Buspirone, a new drug for the management of patients with ineffective esophageal motility?

Abstract:

:Ineffective esophageal motility (IEM) is the most frequently encountered esophageal motility disorder. Patients may present with a variety of symptoms, such as dysphagia, heartburn, odynophagia, and regurgitation. Over the past years, the landscape of esophageal motility testing has been revolutionized; however, our current treatment options for IEM still remain limited. Previous studies have suggested that buspirone, a serotonin receptor agonist, enhances esophageal peristalsis and lower esophageal sphincter (LES) function. Recent work provides the first evidence that buspirone may influence LES resting pressure in patients with systemic sclerosis. Future research should evaluate whether the beneficial effects of buspirone also apply to the broad clinical entity of esophageal dysphagia patients with IEM.

authors

Scheerens C,Tack J,Rommel N

doi

10.1177/2050640615585688

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

261-5

issue

3

eissn

2050-6406

issn

2050-6414

pii

10.1177_2050640615585688

journal_volume

3

pub_type

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