Abstract:
Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective:The objective of this article is to determine whether fecal C. difficile toxin (CDT) levels are associated with disease severity and prognosis. Methods:A cross-sectional study of patients admitted with CDI in a tertiary center between 2011 and 2015 was conducted. Fecal CDT levels were determined by quantitative ELISA. Severe CDI was defined as a leukocyte count of > 15 × 103 cells/μl, creatinine levels that deteriorated by > 1.5 times the baseline level, or albumin levels < 3 g/dl. Results:Seventy-three patients were recruited for this study. Patients with severe CDI (n = 47) had significantly higher toxin levels compared to patients with mild to moderate CDI (n = 26) (651 ng/ml (IQR 138-3200) versus 164 ng/ml (IQR 55.2-400.1), respectively; p = 0.001). A high toxin level (>2500 ng/ml) was associated with an increased mortality rate (odds ratio 11.8; 95% confidence interval 2.5-56). Conclusions:The fecal CDT level is associated with disease severity and mortality rate. Measuring CDT levels may be an objective and accurate way to define the severity of CDI.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Cohen NA,Miller T,Na'aminh W,Hod K,Adler A,Cohen D,Guzner-Gur H,Santo E,Halpern Z,Carmeli Y,Maharshak Ndoi
10.1177/2050640617750809subject
Has Abstractpub_date
2018-06-01 00:00:00pages
773-780issue
5eissn
2050-6406issn
2050-6414pii
10.1177_2050640617750809journal_volume
6pub_type
杂志文章abstract:Objective:The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods:Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to...
journal_title:United European gastroenterology journal
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abstract:Aims:The purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU-funded digestive health research by providin...
journal_title:United European gastroenterology journal
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doi:10.1177/0142064X19858164
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abstract:Background:Pancreatic function testing and imaging are used to inform the diagnosis of chronic pancreatitis, but most of these methods are time- and cost-consuming or lack diagnostic accuracy. Objective:We investigated the utility of pancreas-specific plasma amylase for assessment and diagnosis of chronic pancreatitis...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
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abstract:Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab wer...
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abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...
journal_title:United European gastroenterology journal
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journal_title:United European gastroenterology journal
pub_type: 新闻
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,meta分析
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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更新日期:2014-10-01 00:00:00
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doi:10.1177/2050640613491254
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Acute upper abdominal pain is a frequent symptom leading to hospital admission. OBJECTIVE:To determine whether a primary intra- and extraluminal diagnostic approach enabled by endoscopic ultrasound is as effective as a conventional diagnostic algorithm of transabdominal ultrasound followed by oesophagogastr...
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doi:10.1177/2050640613498589
更新日期:2013-10-01 00:00:00
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doi:10.1177/2050640617733923
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更新日期:2020-08-01 00:00:00
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journal_title:United European gastroenterology journal
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doi:10.1177/2050640614532458
更新日期:2014-06-01 00:00:00
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journal_title:United European gastroenterology journal
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更新日期:2015-06-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2020-04-01 00:00:00
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journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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更新日期:2019-02-01 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2019-11-01 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Patients with primary oesophageal squamous cell carcinoma are at risk of developing multiple primary tumours in the upper aero digestive tract. To date, most studies are performed in the Asian population. We aimed to evaluate the risk of multiple primary tumours in the upper aero digestive tract and stomach ...
journal_title:United European gastroenterology journal
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doi:10.1177/2050640620977129
更新日期:2020-12-03 00:00:00