficacy and safety of POEM for achalasia.

    abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640615581732

    authors: Barbieri LA,Hassan C,Rosati R,Romario UF,Correale L,Repici A

    更新日期:2015-08-01 00:00:00

  • Clostridium difficile fecal toxin level is associated with disease severity and prognosis.

    abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640617750809

    authors: Cohen NA,Miller T,Na'aminh W,Hod K,Adler A,Cohen D,Guzner-Gur H,Santo E,Halpern Z,Carmeli Y,Maharshak N

    更新日期:2018-06-01 00:00:00

  • Suboptimal care for chronic pancreatitis patients revealed by moderate to low adherence to the United European Gastroenterology evidence-based guidelines (HaPanEU): A Netherlands nationwide analysis.

    abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640620937610

    authors: de Rijk FE,Kempeneers MA,Bruno MJ,Besselink MG,van Goor H,Boermeester MA,van Geenen EJ,van Hooft JE,van Santvoort HC,Verdonk RC,Dutch Pancreatitis Study Group.

    更新日期:2020-08-01 00:00:00

  • Efficacy and safety of oral prucalopride in women with chronic constipation in whom laxatives have failed: an integrated analysis.

    abstract:BACKGROUND:Prucalopride is a selective, high-affinity, 5-hydroxytryptamine (serotonin) type 4 (5-HT4) receptor agonist with gastrointestinal prokinetic activities. This integrated analysis of data from three double-blind phase III trials (ClinicalTrials.gov: NCT00488137, NCT00483886, NCT00485940) compared the efficacy ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640612474651

    authors: Tack J,Quigley E,Camilleri M,Vandeplassche L,Kerstens R

    更新日期:2013-02-01 00:00:00

  • Effect of low-dose aspirin use on pancreatic cancer development and morphological changes on imaging in IPMN: A long-term cohort study.

    abstract:Background:Aspirin use may reduce the incidence of pancreatic cancer (PC), but no data are available regarding its chemopreventive effects on intraductal papillary mucinous neoplasm (IPMN). We aimed to determine whether low-dose aspirin (LDA) reduces PC development and morphological changes on imaging in IPMN patients....

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640617693524

    authors: Takasaki Y,Nagata N,Imbe K,Hisada Y,Sekine K,Tajima T,Yanase M,Fujimoto K,Akiyama J,Uemura N

    更新日期:2017-11-01 00:00:00

  • Changes in inflammatory bowel disease patients' perspectives on biosimilars: A follow-up survey.

    abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640619883704

    authors: Peyrin-Biroulet L,Lönnfors S,Avedano L,Danese S

    更新日期:2019-12-01 00:00:00

  • Endoscopic modalities for the diagnosis of Barrett's oesophagus.

    abstract::Barrett's oesophagus is a pre-malignant condition associated with the development of oesophageal adenocarcinoma. Currently white light endoscopy and biopsy is the mainstay diagnostic tool. Yet this approach is troubled by issues related to cumbersome biopsy sampling, biopsy sampling errors and cost. Therefore in order...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,评审

    doi:10.1177/2050640615619281

    authors: Sharma N,Srivastava S,Kern F,Xian W,Ming T,McKeon F,Ho KY

    更新日期:2016-12-01 00:00:00

  • European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders.

    abstract::This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,实务指引

    doi:10.1177/2050640619844125

    authors: Al-Toma A,Volta U,Auricchio R,Castillejo G,Sanders DS,Cellier C,Mulder CJ,Lundin KEA

    更新日期:2019-06-01 00:00:00

  • Low risk of adenocarcinoma and high-grade dysplasia in patients with non-dysplastic Barrett's esophagus: Results from a cohort from a country with low esophageal adenocarcinoma incidence.

    abstract:BACKGROUND:The risk of esophageal adenocarcinoma (EAC) in non-dysplastic Barrett's esophagus (NDBE) is considered to be approximately 0.3% per year or even lower, according to population-based studies. Data from countries with low EAC incidence are scarce. Our principal aim was to determine the incidence of high-grade ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640615612409

    authors: Pereira AD,Chaves P

    更新日期:2016-06-01 00:00:00

  • Buspirone, a new drug for the management of patients with ineffective esophageal motility?

    abstract::Ineffective esophageal motility (IEM) is the most frequently encountered esophageal motility disorder. Patients may present with a variety of symptoms, such as dysphagia, heartburn, odynophagia, and regurgitation. Over the past years, the landscape of esophageal motility testing has been revolutionized; however, our c...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640615585688

    authors: Scheerens C,Tack J,Rommel N

    更新日期:2015-06-01 00:00:00

  • Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis.

    abstract:BACKGROUND:Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characte...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640616644142

    authors: Jeong S,Choi E,Petersen CP,Roland JT,Federico A,Ippolito R,D'Armiento FP,Nardone G,Nagano O,Saya H,Romano M,Goldenring JR

    更新日期:2017-02-01 00:00:00

  • Italian consensus conference for colonic diverticulosis and diverticular disease.

    abstract::The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. Topics such as epidemiology, risk factors, diagnosis, medical and surgical treatment of diverticular disease (DD) in patients wit...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640614547068

    authors: Cuomo R,Barbara G,Pace F,Annese V,Bassotti G,Binda GA,Casetti T,Colecchia A,Festi D,Fiocca R,Laghi A,Maconi G,Nascimbeni R,Scarpignato C,Villanacci V,Annibale B

    更新日期:2014-10-01 00:00:00

  • Feasibility study of minimal prepared hydroflush screening colonoscopy.

    abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640615583409

    authors: Moshkowitz M,Fokra A,Itzhak Y,Arber N,Santo E

    更新日期:2016-02-01 00:00:00

  • Terlipressin and albumin combination treatment in patients with hepatorenal syndrome type 2.

    abstract:Background:Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effect...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640619825719

    authors: Nguyen-Tat M,Jäger J,Rey JW,Nagel M,Labenz C,Wörns MA,Galle PR,Marquardt JU

    更新日期:2019-05-01 00:00:00

  • The XL probe: A luxury or a necessity? Risk stratification in an obese community cohort using transient elastography.

    abstract:Background:Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective:The purpose of this study was to analyse the performance of two probes (M/XL) on ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640618772944

    authors: Harris R,Card TR,Delahooke T,Aithal GP,Guha IN

    更新日期:2018-11-01 00:00:00

  • Effect of aspirin cessation before endoscopy in Japanese patients with low-dose-aspirin-associated gastroduodenal mucosal injury.

    abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640613491254

    authors: Ito Y,Sasaki M,Noguchi S,Yamaguchi S,Okaniwa N,Tanabe A,Noda H,Yanamoto K,Tamura Y,Kondo Y,Masui R,Izawa S,Iida A,Mizuno M,Ogasawara N,Funaki Y,Kasugai K

    更新日期:2013-08-01 00:00:00

  • Absence of high-risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding.

    abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640618764161

    authors: Horibe M,Ogura Y,Matsuzaki J,Kaneko T,Yokota T,Okawa O,Nakatani Y,Iwasaki E,Nishizawa T,Hosoe N,Masaoka T,Yahagi N,Namiki S,Kanai T

    更新日期:2018-06-01 00:00:00

  • Lack of seasonal variation in the incidence of eosinophilic oesophagitis in adolescent and adult non-PPI-responsive oesophageal eosinophilia midwestern US populations.

    abstract:BACKGROUND:Eosinophilic oesophagitis (EoO) has been associated with allergic disorders as well as aeroallergens. The current literature has shown a possible association between seasonal variation, mainly in the spring, and the incidence of EoO. However, this data was based on small population studies that did not exclu...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640614525152

    authors: Frederickson NW,Bayman L,Valestin J,Redd M,Lee YJ,Soubra M,Schey R

    更新日期:2014-04-01 00:00:00

  • Gray scale and contrast-enhanced ultrasound imaging of malignant liver tumors of vascular origin.

    abstract:OBJECTIVES:Malignant vascular tumors of the liver are rare. The aim of this study was to investigate the applicability of gray scale and contrast-enhanced ultrasonography in patients with epithelioid hemangioendothelioma (EHE) of the liver and hepatic angiosarcoma (HA) and to describe the clinical presentation. METHOD...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640614560604

    authors: Schweitzer N,Soudah B,Gebel M,Manns MP,Boozari B

    更新日期:2015-02-01 00:00:00

  • Deprescribing medications that may increase the risk of hepatic encephalopathy: A qualitative study of patients with cirrhosis and their doctors.

    abstract:BACKGROUND AND AIMS:Multiple medications are associated with an increased risk of incident hepatic encephalopathy. Despite this known risk, medications such as opioids, benzodiazepines, gabapentin/pregabalin, and/or proton pump inhibitors are increasingly prescribed to persons with cirrhosis. Deprescribing is a promisi...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640620975224

    authors: Williams S,Louissaint J,Nikirk S,Bajaj JS,Tapper EB

    更新日期:2020-11-23 00:00:00

  • Underwater endoscopic colorectal polyp resection: Feasibility in everyday clinical practice.

    abstract:Background:Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of singl...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640617733923

    authors: Cadoni S,Liggi M,Gallittu P,Mura D,Fuccio L,Koo M,Ishaq S

    更新日期:2018-04-01 00:00:00

  • Acute abdominal pain in the emergency department of a university hospital in Italy.

    abstract:BACKGROUND:Acute abdominal pain (AAP) is one of the most common causes of referral to an emergency department (ED), but information about its impact is limited. OBJECTIVES:The objectives of this article are to define the prevalence of AAP among ED visits in a large university hospital and analyze its main clinical fea...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640615606012

    authors: Caporale N,Morselli-Labate AM,Nardi E,Cogliandro R,Cavazza M,Stanghellini V

    更新日期:2016-04-01 00:00:00

  • The microbiome in pancreatic diseases: Recent advances and future perspectives.

    abstract::The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about th...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章

    doi:10.1177/2050640620944720

    authors: Ammer-Herrmenau C,Pfisterer N,Weingarten MF,Neesse A

    更新日期:2020-10-01 00:00:00