Abstract:
Background:Aspirin use may reduce the incidence of pancreatic cancer (PC), but no data are available regarding its chemopreventive effects on intraductal papillary mucinous neoplasm (IPMN). We aimed to determine whether low-dose aspirin (LDA) reduces PC development and morphological changes on imaging in IPMN patients. Methods:A cohort of 448 IPMN patients periodically followed up with imaging tests was analyzed. We used one-to-two propensity score matching to adjust for differences between an LDA group (n = 63) and a non-LDA group (n = 385). Outcomes included increasing cyst diameter, increasing main pancreatic duct (MPD) diameter, mural nodule (MN) appearance and PC development. Results:After matching, 63 LDA and 126 non-LDA patients were selected. During follow-up (median, 5.5 years), no significant differences were found in increasing cyst diameter, MN appearance, or PC development. However, there were significantly fewer cases of increasing MPD diameter in the LDA group (4.8% vs. 12.7%; p = 0.02). After adjustment for age and sex, LDA still decreased the risk of increasing MPD diameter (hazard ratio, 0.17; p = 0.02). Conclusion:Our results do not support a chemopreventive effect of LDA on PC development. However, LDA reduces further MPD dilation in IPMN patients.
journal_name
United European Gastroenterol Jjournal_title
United European gastroenterology journalauthors
Takasaki Y,Nagata N,Imbe K,Hisada Y,Sekine K,Tajima T,Yanase M,Fujimoto K,Akiyama J,Uemura Ndoi
10.1177/2050640617693524subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1030-1036issue
7eissn
2050-6406issn
2050-6414pii
10.1177_2050640617693524journal_volume
5pub_type
杂志文章abstract::Ineffective esophageal motility (IEM) is the most frequently encountered esophageal motility disorder. Patients may present with a variety of symptoms, such as dysphagia, heartburn, odynophagia, and regurgitation. Over the past years, the landscape of esophageal motility testing has been revolutionized; however, our c...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615585688
更新日期:2015-06-01 00:00:00
abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617750809
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To determine the survival outcome and prognostic factors of hepatocellular carcinoma (HCC) survival in patients who underwent radiofrequency ablation (RFA). METHODS:The Surveillance, Epidemiology and End Results (SEER) database was queried: There were 2588 HCC patients from 2004 to 2012 who underwent RFA. Th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616659024
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Women conceiving following in vitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future. OBJECTIVE:We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF....
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615597836
更新日期:2016-04-01 00:00:00
abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764161
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Malignant vascular tumors of the liver are rare. The aim of this study was to investigate the applicability of gray scale and contrast-enhanced ultrasonography in patients with epithelioid hemangioendothelioma (EHE) of the liver and hepatic angiosarcoma (HA) and to describe the clinical presentation. METHOD...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640614560604
更新日期:2015-02-01 00:00:00
abstract:Background:Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective:The objective of this article is to determine the degree of histologic BE risk difference between...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617707862
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620948802
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Reliable and safe sedation is a prerequisite for endoscopic interventions. The current standard is rather safe, yet, an objective device to measure sedation depth is missing. To date, anaesthesia monitors based on processed electroencephalogram (EEG) have not been utilised in conscious sedation. OBJECTIVE:T...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620959153
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The 2016, United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) provided evidence-based recommendations for the management of chronic pancreatitis and allowed for the objective evaluation of the quality of care in several doma...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620937610
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Acute upper abdominal pain is a frequent symptom leading to hospital admission. OBJECTIVE:To determine whether a primary intra- and extraluminal diagnostic approach enabled by endoscopic ultrasound is as effective as a conventional diagnostic algorithm of transabdominal ultrasound followed by oesophagogastr...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640613498589
更新日期:2013-10-01 00:00:00
abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619883704
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND AIM:The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS:We searched PubMed, the Cochrane library, and the Igaku-chuo-z...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640616687837
更新日期:2017-10-01 00:00:00
abstract:Background:Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective:The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case se...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617722901
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The risk of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection and clinical outcomes of coronavirus disease (COVID-19) in inflammatory bowel disease are unclear. METHODS:We searched PubMed and Embase with the keywords: inflammatory bowel disease, Crohn's disease, ulcerative colit...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620972602
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Recent reports from western countries have indicated an increased incidence and a decreased mortality in acute pancreatitis. However, the incidence assessment has often been hampered by the inclusion of both first-time and recurrent episodes of acute pancreatitis. METHODS:In this retrospective cohort study,...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620913737
更新日期:2020-05-01 00:00:00
abstract:Background:Dysplasia in Barrett's esophagus (BE) biopsies is associated with low observer agreement among general pathologists. Therefore, expert review is advised. We are developing a web-based, national expert review panel for histological review of BE biopsies. Objective:The aim of this study was to create benchmar...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618764710
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640615603009
更新日期:2016-06-01 00:00:00
abstract:Background:Modulating gut microbiota is a potential treatment for irritable bowel syndrome (IBS). This meta-analysis explored whether fecal microbiota transplantation (FMT) is successful in treating IBS. Methods:A systematic review was performed to find trials on FMT in IBS. Ratios and relative ratios (RR) of improvem...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,meta分析
doi:10.1177/2050640619866990
更新日期:2019-10-01 00:00:00
abstract:Background:There is no consensus on what constitutes adequate training for needle knife precut sphincterotomy. Objective:The purpose of this study was to determine the number of procedures required before effective and safe precut sphincterotomy can be achieved. Methods:This retrospective study examined the cumulativ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640617701808
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE:The objective of this article is to objectively measure cognitive i...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616663397
更新日期:2017-06-01 00:00:00
abstract:Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab wer...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640619847592
更新日期:2019-07-01 00:00:00
abstract:Aims:The purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU-funded digestive health research by providin...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/0142064X19858164
更新日期:2019-07-01 00:00:00
abstract:Background:Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis. Objective:A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640618817689
更新日期:2019-03-01 00:00:00
abstract::The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about th...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620944720
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colono...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640620982952
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616687836
更新日期:2017-08-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may he...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,评审
doi:10.1177/2050640616672953
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...
journal_title:United European gastroenterology journal
pub_type: 杂志文章
doi:10.1177/2050640616662432
更新日期:2017-04-01 00:00:00
abstract:Introduction:Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain largely elusive. The aim of the present study w...
journal_title:United European gastroenterology journal
pub_type: 杂志文章,多中心研究
doi:10.1177/2050640619839918
更新日期:2019-06-01 00:00:00