Future research demands of the United European Gastroenterology (UEG) and its member societies.


Aims:The purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU-funded digestive health research by providing evidence and advice to funding bodies on priority areas. The UEG Research Committee initiated a survey of the current and future research interests of each individual UEG ordinary member society (specialist societies). Methods:A questionnaire was sent by mail to 17 UEG ordinary member societies asking them to specify research demands related to the most urgent medical need including basic science research, translational research, clinical research, patient management research and research on disease prevention, in an open fashion but with limited word count. Results:The responses from 13 societies were analysed in a semi-quantitative and in a qualitative way, and were clustered into five domains with two aspects each that were consented and shared between three and seven of the responding 13 societies. These clusters resemble topics such as 'Hot topics' (e.g. life-style, nutrition, microbial-host interaction), Biomarkers (genetic profiling, gut-brain interaction), Advanced technology (artificial intelligence, personalised medicine), Global research tools (bio-banking, EU trials), and Medical training (education, prevention). Conclusion:The generated topic list allows both collaboration between individual specialist societies as well as initiating and fostering future research calls at the EU level and beyond when approaching stakeholders.


Enck P,Meisner S,Figueiredo C,Mayerle J,Ricciardiello L,UEG Research Committee.




Has Abstract


2019-07-01 00:00:00














  • Association of proton pump inhibitors with the risk of hepatic encephalopathy during hospitalization for liver cirrhosis.

    abstract:Background:Hepatic encephalopathy is associated with altered gut microbiota. Proton pump inhibitors increase the risk of small bowel bacterial overgrowth. Objectives:This was a case-control study aimed at exploring the relationship of proton pump inhibitor use with the risk of hepatic encephalopathy during hospitaliza...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Zhu J,Qi X,Yu H,Yoshida EM,Mendez-Sanchez N,Zhang X,Wang R,Deng H,Li J,Han D,Guo X

    更新日期:2018-10-01 00:00:00

  • Cognitive impairment in Crohn's disease is associated with systemic inflammation, symptom burden and sleep disturbance.

    abstract:BACKGROUND:Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE:The objective of this article is to objectively measure cognitive i...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: van Langenberg DR,Yelland GW,Robinson SR,Gibson PR

    更新日期:2017-06-01 00:00:00

  • Clostridium difficile fecal toxin level is associated with disease severity and prognosis.

    abstract:Background:Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins. Objective...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Cohen NA,Miller T,Na'aminh W,Hod K,Adler A,Cohen D,Guzner-Gur H,Santo E,Halpern Z,Carmeli Y,Maharshak N

    更新日期:2018-06-01 00:00:00

  • Lack of seasonal variation in the incidence of eosinophilic oesophagitis in adolescent and adult non-PPI-responsive oesophageal eosinophilia midwestern US populations.

    abstract:BACKGROUND:Eosinophilic oesophagitis (EoO) has been associated with allergic disorders as well as aeroallergens. The current literature has shown a possible association between seasonal variation, mainly in the spring, and the incidence of EoO. However, this data was based on small population studies that did not exclu...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Frederickson NW,Bayman L,Valestin J,Redd M,Lee YJ,Soubra M,Schey R

    更新日期:2014-04-01 00:00:00

  • Effect of aspirin cessation before endoscopy in Japanese patients with low-dose-aspirin-associated gastroduodenal mucosal injury.

    abstract:BACKGROUND:The incidence of upper gastrointestinal injury by low-dose aspirin (LDA) has increased. OBJECTIVE:We aimed to clarify the risk factors and prevention strategies associated with LDA-induced gastroduodenal ulcer in Japanese patients. METHODS:A retrospective study involving 284 LDA users who underwent oesopha...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Ito Y,Sasaki M,Noguchi S,Yamaguchi S,Okaniwa N,Tanabe A,Noda H,Yanamoto K,Tamura Y,Kondo Y,Masui R,Izawa S,Iida A,Mizuno M,Ogasawara N,Funaki Y,Kasugai K

    更新日期:2013-08-01 00:00:00

  • Systematic review and meta-analysis: Efficacy and safety of POEM for achalasia.

    abstract:BACKGROUND:Peroral endoscopic esophageal myotomy (POEM) represents a less invasive alternative, as compared with conventional laparoscopic Heller myotomy for treating achalasia patients. In the last years, a number of prospective and retrospective experiences with POEM use for achalasia have been published. METHODS:Re...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Barbieri LA,Hassan C,Rosati R,Romario UF,Correale L,Repici A

    更新日期:2015-08-01 00:00:00

  • Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

    abstract:Background:Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis. Objective:A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Matsuzaki J,Suzuki H,Shimoda M,Mori H,Fukuhara S,Miyoshi S,Masaoka T,Iwao Y,Kanai Y,Kanai T

    更新日期:2019-03-01 00:00:00

  • Prevalence of constipation in the German population - a representative survey (GECCO).

    abstract:BACKGROUND:Variable prevalence rates between 2.4 and 35% have been reported for chronic constipation across different countries worldwide, with a low 5% for Germany. OBJECTIVES AND METHODS:We conducted a computer-assisted telephone interview among 15,002 representative individuals in Germany, asking about health-relat...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Enck P,Leinert J,Smid M,Köhler T,Schwille-Kiuntke J

    更新日期:2016-06-01 00:00:00

  • Absence of high-risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding.

    abstract:Background:The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective:We assessed the clinical predictive factors associate...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Horibe M,Ogura Y,Matsuzaki J,Kaneko T,Yokota T,Okawa O,Nakatani Y,Iwasaki E,Nishizawa T,Hosoe N,Masaoka T,Yahagi N,Namiki S,Kanai T

    更新日期:2018-06-01 00:00:00

  • Feasibility study of minimal prepared hydroflush screening colonoscopy.

    abstract:BACKGROUND:Although screening colonoscopy is effective for early detection of colorectal cancer (CRC), screening rates remain low. Multiple factors are thought to be responsible for the low rates of screening colonoscopy, but bowel preparation appears to be a key deterrent. Tolerability issues with bowel preparations m...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Moshkowitz M,Fokra A,Itzhak Y,Arber N,Santo E

    更新日期:2016-02-01 00:00:00

  • Changes in inflammatory bowel disease patients' perspectives on biosimilars: A follow-up survey.

    abstract:Background and aims:The aim of this survey was to find out whether the perspectives of patients with inflammatory bowel disease concerning biosimilars have changed since the publication of our last survey carried out in 2014-2015. Methods:An online survey consisting of 19 questions was made available by the European F...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Peyrin-Biroulet L,Lönnfors S,Avedano L,Danese S

    更新日期:2019-12-01 00:00:00

  • A multicentre prospective cohort study assessing the effectiveness of budesonide MMX® (Cortiment®MMX®) for active, mild-to-moderate ulcerative colitis.

    abstract:Background:Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods:This was a multicentre observational prospective cohort study conducted in Europe...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,多中心研究


    authors: Danese S,Hart A,Dignass A,Fiorino G,Louis E,Bonovas S,D'Haens G,Dotan I,Rogler G,Paridaens K,Peyrin-Biroulet L

    更新日期:2019-11-01 00:00:00

  • The microbiome in pancreatic diseases: Recent advances and future perspectives.

    abstract::The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about th...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Ammer-Herrmenau C,Pfisterer N,Weingarten MF,Neesse A

    更新日期:2020-10-01 00:00:00

  • Development of benchmark quality criteria for assessing whole-endoscopy Barrett's esophagus biopsy cases.

    abstract:Background:Dysplasia in Barrett's esophagus (BE) biopsies is associated with low observer agreement among general pathologists. Therefore, expert review is advised. We are developing a web-based, national expert review panel for histological review of BE biopsies. Objective:The aim of this study was to create benchmar...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: van der Wel MJ,Duits LC,Klaver E,Pouw RE,Seldenrijk CA,Offerhaus G,Visser M,Ten Kate F,Tijssen JG,Bergman J,Meijer SL

    更新日期:2018-07-01 00:00:00

  • When to let the fellow do the procedure.

    abstract:Background and aims:In complex endoscopies, the initial attempt is often associated with the highest success and subsequent attempts to achieve the same outcome have a higher failure rate. An attending physician needs to decide how the ultimate success may become compromised by letting a fellow start the procedure. A d...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Sonnenberg A

    更新日期:2017-11-01 00:00:00

  • Fecal microbiota transplantation in irritable bowel syndrome: A systematic review and meta-analysis.

    abstract:Background:Modulating gut microbiota is a potential treatment for irritable bowel syndrome (IBS). This meta-analysis explored whether fecal microbiota transplantation (FMT) is successful in treating IBS. Methods:A systematic review was performed to find trials on FMT in IBS. Ratios and relative ratios (RR) of improvem...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,meta分析


    authors: Myneedu K,Deoker A,Schmulson MJ,Bashashati M

    更新日期:2019-10-01 00:00:00

  • Rising incidence of acute pancreatitis in Sweden: National estimates and trends between 1990 and 2013.

    abstract:BACKGROUND:Recent reports from western countries have indicated an increased incidence and a decreased mortality in acute pancreatitis. However, the incidence assessment has often been hampered by the inclusion of both first-time and recurrent episodes of acute pancreatitis. METHODS:In this retrospective cohort study,...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Oskarsson V,Hosseini S,Discacciati A,Videhult P,Jans A,Ekbom A,Sadr-Azodi O

    更新日期:2020-05-01 00:00:00

  • Natural history, diagnosis and treatment approach to fibrostenosing Crohn's disease.

    abstract::Stricturing Crohn's disease (CD) is a significant clinical problem. The presence of a stricture may be suggested by clinical symptoms. Cross-sectional imaging using computed tomography or magnetic resonance enterography is essential in diagnosing strictures as it allows further characterization and evaluation for comp...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: El Ouali S,Click B,Holubar SD,Rieder F

    更新日期:2020-04-01 00:00:00

  • Eosinophilic esophagitis: What can we learn from Crohn's disease?

    abstract::Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may he...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,评审


    authors: Molina-Infante J,Schoepfer AM,Lucendo AJ,Dellon ES

    更新日期:2017-10-01 00:00:00

  • Impact of obesity on disease activity and disease outcome in inflammatory bowel disease: Results from the Swiss inflammatory bowel disease cohort.

    abstract:OBJECTIVE:The purpose of this study was to investigate the impact of obesity on disease activity and disease outcome in patients with inflammatory bowel disease. PATIENTS AND METHODS:The impact of obesity on inflammatory bowel disease disease activity and outcome was retrospectively assessed in 3075 patients enrolled ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Greuter T,Porchet F,Braga-Neto MB,Rossel JB,Biedermann L,Schreiner P,Scharl M,Schoepfer AM,Safroneeva E,Straumann A,Rogler G,Vavricka SR

    更新日期:2020-12-01 00:00:00

  • The European Society of Gastrointestinal Endoscopy Quality Improvement Initiative: developing performance measures.

    abstract::The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) have a vision to create a thriving community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centered and accessible endoscopic care. Whilst the bound...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Rutter MD,Senore C,Bisschops R,Domagk D,Valori R,Kaminski MF,Spada C,Bretthauer M,Bennett C,Bellisario C,Minozzi S,Hassan C,Rees C,Dinis-Ribeiro M,Hucl T,Ponchon T,Aabakken L,Fockens P

    更新日期:2016-02-01 00:00:00

  • Effects of conventional and a novel colonic-release bile acid sequestrant, A3384, on fibroblast growth factor 19 and bile acid metabolism in healthy volunteers and patients with bile acid diarrhoea.

    abstract:BACKGROUND:Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM:The purpose of this study was to evaluate the pharmacological effects ...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Appleby RN,Bajor A,Gillberg PG,Graffner H,Simrén M,Ung KA,Walters J

    更新日期:2017-04-01 00:00:00

  • Underwater endoscopic colorectal polyp resection: Feasibility in everyday clinical practice.

    abstract:Background:Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of singl...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Cadoni S,Liggi M,Gallittu P,Mura D,Fuccio L,Koo M,Ishaq S

    更新日期:2018-04-01 00:00:00

  • Italian consensus conference for colonic diverticulosis and diverticular disease.

    abstract::The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. Topics such as epidemiology, risk factors, diagnosis, medical and surgical treatment of diverticular disease (DD) in patients wit...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Cuomo R,Barbara G,Pace F,Annese V,Bassotti G,Binda GA,Casetti T,Colecchia A,Festi D,Fiocca R,Laghi A,Maconi G,Nascimbeni R,Scarpignato C,Villanacci V,Annibale B

    更新日期:2014-10-01 00:00:00

  • A combined bile and urine proteomic test for cholangiocarcinoma diagnosis in patients with biliary strictures of unknown origin.

    abstract:BACKGROUND:Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC). We recently established diagnostic peptide marker models in bile and urine to detect CC. Our aim was to combine both models to reach a higher diagnostic accuracy of CC diagn...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Voigtländer T,Metzger J,Schönemeier B,Jäger M,Mischak H,Manns MP,Lankisch TO

    更新日期:2017-08-01 00:00:00

  • Deprescribing medications that may increase the risk of hepatic encephalopathy: A qualitative study of patients with cirrhosis and their doctors.

    abstract:BACKGROUND AND AIMS:Multiple medications are associated with an increased risk of incident hepatic encephalopathy. Despite this known risk, medications such as opioids, benzodiazepines, gabapentin/pregabalin, and/or proton pump inhibitors are increasingly prescribed to persons with cirrhosis. Deprescribing is a promisi...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Williams S,Louissaint J,Nikirk S,Bajaj JS,Tapper EB

    更新日期:2020-11-23 00:00:00

  • Risk and outcomes of coronavirus disease (COVID-19) in patients with inflammatory bowel disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:The risk of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection and clinical outcomes of coronavirus disease (COVID-19) in inflammatory bowel disease are unclear. METHODS:We searched PubMed and Embase with the keywords: inflammatory bowel disease, Crohn's disease, ulcerative colit...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Singh AK,Jena A,Kumar-M P,Sharma V,Sebastian S

    更新日期:2020-11-19 00:00:00

  • Terlipressin and albumin combination treatment in patients with hepatorenal syndrome type 2.

    abstract:Background:Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effect...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Nguyen-Tat M,Jäger J,Rey JW,Nagel M,Labenz C,Wörns MA,Galle PR,Marquardt JU

    更新日期:2019-05-01 00:00:00

  • Efficacy and safety of infliximab in very early onset inflammatory bowel disease: a national comparative retrospective study.

    abstract:Background:Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported. Objective:We aimed to assess the efficacy and the safety of infliximab in children with VEO-IBD compared with older children. Methods:Children treated with infliximab wer...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章


    authors: Bramuzzo M,Arrigo S,Romano C,Filardi MC,Lionetti P,Agrusti A,Dipasquale V,Paci M,Zuin G,Aloi M,Strisciuglio C,Miele E,Pastore M,Martelossi S,Alvisi P,SIGENP IBD Working Group.

    更新日期:2019-07-01 00:00:00

  • Effect of prophylactic clipping in colorectal endoscopic resection: A meta-analysis of randomized controlled studies.

    abstract:BACKGROUND AND AIM:The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS:We searched PubMed, the Cochrane library, and the Igaku-chuo-z...

    journal_title:United European gastroenterology journal

    pub_type: 杂志文章,评审


    authors: Nishizawa T,Suzuki H,Goto O,Ogata H,Kanai T,Yahagi N

    更新日期:2017-10-01 00:00:00