Eosinophilic esophagitis: What can we learn from Crohn's disease?

Abstract:

:Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may help optimize EoE patient management. Commonalities include epidemiologic trends (Westernized diseases, rising incidence, early-life risk factors), diagnostic considerations (symptoms are poor predictors of disease activity, difficulties in disease activity assessment) and therapeutic issues (similar natural history and therapeutic goals, induction and maintenance phases, combination of drug and endoscopic treatment, potential drug interchangeability, long-term unsolved issues). Physicians devoted to EoE should learn from the extraordinary achievements fulfilled in Crohn's disease: increased disease awareness, multidisciplinary specialized clinics, structured childhood and transition programs, and an ongoing roadmap for personalized treatments, including genetic susceptibility, risk factors for progression, genotype-phenotype correlation, drug monitoring and microbial data.

authors

Molina-Infante J,Schoepfer AM,Lucendo AJ,Dellon ES

doi

10.1177/2050640616672953

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

762-772

issue

6

eissn

2050-6406

issn

2050-6414

pii

10.1177_2050640616672953

journal_volume

5

pub_type

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